公开(公告)号：WO2005015173A1

公开(公告)日：2005-02-17

申请号：PCT/NL2004/000431

申请日：2004-06-17

Applicant: NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWE- TENSCHAPPELIJK ONDERZOEK TNO ,  SCHOO, Harmannus, Franciscus, Maria ,  VAN VEEN, Jacobus, Johannes, Frederik ,  BEKMAN, Hermanus, Hendricus, Petrus, Theodorus

Inventor： SCHOO, Harmannus, Franciscus, Maria ,  VAN VEEN, Jacobus, Johannes, Frederik ,  BEKMAN, Hermanus, Hendricus, Petrus, Theodorus

IPC: G01N21/25

CPC classification number: G01N21/7703 ,  G01N21/274 ,  G01N21/4133 ,  G01N21/43 ,  G01N21/645 ,  G01N2021/7786 ,  G01N2201/0628 ,  H01L27/288 ,  H01L51/5036

Abstract: The invention relates to an optical sensor comprising at least one detection module which comprises an organic light emitting diode (1) and an organic detection photodiode (2, 2a) for measuring emitted light which during the use of the sensor reaches the photodiode via the sample holder. Optionally, a sensor according to the invention further comprises a plastic waveguide.

Abstract translation: 本发明涉及一种光学传感器，其包括至少一个检测模块，该检测模块包括有机发光二极管（1）和用于测量发射光的有机检测光电二极管（2,2a），其在传感器的使用期间通过样品到达光电二极管 持有人。 可选地，根据本发明的传感器还包括塑料波导。

公开(公告)号：WO03098277A8

公开(公告)日：2004-10-21

申请号：PCT/US0315798

申请日：2003-05-19

Applicant: APPLERA CORP

Inventor： BOEGE STEVEN J ,  KING HOWARD G ,  YOUNG EUGENE F ,  SLUIS JOHANNES PAUL ,  OLDHAM MARK F

IPC: C12M1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/78

CPC classification number: G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6463 ,  G01N2021/6478 ,  G01N2201/0627 ,  G01N2201/0628

Abstract: An optical instrument for simultaneously illuminating two or more spaced-apart reaction regions (40) comprises an area light array of light emitting diodes (10).

Abstract translation: 用于同时照射两个或更多个间隔开的反应区域（40）的光学仪器包括发光二极管（10）的区域光阵列。

公开(公告)号：WO2003098277A2

公开(公告)日：2003-11-27

申请号：PCT/US2003/015798

申请日：2003-05-19

Applicant: APPLERA CORPORATION

Inventor： BOEGE, Steven, J. ,  KING, Howard, G. ,  YOUNG, Eugene, F. ,  SLUIS, Johannes, Paul ,  OLDHAM, Mark, F.

IPC: G02B

CPC classification number: G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6463 ,  G01N2021/6478 ,  G01N2201/0627 ,  G01N2201/0628

Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instruments are also provided.

Abstract translation: 提供了一种光学仪器，用于同时用由光源产生的激发光束照射两个或更多个间隔开的反应区域。 光源可以包括发光二极管的区域光阵列，一个或多个固态激光器，一个或多个微线激光器，或其组合。 根据各种实施例，菲涅耳透镜可以沿着光源和反应区域之间的光束槽设置。 还提供了使用光学仪器的分析方法。

公开(公告)号：WO03060461A2

公开(公告)日：2003-07-24

申请号：PCT/IL0201040

申请日：2002-12-26

Applicant: ORGENICS LTD ,  FISH FALK ,  GREENBERG ZVI ,  FAKTOR OURIEL

Inventor： FISH FALK ,  GREENBERG ZVI ,  FAKTOR OURIEL

IPC: G01N21/64 ,  G01N21/75 ,  G01N21/77 ,  G01N21/86 ,  G01N

CPC classification number: G01N21/645 ,  G01N21/64 ,  G01N21/8483 ,  G01N33/549 ,  G01N2021/6439 ,  G01N2021/757 ,  G01N2021/7759 ,  G01N2021/7763 ,  G01N2021/7786 ,  G01N2201/0221 ,  G01N2201/0222 ,  G01N2201/0245 ,  G01N2201/062 ,  G01N2201/0628

Abstract: A device, system and method for portable fluorescence detection. The portable device of the present invention features a low power light, in which a wavelength range is defined as at least one wavelength of light. The light source is preferably highly energy efficient, such that a majority of the electrical power which is consumed is then converted into transmitted light. The emitted light from the excited fluorophore is then preferably detected with any low cost and low power photodetector. Although optionally a highly sensitive optical detector may be used, preferably fluorescence is detected with any light sensing device, such as a regular photodiode or a CCD (charge-coupled device) sensor for example.

Abstract translation: 用于便携式荧光检测的装置，系统和方法。 本发明的便携式装置具有低功率光，其中波长范围被定义为至少一个波长的光。 光源优选地是高能量的，使得消耗的大部分电功率然后被转换成透射光。 然后优选用任何低成本和低功率光电检测器检测来自激发的荧光团的发射光。 尽管可选地使用高灵敏度的光学检测器，但是优选地，例如使用诸如常规光电二极管或CCD（电荷耦合器件）传感器的任何光感测装置来检测荧光。

公开(公告)号：EP3312594A1

公开(公告)日：2018-04-25

申请号：EP17190044.2

申请日：2003-05-19

Applicant: Life Technologies Corporation

Inventor： King, Howard G. ,  Boege, Steven ,  Young, Eugene F. ,  Oldman, Mark

IPC: G01N21/64 ,  B01L7/00

CPC classification number: G01N21/6428 ,  B01L7/52 ,  B01L2300/1805 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/062 ,  G01N2201/0627 ,  G01N2201/0628 ,  Y10S435/808

Abstract: An instrument may include an array of sample wells, a plurality of samples arranged in the array of sample wells, a plurality of light sources, a plurality of detectors, a plurality of lightpipes arranged between the plurality of samples and the plurality of detectors, and a plurality of lightpipes arranges between the plurality of light sources and the plurality of detectors. The samples include a plurality of detectable markers being capable of generating increased emission due to a presence of a target component in the sample. The detectable markers have a respective excitation wavelength range and a respective emission wavelength range. The light sources are capable of emitting a plurality of excitation wavelength ranges toward the plurality of samples to respectively excite the detectable markers. The detectors are capable of detecting an emission wavelength range emitted from the detectable markers.

Abstract translation: 仪器可以包括样品孔阵列，排列在样品孔阵列中的多个样品，多个光源，多个检测器，布置在多个样品和多个检测器之间的多个光导管，以及 多个光导管布置在多个光源和多个检测器之间。 样品包括多个可检测标记物，由于样品中存在目标组分，所述多个可检测标记物能够产生增加的发射。 可检测标记具有各自的激发波长范围和各自的发射波长范围。 光源能够向多个样品发射多个激发波长范围以分别激发可检测标记。 检测器能够检测从可检测标记发射的发射波长范围。

公开(公告)号：EP3035037A1

公开(公告)日：2016-06-22

申请号：EP16150671.2

申请日：2003-05-19

Applicant: Life Technologies Corporation

Inventor： King, Howard G. ,  Boege, Steven ,  Young, Eugene F. ,  Oldman, Mark

IPC: G01N21/64 ,  B01L7/00

CPC classification number: G01N21/6428 ,  B01L7/52 ,  B01L2300/1805 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/062 ,  G01N2201/0627 ,  G01N2201/0628 ,  Y10S435/808

Abstract: An instrument is described that includes an array of sample wells (10), a plurality of samples (12) arranged in the array of sample wells, a light source (16), a plurality of detectors (18), a light dividing device, and a plurality of light pipes (24) arranged between the plurality of detectors and the plurality of samples. The samples include a plurality of detectable markers that are capable of generating increased emission due to a presence of a target component in the sample. The detectable markers have a respective excitation wavelength range and a respective emission wavelength range. The light source is capable of emitting excitation wavelength ranges toward the samples to respectively excite the detectable markers. The detectors are capable of detecting an emission wavelength range emitted from the detectable markers. The light dividing device is configured to divide light from the light source between the sample wells of the array of sample wells.

Abstract translation: 描述了包括样品阱阵列（10），布置在样品阱阵列中的多个样品（12），光源（16），多个检测器（18），光分离装置， 以及布置在所述多个检测器和所述多个样品之间的多个光管（24）。 样品包括能够由于样品中目标组分的存在而产生增加的发射的多个可检测标记。 可检测标记具有相应的激发波长范围和相应的发射波长范围。 光源能够向样品发射激发波长范围以分别激发可检测标记。 检测器能够检测从可检测标记物发射的发射波长范围。 光分离装置被配置为将来自光源的光分离在样品阱阵列的样品阱之间。

公开(公告)号：EP2674745A1

公开(公告)日：2013-12-18

申请号：EP13184168.6

申请日：2003-05-19

Applicant: Life Technologies Corporation

Inventor： Boege, Steven ,  Oldman, Mark ,  Young, Eugene

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6463 ,  G01N2021/6478 ,  G01N2201/0627 ,  G01N2201/0628

Abstract: An instrument comprises a reaction region holding assembly (48) including wells for holding a plurality of spaced-apart reaction regions (40) and a light emitting source (10) adapted to direct excitation beams (15) toward the plurality of reaction regions and to simultaneously illuminate two or more of the spaced-apart reaction regions. The light emitting source includes an array of light emitting diode sources that are arranged in groups, wherein different groups of predetermined numbers of light emitting diode sources are configured to emit different excitation frequencies. The instrument further includes a collimating lens system (20) disposed along the path of excitation beams between the light emitting source and the plurality of reaction regions wherein the collimating lens system is capable of collimating the excitation beams emitted from the light emitting source into two or more spaced-apart bundles of collimated excitation beams (25) and wherein the instrument is capable of directing each of two or more bundles of collimated excitation beams toward a respective reaction region of the plurality of reaction regions.

Abstract translation: 仪器包括反应区域保持组件（48），其包括用于保持多个间隔开的反应区域（40）的孔和适于将激发束（15）朝向多个反应区域引导的发光源（10），并且 同时照亮两个或更多个间隔开的反应区域。 发光源包括以组为单位布置的发光二极管源的阵列，其中预定数量的发光二极管源的不同组被配置为发射不同的激发频率。 仪器还包括沿着发光源和多个反应区域之间的激发光束路径设置的准直透镜系统（20），其中准直透镜系统能够将从发光源发射的激发光束准直成两个或 更均匀分布的准直激励束束（25），并且其中仪器能够将两个或更多个准直激励束束中的每一个朝着多个反应区域的相应反应区域引导。

公开(公告)号：EP2564184A1

公开(公告)日：2013-03-06

申请号：EP11754274.6

申请日：2011-04-25

Applicant: Jenoptik Polymer Systems GmbH

Inventor： FISCHER, Andreas

IPC: G01N21/77

CPC classification number: G01N21/554 ,  G01N2201/0628

Abstract: The invention relates to a method and at least one arrangement for detecting biological and/or chemical substances. A light beam or a light bundle generated by a pumped light energy source with an excitation wavelength λ
Α is directed onto a carrier substrate, on which an optical function structure in the form of an organic luminous means is situated, on which in turn the substance(s) to be detected is/are deposited in a suitable form, such that the difference wavelength λ
ΔΑ or X
R produced as a result of absorption and changed diffraction optical properties is captured using a suitable receiver, and an evaluation unit that is coupled thereto is used to detect the substances on the basis of a data comparison system. The organic phosphor is preferably at least one organic distributed feedback laser (DFB laser). The method and a special arrangement can also be used to detect a specific substance using individual laser pixels (2P).

公开(公告)号：EP2124039A1

公开(公告)日：2009-11-25

申请号：EP08425369.9

申请日：2008-05-22

Applicant: Centro Ricerche Plast-Optica S.p.A.

Inventor： Melpignano, Patrizia ,  Biondo, Viviana ,  Sinesi, Sabino

IPC: G01N21/64

CPC classification number: G01N21/6454 ,  G01N21/0332 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2021/056 ,  G01N2201/0628

Abstract: A biochip (1) for the detection of at least one analyte in a biological sample, comprising:
- a transparent substrate (2) provided with a first surface (3) and a second surface (4),
- a first thin film of transparent conductive material (5) positioned on the first surface (3) of the substrate (1),
- a second thin film of transparent conductive material (6) positioned on the second surface (4) of the substrate (2),
- a light source (7) positioned in direct contact with the first thin film of transparent conductive material (5), and
- a microfluidic system (8) positioned in direct contact with the second layer of thin film of transparent conductive material (6), where the microfluidic system (8) is constituted by a material with low thermal resistance.

Abstract translation: 一种用于检测生物样品中至少一种分析物的生物芯片（1），包括： - 设置有第一表面（3）和第二表面（4）的透明基底（2）， - 透明的第一薄膜 位于基板（1）的第一表面（3）上的导电材料（5）， - 位于基板（2）的第二表面（4）上的透明导电材料（6）的第二薄膜， - 光 源极（7）定位成与透明导电材料（5）的第一薄膜直接接触;以及 - 微透镜系统（8），定位成与透明导电材料（6）的第二薄膜层直接接触，其中 微流体系统（8）由热阻低的材料构成。

公开(公告)号：EP2082216A2

公开(公告)日：2009-07-29

申请号：EP07858657.5

申请日：2007-10-24

Applicant: Tiama

Inventor： LECONTE, Marc

IPC: G01N21/90

CPC classification number: G01N21/90 ,  G01N2021/8832 ,  G01N2201/0628

Abstract: The invention relates to an in-line optical method of inspecting transparent or translucent objects (2) running at high speed between a light source (3) and means (4) for taking images of the objects and for analyzing the images taken, so as to detect defects in the objects. According to the invention the method consists: in controlling the single light source (3) so that said source produces in succession two types of illumination for each object running past said source, the first type being a homogenous illumination whereas the second type is formed from alternate dark zones and light zones with a discontinuous spatial variation; in taking images of each running object when each of them is illuminated in succession by the two types of illumination; and in analyzing the images taken with the illuminations of the first and second types for the purpose of detecting high-contrast defects and low-contrast defects respectively.