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    GENERATION OF OLIGODENDROGENIC NEURAL PROGENITOR CELLS
    111.
    发明专利
    GENERATION OF OLIGODENDROGENIC NEURAL PROGENITOR CELLS 未知

    公开(公告)号：CA3071893A1

    公开(公告)日：2019-02-07

    申请号：CA3071893

    申请日：2018-07-30

    Applicant: UNIV HEALTH NETWORK

    Inventor： KHAZAEI MOHAMAD ,  FEHLINGS MICHAEL G

    IPC: C12N5/0797 ,  A61K35/30 ,  A61P25/28 ,  A61P35/00

    Abstract: Provided herein are methods of producing, compositions comprising and uses of oligodendrogenic neural progenitor cells (o-NPCs), made using a combination of PDGFR agonist and thyroxin or a thyroxin analogue. The method includes; obtaining ventralized neural progenitor cells (NPCs), the ventralized NPCs expressing Sox2, Nkx6-1, decreased level of Pax6 compared to unpatterned NPCs, and elevated expression of HoxA4 compared to unpatterned NPCs; culturing the ventralized NPCs for about 12 to about 16 days (days 26-40 of Fig. 7; days 12 to 27 of Fig. 10) in neural expansion media (NEM) supplemented with i) PDGFR agonist for the about 12 to about 16 days and ii) thyroxine or a thyroxine analogue for the latter about 7 to about 9 days, to produce o-NPC expressing Sox2 and Nkx2.2, decresed level of Pax6 and Nkx6.1 compared to ventralized NPCs and elevated level of HoxA4 and Olig2 compared to ventralized NPCs.

    Salt and crystal forms of PLK-4 inhibitor
    113.
    发明专利
    Salt and crystal forms of PLK-4 inhibitor 未知

    公开(公告)号：AU2014336929B2

    公开(公告)日：2018-11-22

    申请号：AU2014336929

    申请日：2014-10-17

    Applicant: UNIV HEALTH NETWORK

    Inventor： SAMPSON PETER BRENT ,  FEHER MIKLOS ,  PAULS HEINZ W

    IPC: C07D413/14 ,  A61K31/5377 ,  A61P35/00

    Abstract: A fumarate salt and a maleate salt of compound (I) represented by the following structural formula, as well as their corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1 compound (I) fumarate and 1:1 compound (I) maleate are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms of 1:1 compound (I) fumarate and 1:1 compound (I) maleate are also disclosed. The present invention also provides methods of treating a subject with a cancer. Compound (I)

    BIODEGRADABLE SOFT TISSUE FILLER
    119.
    发明专利
    BIODEGRADABLE SOFT TISSUE FILLER 未知

    公开(公告)号：CA2979429C

    公开(公告)日：2018-08-21

    申请号：CA2979429

    申请日：2017-02-16

    Applicant: GOVERNING COUNCIL UNIV TORONTO ,  UNIV HEALTH NETWORK

    Inventor： LEONG LIANG WEY ,  SANTERRE PAUL ,  SHARIFPOOR SOROR

    IPC: A61L27/18 ,  A61L27/56

    Abstract: A soft tissue filler comprising a biodegradable amino-acid derived polycarbonate-urethanes and methods of repairing soft tissue defects are provided. The biodegradable soft tissue filler comprises a porous scaffold that is the reaction product of: a) a divinyl oligomer component that comprises a carbonate-derived divinyl oligomer that is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and a polycarbonate and, optionally, an ether-derived divinyl oligomer, wherein the ether-derived divinyl oligomer is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and an ether; b) at least one anionic monomer; and c) at least one hydrophobic monomer. The molar ratio of (a) : (b+c) is between about 1>=21 and about 1:30, the soft tissue filler has a porosity of > 75 %; and a compressive moduli of between about 1 kPa and about 50 kPa.

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