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    MULTI-TRACK RAMAN WELL PLATE READER
    102.
    发明公开
    MULTI-TRACK RAMAN WELL PLATE READER 审中-公开

    公开(公告)号：US20230204515A1

    公开(公告)日：2023-06-29

    申请号：US18087341

    申请日：2022-12-22

    Applicant: HORIBA INSTRUMENTS INCORPORATED

    Inventor： Nicolas VEZARD ,  Beth FINAMORE ,  Aashish TULADHAR

    IPC: G01N21/65 ,  G01N21/64

    CPC classification number: G01N21/65 ,  G01N21/6428 ,  G01N2201/06113 ,  G01N2201/0633 ,  G01N2201/0636 ,  G01N2201/08 ,  G01N2201/0635 ,  G01N2201/127

    Abstract: A microplate reader simultaneously obtains Raman measurements from samples contained in non-adjacent wells. At least two Raman probes are positioned perpendicularly above or below the microplate to simultaneously acquire Raman spectra data of the non-adjacent liquid samples. Each probe is coupled to a laser and a spectrometer and includes a lens focusing laser light within the sample and collecting light from the sample for the spectrometer. The spectrometer may include a 2D imaging sensor (sCMOS or CCD) to image light from multiple probes simultaneously, spaced from one another to reduce crosstalk. A positioner moves the microplate plate or probes to acquire data from a different subset of non-adjacent samples, and may also vary laser focus within wells during data acquisition. Multiple fluorescence probes may simultaneously acquire fluorescence data from the same samples, or non-adjacent samples. Probes may be fiber-coupled and positioned within a reaction chamber of a liquid handling system.

    Multichannel angular spectrometer
    103.
    发明授权
    Multichannel angular spectrometer 有权

    公开(公告)号：US11656172B1

    公开(公告)日：2023-05-23

    申请号：US17335921

    申请日：2021-06-01

    Applicant: Photonics Automation Specialties LLC

    Inventor： Gerard Knight-Rubino ,  Xiyao Zhang

    IPC: G01N21/31

    CPC classification number: G01N21/31 ,  G01N2201/0635 ,  G01N2201/0638 ,  G01N2201/08

    Abstract: A multichannel angular spectrometer includes an array of fiber pickups having an arcuate arrangement and focused about a sample volume. A broadband light source is configured to illuminate a sample within the sample volume. At least one dispersion element is in optical communication with the array of fiber pickups. An imaging sensor is in optical communication with the array of fiber pickups. The imaging sensor is configured to image the broadband light received by the array of fiber pickups and dispersed by the at least one dispersion element. A processor is in electrical communication with the imaging sensor. The processor has a power supply and computer-readable memory.

    MEASUREMENT METHOD, AND MEASURING CHIP AND MEASURING KIT USED FOR THE SAME
    104.
    发明申请
    MEASUREMENT METHOD, AND MEASURING CHIP AND MEASURING KIT USED FOR THE SAME 审中-公开

    公开(公告)号：US20180180545A1

    公开(公告)日：2018-06-28

    申请号：US15739435

    申请日：2016-06-10

    Applicant: KONICA MINOLTA, INC.

    Inventor： SHINICHI MURAMATSU ,  KEIZOU TAKANO

    IPC: G01N21/64 ,  G01N21/552 ,  G01N33/553

    CPC classification number: G01N21/6428 ,  G01N21/554 ,  G01N21/64 ,  G01N21/645 ,  G01N33/543 ,  G01N33/553 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2201/0635 ,  G01N2333/8139

    Abstract: Provided is a measurement method with which an analyte in a sample containing a high concentration of the analyte can be measured with high accuracy without diluting the sample in multiple stages. An embodiment of the present invention relates to a measurement method for measuring an amount of an analyte in a sample, the method including: a binding step of providing the sample to a containing part of a measuring chip including the containing part for containing liquid, and a first capture body immobilized inside the containing part and having a recognition site that specifically binds to the analyte so as to bind the analyte contained in the sample to the first capture body; and a measurement step of measuring an amount of the analyte bound to the first capture body. The measurement method includes an adjustment step in which a second capture body having a recognition site that specifically binds to the analyte is bound to a part of the analyte in the sample in parallel with the binding step or before the binding step so as to reduce the amount of the analyte capable of binding to the first capture body.

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