公开(公告)号：JPH09110901A

公开(公告)日：1997-04-28

申请号：JP1184596

申请日：1996-01-26

Applicant: KAO CORP

Inventor： KAMIYA HIROSHI ,  KITA KATSUMI ,  YONEDA OSATOSHI ,  ABE AKIHITO

IPC: A61K8/72 ,  A61K8/00 ,  A61K8/02 ,  A61K8/73 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/12 ,  A61Q19/00 ,  C08B11/193 ,  C08B37/00 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain a new polysaccharide deriv. which is formed by substituting hydrogen atoms of at least two hydroxyl groups of a polysaccharide with alkyl, alkenylated glyceryl ether, and carboxymethyl groups in a specified ratio and which has thickening and gelling properties suitable for cosmetics, etc. SOLUTION: This deriv. is polysaccharide deriv. or its salt formed by substituting hydrogen atoms of at least two hydroxyl groups of a polysaccharide with 8-40C alkyl, alkenylated gryceryl ether, and carboxymethyl groups, the degree of substitution per monosaccharide unit with the alkyl and alkenylated glyceryl ether groups being 0.01-1.0 and that with carboxymethyl group being 0.01-2.0. Examples of the polysaccharide are cellulose, guar gum, starch, and their derivs., an esp. pref. one being methyl cellulose having a mo.wt. of 400,000-5,000,000. This deriv. is obtd. by reacting a polysaccharide with an alkyl or alkenyl glycidyl ether to make it hydrophobic and carboxymethylating the resulting product with a monohalogenacetic acid. A water soln. of the deriv. is clear, has a high thickening properties at a low concn., has a viscosity stable to temp. change, and is suitable for a thickening agent, gelling agent, or excipient for cosmetics.

公开(公告)号：JPH0967289A

公开(公告)日：1997-03-11

申请号：JP22016595

申请日：1995-08-29

Applicant: KAO CORP

Inventor： FUJII YASUYUKI ,  FURUGAKI HISAKAZU ,  KITA KATSUMI

IPC: B01J23/44 ,  C07B61/00 ,  C07C41/06 ,  C07C43/04

Abstract: PROBLEM TO BE SOLVED: To simply and inexpensively obtain an ether compound available for solvents, cosmetics, cleaning agent compositions, lubricating agents, emulsifiers, etc., in wide range. SOLUTION: (A) A hydroxy compound [e.g. a compound of the formula R -(OA)n -OH (R is a 1-40C alkyl or alkenyl; A is a 2-12C alkylene; (n) is 0-30)] is reacted with (B) a carbonyl compound excluding carbonyl compounds of formula I [R is methyl; R is formula II, CH3 or CH3 CH2 or R and R together form a (substituted)5-7C cycloalkyl] in a hydrogen atmosphere using a catalyst (e.g. Pa-C) having pH1-8 (the pH is of an aqueous solution obtained when 2g catalyst power is dispersed into 30g ion exchange water). N-Butyltetradecyl ether is exemplified as the ether compound.

公开(公告)号：JPH0920789A

公开(公告)日：1997-01-21

申请号：JP16854795

申请日：1995-07-04

Applicant: KAO CORP

Inventor： MIZOOKU TAKASHI ,  YANO SHINJI ,  KITA KATSUMI

IPC: C07F9/11

Abstract: PROBLEM TO BE SOLVED: To efficiently obtain the subject compound useful for antistatic agents, lubricants, fiber-oiling agents, cosmetics, external medicines, etc., in a high purity and in a high yield by reacting a specific alcohol or alcoholate with an alkyl-phosphoric acid halide. SOLUTION: An alcohol or alcolate of formula I [R is a 1-36C alkyl, an alkenyl; A is a 2-3C alkylene; (d) is a number of 0-20 which exhibits the average addition mole number of an alkylene oxide; M is H, an alkali (alkaline earth) metal] is reacted with an alkyl-phosphoric acid halide of formula II [R is a 1-36C alkyl, an alkenyl; A is a 2-3C alkylene; (a) is the number of 0-20 which exhibits the average addition number of an alkylene oxide; X is R (OA )b O (R is a 1-36C alkyl, an alkenyl; A is a 2-3C alkylene; (b) is the number of 0-20 which exhibits the average addition number of an alkylene oxide); Y is a halogen] to obtain the objective asymmetric phosphoric acid triester of formula III [Z is R (OA )b O-].

公开(公告)号：JPH08301828A

公开(公告)日：1996-11-19

申请号：JP11033595

申请日：1995-05-09

Applicant: KAO CORP

Inventor： MIYAJIMA TETSUYA ,  KITSUKI TOMOHITO ,  KITA KATSUMI

IPC: A61K8/00 ,  A61K8/40 ,  A61K8/42 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/10 ,  C07C231/04 ,  C07C233/36 ,  C07C233/38 ,  C07C235/10 ,  C07C235/28 ,  A61K7/075 ,  A61K7/50

Abstract: PURPOSE: To produce a new di-chain type amide compound, useful as various detergents, etc., low irritant to the skin and excellent in foaming properties. CONSTITUTION: This compound is represented by formula I [two groups R are each independently a straight-chain or a branched chain 1-24C alkyl, etc.; six groups R are each independently a straight-chain or branched chain 1-4C alkyl, etc.; X is a halogen; (m) and (n) are each an integer of 1-6], e.g. 4,8-bis(1- oxododenyl)-1,11-di(trimethlamium)-6-hydroxy-4,8-diazaundecane chloride. The compound of formula I is obtained by reacting a tetraazaalkane derivative of formula II with one or two acyl compounds of formula III (Y is hydroxyl, etc.), providing an amide compound of formula IV (e.g. 2,14-dimethyl-8- hydroxy-2,6,10,14-tetraazapentadecane) which is an intermediate and further reacting the resultant compound with one or two alkyl halides of formula V.

公开(公告)号：JPH08109263A

公开(公告)日：1996-04-30

申请号：JP24587094

申请日：1994-10-12

Applicant: KAO CORP

Inventor： IHARA TAKESHI ,  YANO SHINJI ,  KITA KATSUMI

IPC: A61K8/72 ,  A61K8/00 ,  A61K8/02 ,  A61K8/89 ,  A61Q1/00 ,  A61Q1/12 ,  A61Q17/00 ,  A61Q19/10 ,  C08G77/22 ,  C08G77/38 ,  C08G77/398 ,  C08L83/08 ,  A61K7/00 ,  A61K7/40 ,  A61K7/50

Abstract: PURPOSE: To obtain an organopolysiloxane which has a polyvalent metal carboxylate group and forms a gell which is highly safe and transparent, provides a good feeling in use, and has no spinnability. CONSTITUTION: The organo(poly)siloxane has at least one silicon atom which is modified with a polyvalent metal carboxylate group represented by the formula: -R -(OR2 )p -(O)w -R -COO-.(M )1/n (wherein R is 2-22C linear or branched alkylene; R is 2-4C linear or branched alkylene; R is a direct bond or 1-22C linear or branched alkylene; M is a divalent or higher metal; p is 0-200; w is 0 or 1; and n is the valency of M).

公开(公告)号：JPH0892262A

公开(公告)日：1996-04-09

申请号：JP7755695

申请日：1995-04-03

Applicant: KAO CORP

Inventor： IHARA TAKESHI ,  YANO SHINJI ,  KITA KATSUMI

IPC: C07F9/09 ,  C07F9/11 ,  C07F9/113 ,  C07F9/12

Abstract: PURPOSE: To obtain a phosphoric ester useful for detergents, emulsifying agents, antistatic agents, etc., in high yield by reacting a phosphorus oxyhalide with an organic hydroxy compound in the coexistence of a specific metallic salt and completely trapping hydrogen chloride gas formed as a by-product. CONSTITUTION: This method for producing a phosphoric ester is to react a phosphorus oxyhalide such as phosphorus oxychloride with an organic hydroxy compound such as methyl alcohol in the presence of one or more metallic salts of an acid such as a 1-5C (OH-substituted) organic monocarboxylic acid or boric acid having -5 to +13pKa. Furthermore, the metallic salts of the acid having -5 to +13pKa are preferably used in an amount of 0.8-4mol based on 1mol phosphorus oxyhalide.

公开(公告)号：JPH0859549A

公开(公告)日：1996-03-05

申请号：JP14725895

申请日：1995-06-14

Applicant: KAO CORP

Inventor： HASHIZUME NAOMICHI ,  KAMIYA HIROSHI ,  KITA KATSUMI

IPC: C07H13/06 ,  A61K8/30 ,  A61K8/37 ,  A61K8/55 ,  A61K8/58 ,  C07C69/12 ,  C07C69/18 ,  C07C69/21 ,  C07C69/22 ,  C07C69/30 ,  C07C69/33 ,  A61K7/00

Abstract: PURPOSE: To obtain a new etherified polyhydric alcohol fatty acid ester useful as a base for cosmetics, an emulsifier, a lubricating agent, a lubricant, an intermediate, etc., for producing etherified polyhydric alcohols. CONSTITUTION: A compound of formula I [G is a residue obtained by removing H of all hydroxyl groups in polyhydric alcohol having >=3 hydroxyl groups; A is formula II or III (R is R' or CH2 OR'; R' is a 1-36C alkyl or an alkenyl); B is H or a 1-11C acyl; the sum of x and y is number of hydroxyl of polyhydric alcohol in G and x and y are each >=1], e.g. pentaerythritolmonoisostearyl glyceryl ether monoacetate. Furthermore, the compound of formula I is obtained by reacting a polyhydric alcohol fatty acid ester of the formula G(B)z [z is number of hydroxyl of polyhydric alcohol] with an epoxy compound of formula IV.

公开(公告)号：JPH0827084A

公开(公告)日：1996-01-30

申请号：JP15755394

申请日：1994-07-08

Applicant: KAO CORP

Inventor： UNO MITSURU ,  KITSUKI TOMOHITO ,  KITA KATSUMI

IPC: C07C231/02 ,  A61K8/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/10 ,  C07C233/35 ,  C07C235/10 ,  C07C309/14 ,  C07C309/17 ,  C11D3/32 ,  C11D3/34

Abstract: PURPOSE:To obtain the new amide compound little in the irritation of skin, excellent in foamability, washability and touch, and useful as a washing agent, an emulsifier, a wetting agent, a conditioning agent, a base material for hair and skin cosmetics, etc. CONSTITUTION:This compound is expressed by formula I [R , R are (OH- substituted) 1-24C (branched)alkyl, (OH-substituted) 1-24C (branched)alkenyl; X is 1-6C (branched)alkylene (substituted with an OH, a carboxyl group, etc.), 1-6C (branched)alkylene (substituted with an OH, a carboxyl group, etc.), 1-6C alkenylene (substituted with an OH, a carboxyl group, etc.,); Y is carboxyl, sulfonic acid group, etc.; Y is OH, sulfonic acid residue, etc.; Z is sulfoalkyl, amino acid (salt) from which an NH2 is removed], for example, 6,10- dihydroxy-4,12-dioctyl-3,13-dioxo-8-sulfoethyl-4,8,12-triaza-1,15- pentadecanedicarboxylic acid. The example compound is obtained by reacting 11,15-dihydroxy-13-sulfoethyl-9,13,17-triazapentacosane of formula II with succinic anhydride.

公开(公告)号：JPH07173027A

公开(公告)日：1995-07-11

申请号：JP31826393

申请日：1993-12-17

Applicant: KAO CORP

Inventor： KAMIYA HIROSHI ,  KITA KATSUMI ,  FUJIKURA YOSHIAKI

IPC: A61K8/72 ,  A61K8/00 ,  A61K8/73 ,  A61Q17/04 ,  C08B37/00 ,  C09K3/00 ,  A61K7/00 ,  A61K7/42

Abstract: PURPOSE:To obtain a polysaccharide cinnamic acid derivative having ultraviolet ray absorbing action and high safety, and excellent in compatibility with an oil agent for cosmetics. CONSTITUTION:This polysaccharide cinnamic acid derivative is obtained by replacing a part or all of hydroxyl groups in polysacharride molecule with a cinnamic acid ester group of formula I (X is an alkoxy; (a) is 1-3) and a fatty acid ester group of formula II (R is a 5-21C straight-chain or a branched alkyl or alkenyl). The compound is obtained by esterification reaction of the polysaccharide with a cinnamic chloride of formula III and a fatty acid chloride of formula IV. In the derivative, average degree of substitution of the group of formula I per monosaccharide unit in polysaccharide molecule is preferably 0.1-2.9 and average degree of substitution of the group of formula II is preferably 0.1-2.9 and degree of total substitution of both is preferably 0.2-3.0. As the polysaccharide, beta-1,4-glucan, alpha-1,4-glucan, alpha-1,6-glucan or their hydroxyethyl derivatives, hydroxypropyl derivatives or 2,3-dihydroxypropyl derivatives are exemplified.

公开(公告)号：JPH0753431A

公开(公告)日：1995-02-28

申请号：JP20770593

申请日：1993-08-23

Applicant: KAO CORP

Inventor： HASHIZUME NAOMICHI ,  KAMIYA HIROSHI ,  KITA KATSUMI ,  FUJIKURA YOSHIAKI

IPC: B01J31/02 ,  C07B61/00 ,  C07C41/03 ,  C07C43/13 ,  C07C43/178

Abstract: PURPOSE:To readily produce an alpha-monoalkyl glyceryl ether useful as an emulsifying agent, etc., in high yield and purity by carrying out the hydrolytic reaction of a glycidyl ether in the presence of a tertiary amine. CONSTITUTION:This method for producing a glyceryl ether expressed by formula II (R is a 1-32C saturated or unsaturated straight-chain or a branched chain alkyl) is to hydrolyze a glycidyl ether expressed by formula I in the presence of a tertiary amine. A compound expressed by formula III [R to R are 1-10C alkyls; (n) is 2-5; (m) is 0-3] (e.g. tetramethyl-1,3-diaminopropane) is especially cited as the tertiary amine. The compound expressed by formula II has excellent performances as a W/O type emulsifying agent and is capable of manifesting pharmacological actions such as hematopoietic promoting effects, antiinflammatory actions and antitumor activities and further utilizable as an antimicrobial and an antifungal agents, etc.