公开(公告)号：WO1992022880A1

公开(公告)日：1992-12-23

申请号：PCT/US1992005105

申请日：1992-06-12

Applicant: ABBOTT LABORATORIES ,  KOTLARIK, John, J. ,  WROBLEWSKI, Mieczyslaw

Inventor： ABBOTT LABORATORIES

IPC: G06K09/00

CPC classification number: G01N35/109 ,  B01L3/0262 ,  B01L3/5085 ,  G01N15/1468 ,  G01N21/82 ,  G01N35/0095 ,  G01N35/0098 ,  G01N35/028 ,  G01N35/1004 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0491 ,  G01N2035/1018 ,  G01N2035/1025 ,  G01N2035/1034 ,  G01N2201/0446 ,  G01N2201/0461 ,  G01N2201/0492 ,  G02B7/28 ,  Y10T137/7306 ,  Y10T436/115831

Abstract: A method for agglutination detection using optical imaging of reaction wells containing agglutination objects in a programmable random access automated apparatus for perforing agglutination assays is provided. An image of the agglutination objects in the reaction wells is taken with analyzation of the intensity values and transitions through relative portions of the image and background which provides intensity values suitable for classifying. The method utilizes slope information from a derivative (Fig. 34 A-E, second row) rather than absolute intensities, thus allowing scoring algorithm based on slope total information. The agglutination detection method uses a CCD camera to take an image at each well (Fig. 34 A-E, first row) of a multiple well cartridge, thus providing information suitable for analyzing from the image detection apparatus, the apparatus processes the information to generate a visual indication of the results of the assays being performed. A micro-processor is provided to assist in the operation of the apparatus as well as the image processing data collection and analysis.

Abstract translation: 本发明提供了一种用于穿孔凝集试验的可编程随机存取自动装置中使用含有凝集物的反应孔的光学成像的凝集检测方法。 通过分析强度值和通过图像和背景的相对部分的转变来获取反应井中的凝集物体的图像，其提供适于分类的强度值。 该方法利用来自导数（图34A-E，第二行）的斜率信息，而不是绝对强度，从而允许基于斜率总信息的评分算法。 凝集检测方法使用CCD照相机在多孔盒的每个孔（图34 AE，第一排）拍摄图像，从而提供适合于从图像检测装置进行分析的信息，该装置处理该信息以产生 正在进行测定结果的视觉指示。 提供微处理器以协助装置的操作以及图像处理数据的收集和分析。

公开(公告)号：WO1992022561A1

公开(公告)日：1992-12-23

申请号：PCT/US1992004724

申请日：1992-06-05

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  CELEBUSKI, Joseph, E.

IPC: C07F07/08

CPC classification number: C07H21/00 ,  C07F7/081 ,  C07F7/083 ,  C07F9/2408 ,  Y02P20/55

Abstract: Novel silyl alcohols having bulky substituents bonded to the silicon, and the silyl group attached to a carbon include the preferred 2-silyl-ethan-1-ols. A method for synthesizing silyl substituted alcohols include hydrosilation of a vinylic ester, especially vinyl acetate, followed by hydrolysis in mild base. The silyl alcohols are useful in preparing phosphorylating reagents for phosphorylating an oligonucleotide. The phosphorylated intermediate bearing the silyl group may be separated from failure product on the basis of bulky substituents on the silyl protecting group, which is later removed, e.g. by fluoride ion.

公开(公告)号：WO1992022557A1

公开(公告)日：1992-12-23

申请号：PCT/US1992004723

申请日：1992-06-05

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  CELEBUSKI, Joseph, E.

IPC: C07F07/08

CPC classification number: C07H1/02 ,  C07F7/081 ,  C07F9/2408 ,  Y02P20/55

Abstract: Novel silyl alcohols having bulky substituents bonded to the silicon, and the silyl group attached to a carbon include the preferred 2-silyl-ethan-1-ols. A method for synthesizing substituted alcohols include hydrosilation of a vinylic ester, especially vinyl acetate, followed by hydrolysis in mild base. The silyl alcohols are useful in preparing phosphorylating reagents for phosphorylating an oligonucleotide. The phosphorylated intermediate bearing the silyl group may be separated from failure product on the basis of bulky substituents on the silyl protecting group, which is later removed, e.g. by fluoride ion.

公开(公告)号：WO1992020587A1

公开(公告)日：1992-11-26

申请号：PCT/US1992004082

申请日：1992-05-14

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GYGAX, Ralph, Allen ,  LIPPIAN, Joseph, Michael ,  LOUGHRIN, Thomas, Daniel ,  MALONE, William, Thomas ,  OSIP, Thomas, Walter ,  PEZZOLI, Paul, Anthony

IPC: B65D23/00

CPC classification number: B65D1/0276 ,  B65D1/0215 ,  B65D2501/0036

Abstract: A retortable high panel strength plastic container (10) that includes a sidewall (11) and a bottom wall (12). The container (10) has a recessed circular center portion (17) in the bottom wall (12) that is designed to facilitate the volumetric changes that occur in the container during sterilization. These volumetric changes occur without catastrophic failure. Examples of containers having this feature are disclosed as well as the cross-sectional profile of the recessed circular center portions of the bottom walls of the containers.

公开(公告)号：WO1992018134A1

公开(公告)日：1992-10-29

申请号：PCT/US1992002590

申请日：1992-03-30

Applicant: ABBOTT LABORATORIES ,  FREIBERG, Leslie, A. ,  EDWARDS, Carla ,  PARIZA, Richard, J. ,  NELLANS, Hugh, N.

Inventor： ABBOTT LABORATORIES

IPC: A61K31/70

CPC classification number: C07H17/08 ,  C07H17/00 ,  C07H17/02

Abstract: Macrocyclic lactam compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein A is selected from (II), (III) and (IV); also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.

Abstract translation: 式（I）的大环内酰胺化合物及其药学上可接受的盐，其中A选自（II），（III）和（IV）; 还公开了可用于制备本发明化合物的合成方法和中间体，以及含有本发明化合物的组合物以及用于刺激胃肠道收缩运动的方法。

公开(公告)号：WO1992015709A1

公开(公告)日：1992-09-17

申请号：PCT/US1992001572

申请日：1992-02-28

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  STROUPE, Stephen, D.

IPC: C12Q01/68

CPC classification number: C12Q1/6825 ,  B82Y35/00 ,  G01N33/53 ,  G01N33/54373

Abstract: Methods and test kits for detecting the presence of an analyte in a test sample on a molecule-by-molecule basis by using scanning probe microscopy, in which the test sample suspected of containing the analyte of interest is exposed to a test piece to which an analyte specific substance has been attached, and the test piece is scanned by scanning probe microscopy to determine the presence or absence of the analyte.

Abstract translation: 用于通过使用扫描探针显微镜在分子基础上检测测试样品中分析物的存在的方法和测试试剂盒，其中将怀疑含有感兴趣分析物的测试样品暴露于试验片， 已经附着分析物特异性物质，并通过扫描探针显微镜扫描测试片以确定分析物的存在或不存在。

公开(公告)号：WO1992013941A1

公开(公告)日：1992-08-20

申请号：PCT/US1992000901

申请日：1992-02-05

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WILCOX, David, R. ,  SMITH, Robert, A. ,  BENSON, Terry, A.

IPC: C12N01/00

CPC classification number: C12R1/075 ,  A01N63/00 ,  C07K14/325

Abstract: Novel bacterial isolates of B. thuringiensis are having enhanced toxicity with respect to previously resistant or insufficiently susceptible insect species, including, but not limited to, Plutella xylostella, Spodoptera frugiperda and Spodoptera exigua, as well as certain secondary pests such as Trichoplusia ni. Such isolates may be characterized by their possession of a particular subset of the genes coding for the various B. thuringiensis delta -endotoxin proteins and by a characteristic plasmid profile, or array, known to be associated therewith. Also disclosed are a method for the efficient identification of such bacterial isolates utilizing generalized or, alternatively, gene-specific DNA probes; cloned or synthesized nucleotide sequences which are useful in the preparation of those probes; compositions containing an insecticidally effective amount of a bacterial isolate of the invention in combination with an acceptable carrier; and a method for the use thereof in the control or eradication of insect pests.

Abstract translation: 苏云金芽孢杆菌的新型细菌分离物对先前抗性或不充分易感的昆虫物种具有增强的毒性，包括但不限于小菜蛾，草地贪夜蛾和草地夜蛾，以及某些次生害虫如毛滴虫（Trichoplusia ni）。 这些分离物的特征在于它们具有编码各种苏云金芽孢杆菌δ-内毒素蛋白质的基因的特定子集，以及已知与之相关的特征性质粒谱或阵列。 还公开了利用广泛的或者基因特异性DNA探针有效鉴定这种细菌分离物的方法; 克隆或合成的可用于制备这些探针的核苷酸序列; 含有杀虫有效量的本发明细菌分离物与可接受载体组合的组合物; 以及用于控制或根除害虫的方法。

公开(公告)号：WO1992012168A1

公开(公告)日：1992-07-23

申请号：PCT/US1991009320

申请日：1991-12-10

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  KAWAI, Megumi ,  WIEDEMAN, Paul, E. ,  LULY, Jay, R. ,  OR, Yat, Sun

IPC: C07K07/02

CPC classification number: C07K7/02 ,  A61K38/00 ,  C07K14/472

Abstract: Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states. Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.

Abstract translation: 式A-B-D-E-G-J-L-M-Q的寡肽化合物或寡肽类似物化合物是过敏毒素受体的配体，可用于治疗炎性疾病状态。 还公开了过敏毒素受体配体组合物和调节过敏毒素活性的方法。

公开(公告)号：WO1992007088A1

公开(公告)日：1992-04-30

申请号：PCT/US1991007629

申请日：1991-10-18

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SALDIVAR, Louis, Jr. ,  ENGLAND, Barbara, J.

IPC: C12Q01/54

CPC classification number: G01N33/96 ,  G01N33/72 ,  G01N2333/675 ,  G01N2496/80 ,  Y10S435/801 ,  Y10T436/146666

Abstract: A stabilized anoxic diagnostic reagent solution comprising an oxygen labile reagent, glucose oxidase, glucose, a hydrogen donor, sterile membrane fragments derived from bacteria having membranes containing an oxygen transfer system, and a reagent binding agent. The stabilized reagent has at least six months storage stability at 2-8 DEG C and open vial stability of at least three weeks.

Abstract translation: 一种稳定的缺氧诊断试剂溶液，其包含氧不稳定试剂，葡萄糖氧化酶，葡萄糖，氢供体，衍生自具有含氧转移系统的膜的细菌的无菌膜片段和试剂结合剂。 稳定的试剂在2-8℃具有至少六个月的储存稳定性，并且开瓶至少三周的稳定性。

公开(公告)号：WO1992004356A1

公开(公告)日：1992-03-19

申请号：PCT/US1991006440

申请日：1991-09-06

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  KEBABIAN, John, W. ,  MICHAELIDES, Michael, R. ,  SCHOENLEBER, Robert, W.

IPC: C07F07/02

CPC classification number: C07D221/18

Abstract: Novel compounds are provided of formula (I) or a pharmaceutically acceptable salt, amide or ester thereof, wherein R is selected from hydrogen, methyl, ethyl and prodrug amide group. R is selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, halo-substituted lower alkyl, lower alkylthio, nitro, acetamino and -SO2R wherein R is lower alkyl. R is selected from hydrogen and prodrug ester group. R , R and R are independently selected from the group consisting of hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, halo-substituted lower alkyl, nitro, amino, acetamino, aminomethyl and -SO2R wherein R is lower alkyl. The compounds of formula (I) are subject to the proviso that: 1) when R , R and R are hydrogen, R is not methoxy and 2) not more than one of R , R and R is nitro or -SO2R . The compounds of the present invention are useful in the treatment of dopamine-related neurological and psychological disorders, as well as in the treatment of cognitive impairment, attention deficit disorders and addictive behavior disorders.

Abstract translation: 提供式（I）的新化合物或其药学上可接受的盐，酰胺或酯，其中R 1选自氢，甲基，乙基和前药酰胺基。 R 2选自氢，卤素，低级烷基，低级烷氧基，卤素取代的低级烷基，低级烷硫基，硝基，乙酰氨基和-SO 2 R 7，其中R 7为低级烷基。 R 3选自氢和前药酯基。 R 4，R 5和R 6独立地选自氢，羟基，卤素，低级烷基，低级烷氧基，卤素取代的低级烷基，硝基，氨基，乙酰氨基，氨基甲基和-SO 2 R 其中R 7为低级烷基。 式（I）化合物的条件是：1）当R 4，R 5和R 6为氢时，R 2不是甲氧基，且2）不超过一个R R 5，R 5和R 6是硝基或-SO 2 R 7。 本发明的化合物可用于治疗多巴胺相关的神经和心理障碍，以及治疗认知障碍，注意力缺陷障碍和成瘾行为障碍。