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    SYSTEMS AND METHODS FOR COOLING IN A THERMAL CYCLER
    2.
    发明申请
    SYSTEMS AND METHODS FOR COOLING IN A THERMAL CYCLER 审中-公开
    用于在热循环中冷却的系统和方法

    公开(公告)号：WO2007150043A3

    公开(公告)日：2008-09-12

    申请号：PCT/US2007071930

    申请日：2007-06-22

    Applicant: APPLERA CORP ,  OLDHAM MARK F ,  HENDERSON ERIC G ,  MIRCHANDANI VINOD ,  NORDMAN ERIC S ,  HABERSTROH MARC ,  SLUIS JOHANNES PAUL

    Inventor： OLDHAM MARK F ,  HENDERSON ERIC G ,  MIRCHANDANI VINOD ,  NORDMAN ERIC S ,  HABERSTROH MARC ,  SLUIS JOHANNES PAUL

    IPC: C12M1/36

    CPC classification number: B01L7/52 ,  B01L2300/0636 ,  B01L2300/0829 ,  B01L2300/0877 ,  B01L2300/1822 ,  B01L2300/1844 ,  B01L2300/185

    Abstract: A device for performing polymerase chain reactions using cooling members not used in conventional thermal cyclers. A device for performing polymerase chain reactions may include a sample holder configured to receive a nucleic acid sample, a heating system configured to raise the temperature of the sample, a cooling system configured to lower the temperature of the sample, and a controller configured to operably control the heating system and the cooling system to cycle the device through a desired time-temperature profile. The cooling system may comprise at least one cooling member selected from a synthetic jet ejector array, a vibration-induced droplet atomization system, a vibrating diaphragm system, a piezo fan, a Cold Gun, a microchannel cooling loop, and a Cool Chip.

    Abstract translation: 使用不用于常规热循环仪的冷却部件进行聚合酶链反应的装置。 用于进行聚合酶链式反应的装置可以包括配置成接收核酸样品的样品架，配置成提高样品温度的加热系统，配置成降低样品温度的冷却系统，以及配置成可操作地 控制加热系统和冷却系统以使设备循环所需的时间 - 温度曲线。 冷却系统可以包括选自合成射流喷射器阵列，振动诱导液滴雾化系统，振动膜系统，压电风扇，冷枪，微通道冷却回路和冷却芯片中的至少一个冷却构件。

    Optical instrument including excitation source
    3.
    发明专利
    Optical instrument including excitation source 未知

    公开(公告)号：AU2003243268A8

    公开(公告)日：2003-12-02

    申请号：AU2003243268

    申请日：2003-05-19

    Applicant: APPLERA CORP

    Inventor： OLDHAM MARK F ,  KING HOWARD G ,  SLUIS JOHANNES PAUL ,  BOEGE STEVEN J ,  YOUNG EUGENE F

    IPC: C12M1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/78

    Abstract: An instrument comprises a reaction region holding assembly (48) including wells for holding a plurality of spaced-apart reaction regions (40) and a light emitting source (10) adapted to direct excitation beams (15) toward the plurality of reaction regions and to simultaneously illuminate two or more of the spaced-apart reaction regions. The light emitting source includes an array of light emitting diode sources that are arranged in groups, wherein different groups of predetermined numbers of light emitting diode sources are configured to emit different excitation frequencies. The instrument further includes a collimating lens system (20) disposed along the path of excitation beams between the light emitting source and the plurality of reaction regions wherein the collimating lens system is capable of collimating the excitation beams emitted from the light emitting source into two or more spaced-apart bundles of collimated excitation beams (25) and wherein the instrument is capable of directing each of two or more bundles of collimated excitation beams toward a respective reaction region of the plurality of reaction regions.

    OPTICAL INSTRUMENT INCLUDING EXCITATION SOURCE
    4.
    发明专利
    OPTICAL INSTRUMENT INCLUDING EXCITATION SOURCE 未知

    公开(公告)号：AU2003243268A1

    公开(公告)日：2003-12-02

    申请号：AU2003243268

    申请日：2003-05-19

    Applicant: APPLERA CORP

    Inventor： OLDHAM MARK F ,  BOEGE STEVEN J ,  KING HOWARD G ,  YOUNG EUGENE F ,  SLUIS JOHANNES PAUL

    IPC: C12M1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/78

    Abstract: An instrument comprises a reaction region holding assembly (48) including wells for holding a plurality of spaced-apart reaction regions (40) and a light emitting source (10) adapted to direct excitation beams (15) toward the plurality of reaction regions and to simultaneously illuminate two or more of the spaced-apart reaction regions. The light emitting source includes an array of light emitting diode sources that are arranged in groups, wherein different groups of predetermined numbers of light emitting diode sources are configured to emit different excitation frequencies. The instrument further includes a collimating lens system (20) disposed along the path of excitation beams between the light emitting source and the plurality of reaction regions wherein the collimating lens system is capable of collimating the excitation beams emitted from the light emitting source into two or more spaced-apart bundles of collimated excitation beams (25) and wherein the instrument is capable of directing each of two or more bundles of collimated excitation beams toward a respective reaction region of the plurality of reaction regions.

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