公开(公告)号：DE10015470A1

公开(公告)日：2001-10-11

申请号：DE10015470

申请日：2000-03-29

Applicant: BASF AG

Inventor： ERNST HANSGEORG ,  FRAUENKRON MATTHIAS ,  MELDER JOHANN-PETER ,  FUNKE FRANK ,  KELLER ANDREAS

IPC: C07B61/00 ,  C07D239/42 ,  C07D239/48

Abstract: Preparation of 2-methyl-4-amino-5-aminomethyl-pyrimidine (I) involves reaction of a 2-methyl-4-amino-5-alkoxymethyl-pyrimidine (II) with ammonia in presence of a catalyst. Preparation of 2-methyl-4-amino-5-aminomethyl-pyrimidine of formula (I) involves reaction of a 2-methyl-4-amino-5-alkoxymethyl-pyrimidine of formula (II) with ammonia in the presence of a catalyst. R = 1-6C alkyl.

公开(公告)号：NO20013912L

公开(公告)日：2001-08-10

申请号：NO20013912

申请日：2001-08-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08

Abstract: A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III and the amine of the formula R3NH2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.

公开(公告)号：DE19910960A1

公开(公告)日：2000-09-14

申请号：DE19910960

申请日：1999-03-12

Applicant: BASF AG

Inventor： FUNKE FRANK ,  WULFF-DOERING JOACHIM ,  SCHULZ GERHARD ,  SIEGEL WOLFGANG ,  KRAMER ANDREAS ,  MELDER JOHANN-PETER ,  HOEHN ARTHUR ,  BUSKENS PHILIPP ,  REIF WOLFGANG ,  NOUWEN JAN

IPC: B01J23/88 ,  B01J23/885 ,  B01J37/03 ,  C07B61/00 ,  C07C209/26 ,  C07C211/06 ,  C07C211/07 ,  C07C211/17 ,  C07C211/27 ,  C07C211/30 ,  C07C211/35 ,  C07C211/38 ,  C07C211/42 ,  C07C213/02 ,  C07C217/58 ,  C07B43/04

公开(公告)号：AU4140899A

公开(公告)日：2000-08-29

申请号：AU4140899

申请日：1999-05-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08

Abstract: A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III and the amine of the formula R3NH2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.

公开(公告)号：CA2362365A1

公开(公告)日：2000-08-17

申请号：CA2362365

申请日：1999-05-10

Applicant: BASF AG

Inventor： FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUBLING CHRISTOPH ,  KRAMER ANDREAS ,  RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOHN ARTHUR

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08

Abstract: The invention relates to a method for producing racemic amines of formula (I ), in which R1 and R2 are not the same and R1, R2, R3 are alkyl-, cycloalkyl-, arylalkyl-, aryl-, heteroaryl rests and heterocyclic rests and R3 also represents hydrogen. Said rests can carry substituents selected from the gro up of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino. T he method is characterized in that the corresponding optically active amine (I) and the secondary alcohol of formula (II) and/or the asymmetrical ketone of formula (III) and the amine of the formula R3NH2 are simultaneously reacted in situ in the presence of hydrogen and a hydrogenation or dehydrogenation catalyst at an elevated temperature.

公开(公告)号：DE19859775A1

公开(公告)日：2000-06-29

申请号：DE19859775

申请日：1998-12-23

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: C07C209/00 ,  C07C209/68 ,  C07C213/08 ,  C07C217/08 ,  C07B55/00

Abstract: Gas phase racemisation of an optically active amine uses a hydrogenation or dehydrogenation catalyst in the presence of hydrogen at an elevated temperature. Production of racemic amines (I) comprises racemisation of a corresponding optically active amine by reaction with a hydrogenation or dehydrogenation catalyst in the presence of hydrogen at an elevated temperature in the gas phase. R , R = different and are alkyl, cycloalkyl, aralkyl, aryl, heteroaryl or heterocyclyl, all optionally substituted by Q; provided that R and R = different; R = H or alkyl, cycloalkyl, aralkyl, aryl, heteroaryl or heterocyclyl, all optionally substituted by Q; Q = alkyl, cycloalkyl, alkoxy, aryloxy, NH2, NH(alkyl) or N(alkyl)2.

公开(公告)号：AU4034699A

公开(公告)日：2000-06-05

申请号：AU4034699

申请日：1999-04-28

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOHN ARTHUR ,  KRAMER ANDREAS DR ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUBLING CHRISTOPH

IPC: B01J23/72 ,  B01J23/755 ,  B01J37/18 ,  C07B55/00 ,  C07B61/00 ,  C07C209/00 ,  C07C209/68 ,  C07C211/00 ,  C07C211/07 ,  C07C213/08 ,  C07C217/08

Abstract: Optically active amines are racemized by reaction of the optically active amine in the gas phase at elevated temperature in the presence of hydrogen and a hydrogenation or dehydrogenation catalyst.