公开(公告)号：CA2362365C

公开(公告)日：2009-07-14

申请号：CA2362365

申请日：1999-05-10

Applicant: BASF AG

Inventor： SIEGEL WOLFGANG ,  NUBLING CHRISTOPH ,  HOHN ARTHUR ,  FUNKE FRANK ,  KRAMER ANDREAS ,  SIMON JOACHIM ,  RIECHERS HARTMUT

IPC: B01J23/755 ,  C07C209/88 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C213/10 ,  C07C217/08

Abstract: The invention relates to a method for producing racemic amines of formula (I ), in which R1 and R2 are not the same and R1, R2, R3 are alkyl-, cycloalkyl-, arylalkyl-, aryl-, heteroaryl rests and heterocyclic rests and R3 also represents hydrogen. Said rests can carry substituents selected from the group of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino. The method is characterized in that the corresponding optically active amine (I) and the secondary alcoh ol of formula (II) and/or the asymmetrical ketone of formula (III) and the amine of the formula R3NH2 are simultaneously reacted in situ in the presence of hydrogen and a hydrogenation or dehydrogenation catalyst at an elevated temperature.

公开(公告)号：BR9508556A

公开(公告)日：1997-11-11

申请号：BR9508556

申请日：1995-07-27

Applicant: BASF AG

Inventor： PLATH PETER ,  DEYN WOLFGANG VON ,  ENGEL STEFAN ,  KARDORFF UWE ,  NUBLING CHRISTOPH ,  KOENIG HARTMANN ,  RANG HARALD ,  GERBER MATTHIAS ,  WALTER HELMUT ,  WESTPHALEN KARL-OTTO

IPC: C07D275/04 ,  A01N43/80 ,  C07D275/06

Abstract: PCT No. PCT/EP95/02977 Sec. 371 Date Feb. 3, 1997 Sec. 102(e) Date Feb. 3, 1997 PCT Filed Jul. 27, 1995 PCT Pub. No. WO96/05183 PCT Pub. Date Feb. 22, 1996Saccharin derivatives of the formula I I where the substituents have the following meanings: L and M are hydrogen, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkylthio, chlorine, cyano, methylsulfonyl, nitro or trifluoromethyl; Z is hydrogen, C1-C4-alkyl, C3-C8-cycloalkyl, C3-C6-alkenyl, C3-C5-alkynyl, C1-C4-acyl, benzyl or phenyl, the phenyl rings being unsubstituted or substituted by halogen or C1-C4-alkyl; R1 is cyclopropyl, 1-methylcyclopropyl, 1-methylthiocyclopropyl or tert-butyl; and agriculturally customary salts of the compounds I are described.

公开(公告)号：ES2221423T3

公开(公告)日：2004-12-16

申请号：ES99941616

申请日：1999-08-13

Applicant: BASF AG

Inventor： NUBLING CHRISTOPH ,  DITRICH KLAUS ,  DULLY CHRISTIAN

IPC: C07C213/08 ,  C07C217/08 ,  C12P13/02 ,  C12P41/00

Abstract: Procedimiento para la obtención de aminas primarias con actividad óptica de la fórmula 2 en la que significan n = 0 o 1 R4, R5 independientemente entre sí, H, alquilo con 1 a 8 átomos de carbono o fenilo, R6 = alquilo con 1 a 6 átomos de carbono o bencilo, mediante a) reacción de las aminas primarias con un éster de la fórmula 1 en la que significan m = 0 o 1, R1 = alquilo con 6 a 20 átomos de carbono ramificado o no ramificado, o heteroalquilo con 6 a 20 átomos de esqueleto, pudiendo estar substituido el resto alquilo o heteroalquilo, independientemente entre sí, por 1 a 5 átomos de halógeno, y/o un grupo oxo, R2 = alquilo con 1 a 8 átomos de carbono o fenilo, R3 = H, alquilo con 1 a 4 átomos de carbono, en presencia de una lipasa, y subsiguiente b) separación de la amina acilada por vía enantioselectiva y de la amina no transformada.

公开(公告)号：ES2176429T3

公开(公告)日：2002-12-01

申请号：ES96900601

申请日：1996-01-20

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM ,  DITRICH KLAUS ,  NUBLING CHRISTOPH

IPC: C12P13/02 ,  C12P41/00

Abstract: A process for preparing optically active primary and secondary heteroatom-substituted amines from the corresponding racemates, which comprisesa) enantioselective acylation of a racemic heteroatom-substituted amine with an ester whose acid component carries a fluorine, nitrogen, phosphorus, oxygen or sulfur atom in the vicinity of the carbonyl carbon, in the presence of a hydrolase,b) separation of the mixture of optically active heteroatom-substituted amine and optically active acylated heteroatom-substituted amine to obtain one enantiomer of the heteroatom-substituted amine,c) if required isolation of the other enantiomer of the heteroatom-substituted amine from the acylated heteroatom-substituted amine by amide cleavage.

公开(公告)号：ES2141254T3

公开(公告)日：2000-03-16

申请号：ES94928365

申请日：1994-09-16

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  PRESSLER UWE ,  NUBLING CHRISTOPH

IPC: C12P13/02 ,  C12P41/00 ,  C12R1/38

Abstract: PCT No. PCT/EP94/03102 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/08636 PCT Pub. Date Mar. 30, 1995A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.

公开(公告)号：CA2341345C

公开(公告)日：2010-10-26

申请号：CA2341345

申请日：1999-08-13

Applicant: BASF AG

Inventor： NUBLING CHRISTOPH ,  DITRICH KLAUS ,  DULLY CHRISTIAN

IPC: C12P41/00 ,  C07C213/08 ,  C07C217/08 ,  C12P13/02

Abstract: The invention relates to a method for the racemic cleavage of alkoxy-substituted primary amines by reaction with an ester in the presence of a lipase and subsequent separation of the resulting optically active amide from the optically active unreacted amine. This is possibly followed by hydrolysis of the optically active amide, separation of the resulting optically active amine from the acid at the origin of the ester, racemization and recirculation of the undesirable enantiomer of the amine and esterification and recirculation of the acid.

公开(公告)号：ES2153578T3

公开(公告)日：2001-03-01

申请号：ES96915021

申请日：1996-05-07

Applicant: BASF AG

Inventor： NUBLING CHRISTOPH ,  LADNER WOLFGANG

IPC: C07C213/02 ,  C07C213/08 ,  C07C213/10 ,  C07C217/52 ,  C07C233/23 ,  C07C271/24 ,  C07C271/56

Abstract: PCT No. PCT/EP96/01884 Sec. 371 Date Oct. 28, 1997 Sec. 102(e) Date Oct. 28, 1997 PCT Filed May 7, 1996 PCT Pub. No. WO96/35660 PCT Pub. Date Nov. 14, 1996A process for preparing enantiomerically pure cis-1-amino-2-hydroxyindane, which comprises a) converting racemic trans-1-aminoindan-2-ol with acids or acid derivatives of the general formula RCOX by conventional methods into amides of type A A b) adding seed crystals of one enantiomer to a super-saturated solution or melt of the racemic amide A, c) isolating the crystals which have separated out, and again supersaturating the remaining mother liquor or melt after dissolving racemic amide A, and adding seed crystals of the other enantiomer, leading to selective crystallization of the latter, d) converting the resulting enantiomerically pure trans amide by conventional methods into the enantiomerically pure cis-1-amino-2-hydroxyindane.

公开(公告)号：AU5516499A

公开(公告)日：2000-03-14

申请号：AU5516499

申请日：1999-08-13

Applicant: BASF AG

Inventor： NUBLING CHRISTOPH ,  DITRICH KLAUS ,  DULLY CHRISTIAN

IPC: C07C213/08 ,  C07C217/08 ,  C12P13/02 ,  C12P41/00

Abstract: The present invention relates to a process for resolving racemates of alkoxy-substituted primary amines by reacting with an ester in the presence of a lipase and subsequently separating the optically active amide which is formed from the unreacted optically active amine. This is followed where appropriate by hydrolysis of the optically active amide, separation of the optically active amine produced thereby from the acid from which the ester is derived, racemization and recycling of the unwanted enantiomer of the amine, and esterification and recycling of the acid.

公开(公告)号：CA2341345A1

公开(公告)日：2000-03-02

申请号：CA2341345

申请日：1999-08-13

Applicant: BASF AG

Inventor： DULLY CHRISTIAN ,  DITRICH KLAUS ,  NUBLING CHRISTOPH

IPC: C07C213/08 ,  C07C217/08 ,  C12P13/02 ,  C12P41/00

Abstract: The invention relates to a method for the racemic cleavage of alkoxy- substituted primary amines by reaction with an ester in the presence of a lipase and subsequent separation of the resulting optically active amide fro m the optically active unreacted amine. This is possibly followed by hydrolysi s of the optically active amide, separation of the resulting optically active amine from the acid at the origin of the ester, racemization and recirculati on of the undesirable enantiomer of the amine and esterification and recirculation of the acid.

公开(公告)号：AU8404701A

公开(公告)日：2002-03-13

申请号：AU8404701

申请日：2001-08-30

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  FRIEDRICH THOMAS ,  NUBLING CHRISTOPH ,  STURMER RAINER ,  LADNER WOLFGANG

IPC: C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/16 ,  C12N9/18 ,  C12N15/55 ,  C12P7/62 ,  C12P41/00

Abstract: The invention relates to novel proteins from Pseudomonas glumae, having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefore, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.