公开(公告)号：WO1995016475A1

公开(公告)日：1995-06-22

申请号：PCT/US1994014650

申请日：1994-12-14

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  HOFFMAN, Allan, S. ,  PATEL, Anilbhai, S. ,  LLANOS, Gerard

IPC: A61L27/00

CPC classification number: A61F2/16 ,  A61L27/16 ,  A61L27/34 ,  A61L2430/16 ,  C08L71/02 ,  C08L33/14 ,  C08L33/08

Abstract: An intraocular lens having improved biocompatibility is coated with polyethylene oxide through covalent bonding, preferably using a plasma-deposited amine layer. The lens is then sterilized with ethylene oxide and extracted with water.

Abstract translation: 具有改善的生物相容性的眼内透镜通过共价键，优选使用等离子体沉积的胺层涂覆聚环氧乙烷。 然后将镜片用环氧乙烷灭菌并用水萃取。

公开(公告)号：WO1995008266A1

公开(公告)日：1995-03-30

申请号：PCT/US1994010695

申请日：1994-09-21

Applicant: ALCON LABORATORIES, INC. ,  DASSANAYAKE, Nissanke, L. ,  SCHLITZER, Ronald, L. ,  PARK, Joonsup

Inventor： ALCON LABORATORIES, INC.

IPC: A01N37/20

CPC classification number: A01N37/20 ,  A61L12/12 ,  Y10S514/84

Abstract: The use of certain amidoamines to disinfect contact lenses and preserve ophthalmic compositions is described. Ophthalmic compositions containing these compounds as disinfecting agents or preservatives are also described. The amidoamines utilized in the present invention have potent antibacterial and antifungal activity, and are chemically compatible with inorganic ions and other materials utilized in ophthalmic compositions.

Abstract translation: 描述了使用某些酰氨基胺消毒隐形眼镜并保护眼用组合物。 还描述了含有这些化合物作为消毒剂或防腐剂的眼科组合物。 本发明中使用的酰氨基胺具有有效的抗细菌和抗真菌活性，并且与眼用组合物中所用的无机离子和其它材料化学相容。

公开(公告)号：WO1995006099A1

公开(公告)日：1995-03-02

申请号：PCT/US1994009521

申请日：1994-08-24

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  CHOWHAN, Masood ,  BILBAULT, Thierry ,  QUINTANA, Ronald, P.

IPC: C11D03/00

CPC classification number: C11D7/34 ,  A61L12/08 ,  A61L12/143 ,  A61L12/145 ,  C11D3/0078 ,  C11D3/2082 ,  C11D3/2086 ,  C11D3/378 ,  C11D3/48 ,  C11D7/16 ,  C11D7/265 ,  C11D7/3245 ,  C11D7/3272

Abstract: An improved process for cleaning and disinfecting contact lenses with a single solution is described. The process utilizes the cleaning effect of a cleaning agent in combination with the solvent action of water and physical agitation of the lens (i.e., by means of rubbing) to achieve a degree of cleaning which is comparable to or better than prior processes which utilize surfactant-cleaners. The cleaning agent is selected from polycarboxylates, polysulfonates and polyphosphates. The preferred cleaning agent is citrate. The process also offers greater convenience, relative to many prior systems for cleaning and disinfecting contact lenses, since the need to utilize additional products to clean the lenses is eliminated.

Abstract translation: 描述了用单一溶液清洁和消毒隐形眼镜的改进方法。 该方法利用清洁剂的清洁效果与水的溶剂作用和晶状体的物理搅拌（即，通过摩擦）相结合以达到与使用表面活性剂的先前方法相当或优于先前方法的清洁度 -cleaners。 清洁剂选自聚羧酸盐，聚磺酸盐和多磷酸盐。 优选的清洁剂是柠檬酸盐。 相对于许多用于清洁和消毒隐形眼镜的现有系统，该方法也提供了更大的便利性，因为消除了需要利用额外的产品来清洁镜片。

公开(公告)号：WO1994008585A1

公开(公告)日：1994-04-28

申请号：PCT/US1993009742

申请日：1993-10-12

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  DESANTIS, Louis, Jr. ,  SALLEE, Verney, L.

IPC: A61K31/557

CPC classification number: A61K31/557 ,  Y10S514/913 ,  A61K31/415 ,  A61K2300/00

Abstract: Combinations of at least one clonidine derivative and at least one prostaglandin are used to treat glaucoma and ocular hypertension without some of the side effects typically associated with topical administration of prostaglandins.

Abstract translation: 使用至少一种可乐定衍生物和至少一种前列腺素的组合来治疗青光眼和高眼压症，而没有通常与局部施用前列腺素相关的一些副作用。

公开(公告)号：WO1993016701A2

公开(公告)日：1993-09-02

申请号：PCT/US1993001487

申请日：1993-02-19

Applicant: ALCON LABORATORIES, INC. ,  DEAN, Thomas, Robert ,  DESANTIS, Louis, Jr.

Inventor： ALCON LABORATORIES, INC.

IPC: A61K31/54

CPC classification number: A61K31/38 ,  A61K31/425 ,  A61K31/54 ,  A61K31/135 ,  A61K2300/00

Abstract: Ophthalmic pharmaceutical compositions useful in controlling elevated intraocular pressure associated with glaucoma and ocular hypertension are described. The compositions comprise a combination of a beta-blocker and a carbonic anhydrase inhibitor to reduce the production of aqueous humor, preferably formulated as a suspension having a pH between about 6.8 and about 7.8. These compositions may additionally contain a mucomimetic anionic polymer and/or a finely-divided drug carrier substrate to provide sustained release. A method of controlling elevated intraocular pressure with these compositions is also described.

Abstract translation: 描述了可用于控制与青光眼和高眼压相关的升高的眼内压的眼用药物组合物。 组合物包含β-阻断剂和碳酸酐酶抑制剂的组合以减少房水的产生，优选配制为pH在约6.8至约7.8之间的悬浮液。 这些组合物可另外含有模拟阴离子聚合物和/或细碎药物载体底物以提供持续释放。 还描述了使用这些组合物来控制眼内压升高的方法。

公开(公告)号：WO1990011781A1

公开(公告)日：1990-10-18

申请号：PCT/US1990001664

申请日：1990-04-03

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  SHAW, Jack, Michael ,  CORDOVA, Diana, Maria

IPC: A61K43/00

CPC classification number: A61K9/0048 ,  A61K9/127

Abstract: Methods for delivering therapeutic agents to wounds in liposomes which preferentially bind to the wounds are disclosed. Methods for delivering therapeutic agents in liposomes to wounds on the ocular surface of the eye are included.

Abstract translation: 公开了将治疗剂递送至优先结合伤口的脂质体中的伤口的方法。 包括将脂质体中的治疗剂递送到眼睛的眼表面上的伤口的方法。

公开(公告)号：WO1984004680A1

公开(公告)日：1984-12-06

申请号：PCT/US1983000840

申请日：1983-05-25

Applicant: ALCON LABORATORIES, INC. ,  GRESSEL, Philip, D. ,  ROEHRS, Robert, E.

Inventor： ALCON LABORATORIES, INC.

IPC: A61K31/74

CPC classification number: A61K31/78 ,  A61K9/0048

Abstract: Ophthalmic gel composition of unique rheological and lubricating properties comprising, inter alia, a polyanionic polymer for use as a long lasting artificial tear. Also disclosed is a method of treatment comprising totally administering the composition when indicated for relief of dry eye syndrome, foreign body sensation, burning, hyperemia, corneal staining, and the like.

Abstract translation: 独特的流变学和润滑性能的眼用凝胶组合物，尤其包括用作持久人造泪液的聚阴离子聚合物。 还公开了一种治疗方法，包括当指定用于缓解干眼综合征，异物感觉，烧灼，充血，角膜染色等时全面施用组合物。

公开(公告)号：WO1983003543A1

公开(公告)日：1983-10-27

申请号：PCT/US1983000546

申请日：1983-04-11

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  YORK, Jr., Billie, Murray

IPC: A61K31/415

CPC classification number: C07D235/02

Abstract: Accumulation of polyols in diabetic subjects causes and/or is associated with diabetic complications. Aldose reductase inhibition prevents the production of polyols. Aldose reductase activity is inhibited with tetracyclic spiro-hydantoins, which makes these compounds useful in the treatment of complications arising from diabetes mellitus. A process for preparing said tetracyclic spiro-hydantoins by reacting a mono- or di-fluorofluorene with an excess of oxygen and a tetralkyl- or arylalkyl-trialkyl-ammonium hydroxides followed by cyclization of the reaction product with ammonium carbonate and potassium cyanide at elevated temperature is also disclosed.

Abstract translation: 糖尿病患者多元醇的积累导致和/或与糖尿病并发症有关。 醛糖还原酶抑制可防止多元醇的生产。 醛糖还原酶活性被四环螺 - 乙内酰脲抑制，这使得这些化合物可用于治疗由糖尿病引起的并发症。 通过使单 - 或二 - 氟芴与过量的氧和四烷基 - 或芳烷基 - 三烷基 - 氢氧化铵反应来制备所述四环螺 - 乙内酰脲的方法，然后在高温下将反应产物与碳酸铵和氰化钾环化 也被披露。

公开(公告)号：WO1998026739A1

公开(公告)日：1998-06-25

申请号：PCT/US1997015942

申请日：1997-09-09

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  BOUKHNY, Mikhail

IPC: A61F09/00

CPC classification number: A61F9/00745 ,  A61B2017/00017 ,  A61B2017/00725 ,  B06B1/0276 ,  B06B2201/40 ,  B06B2201/76

Abstract: A system and method for tuning and controlling ultrasonic handpieces by incorporating a broad-spectrum signal as at least a component of the signal used to drive the handpiece. The response of the handpiece to this broad-spectrum signal is measured and the frequency or amplitude or both of the drive signal are adjusted in order to maintain the desired level of handpiece performance. The operation of the systems and the performance of the methods described enable the handpiece to be operated in a most effective manner over a more widely varying range of mechanical load and thermal conditions than was possible through the use of prior control systems and methods.

Abstract translation: 一种用于通过将广谱信号作为至少用于驱动手持件的信号的分量的组合来调谐和控制超声波手机的系统和方法。 测量手持件对该广谱信号的响应，调节驱动信号的频率或振幅或两者以保持手机性能的期望水平。 系统的操作和所描述的方法的性能使得能够在比通过使用现有控制系统和方法可能的机械负载和热条件更广泛变化的范围内以最有效的方式操作手机。

公开(公告)号：WO1998025548A1

公开(公告)日：1998-06-18

申请号：PCT/US1997021236

申请日：1997-11-18

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  BROWN, Kyle ,  VAN NOY, Stephen, J. ,  WOO, Yi-Ren

IPC: A61F02/16

CPC classification number: A61F2/1664 ,  Y10S623/907

Abstract: A single piece intraocular lens folder that has a generally planar, open frame in the shape of a rounded "A" with a rimmed, open head at the top of the "A". The base of the "A" forms a pair of opposing legs or handles that join to form a hinge at the intersection where the handles attach to the head. The hinge allows the handle to be squeezed together and spring apart when released. Squeezing the handles together causes the sides of the head to spread apart, thereby stretching the top edge of the head rim and pulling the top edge downward toward the hinge. The open head contains a pair of support jaws and a pair of serpentine folding jaws. The location of the serpentine jaws is such that when the top edge of the head rim moves toward the hinge, the serpentine jaws are squeezed together, causing the IOL to be folded in half. The serpentine shape of the folding jaws allow the haptics to pivot downward, thereby permitting the IOL to be folded along a plurality of axes.

Abstract translation: 单片式眼内透镜夹具，其具有大致平坦的开放框架，其形状为圆形“A”，在“A”的顶部具有边缘的开放头部。 “A”的底部形成一对相对的腿部或手柄，它们在手柄附接到头部的交点处连接以形成铰链。 铰链允许将手柄挤压在一起，释放时弹开。 将手柄压在一起使头部的两侧分开，从而拉伸头部边缘的顶部边缘并将顶部边缘向下拉向铰链。 敞开的头部包含一对支撑爪和一对蛇形折叠夹。 蛇形爪的位置使得当头部边缘的顶部边缘朝向铰链移动时，蛇形钳口被挤压在一起，使IOL折叠成一半。 折叠爪的蛇形形状允许触觉件向下枢转，从而允许IOL沿着多个轴线折叠。