SULFUR (VI) FLUORIDE COMPOUNDS AND THEIR USE AS SCREENING AGENT

    公开(公告)号:EP3892610A1

    公开(公告)日:2021-10-13

    申请号:EP21159735.6

    申请日:2015-06-05

    Abstract: This application describes a compound represented by Formula (III):

    wherein: A is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X 1 is a covalent bond or -CH 2 CH 2 -, and R comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group.
    Methods of using the compounds as screening agent to identify drug targets, and pharmaceutical compositions comprising the compounds are described as well.

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