公开(公告)号：DE10004661B4

公开(公告)日：2008-10-16

申请号：DE10004661

申请日：2000-02-03

Applicant: LEICA MICROSYSTEMS

Inventor： ENGELHARDT JOHANN

IPC: G02B7/00 ,  F16M11/06 ,  F16M11/20 ,  G02B6/36

公开(公告)号：DE50307823D1

公开(公告)日：2007-09-13

申请号：DE50307823

申请日：2003-06-13

Applicant: LEICA MICROSYSTEMS

Inventor： ENGELHARDT JOHANN

IPC: G02B27/12 ,  G02B21/00 ,  G02B26/08

Abstract: An optical device for combining a first light beam and at least one second light beam includes a first beam splitting device, a second beam splitting device and a position detector. The first beam splitting device splits a first reference beam from the first light beam and a second reference beam from the second light beam. The second beam splitting device splits a third reference beam from the first light beam and a fourth reference beam from the second light beam. The position detector detects respective positions of the reference beams so as to enable a respective propagation direction and/or a respective position of the first and/or second light beams to be adjusted as a function of the detected positions of the reference beams.

公开(公告)号：DE10024132B4

公开(公告)日：2007-03-22

申请号：DE10024132

申请日：2000-05-18

Applicant: LEICA MICROSYSTEMS

Inventor： ENGELHARDT JOHANN

IPC: G01N21/64 ,  C12M1/00 ,  C12N15/09 ,  G01N21/03 ,  G01N33/53 ,  G01N37/00

Abstract: The arrangement has at least one light source for simultaneous illumination of specimen points (2) with stimulation light and a detection arrangement with detection elements (3) for simultaneous detection of the fluorescent light from the individual specimen points. The distance (d) between the specimen points and the associated detection elements is chosen to be as small as possible.

公开(公告)号：DE10122607B4

公开(公告)日：2006-11-30

申请号：DE10122607

申请日：2001-05-10

Applicant: LEICA MICROSYSTEMS

Inventor： ENGELHARDT JOHANN

IPC: G01J1/42 ,  G02B21/00 ,  G02B27/46

公开(公告)号：DE19924709B4

公开(公告)日：2005-01-20

申请号：DE19924709

申请日：1999-05-28

Applicant: LEICA MICROSYSTEMS

Inventor： ENGELHARDT JOHANN ,  KIERSCHKE KLAUS

IPC: G02B7/16 ,  G02B21/24 ,  G02B21/26 ,  G12B5/00

公开(公告)号：AU2003246422A1

公开(公告)日：2004-02-09

申请号：AU2003246422

申请日：2003-06-13

Applicant: LEICA MICROSYSTEMS

Inventor： ENGELHARDT JOHANN

IPC: G02B21/00 ,  G02B26/08 ,  G02B27/12

Abstract: An optical device for combining a first light beam and at least one second light beam includes a first beam splitting device, a second beam splitting device and a position detector. The first beam splitting device splits a first reference beam from the first light beam and a second reference beam from the second light beam. The second beam splitting device splits a third reference beam from the first light beam and a fourth reference beam from the second light beam. The position detector detects respective positions of the reference beams so as to enable a respective propagation direction and/or a respective position of the first and/or second light beams to be adjusted as a function of the detected positions of the reference beams.

公开(公告)号：DE10120425C2

公开(公告)日：2003-12-18

申请号：DE10120425

申请日：2001-04-26

Applicant: LEICA MICROSYSTEMS

Inventor： ENGELHARDT JOHANN ,  HOFFMANN JUERGEN

IPC: G01J3/36 ,  G01N21/64 ,  G02B21/00 ,  G02B21/06

Abstract: A method for examining a specimen ( 27 ) that exhibits at least two optical transition lines and is optically excitable at least with light of a first and light of a second wavelength is characterized by the step of illuminating the specimen ( 27 ) with illuminating light ( 15 ) that generates at least a multiple of the first wavelength and a multiple of the second wavelength; and by the step of detecting the detected light ( 29 ) proceeding from the specimen ( 27 ). Also disclosed is a scanning microscope system ( 1 ) having at least one light source ( 3 ) that emits illuminating light ( 15 ) for illumination of a specimen ( 27 ), the specimen ( 27 ) exhibiting at least two optical transition lines and being optically excitable at least with light of a first and light of a second wavelength, having at least one detector ( 41, 43, 65, 77, 79 ) for detection of the detected light ( 29 ) proceeding from the specimen ( 27 ) and an objective ( 25 ) for focusing the illuminating light ( 15 ) onto a subregion of the specimen ( 27 ). The scanning microscope system is characterized in that the illuminating light ( 15 ) generates at least a multiple of the first wavelength and a multiple of the second wavelength.

公开(公告)号：DE19944148C2

公开(公告)日：2003-08-21

申请号：DE19944148

申请日：1999-09-15

Applicant: LEICA MICROSYSTEMS

Inventor： ENGELHARDT JOHANN ,  ULRICH HEINRICH ,  HAY WILIAM C

IPC: G01N21/63 ,  G02B21/00

Abstract: The microscope has an illumination beam path between a laser light source (1,2) and an object (3), and a detection beam path (7) between the object and a detector (6). At least one reference beam path (9) is provided for reference measurements. Reference light is coupled from the illumination beam path into the reference beam path. The reference light is qualitatively and/or quantitively detected by the detector (6). A scattering optical component (11) and/or a beam deflector (25) may be arranged in the reference beam path. An Independent claim is included for a method of reference correction in a laser scanning microscope.

公开(公告)号：DE10159239A1

公开(公告)日：2003-06-26

申请号：DE10159239

申请日：2001-12-03

Applicant: LEICA MICROSYSTEMS

Inventor： ENGELHARDT JOHANN ,  STORZ RAFAEL

IPC: G02B7/04 ,  G02B21/00 ,  G02B21/02 ,  G02B21/24

Abstract: The microscope objective (1) has several lenses (7,9,11,13) together displaceable within an objective housing. A drive unit (17) displaces the lenses in the objective housing. Independent claims are included for the following: (a) the microscope; and (b) the imaging of a specimen using microscope objective.

公开(公告)号：DE59709530D1

公开(公告)日：2003-04-24

申请号：DE59709530

申请日：1997-12-20

Applicant: LEICA MICROSYSTEMS

Inventor： ENGELHARDT JOHANN ,  HOPPE MARTIN

IPC: G02B21/00 ,  G02B21/36 ,  H04N5/225 ,  H04N9/04

Abstract: A TV camera for microscopic or macroscopic imaging is characterized by a confocal lens with a laser light source (1), a scanner (2), a detector (3) and an electronic control unit (4), for using confocal characteristics in the most compact possible format.