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    113.
    发明专利
    未知

    公开(公告)号：DE3766536D1

    公开(公告)日：1991-01-17

    申请号：DE3766536

    申请日：1987-05-07

    Applicant: BASF AG

    Inventor： ERNST HANSGEORG DR ,  LEININGER HARTMUT DR ,  PAUST JOACHIM DR

    IPC: C07B61/00 ,  B01J25/00 ,  B01J25/02 ,  C07C67/00 ,  C07C213/00 ,  C07C213/02 ,  C07C215/10 ,  C07C215/16 ,  C07C215/68 ,  C07H5/04

    Abstract: N-(D)-ribitylxylidine (I) is prepared by reacting (D)-ribose (II) with 3,4-dimethylaniline (III) or 3,4-dimethyl-1-nitrobenzene (IV) in aqueous or aqueous/organic solution or in solution in a water-soluble organic solvent under an elevated hydrogen pressure and in the presence of a hydrogenation catalyst and of a boric acid compound, (a) using the boric acid compound in a catalytic amount of from about 6 to 35 mmol, preferably from 6 to 20 mmol, per mol of ribose, (b) carrying out the reaction under a hydrogen pressure of from 1 to 20, preferably from 2 to 9, bar and (c) carrying out the hydrogenation at from 40 DEG to 80 DEG C. over Raney nickel as hydrogenation catalyst.

    115.
    发明专利
    未知

    公开(公告)号：DE3906633A1

    公开(公告)日：1990-09-06

    申请号：DE3906633

    申请日：1989-03-02

    Applicant: BASF AG

    Inventor： SCHUL WOLFGANG DR ,  PAUST JOACHIM DR

    IPC: B01D11/04 ,  C07F9/02 ,  C07F9/6558

    Abstract: Process for separating phosphoric acid from aqueous solutions of thiamine phosphates which are produced during the phosphorylation of thiamine and optional subsequent partial hydrolysis, characterised in that the phosphoric acid is converted into the corresponding salt by use of a tertiary amine which is practically insoluble or only slightly soluble in water and this salt is extracted with a solvent of moderate polarity which is practically immiscible or only slightly miscible with water. An especially advantageous method of working is to extract the phosphoric acid with a mixture of a tertiary amine which is practically insoluble or only slightly soluble in water and a solvent of moderate polarity which is practically immiscible or only slightly miscible with water.

    OPTICALLY ACTIVE CHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES
    117.
    发明专利
    OPTICALLY ACTIVE CHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES 未知

    公开(公告)号：DE3469029D1

    公开(公告)日：1988-03-03

    申请号：DE3469029

    申请日：1984-03-07

    Applicant: BASF AG

    Inventor： GEHRKEN HENNING-PETER DR ,  ERNST HANSGEORG DR ,  PAUST JOACHIM DR

    IPC: C07D311/58 ,  C07D311/72

    Abstract: Novel optically active chroman derivatives of the general formulae Ia and Ib (Ia) (Ib) where R1, R2, R3 and R4 are each hydrogen or alkyl and X is -OH, -O-CO-alkyl, -O-alkyl, -O-tosyl, -O-mesyl, -O-benzenesulfonyl, Cl, Br or I, are prepared by a process in which (a) the racemate of the formula I' (I') is esterified in the side chain with a carboxylic acid and then acylated with an optically active carboxylic acid halide of the general formula III (III) or with the corresponding carboxylic anhydride, to give a chroman derivative IV (IV) or (b) the racemate I' is esterified in the side chain with the carboxylic acid from which III is derived, and, if required, the resulting ester is acylated with a carboxylic acid halide to give IV' (IV') the resulting mixture IV or IV', which consists of two diastereomers, is resolved by fractional crystallization, the diastereomers are hydrolyzed to the alcohols Ia and Ib and, if desired, these are converted to the other compounds Ia and Ib in a conventional manner. Useful optically active chroman derivatives Ia and Ib and diastereomeric chromanyl esters IV and IV' are also claimed.

    Improved process for the preparation of 2-methyl-4-amino-5-aminomethylpyrimidine
    120.
    发明专利
    Improved process for the preparation of 2-methyl-4-amino-5-aminomethylpyrimidine 未知

    公开(公告)号：DE3511273A1

    公开(公告)日：1986-10-09

    申请号：DE3511273

    申请日：1985-03-28

    Applicant: BASF AG

    Inventor： ERNST HANSGEORG DR ,  PAUST JOACHIM DR

    IPC: C07D239/42

    Abstract: Process for the direct preparation of 2-methyl-4-amino-5-aminomethylpyrimidine of the formula I starting from an enolate of alpha -formyl- beta -formylaminopropionitrile of the formula II in which Me represents a metal cation, preferably an alkali metal cation, which is characterised in that the enolate of the formula II is reacted with a salt of the acetamidine in an inert solvent at temperatures from 50 to 150 DEG C and the 2-methyl-4-amino-5-formylaminoemthylpyridine obtained of the formula II is then hydrolysed in a manner known per se. I is an important intermediate for the preparation of vitamin B1.

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