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    MICROORGANISMS AND PROCESSES FOR ENHANCED PRODUCTION OF PANTOTHENATE
    3.
    发明申请
    MICROORGANISMS AND PROCESSES FOR ENHANCED PRODUCTION OF PANTOTHENATE 审中-公开
    增强生物活性的微生物和方法

    公开(公告)号：WO2004005525A3

    公开(公告)日：2006-02-02

    申请号：PCT/US0321305

    申请日：2003-07-03

    Applicant: BASF AG ,  YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

    Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

    IPC: C12N1/21 ,  C12P13/02 ,  C12P1/00 ,  C07H21/04 ,  C12N9/00 ,  C12N9/10 ,  C12P19/02

    CPC classification number: C12N15/52 ,  C12P13/02

    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

    Abstract translation: 本发明的特征在于利用具有改良的泛酸生物合成酶活性并具有改性的亚甲基四氢叶酸（MTF）生物合成酶活性的微生物增强生产泛酸盐和泛酸盐的改进方法。 特别地，本发明的特征在于通过增加对其合成直接或间接有贡献的酶或底物来增加关键中间体酮托品酸的水平来增加所需产物的产生的方法。 还具有重组微生物和培养条件。 还有这些微生物产生的组合物。

    USE OF DIMETHYL DISULFIDE FOR METHIONINE PRODUCTION IN MICROORGANISMS
    4.
    发明申请
    USE OF DIMETHYL DISULFIDE FOR METHIONINE PRODUCTION IN MICROORGANISMS 审中-公开
    二甲基磺脲在微生物中的生产中的应用

    公开(公告)号：WO2007011939A3

    公开(公告)日：2007-07-05

    申请号：PCT/US2006027855

    申请日：2006-07-18

    Applicant: BASF AG ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  HEROLD ANDREA ,  KLOPPROGGE CORINNA ,  SCHRODER HARTWIG ,  YOCUM R ROGERS ,  WILLIAMS MARK K

    Inventor： ZELDER OSKAR ,  HAEFNER STEFAN ,  HEROLD ANDREA ,  KLOPPROGGE CORINNA ,  SCHRODER HARTWIG ,  YOCUM R ROGERS ,  WILLIAMS MARK K

    IPC: C12P13/12

    CPC classification number: C12P13/12

    Abstract: The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ?metF organism or a ?metE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/Met? and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ?metF ?metB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.

    Abstract translation: 本发明的特征在于用于生产甲硫氨酸的改进方法和生物体。 本发明证明，metF生物体或αmetE AmetH生物体，例如谷氨酸棒状杆菌或大肠杆菌的突变体可以使用甲基封端的硫化物源，例如二甲基二硫（DMDS）作为硫的来源 和甲基，绕过MetH / Met？ 和MetF活性以及减少硫酸盐的需要，用于合成甲硫氨酸。 该专利中还描述了涉及MetY（也称为MetZ）的数据，其作为将甲基封端的硫化物源（例如DMDS）并入甲硫氨酸中的酶。 谷氨酸棒状芽孢杆菌的ΔFIFFmetB菌株可以使用甲基封端的硫化物源，例如DMDS，作为硫化物和甲基两者的来源。 此外，通过加入甲基封端的硫化物源（例如DMDS），改善过度产生O-乙酰高丝氨酸的工程化原养殖生物体的甲硫氨酸生产。

    5.
    发明专利
    未知

    公开(公告)号：AT347589T

    公开(公告)日：2006-12-15

    申请号：AT02709018

    申请日：2002-01-18

    Applicant: BASF AG

    Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

    IPC: C12N15/09 ,  C12N1/21 ,  C12N9/00 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125 ,  C12N15/03 ,  C07C235/12

    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

    MICROORGANISMS AND PROCESSES FOR ENHANCED PRODUCTION OF PANTOTHENATE
    8.
    发明专利
    MICROORGANISMS AND PROCESSES FOR ENHANCED PRODUCTION OF PANTOTHENATE 未知

    公开(公告)号：CA2491145A1

    公开(公告)日：2004-01-15

    申请号：CA2491145

    申请日：2003-07-03

    Applicant: BASF AG

    Inventor： HERMANN THERON ,  PERO JANICE G ,  YOCUM R ROGERS ,  PATTERSON THOMAS A

    IPC: C12N1/21 ,  C12P13/02

    Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particula r, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

    USE OF DIMETHYL DISULFIDE FOR METHIONINE PRODUCTION IN MICROORGANISMS
    10.
    发明专利
    USE OF DIMETHYL DISULFIDE FOR METHIONINE PRODUCTION IN MICROORGANISMS 未知

    公开(公告)号：CA2615315A1

    公开(公告)日：2007-01-25

    申请号：CA2615315

    申请日：2006-07-18

    Applicant: BASF AG

    Inventor： YOCUM R ROGERS ,  SCHRODER HARTWIG ,  KLOPPROGGE CORINNA ,  HAEFNER STEFAN ,  HEROLD ANDREA ,  WILLIAMS MARK K ,  ZELDER OSKAR

    IPC: C12P13/12

    Abstract: The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a &Dgr;metF organism or a &Dgr;metE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/MetE and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A &Dgr;metF &Dgr;metB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.

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