公开(公告)号：WO2004002627A3

公开(公告)日：2004-01-08

申请号：PCT/US2003/020542

申请日：2003-06-03

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  STONE, Howard, A. ,  ANNA, Shelly, L. ,  BONTOUX, Nathalie ,  LINK, Darren Roy ,  WEITZ, David, A. ,  GITLIN, Irina ,  GARSTECKI, Piotr ,  DILUZIO, Willow ,  WHITESIDES, George, M. ,  KUMACHEVA, Eugenia

Inventor： STONE, Howard, A. ,  ANNA, Shelly, L. ,  BONTOUX, Nathalie ,  LINK, Darren Roy ,  WEITZ, David, A. ,  GITLIN, Irina ,  GARSTECKI, Piotr ,  DILUZIO, Willow ,  WHITESIDES, George, M. ,  KUMACHEVA, Eugenia

IPC: B01L3/00

Abstract: A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.

公开(公告)号：WO2003087590A3

公开(公告)日：2003-10-23

申请号：PCT/US2003/011078

申请日：2003-04-10

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  JACOBS, Heiko, O. ,  TAO, Andrea, R. ,  SCHWARTZ, Alexander ,  GRACIAS, David, H. ,  WHITESIDES, George, M.

Inventor： JACOBS, Heiko, O. ,  TAO, Andrea, R. ,  SCHWARTZ, Alexander ,  GRACIAS, David, H. ,  WHITESIDES, George, M.

IPC: H01L21/469

Abstract: The present invention is directed to self-assembly of structures, and, in particular, to self-assembly by action of a liquid patterned onto a substrate. In one embodiment, the present invention is directed to method of self-assembling a plurality of structures. The method includes patterning a first liquid onto a first substrate, and, while at least a portion of the first liquid remains in liquid form, self-assembling at least a portion of the plurality of structures onto the substrate by action of the first liquid and according to the pattern of the first liquid. In another embodiment, the present invention is directed to a display. The display includes a first substrate and a first plurality of electrical connectors being in electrical connection with one another. The display further includes a second substrate, at least some of the second plurality of electrical connectors being in electrical connection with one another. The display further includes a plurality of display elements each electrically connected to at least one of the first plurality of electrical connectors and the second plurality of connectors. In this embodiment, each of the plurality of display elements has an average diameter of less than 1 millimeter.

公开(公告)号：WO03011443A3

公开(公告)日：2003-07-03

申请号：PCT/US0223462

申请日：2002-07-24

Applicant: HARVARD COLLEGE ,  STROOCK ABRAHAM D ,  DERTINGER STEPHAN K W ,  AJDARI ARMAND ,  MEZIC IGOR ,  STONE HOWARD A ,  WHITESIDES GEORGE M

Inventor： STROOCK ABRAHAM D ,  DERTINGER STEPHAN K W ,  AJDARI ARMAND ,  MEZIC IGOR ,  STONE HOWARD A ,  WHITESIDES GEORGE M

IPC: B01F5/00 ,  B01F5/06 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  B81C1/00 ,  G01N27/447

CPC classification number: B01F5/061 ,  B01F5/0646 ,  B01F13/0059 ,  B01F2005/0028 ,  B01F2005/0621 ,  B01F2005/0636 ,  B01F2215/0422 ,  B01F2215/0431 ,  B01J2219/00889 ,  Y10T137/2224 ,  Y10T436/255

Abstract: A mixing apparatus is used to effect mixing between one or more fluid streams. The mixing apparatus generally functions by creating a transverse flow component in the fluid flowing within a channel without the use of moving mixing elements. The transverse or helical flow component of the flowing fluid or fluids can be created by weak modulations of the shape of the walls of the channel. Transverse or helical flow component can be created by grooves features defined on the channel wall. Specifically, the present invention can be used in laminarly flowing fluids. The mixing apparatus and methods thereof can effect mixing of a fluid or fluids flowing with a Reynolds number of less than about 100. Thus, the present invention can be used to mix a fluid flowing in the micro-regime. The mixing apparatus can be used to mix a fluid in a microfluidic system to significantly reduce the Taylor dispersion along the principal direction. The mixing apparatus can be used to increase the effective exposed area to promote diffusion of components between or within the fluid or fluids.

Abstract translation: 使用混合装置来实现一个或多个流体流之间的混合。 混合装置通常通过在不使用移动的混合元件的情况下在通道内流动的流体中产生横向流动分量来起作用。 流动流体或流体的横向或螺旋流动分量可以通过通道壁的形状的弱调制而产生。 横向或螺旋流分量可以通过在通道壁上定义的凹槽特征来创建。 具体而言，本发明可用于层流流体。 该混合装置及其方法可以实现以小于约100的雷诺数流动的一种或多种流体的混合。因此，本发明可以用于混合在微观状态下流动的流体。 混合装置可以用来在微流体系统中混合流体以显着减少沿主方向的泰勒色散。 混合装置可以用来增加有效暴露面积以促进流体之间或流体内部的组分的扩散。

公开(公告)号：WO0203142A9

公开(公告)日：2003-01-30

申请号：PCT/US0121151

申请日：2001-07-02

Applicant: HARVARD COLLEGE ,  JACOBS HEIKO O ,  WHITESIDES GEORGE M

Inventor： JACOBS HEIKO O ,  WHITESIDES GEORGE M

IPC: G03F7/00 ,  G03G5/02 ,  G03F7/20

CPC classification number: G03G5/02 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  G03F7/0002

Abstract: A method and apparatus for providing electric microcontact printing is provided. A stamp is brought into contact with the surface of a substrate to provide high resolution features. Aspects of the invention may be used for data storage, microcontact printing, and for other applications requiring high resolution pattern transfer.

Abstract translation: 提供了一种用于提供电微接触印刷的方法和装置。 使印模与基板的表面接触以提供高分辨率特征。 本发明的各方面可用于数据存储，微接触印刷以及需要高分辨率图案转印的其它应用。

公开(公告)号：WO0189788A9

公开(公告)日：2002-12-12

申请号：PCT/US0117246

申请日：2001-05-25

Applicant: HARVARD COLLEGE ,  CHILDRENS MEDICAL CENTER ,  CHIU DANIEL T ,  JEON NOO-LI ,  HUANG SUI ,  KANE RAVI ,  CHOI INSUNG S ,  INGBER DONALD E ,  WHITESIDES GEORGE M ,  ANDERSON JANELLE R

Inventor： CHIU DANIEL T ,  JEON NOO-LI ,  HUANG SUI ,  KANE RAVI ,  CHOI INSUNG S ,  INGBER DONALD E ,  WHITESIDES GEORGE M ,  ANDERSON JANELLE R

IPC: B01F13/00 ,  B01L3/00 ,  B01L3/02 ,  B29C31/04 ,  B29C33/42 ,  B29C39/10 ,  B81B1/00 ,  B81C1/00 ,  C40B40/10 ,  C40B60/14 ,  G01N33/50 ,  B01J4/00 ,  B29C39/02

CPC classification number: C12N11/00 ,  B01F13/0059 ,  B01J2219/00382 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/0072 ,  B01J2219/00725 ,  B01J2219/00743 ,  B01L3/0258 ,  B01L3/0262 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0874 ,  B01L2300/0887 ,  B29C31/04 ,  B29C33/424 ,  B29C39/10 ,  B33Y80/00 ,  B81B1/00 ,  B81C99/009 ,  B82Y5/00 ,  B82Y30/00 ,  C40B40/10 ,  C40B60/14 ,  G01N33/5005 ,  Y10S530/81 ,  Y10S530/811 ,  Y10S530/812 ,  Y10S530/815

Abstract: The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems. Specifically, the invention provides microfluidic surface patterning systems and methods for fabricating complex, discontinuous patterns on surfaces that can incorporate or deposit multiple materials onto the surfaces. The present invention also provides improved microfluidic stamps or applicators for microcontact surface patterning, which are able to pattern onto a surface arbitrary two-dimensional patterns, and which are able to pattern multiple substances onto a surface without the need for multiple steps of registration or stamping during patterning and without the need to selectively "ink" different regions of the stamp with different materials.

Abstract translation: 本发明描述了改进的微流体系统和用于制造改进的微流体系统的程序，其包含一个或多个水平的微流体通道。 用于制造所公开的系统的方法可以提供拓扑复杂和改进的微流体系统的方便的途径。 微流体系统可以包括其中的流体流动路径的三维排列的网络，其中包括在交叉点处交叉的网络上或下方的通道，而没有物理交叉点。 微流体网络可以通过使用模具主体的复制模制工艺制造，其中包括具有通过光刻形成的拓扑特征的表面。 本发明还涉及在利用微流体系统的表面上制造诸如生物材料和细胞的复杂图案的微流体系统和方法。 具体地，本发明提供了微流体表面图案化系统和用于在表面上制造复杂的不连续图案的方法，所述图案可以将多种材料结合或沉积到表面上。 本发明还提供了用于微接触表面图案化的改进的微流体标记或涂布器，其能够将图案图案化成任意的二维图案，并且能够将多种物质图案化到表面上，而不需要多个对准或冲压的步骤 在图案化期间，并且不需要使用不同材料选择性地“印刷”印模的不同区域。

公开(公告)号：WO2002086452A3

公开(公告)日：2002-10-31

申请号：PCT/US2002/009149

申请日：2002-03-25

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  CHILDREN'S MEDICAL CENTER CORPORATION ,  OSTUNI, Emanuele ,  CHEN, Christopher, S. ,  INGBER, Donald, E. ,  WHITESIDES, George, M.

Inventor： OSTUNI, Emanuele ,  CHEN, Christopher, S. ,  INGBER, Donald, E. ,  WHITESIDES, George, M.

IPC: C12N11/08

Abstract: A material is selectively deposited on substrate having a contoured surface including protrusions and recesses. A first fluid is applied to the surface to contact the protrusions and not the recesses, and a first material is deposited on the substrate where the substrate is in contact with the fluid. A second fluid may be applied to contact the recesses, and a second material is deposited on the substrate where the substrate is in contact with the fluid. A third fluid may be applied, and a third material having affinity for one of the first and second materials is deposited only where one of the first and second materials is deposited. The first and second material may be a protein, and the first, second and third materials may respectively be cytophobic, cytophilic and a cell. The substrate may be formed of a polymer such as polydimethylsiloxane. A cell containment device is provided containing the substrate with a cytophobic material connected to the protrusions and a cytophilic material connected to the recesses.

公开(公告)号：WO2001089788A3

公开(公告)日：2001-11-29

申请号：PCT/US2001/017246

申请日：2001-05-25

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  CHILDREN'S MEDICAL CENTER CORPORATION ,  CHIU, Daniel, T. ,  JEON, Noo-Li ,  HUANG, Sui ,  KANE, Ravi ,  CHOI, Insung, S. ,  INGBER, Donald, E. ,  WHITESIDES, George, M. ,  ANDERSON, Janelle, R.

Inventor： CHIU, Daniel, T. ,  JEON, Noo-Li ,  HUANG, Sui ,  KANE, Ravi ,  CHOI, Insung, S. ,  INGBER, Donald, E. ,  WHITESIDES, George, M. ,  ANDERSON, Janelle, R.

IPC: B01L3/00

Abstract: The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems. Specifically, the invention provides microfluidic surface patterning systems and methods for fabricating complex, discontinuous patterns on surfaces that can incorporate or deposit multiple materials onto the surfaces. The present invention also provides improved microfluidic stamps or applicators for microcontact surface patterning, which are able to pattern onto a surface arbitrary two-dimensional patterns, and which are able to pattern multiple substances onto a surface without the need for multiple steps of registration or stamping during patterning and without the need to selectively "ink" different regions of the stamp with different materials.

公开(公告)号：WO9954786A9

公开(公告)日：2000-02-03

申请号：PCT/US9908623

申请日：1999-04-20

Applicant: HARVARD COLLEGE ,  MASSACHUSETTS INST TECHNOLOGY ,  JACKMAN REBECCA J ,  DUFFY DAVID C ,  WHITESIDES GEORGE M ,  VAETH KATHLEEN M ,  JENSEN KLAVS F

Inventor： JACKMAN REBECCA J ,  DUFFY DAVID C ,  WHITESIDES GEORGE M ,  VAETH KATHLEEN M ,  JENSEN KLAVS F

IPC: B41C1/14 ,  B05D1/32 ,  G03F1/00 ,  G03F7/00 ,  G03F7/12 ,  H01L27/32 ,  H01L51/50 ,  H05B33/10

CPC classification number: C23C14/042 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  G03F1/00 ,  G03F7/0002 ,  G03F7/0007 ,  G03F7/12 ,  H01L27/32 ,  H01L27/3211 ,  H01L51/0011 ,  H01L51/56

Abstract: An elastomeric mask is provided that allows deposition of a variety of materials through mask openings. The mask seals effectively against substrate surfaces, allowing simple deposition from fluid phase, gas phase, and the like or removal of material using gaseous or liquid etchants. The mask then can be simply peeled from the surface of the substrate leaving the patterned material behind. Multi-layered mask techniques are described in which openings in an upper mask allow selected openings of a lower mask to remain unshielded, while other openings of the lower mask are shielded. A first deposition step, followed by re-orientation of the upper mask to expose a different set of lower mask openings, allows selective deposition of different materials in different openings of the lower mask. Pixelated organic electroluminescent devices are provided via the described technique.

Abstract translation: 提供了一种弹性体掩模，其允许通过掩模开口沉积各种材料。 掩模有效地密封衬底表面，允许从流体相，气相等简单沉积或使用气体或液体蚀刻剂去除材料。 然后可以从掩模的表面简单地剥离掩模，留下图案化材料。 描述了多层掩模技术，其中上掩模中的开口允许下掩模的选定开口保持未屏蔽，而下掩模的其它开口被屏蔽。 第一沉积步骤，随后重新取向上掩模以暴露不同组的下掩模开口，允许不同材料在下掩模的不同开口中的选择性沉积。 通过所述技术提供像素化的有机电致发光器件。

公开(公告)号：WO9929280A2

公开(公告)日：1999-06-17

申请号：PCT/US9826352

申请日：1998-12-11

Applicant: HARVARD COLLEGE ,  JOSEPH MCCARTHY DIANE M ,  ISAACS LYLE D ,  WHITESIDES GEORGE M ,  KARPLUS MARTIN ,  HOGLE JAMES M ,  CHEH JAMES LI WEN

Inventor： JOSEPH-MCCARTHY DIANE M ,  ISAACS LYLE D ,  WHITESIDES GEORGE M ,  KARPLUS MARTIN ,  HOGLE JAMES M ,  CHEH JAMES LI-WEN

IPC: A61K47/48 ,  A61K

CPC classification number: A61K47/6901 ,  Y10T436/14 ,  Y10T436/141111 ,  Y10T436/147777

Abstract: The present invention provides structure-based combinatorial libraries of compounds containing the functional group minima of picornaviruses including poliovirus and rhinovirus. The libraries can be used to screen for therapeutical antiviral compounds, e.g., anti-picornaviral capsid-binding compounds.

Abstract translation: 本发明提供了包含小核糖核酸病毒（包括脊髓灰质炎病毒和鼻病毒）的功能组最小值的化合物的基于结构的组合文库。 文库可以用于筛选治疗性抗病毒化合物，例如抗小RNA病毒衣壳结合化合物。