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公开(公告)号:HU0203340A2
公开(公告)日:2003-01-28
申请号:HU0203340
申请日:2000-06-23
Applicant: BASF AG
Inventor: HABERHAUER GREGOR , KIM HYUNG-JOON , KROEGER BURKHARD , LEE HEUNG-SHICK , POMPEJUS MARKUS , SCHROEDER HARTWIG , ZELDER OSKAR
IPC: G01N33/53 , C07K20060101 , C07K14/34 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/18 , C12N15/09 , C12N15/31 , C12P20060101 , C12P1/04 , C12P13/04 , C12P21/02 , C12Q20060101 , C12Q1/04 , C12Q1/68 , C12R1/13 , C12R1/15 , C12R1/16 , G01N33/569 , G01N37/00 , C12N15/00
Abstract: Isolated nucleic acid molecules, designated SRT nucleic acid molecules, which encode novel SRT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SRT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SRT proteins, mutated SRT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SRT genes in this organism.
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公开(公告)号:ES2178979T1
公开(公告)日:2003-01-16
申请号:ES00940687
申请日:2000-06-23
Applicant: BASF AG
Inventor: POMPEJUS MARKUS , KROEGER BURKHARD , SCHROEDER HARTWIG , ZELDER OSKAR , HABERHAUER GREGOR
IPC: G01N33/53 , C07K20060101 , C07K14/34 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/12 , C12N9/18 , C12N9/88 , C12N15/09 , C12N15/31 , C12N15/55 , C12P20060101 , C12P13/04 , C12P13/08 , C12P21/02 , C12Q20060101 , C12Q1/68 , C12R1/15 , G01N33/566 , G01N33/569
Abstract: Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.
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103.
公开(公告)号:SK18912001A3
公开(公告)日:2002-10-08
申请号:SK18912001
申请日:2000-06-23
Applicant: BASF AG
Inventor: POMPEJUS MARKUS , KROEGER BURKHARD , SCHROEDER HARTWIG , ZELDER OSKAR , HABERHAUER GREGOR
IPC: G01N33/53 , C07K20060101 , C07K14/34 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/18 , C12N15/09 , C12N15/31 , C12N15/52 , C12P20060101 , C12P1/04 , C12P13/04 , C12P21/02 , C12Q20060101 , C12Q1/04 , C12Q1/68 , C12R1/13 , C12R1/15 , C12R1/16 , G01N33/569
Abstract: Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.
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公开(公告)号:BR0012038A
公开(公告)日:2002-07-02
申请号:BR0012038
申请日:2000-06-27
Applicant: BASF AG
Inventor: POMPEJUS MARKUS , KROEGER BURKHARD , SCHROEDER HARTWIG , ZELDER OSKAR , HABERHAUER GREGOR
IPC: G01N33/53 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/10 , C12N9/12 , C12N15/09 , C12N15/31 , C12N15/54 , C12P1/04 , C12P13/04 , C12Q1/04 , C12Q1/68 , C12R1/13 , C12R1/16 , G01N33/566 , G01N33/569 , C12N15/77
Abstract: Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. Glutamicum based on genetic engineering of PTS genes in this organism.
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105.
公开(公告)号:CA2594201A1
公开(公告)日:2001-01-04
申请号:CA2594201
申请日:2000-06-23
Applicant: BASF AG
Inventor: KROEGER BURKHARD , SCHROEDER HARTWIG , ZELDER OSKAR , HABERHAUER GREGOR , POMPEJUS MARKUS
IPC: C12N15/53 , C07K14/34 , C07K19/00 , C12N1/21 , C12N9/02 , C12N15/31 , C12N15/63 , C12P1/04 , C12P13/04 , C12P21/02 , C12Q1/68
Abstract: Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SMP proteins, mutated SMP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SMP genes in this organism.
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公开(公告)号:BRPI0613660A2
公开(公告)日:2012-11-06
申请号:BRPI0613660
申请日:2006-07-18
Applicant: BASF AG
Inventor: HEROLD ANDREA , KLOPPROGGE CORINNA , YOCUM R ROGERS , ZELDER OSKAR , SCHROEDER HARTWIG , WILLIAMS MARK K
Abstract: The present invention pertains to improved microorganisms and methods for the production of methionine and other sulfur containing fine chemicals using the metI gene from Bacillus subtilis or a gene related to metI. In some embodiments of the present invention, the metI gene or another gene is integrated in a fashion that allows for co-production of a water soluble compound such as methionine or other amino acid and a caortenoid compound.
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公开(公告)号:ZA200605863B
公开(公告)日:2008-01-30
申请号:ZA200605863
申请日:2006-07-17
Applicant: BASF AG
Inventor: KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
IPC: C07K14/34 , C12N20090101 , C12N1/00 , C12N15/63 , C12N15/67 , C12N15/77 , C12P20090101 , C12P1/00 , C12P13/08 , C12P13/12
Abstract: Use, for transcribing genes, of a nucleic acid (I) with promoter activity, where (I) is a 186 base pair sequence (1), reproduced; a variant of (1) with at least 90% identity and derived by substitution, insertion or deletion of nucleotides; a sequence that hybridizes to (1) under stringent conditions; or a functionally equivalent fragment of them, is new. Independent claims are also included for the following: (1) use of an expression unit (EU), containing (I) and functionally linked to a sequence (X) that ensures translation of RNA, for expressing genes; (2) (I), other than sequence (1), i.e. (Ia), as new compounds; (3) EU that contain (Ia) linked to (X); (4) altering (or producing) the transcription rate of genes in a microorganism, relative to the wild type; (5) expression cassette (EC) comprising at least one EU of (1), at least one other nucleic acid sequence (to be expressed) and optionally additional gene control elements, where at least the first two are linked and the sequence being expressed is heterologous with respect to EU; (6) expression vector (EV) that contains EC; (7) genetically modified microorganisms (GMO) having, for at least one gene, an altered (or induced) transcription rate, relative to the wild type; (8) preparing biosynthetic products by culturing GMO of (7); (9) use of the sequence aggagga (42) as a ribosome-binding site in expression units that provide expression of genes in Corynebacterium or Brevibacterium; (10) use of the sequences tagttt (39), taggat (40) or tgcgct (41) as -10 regions for expression of genes in Corynebacterium or Brevibacterium; and (11) expression units that contain sequences (39)-(42).
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公开(公告)号:DK0977867T3
公开(公告)日:2007-06-18
申请号:DK98940118
申请日:1998-07-02
Applicant: BASF AG
Inventor: SCHROEDER HARTWIG , HAUER BERNHARD
IPC: C12N15/09 , C12N15/54 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/12 , C12N15/52 , C12P17/18
Abstract: A gene construct comprising a biotin gene having the sequence SEQ ID No. 1 or SEQ ID No. 3, organisms which comprise this gene construct, the use of these sequences or of the gene construct for preparing biotin, and a process for preparing biotin are described.
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公开(公告)号:BRPI0417728A
公开(公告)日:2007-04-03
申请号:BRPI0417728
申请日:2004-12-16
Applicant: BASF AG
Inventor: KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGER CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
Abstract: Use of a nucleic acid (I) with promoter activity for transcribing genes, where (I) is (a) a 173 nucleotide sequence (SEQ ID No.:1); (b) a variant of (SEQ ID No.:1) with at least 90% identity and derived by substitution, insertion or deletion of nucleotides; (c) a sequence that hybridizes to (SEQ ID No.:1) under stringent conditions; or (d) a functionally equivalent fragment of (a)-(c), is new. Independent claims are also included for: (1) use of an expression unit (EU), containing (I) and functionally linked to a sequence (X) that ensures translation of RNA, for expressing genes; (2) (I), other than sequence (SEQ ID No.:1), i.e. (Ia), as new compounds; (3) EU that contain (Ia) linked to (X); (4) altering (or producing) the transcription rate of genes in a microorganism, relative to the wild type; (5) expression cassette (EC) comprising at least one EU of (SEQ ID No.:1), at least one other nucleic acid sequence (to be expressed) and optionally additional gene control elements, where at least the first two are linked and the sequence being expressed is heterologous with respect to EU; (6) expression vector (EV) that contains EC; (7) genetically modified microorganisms (GMO) having, for at least one gene, an altered (or induced) transcription rate, relative to the wild type; (8) preparing biosynthetic products by culturing GMO of (7); (9) use of the sequence gaaagga (SEQ ID No.:44) as a ribosome-binding site in expression units that provide expression of genes in Corynebacterium or Brevibacterium; (10) use of the sequences tgcaat (SEQ ID No.:42) and tatcatt (SEQ ID No.:43) as -10 regionS for expression of genes in Corynebacterium or Brevibacterium; and (11) expression units that contain sequences (SEQ ID No.:42) - (SEQ ID No.:44).
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公开(公告)号:TR200700067T2
公开(公告)日:2007-03-21
申请号:TR200700067
申请日:2000-06-27
Applicant: BASF AG
Inventor: POMPEJUS MARKUS , KROEGER BURKHARD , HARBERHAUER GREGOR , ZELDER OSKAR , SCHROEDER HARTWIG
IPC: C12N15/00 , G01N33/53 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/10 , C12N9/12 , C12N15/09 , C12N15/31 , C12N15/54 , C12P1/04 , C12P13/04 , C12P21/00 , C12Q1/04 , C12Q1/68 , C12R1/13 , C12R1/15 , C12R1/16 , G01N33/566 , G01N33/569 , C12N15/55
Abstract: Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. Glutamicum based on genetic engineering of PTS genes in this organism.
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