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公开(公告)号：NO20014875A
公开(公告)日：2001-11-13
申请号：NO20014875
申请日：2001-10-08
Applicant: BASF AG
Inventor： BAUCKE DORIT , MACK HELMUT , SEITZ WERNER , HORNBERGER WILFRIED , BACKFISH GISELA , DELZER JUERGEN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P7/02 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07B43/00 , C07K5/02 , C07K5/062 , C07K5/065 , A61K38/05
CPC classification number: C07K5/06078 , A61K38/00 , C07B43/00 , C07K5/0222
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公开(公告)号：CA2379977A1
公开(公告)日：2001-02-15
申请号：CA2379977
申请日：2000-08-01
Applicant: BASF AG
Inventor： HORNBERGER WILFRIED , LANGE UDO , GENESTE HERVE , KLING ANDREAS , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , GRAEF CLAUDIA ISABELLA , LAUTERBACH ARNULF , LAUX VOLKER , SADOWSKI JENS
IPC: A61K31/4402 , A61K31/55 , A61K31/5513 , A61P3/14 , A61P5/18 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D213/74 , C07D223/20 , C07D243/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , C07D221/00 , C07D223/00 , C07D233/00 , C07D333/00 , C07D491/04 , C07D213/73
Abstract: The invention relates to novel compounds of formula (I) which bind to integr in receptors, wherein G and L have the following meaning: L is a structural element of formula IL, wherein T represents a COOH group or a radical that c an be hydrolyzed to obtain COOH and U- represents (XL)a-(CRL1RL2)b-, -CRL1=CRL2 -, ethylene or =CRL1-, wherein a is 0 or 1; b is 0, 1 or 2; XL represents CRL3RL4, NRL5, oxygen or sulfur and G is a structural element of formula IG, wherein the insertion of structural element G can occur in both orientations and XO represents nitrogen or CRG1. The invention also relates to the production of said compounds and to their use as medicaments.
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公开(公告)号：ES2151741T3
公开(公告)日：2001-01-01
申请号：ES97934552
申请日：1997-07-29
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K31/40 , A61K31/44 , A61K38/00 , A61K38/05 , A61P1/18 , A61P7/02 , A61P11/02 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P43/00 , C07D207/22 , C07D211/78 , C07K5/00 , C07K5/02 , C07K5/083
Abstract: Compounds of the formula Iwhere R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.
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公开(公告)号：AU3559000A
公开(公告)日：2000-11-14
申请号：AU3559000
申请日：2000-04-05
Applicant: BASF AG
Inventor： ZIERKE THOMAS , MACK HELMUT
IPC: A61K38/00 , C07B43/00 , C07D333/38 , C07K5/065
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公开(公告)号：CA2369267A1
公开(公告)日：2000-10-19
申请号：CA2369267
申请日：2000-04-05
Applicant: BASF AG
Inventor： ZIERKE THOMAS , MACK HELMUT
IPC: A61K38/00 , C07B43/00 , C07D333/38 , C07K5/065
Abstract: The invention relates to a method for producing amidines that are not substituted on the nitrogen atom and salts thereof with inorganic or organic acids. According to said method, the corresponding carboxylic acid amidoxime s are reacted with Zn in the presence of carboxylic acids.
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Patent Agency Ranking
公开(公告)号：CZ20002463A3
公开(公告)日：2000-10-11
申请号：CZ20002463
申请日：1999-01-23
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , SEITZ WERNER , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
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公开(公告)号：NO20003814D0
公开(公告)日：2000-07-25
申请号：NO20003814
申请日：2000-07-25
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , SEITZ WERNER , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K38/00 , A61P1/18 , A61P7/02 , A61P11/06 , A61P17/04 , A61P19/02 , A61P27/16 , A61P29/00 , C07K5/06 , C07K5/065 , C07K5/08 , A61K38/06
Abstract: Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.
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公开(公告)号：ES2143666T3
公开(公告)日：2000-05-16
申请号：ES95941015
申请日：1995-11-25
Applicant: BASF AG
Inventor： BOHM HANS JOACHIM , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , HOFFKEN HANS WOLFGANG
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公开(公告)号：AU717692B2
公开(公告)日：2000-03-30
申请号：AU3771597
申请日：1997-07-29
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS , HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K31/40 , A61K31/44 , A61K38/00 , A61K38/05 , A61P1/18 , A61P7/02 , A61P11/02 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P43/00 , C07D207/22 , C07D211/78 , C07K5/00 , C07K5/02 , C07K5/083
Abstract: Compounds of the formula Iwhere R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.
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公开(公告)号：NZ302649A
公开(公告)日：2000-01-28
申请号：NZ30264996
申请日：1996-02-12
Applicant: BASF AG
Inventor： BOHM HANS-JOACHIM , HOFFKEN HAN WOLFGANG , HORNBERGER WILFRIED , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K31/00 , A61K38/55 , A61P7/02 , C07D205/04 , C07D207/16 , C07D213/53 , C07D213/63 , C07D213/72 , C07D213/78 , C07D213/79 , C07D239/28 , C07D241/14 , C07D241/24 , C07D401/12 , C07K5/06 , C07K5/062 , C07K5/078 , A61K31/40 , A61K31/445 , A61K31/495
Abstract: he present invention relates to carbo- and heterocyclic amidines, the preparation thereof and the use as thrombin inhibitors of the formula 1 Where D is formula 1a R2 is H, C1-4 alkyl, phenyl and phenyl C1-4 alkyl, R18O-CH2, R18CO- R18-O-CH2-CO-, R18O-CO-CO-, R18-NH-CO-CO, where R18 is H or C1-4-alkyl, CF3-CO- or C2F5-Co- A is formula IIa, IIb or Iic B is selected from IIIa-IIIg The other substituents are defined in the specification.
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