公开(公告)号：WO2007005077A1

公开(公告)日：2007-01-11

申请号：PCT/US2006/010819

申请日：2006-03-24

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： BEDINGHAM, William D., ,  LUDOWISE, Peter D., ,  ROBOLE, Barry W.,

IPC: B01L7/00

CPC classification number: G01N21/645 ,  B01L3/5027 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/147 ,  B01L2300/0806 ,  B01L2300/1805 ,  B01L2300/1844 ,  B01L2300/1872 ,  G01N21/07 ,  G01N21/6428 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/04 ,  G01N2201/0407 ,  G01N2201/08 ,  G01N2201/10 ,  G01N2201/101

Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. The device further includes a heating element for heating one or more process chambers on the disk. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.

Abstract translation: 描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。 例如，系统包括数据采集装置和耦合到数据采集装置的检测装置。 检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。 该装置还包括多个可移除的光学模块，其被光学配置为激发物种并捕获由不同波长的物质发射的荧光。 耦合到多个可移除光学模块的光纤束将来自光学模块的荧光传送到单个检测器。 该装置还包括用于加热盘上的一个或多个处理室的加热元件。 此外，该装置可以通过利用激光加热阀来定位和选择性地打开阀分离腔来控制盘中的流体流动。

公开(公告)号：WO1991012515A1

公开(公告)日：1991-08-22

申请号：PCT/US1991001035

申请日：1991-02-15

Applicant: EQM RESEARCH, INC.

Inventor： EQM RESEARCH, INC. ,  MAGNOTTI, Ralph, A. ,  EBERLY, Patrick, J.

IPC: G01N21/01

CPC classification number: G01N21/253 ,  G01N21/255 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/0621

Abstract: An optoelectronic device (4) for measuring the absorbance of a plurality of samples using a corresponding plurality of light-emitting diode and photodiode pairs is provided. A kit (3) and a process for using modified chemical reactions in 'ELISA' assays adapted for use with the above optoelectronic device is also provided.

公开(公告)号：WO1990007107A1

公开(公告)日：1990-06-28

申请号：PCT/DK1989000300

申请日：1989-12-21

Applicant: RADIOMETER A/S ,  LUNDSGAARD, Finn, Chresten ,  ANDERSEN, Willy ,  JENSEN, Niels-Henrik

Inventor： RADIOMETER A/S

IPC: G01N21/64

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: The method according to the invention is a method of photometric in vitro determination of the content of oxygen in a blood sample. The blood sample is transferred directly from an in vivo locality to an at least partially transparent sample container of a sampling device. The sample container has a measuring chamber wherein a luminophor is provided, whereof the luminescence is quenched in the presence of oxygen. The oxygen content is determined on the basis of the radiation detected by the radiation detector. A sampling device and a system for photometric in vitro determination of oxygen in a blood sample is also described.

Abstract translation: 根据本发明的方法是一种光度测定血样中氧含量的方法。 血液样品直接从体内局部转移到采样装置的至少部分透明的样品容器。 样品容器具有测量室，其中提供发光体，在氧的存在下发光被淬灭。 基于由辐射检测器检测的辐射来确定氧含量。 还描述了用于血液样品中氧的光度测定的取样装置和系统。

公开(公告)号：WO1990007106A1

公开(公告)日：1990-06-28

申请号：PCT/DK1989000302

申请日：1989-12-21

Applicant: RADIOMETER A/S ,  LUNDSGAARD, Finn, Chresten ,  ANDERSEN, Willy ,  JENSEN, Niels-Henrik

Inventor： RADIOMETER A/S

IPC: G01N21/11

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: The method is a method of photometric in vitro determination of a blood gas parameter in a blood sample. The blood sample is transferred directly from an in vivo locality to an at least partially transparent sample container, whereafter the connection between the sample containing sample container and the blood circulation is broken. Subsequently the sample container with its content of blood sample is brought into optical communication with an optical system comprising a radiation source and a radiation detector interacting therewith, preferably by placing the sample container in a sample container system in an analyzer. The blood gas parameter is determined on the basis of the radiation detected by the radiation detector. A system for photometric in vitro determination of a blood gas parameter in a blood sample is also described.

公开(公告)号：EP1991860A4

公开(公告)日：2011-08-03

申请号：EP07717653

申请日：2007-02-23

Applicant: GEN ELECTRIC

Inventor： FOMITCHOV PAVEL A ,  BARASH EUGENE ,  YEKTA AHMAD ,  MASINO JOSEPH

IPC: G01N23/00 ,  G02B21/00

CPC classification number: G01N21/6458 ,  G01N21/47 ,  G01N2201/0407 ,  G01N2201/1042 ,  G02B21/0048 ,  G02B21/0076 ,  G02B21/367

公开(公告)号：EP0565700B1

公开(公告)日：1996-08-21

申请号：EP92923464.9

申请日：1992-10-27

Applicant: Dade MicroScan Inc.

Inventor： GARAND, Steven, A. ,  DANIEL, Carl, P.

IPC: H02P8/00

CPC classification number: G01N35/1002 ,  G01N35/025 ,  G01N35/028 ,  G01N2021/1759 ,  G01N2035/00079 ,  G01N2035/00455 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0463 ,  G01N2035/0475 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/08 ,  G01N2201/1283

Abstract: An improved control system for a stepper motor coil (190) includes a flyback circuit (192) that dissipates coil energy slowly while the coil is energized and operated in the chopping mode, while dissipating coil energy rapidly when the coil is switched to its de-energized phase.

公开(公告)号：EP0449900B1

公开(公告)日：1996-04-10

申请号：EP90900766.8

申请日：1989-12-21

Applicant: RADIOMETER MEDICAL A/S

Inventor： LUNDSGAARD, Finn, Chresten ,  ANDERSEN, Willy ,  JENSEN, Niels-Henrik

IPC: G01N21/11 ,  G01N33/49

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: The method is a method of photometric in vitro determination of a blood gas parameter in a blood sample. The blood sample is transferred directly from an in vivo locality to an at least partially transparent sample container, whereafter the connection between the sample containing sample container and the blood circulation is broken. Subsequently the sample container with its content of blood sample is brought into optical communication with an optical system comprising a radiation source and a radiation detector interacting therewith, preferably by placing the sample container in a sample container system in an analyzer. The blood gas parameter is determined on the basis of the radiation detected by the radiation detector. A system for photometric in vitro determination of a blood gas parameter in a blood sample is also described.

公开(公告)号：EP0449899B1

公开(公告)日：1994-09-28

申请号：EP90900765.0

申请日：1989-12-21

Applicant: RADIOMETER MEDICAL A/S

Inventor： LUNDSGAARD, Finn, Chresten ,  ANDERSEN, Willy ,  JENSEN, Niels-Henrik

IPC: G01N21/64 ,  G01N33/48

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: The method according to the invention is a method of photometric in vitro determination of the content of oxygen in a blood sample. The blood sample is transferred directly from an in vivo locality to an at least partially transparent sample container of a sampling device. The sample container has a measuring chamber wherein a luminophor is provided, whereof the luminescence is quenched in the presence of oxygen. The oxygen content is determined on the basis of the radiation detected by the radiation detector. A sampling device and a system for photometric in vitro determination of oxygen in a blood sample is also described.

公开(公告)号：EP0449900A1

公开(公告)日：1991-10-09

申请号：EP90900766.0

申请日：1989-12-21

Applicant: RADIOMETER A/S

Inventor： LUNDSGAARD, Finn, Chresten ,  ANDERSEN, Willy ,  JENSEN, Niels-Henrik

IPC: G01N33 ,  G01N21 ,  G01N35

CPC classification number: G01N21/03 ,  G01N21/05 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/80 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: On fait passer l'échantillon de sang directement d'un emplacement in vivo à un récipient d'échantillon au moins partiellement transparent, puis on coupe la communication entre le récipient d'échantillon contenant l'échantillon et l'appareil circulatoire. On met ensuite le récipient d'échantillon contenant l'échantillon de sang en communication optique avec un système optique, qui comprend une source de radiation coopérant avec un détecteur de radiation, de préférence en plaçant le récipient d'échantillon dans un système de récipient d'échantillon à l'intérieur d'un analyseur. On détermine le paramètre gazeux du sang sur la base de la radiation détectée par le détecteur de radiation. Est également décrit un système pour déterminer par photométrie in vitro un paramètre gazeux dans un échantillon de sang.

公开(公告)号：EP0387343A1

公开(公告)日：1990-09-19

申请号：EP89910843.0

申请日：1989-09-23

Applicant: DYNATECH AG

Inventor： NITTEL, Alfred

IPC: G01N21

CPC classification number: G01N21/253 ,  G01N2201/0407 ,  G01N2201/0446

Abstract: Un appareil de lecture pour plaques de microtest (1) comprend un dispositif de transport de la plaque de microtest (1). Un groupe d'évidements (2a-2h) de la plaque de microtest (1) est traversé par des faisceaux de lumière (100) qui sont émis par une unité d'éclairage (6) et qui sont captés par une unité de détection (7) après avoir traversé les évidements (2a-2h) de la plaque de microtest (1). Une impulsion générée dans un détecteur (9) de l'unité de détection (7) est transmise à une unité de commande et d'évaluation (45) puis affichée. L'unité de lecture formée par l'unité d'éclairage (6) et par l'unité de détection (7) est inclinée par rapport au sens de déplacement (150) de la plaque de microtest (1).