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    Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
    2.
    发明专利
    Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength 未知

    公开(公告)号：AU2003245302A8

    公开(公告)日：2003-12-02

    申请号：AU2003245302

    申请日：2003-05-19

    Applicant: APPLERA CORP

    Inventor： YOUNG EUGENE F ,  KING HOWARD G ,  OLDMAN MARK ,  BOEGE STEVEN J

    IPC: G01N21/25 ,  G01N21/64

    Abstract: An instrument may include an array of sample wells, a plurality of samples arranged in the array of sample wells, a plurality of light sources, a plurality of detectors, a plurality of lightpipes arranged between the plurality of samples and the plurality of detectors, and a plurality of lightpipes arranges between the plurality of light sources and the plurality of detectors. The samples include a plurality of detectable markers being capable of generating increased emission due to a presence of a target component in the sample. The detectable markers have a respective excitation wavelength range and a respective emission wavelength range. The light sources are capable of emitting a plurality of excitation wavelength ranges toward the plurality of samples to respectively excite the detectable markers. The detectors are capable of detecting an emission wavelength range emitted from the detectable markers.

    COMBINATION READER
    3.
    发明申请
    COMBINATION READER 审中-公开
    组合阅读器

    公开(公告)号：WO2004081227A2

    公开(公告)日：2004-09-23

    申请号：PCT/US2004007103

    申请日：2004-03-09

    Applicant: APPLERA CORP ,  OLDHAM MARK F ,  KING HOWARD G ,  HAGA DOUWE D ,  FEREA TRACY L

    Inventor： OLDHAM MARK F ,  KING HOWARD G ,  HAGA DOUWE D ,  FEREA TRACY L

    IPC: G01N21/64 ,  C12Q

    CPC classification number: G01N21/76 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2201/062 ,  G01N2201/0627 ,  G01N2201/0633 ,  G01N2201/0634

    Abstract: An apparatus for imaging an array of a plurality of features associated with a sample tile. The apparatus includes a stage that supports the sample tile in an illumination region, and an illumination source having a plurality of LEDs adapted to emit light. At least a portion of the light illuminates the illumination region. Additionally, the apparatus includes an image collecting device adapted to selectively collect images of either a first signal when the illumination source is illuminating the illumination region, or a second signal absent illumination of the illumination region. The first signal has wavelengths effectively different from the wavelengths of the portion of the light emitted by the LEDs that illuminates the illumination region.

    Abstract translation: 一种用于对与样本瓦片相关联的多个特征的阵列进行成像的装置。 该装置包括在照明区域中支撑样品瓦的台，以及具有适于发光的多个LED的照明源。 至少一部分光照射照明区域。 另外，该装置包括图像采集装置，适于在照明源照射照明区域时选择性地收集第一信号的图像，或者不存在照明区域的照明的第二信号。 第一信号具有与照亮照明区域的由LED发射的光的部分的波长有效不同的波长。

    Optical instrument including excitation source
    4.
    发明专利
    Optical instrument including excitation source 未知

    公开(公告)号：AU2003243268A8

    公开(公告)日：2003-12-02

    申请号：AU2003243268

    申请日：2003-05-19

    Applicant: APPLERA CORP

    Inventor： OLDHAM MARK F ,  KING HOWARD G ,  SLUIS JOHANNES PAUL ,  BOEGE STEVEN J ,  YOUNG EUGENE F

    IPC: C12M1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/78

    Abstract: An instrument comprises a reaction region holding assembly (48) including wells for holding a plurality of spaced-apart reaction regions (40) and a light emitting source (10) adapted to direct excitation beams (15) toward the plurality of reaction regions and to simultaneously illuminate two or more of the spaced-apart reaction regions. The light emitting source includes an array of light emitting diode sources that are arranged in groups, wherein different groups of predetermined numbers of light emitting diode sources are configured to emit different excitation frequencies. The instrument further includes a collimating lens system (20) disposed along the path of excitation beams between the light emitting source and the plurality of reaction regions wherein the collimating lens system is capable of collimating the excitation beams emitted from the light emitting source into two or more spaced-apart bundles of collimated excitation beams (25) and wherein the instrument is capable of directing each of two or more bundles of collimated excitation beams toward a respective reaction region of the plurality of reaction regions.

    APPARATUS AND METHOD FOR DIFFERENTIATING MULTIPLE FLUORESCENCE SIGNALS BY EXCITATION WAVELENGTH
    5.
    发明专利
    APPARATUS AND METHOD FOR DIFFERENTIATING MULTIPLE FLUORESCENCE SIGNALS BY EXCITATION WAVELENGTH 未知

    公开(公告)号：AU2003245302A1

    公开(公告)日：2003-12-02

    申请号：AU2003245302

    申请日：2003-05-19

    Applicant: APPLERA CORP

    Inventor： KING HOWARD G ,  BOEGE STEVEN J ,  YOUNG EUGENE F ,  OLDMAN MARK

    IPC: G01N21/25 ,  G01N21/64

    Abstract: An instrument may include an array of sample wells, a plurality of samples arranged in the array of sample wells, a plurality of light sources, a plurality of detectors, a plurality of lightpipes arranged between the plurality of samples and the plurality of detectors, and a plurality of lightpipes arranges between the plurality of light sources and the plurality of detectors. The samples include a plurality of detectable markers being capable of generating increased emission due to a presence of a target component in the sample. The detectable markers have a respective excitation wavelength range and a respective emission wavelength range. The light sources are capable of emitting a plurality of excitation wavelength ranges toward the plurality of samples to respectively excite the detectable markers. The detectors are capable of detecting an emission wavelength range emitted from the detectable markers.

    OPTICAL INSTRUMENT INCLUDING EXCITATION SOURCE
    8.
    发明专利
    OPTICAL INSTRUMENT INCLUDING EXCITATION SOURCE 未知

    公开(公告)号：AU2003243268A1

    公开(公告)日：2003-12-02

    申请号：AU2003243268

    申请日：2003-05-19

    Applicant: APPLERA CORP

    Inventor： OLDHAM MARK F ,  BOEGE STEVEN J ,  KING HOWARD G ,  YOUNG EUGENE F ,  SLUIS JOHANNES PAUL

    IPC: C12M1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/78

    Abstract: An instrument comprises a reaction region holding assembly (48) including wells for holding a plurality of spaced-apart reaction regions (40) and a light emitting source (10) adapted to direct excitation beams (15) toward the plurality of reaction regions and to simultaneously illuminate two or more of the spaced-apart reaction regions. The light emitting source includes an array of light emitting diode sources that are arranged in groups, wherein different groups of predetermined numbers of light emitting diode sources are configured to emit different excitation frequencies. The instrument further includes a collimating lens system (20) disposed along the path of excitation beams between the light emitting source and the plurality of reaction regions wherein the collimating lens system is capable of collimating the excitation beams emitted from the light emitting source into two or more spaced-apart bundles of collimated excitation beams (25) and wherein the instrument is capable of directing each of two or more bundles of collimated excitation beams toward a respective reaction region of the plurality of reaction regions.

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