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    치과용 차폐막
    111.
    发明公开
    치과용 차폐막 有权
    牙膏膜

    公开(公告)号：KR1020130033826A

    公开(公告)日：2013-04-04

    申请号：KR1020110097751

    申请日：2011-09-27

    Applicant: 대한민국(농촌진흥청장)

    Inventor： 권해용 ,  조유영 ,  류강선 ,  이광길 ,  강석우 ,  김성곤

    IPC: A61K31/047 ,  A61K38/01 ,  A61C5/00 ,  A61P1/02

    Abstract: PURPOSE: An antibacterial dental membrane is provided to ensure alkaline phosphatase activity in osteoblast, and to improve bond generation in a lesion. CONSTITUTION: A dental membrane contains 0.01-10 wt% of 4-hexylresorcinol, and 90-99.99 wt% of silk proteins. The silk protein is silk fibroin. A method for manufacturing the dental membrane comprises: a step of dissolving the silk fibroin in an ethanol solution containing a salt, and removing the salt and ethanol to prepare a silk fibroin solution; a step of dissolving 4-hexylresorcinol in ethanol and preparing 4-hexylresorcinol ethanol solution; a step of mixing the silk fibroin solution and the 4-hexylresorcinol ethanol solution, and comprising a dental membrane composition; and a step of pouring the dental membrane composition into a container and drying. [Reference numerals] (AA) Control group without applying a membrane; (BB) Experimental group with applying the membrane of the present invention composed of 3% hexylresorcinol and remaining amount of silk fibroin(an arrow indicates a remaining dental membrane);

    Abstract translation: 目的：提供抗菌牙膜，以确保成骨细胞中的碱性磷酸酶活性，并改善病变中的结合产生。 构成：牙膜含有0.01-10重量％的4-己基间苯二酚和90-99.99重量％的丝蛋白。 丝蛋白是丝素蛋白。 一种牙科膜的制造方法，其特征在于，包括将丝素蛋白溶解在含有盐的乙醇溶液中，除去盐和乙醇以制备丝素蛋白溶液的步骤; 将4-己基间苯二酚溶解在乙醇中并制备4-己基间苯二酚乙醇溶液的步骤; 将丝素蛋白溶液与4-己基间苯二酚乙醇溶液混合并包含牙膜组合物的步骤; 以及将牙膜组合物倒入容器中并干燥的步骤。 （标号）（AA）不涂膜的对照组; （BB）使用由3％己基间苯二酚构成的本发明的膜和剩余量的丝素蛋白（箭头表示剩余的牙膜）的实验组。

    누에 실샘 유래 가수분해물의 수득방법
    112.
    发明公开
    누에 실샘 유래 가수분해물의 수득방법 有权
    来自丝M兰的水解产物的获得方法

    公开(公告)号：KR1020130031194A

    公开(公告)日：2013-03-28

    申请号：KR1020120068600

    申请日：2012-06-26

    Applicant: 대한민국(농촌진흥청장) ,  차의과학대학교 산학협력단

    Inventor： 이희삼 ,  조유영 ,  권해용 ,  남성희 ,  류강선 ,  강필돈 ,  박광영 ,  김미자 ,  최용수 ,  김호진 ,  황정욱

    IPC: C07K14/435 ,  C07K1/12

    Abstract: PURPOSE: A method for preparing a silkworm grand-derived hydrolysate is provided to obtain a hydrolysate with excellent cell proliferation effect without a harmful solvent. CONSTITUTION: A method for preparing a silkworm grand-derived hydrolysate comprises: a step of preparing a silkworm; a step of freeze-drying the silkworm and isolating a silk gland; a step of dissolving the silk gland with water and preparing a first lysate; a step of centrifuging the first lysate and collecting supernatant; a step of adding alkali to the supernatant and performing hydrolysate to prepare a second lysate; a step of adding acid to the second lysate and neutralizing to prepare a neutralized solution; a step of desalting the neutralized solution and preparing a hydrolysate; and a step of freeze-drying the hydrolysate. [Reference numerals] (AA) Silkworm; (BB) Freeze-drying and isolating; (CC) Silk gland; (DD) Pulverizing; (EE) Powder; (FF) Dissolving in water; (GG) Centrifuging and isolating supernatant; (HH) Adding alkali; (II) Hydrolyzing; (JJ) Neutralizing; (KK) Desalting; (LL) Freeze-drying; (MM) Hydrolysate

    Abstract translation: 目的：提供一种制备蚕大分子水解物的方法，以获得没有有害溶剂的具有优异细胞增殖作用的水解产物。 构成：一种蚕源水解产物的制备方法，包括：制备蚕的步骤; 冷冻干燥蚕丝并分离丝腺的步骤; 将丝腺溶解在水中并制备第一裂解液的步骤; 离心第一裂解物并收集上清液的步骤; 向上清液中加入碱，并进行水解产物制备第二裂解液的步骤; 将酸添加到第二裂解物中并中和以制备中和溶液的步骤; 将中和溶液脱盐并制备水解产物的步骤; 和冷冻干燥水解物的步骤。 （附图标记）（AA）蚕; （BB）冷冻干燥和隔离; （CC）丝腺; （DD）粉碎; （EE）粉末; （FF）溶于水; （GG）离心分离上清液; （HH）加碱; （二）水解; （JJ）中和; （KK）脱盐; （LL）冷冻干燥; （MM）水解产物

    실크 피브로인 펩타이드를 유효성분으로 포함하는 골 이식재
    116.
    发明公开
    실크 피브로인 펩타이드를 유효성분으로 포함하는 골 이식재 有权
    包含丝状纤维蛋白肽作为活性成分的骨髓

    公开(公告)号：KR1020110121401A

    公开(公告)日：2011-11-07

    申请号：KR1020100040983

    申请日：2010-04-30

    Applicant: 대한민국(농촌진흥청장)

    Inventor： 권해용 ,  이광길 ,  강석우 ,  여주홍 ,  조유영 ,  우순옥 ,  한상미 ,  김성곤 ,  최제용

    IPC: A61L27/22 ,  A61F2/28 ,  C07K1/12 ,  A61L27/54

    CPC classification number: A61L27/22 ,  A61F2/28 ,  A61L27/225 ,  A61L27/54 ,  C07K1/12

    Abstract: PURPOSE: A bone graft material is provided to rapidly regenerate a damaged and lost part of bone by applying the bone graft material to the damaged and lost part of bone. CONSTITUTION: A bone graft material includes silk fibroin peptide as an active ingredient. The silk fibroin peptide has average molecular weight of 100-4,000 Da and is prepared by removing sericin by treating silk with alkaline solution and hydrolyzing the silk with acid. The silk fibroin peptide improves the expression of alkaline phosphatase, collagen type I-alpha 1, fibronectin, or transforming growth factor(TGF)-beta 1.

    Abstract translation: 目的：提供骨移植材料，通过将骨移植材料应用于损伤和丢失的骨头部分，快速再生骨骼损伤部分和损失部分。 构成：骨移植材料包括丝素蛋白肽作为活性成分。 丝素蛋白肽的平均分子量为100-4,000Da，通过用碱性溶液处理丝并用酸水解丝来除去丝胶蛋白。 丝素蛋白肽改善碱性磷酸酶，I-1型胶原，纤连蛋白或转化生长因子（TGF）-β1的表达。

    세포침투성 ＡＭＰ-활성화 단백질 키나아제 및 그 용도
    117.
    发明公开
    세포침투성 ＡＭＰ-활성화 단백질 키나아제 및 그 용도 无效
    细胞转导激活的蛋白激酶及其用途

    公开(公告)号：KR1020110061668A

    公开(公告)日：2011-06-10

    申请号：KR1020090118135

    申请日：2009-12-02

    Applicant: 한림대학교 산학협력단 ,  대한민국(농촌진흥청장)

    Inventor： 권해용 ,  이광길 ,  강석우 ,  여주홍 ,  조유영 ,  최수영 ,  조용준 ,  장상호 ,  음원식 ,  김대원 ,  박진서 ,  조성민 ,  신승훈

    IPC: C12N9/12 ,  C07K19/00 ,  A61K38/45 ,  C12N15/54

    Abstract: PURPOSE: An AMP-activated protein kinase fusion protein is provided to suppress inflammation by intracellular concentration-dependent and time-dependent introduction. CONSTITUTION: A cell permeable AMP-activated protein kinase fusion protein has a protein transport domain which is bound to at least one terminal of the AMP-activated protein kinase. The protein transport domain is PEP-1 peptide. The AMP-activated protein kinase has an amino acid of sequence number 7. A cosmetic composition contains the AMP-activated protein kinase as an active ingredient. A pharmaceutical composition for treating inflammation including type 2 diabetes, obesity, skin cancer, and atopic inflammation contains the AMP-activated protein kinase as an active ingredient and pharmaceutically acceptable carrier.

    Abstract translation: 目的：提供AMP激活的蛋白激酶融合蛋白，以通过细胞内浓度依赖性和时间依赖性介导来抑制炎症。 构成：细胞可渗透的AMP激活蛋白激酶融合蛋白具有蛋白转运结构域，其结合AMP活化蛋白激酶的至少一个末端。 蛋白质转运结构域是PEP-1肽。 AMP活化蛋白激酶具有序列号7的氨基酸。化妆品组合物含有AMP活化蛋白激酶作为活性成分。 用于治疗包括2型糖尿病，肥胖症，皮肤癌和特应性炎症的炎症的药物组合物含有AMP活化蛋白激酶作为活性成分和药学上可接受的载体。

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