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    Monitoring apparatus for dna polymerase chain reaction
    2.
    发明专利
    Monitoring apparatus for dna polymerase chain reaction 审中-公开
    监测DNA聚合酶链反应的装置

    公开(公告)号：JP2005274579A

    公开(公告)日：2005-10-06

    申请号：JP2005119102

    申请日：2005-04-15

    Applicant: Applera Corp ,  アプレラ コーポレイション

    Inventor： GAMBINI MICHAEL R ,  ATWOOD JOHN G ,  YOUNG EUGENE F ,  LAKATOS EDWARD J ,  CERRONE ANTHONY L

    IPC: B01L7/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/68 ,  G01N21/03 ,  G01N21/25 ,  G01N21/64 ,  G01N21/78

    CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/0303 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

    Abstract: PROBLEM TO BE SOLVED: To provide a PCR (polymerase chain reaction) equipment being an optical equipment for quantitative monitoring of replicative DNA which is improved in a dynamic range, capable of automatically selecting the exposure time for expanding a dynamic range, capable of automatic drift adjustment, easy to operate, relatively low price, and easy to change the optical system for storing a different fluorescence dye. SOLUTION: The equipment includes a light source, a light guide means for guiding a light beam, an optical detector, and a means for processing a data signal. The light source emits source beam containing at least one frequency of primary excitation frequency capable of making fluorescence emit with emission frequency. A 1st means is so arranged as to activate an excitation beam of excitation frequency while receiving the source beam. A 1st focus means is arranged to focus the excitation beam in each suspension to make the primary dye emit emission beams with intensity indicating the emission frequency and the DNA concentration of each suspension. A focus means receives an emission beam and makes it pass through. A 2nd means is arranged to receive the emission beam to pass through the emission beam of emission frequency to the other focus means which focuses the emission beam on the detector. The detector generates a primary data signal representing the emission beam and generates the concentration corresponding to the DNA of each small bottle. The processor displays the concentration of DNA by acquiring the primary data signal. COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 要解决的问题：为了提供PCR（聚合酶链反应）设备，其是用于定量监测在动态范围内改进的复制DNA的光学设备，能够自动选择用于扩大动态范围的曝光时间，能够 的自动漂移调整，操作方便，价格相对较低，并且易于更换用于存储不同荧光染料的光学系统。 解决方案：设备包括光源，用于引导光束的光导装置，光学检测器和用于处理数据信号的装置。 光源发射含有能够使荧光发射具有发射频率的初级激发频率的至少一个频率的源束。 第一装置被布置为在接收源光束的同时激活激发频率的激发光束。 第一焦点装置被布置成将激发光束聚焦在每个悬浮液中，以使主染料发射具有指示每个悬浮液的发射频率和DNA浓度的强度的发射光束。 聚焦装置接收发射光束并使其通过。 第二装置被布置为接收发射光束以将发射频率的发射光束传递到将发射光束聚焦在检测器上的另一个聚焦装置。 检测器产生表示发射光束的主要数据信号，并产生与每个小瓶子的DNA相对应的浓度。 处理器通过获取主数据信号显示DNA的浓度。 版权所有（C）2006，JPO＆NCIPI

    OPTICAL INSTRUMENT INCLUDUNG EXCITATION SOURCE
    5.
    发明申请
    OPTICAL INSTRUMENT INCLUDUNG EXCITATION SOURCE 审中-公开
    光学仪器附件激励源

    公开(公告)号：WO03098279A2

    公开(公告)日：2003-11-27

    申请号：PCT/US0315945

    申请日：2003-05-19

    Applicant: APPLERA CORP

    Inventor： BOEGE STEVEN J ,  OLDMAN MARK ,  YOUNG EUGENE F

    IPC: C12M1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/78 ,  G02B

    CPC classification number: G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6463 ,  G01N2021/6478 ,  G01N2201/0627 ,  G01N2201/0628

    Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with an excitation beam generated by a light source. A collimating lens can be disposed along a beam path between the light source and the reaction regions to form bundles of collimated excitation beams, wherein each bundle corresponds to a respective reaction region. Methods of analysis using the optical instrument are also pro vided.

    Abstract translation: 提供了一种光学仪器，用于利用由光源产生的激发光束同时照射两个或更多间隔开的反应区域。 准直透镜可以沿着光源和反应区域之间的光束路径设置，以形成准直激励束的束，其中每个束对应于相应的反应区域。 还提供了使用光学仪器的分析方法。

    SCANNING SYSTEM AND METHOD FOR SCANNING A PLURALITY OF SAMPLES
    6.
    发明申请
    SCANNING SYSTEM AND METHOD FOR SCANNING A PLURALITY OF SAMPLES 审中-公开
    扫描系统和扫描多样本的方法

    公开(公告)号：WO0206796A3

    公开(公告)日：2002-06-13

    申请号：PCT/US0141350

    申请日：2001-07-13

    Applicant: APPLERA CORP

    Inventor： OLDHAM MARK F ,  YOUNG EUGENE F

    IPC: B01L3/00 ,  G01N21/25 ,  G01N21/64

    CPC classification number: G01N21/6452 ,  B01L3/5085 ,  B01L2200/025 ,  B01L2300/0806 ,  B01L2300/0819

    Abstract: A system for detecting fluorescence emitted from a plurality of samples in a sample tray is provided. The system generally includes a plurality of lenses (12) positioned in a linear arrangement, a linear actuator configured to translate the plurality of lenses, an excitation light source (16), an excitation light direction mechanism (18) for directing the excitation light to a single lens of the plurality of lenses at a time so that a single sample holder aligned with the lens is illuminated at a time, and an optical detection system (20) for analyzing light from the sample holders. In certain embodiments, the optical detection system includes a light dispersing element (80), and a lens element (82) to direct the light onto a light detection device (90). A method of scanning a sample tray having a plurality of samples positioned in sample holders to detect fluorescence is also provided.

    Abstract translation: 提供了一种用于检测从样品盘中的多个样品发出的荧光的系统。 该系统通常包括定位在线性布置中的多个透镜（12），被配置为平移多个透镜的线性致动器，激发光源（16），激发光方向机构（18），用于将激发光引导到 一次多个透镜的单一透镜，使得与透镜对准的单个样品保持架一次被照亮，以及用于分析来自样品保持器的光的光学检测系统（20）。 在某些实施例中，光学检测系统包括光分散元件（80）和将光引导到光检测装置（90）上的透镜元件（82）。 还提供了扫描具有位于样品架中的多个样品以检测荧光的样品盘的方法。

    SCANNING SYSTEM AND METHOD FOR SCANNING A PLURALITY OF SAMPLES
    7.
    发明专利
    SCANNING SYSTEM AND METHOD FOR SCANNING A PLURALITY OF SAMPLES 未知

    公开(公告)号：CA2415376C

    公开(公告)日：2007-12-04

    申请号：CA2415376

    申请日：2001-07-13

    Applicant: APPLERA CORP

    Inventor： YOUNG EUGENE F ,  OLDHAM MARK F

    IPC: G01N21/64 ,  B01L3/00 ,  G01N21/25

    Abstract: A system for detecting fluorescence emitted from a plurality of samples in a sample tray is provided. The system generally includes a plurality of lenses (12) positioned in a linear arrangement, a linear actuator configured to translate the plurality of lenses, an excitation light source (16), an excitation light direction mechanism (18) for directing the excitation light to a single lens of the plurality of lenses at a time so that a single sampl e holder aligned with the lens is illuminated at a time, and an optical detection system (20) for analyzing light from the sample holders. In certai n embodiments, the optical detection system includes a light dispersing elemen t (80), and a lens element (82) to direct the light onto a light detection device (90). A method of scanning a sample tray having a plurality of sample s positioned in sample holders to detect fluorescence is also provided.

    10.
    发明专利
    未知

    公开(公告)号：DE60141517D1

    公开(公告)日：2010-04-22

    申请号：DE60141517

    申请日：2001-07-13

    Applicant: APPLERA CORP

    Inventor： OLDHAM MARK F ,  YOUNG EUGENE F

    IPC: G01N21/64 ,  B01L3/00 ,  G01N21/25

    Abstract: A system for detecting fluorescence emitted from a plurality of samples in a sample tray is provided. The system generally includes a plurality of lenses positioned in a linear arrangement, a linear actuator configured to translate the plurality of lenses, an excitation light source for generating an excitation light, an excitation light direction mechanism for directing the excitation light to a single lens of the plurality of lenses at a time so that a single sample holder aligned with the lens is illuminated at a time, and an optical detection system for analyzing light from the sample holders. In certain embodiments, the optical detection system includes a light dispersing element configured to spectrally disperse the light from the sample holder being illuminated, and a lens element configured to receive light from the light dispersing element and direct the light onto a light detection device. A method of scanning a sample tray having a plurality of samples positioned in sample holders to detect fluorescence is also provided.

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