公开(公告)号：US07629591B2

公开(公告)日：2009-12-08

申请号：US11712917

申请日：2007-03-02

Applicant: Matthew P. Nelson ,  Patrick J. Treado

Inventor： Matthew P. Nelson ,  Patrick J. Treado

IPC: G01N21/64

CPC classification number: G01J3/2803 ,  G01J3/0221 ,  G01J3/44 ,  G01N21/474 ,  G01N21/55 ,  G01N21/645 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6423 ,  G01N2021/6484 ,  G01N2201/0833 ,  G01N2201/0846 ,  G02B6/06

Abstract: The disclosure relates generally to methods and apparatus for using a fiber array spectral translator-based (“FAST”) spectroscopic system for improved imaging, spectral analysis, and interactive probing of a sample. In an embodiment, the confocality of a fiber array spectral translator-based spectroscopic system is improved through the use of structured illumination and/or structured collection of photons. User input may be received and acted upon to allow a user to interactively in real time and/or near real time view and analyze specific regions of the sample.

Abstract translation: 本公开一般涉及使用用于改进样品的成像，光谱分析和交互式探测的光纤阵列基于光谱转换器的（“FAST”）光谱系统的方法和装置。 在一个实施例中，通过使用结构化照明和/或光子的结构化收集来提高基于光纤阵列光谱转换器的光谱系统的共焦度。 可以接收用户输入并执行操作以允许用户以实时和/或接近实时的方式进行交互式查看和分析样本的特定区域。

公开(公告)号：US07545498B2

公开(公告)日：2009-06-09

申请号：US11612228

申请日：2006-12-18

Applicant: Robert T. Krivacic ,  Huangpin B. Hsieh ,  Douglas N. Curry ,  Richard H. Bruce

Inventor： Robert T. Krivacic ,  Huangpin B. Hsieh ,  Douglas N. Curry ,  Richard H. Bruce

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  A61B5/0059 ,  G01N21/6456 ,  G01N2021/6421 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0833

Abstract: A system and method permits for the separation of auto-fluorescence from a signal by applying a single probe to a sample, exciting the sample with a single wavelength light source, thereby emitting a light a distance from the light source. The emitted light is split, and the split light is collected into two or more distinct channels. A first channel of the distinct channels is positioned closer to the light source than a second distinct channel of the distinct channels, and the second channel is closer to the emission frequency of the single probe than is the first channel. The light collected in the first channel and the light collected in the second channel are investigated, and an output signal is generated based upon the investigation.

Abstract translation: 一种系统和方法允许通过将单个探针施加到样品上来从信号中分离自体荧光，用单个波长光源激发样品，从而从光源发射一定距离的光。 发射的光被分裂，并且分离的光被收集到两个或更多个不同的通道中。 不同通道的第一通道定位成比不同通道的第二不同通道更靠近光源，并且第二通道比第一通道更接近单个探针的发射频率。 研究在第一通道中收集的光和在第二通道中收集的光，并且基于调查产生输出信号。

公开(公告)号：US07511818B2

公开(公告)日：2009-03-31

申请号：US11280546

申请日：2005-11-15

Applicant: Josep Pagés Pinyol

Inventor： Josep Pagés Pinyol

IPC: G01N21/00

CPC classification number: G01J3/02 ,  G01J3/0213 ,  G01J3/0218 ,  G01J3/12 ,  G01J3/2803 ,  G01N21/03 ,  G01N21/13 ,  G01N21/253 ,  G01N21/272 ,  G01N21/274 ,  G01N2201/0461 ,  G01N2201/082 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: Apparatus for measuring the optical absorbency of samples of liquids, method and reaction container for its implementation.The apparatus comprises a receiving body for receiving the reaction containers carrying the samples to be analyzed, with means for causing each of the reaction containers to be passed through by a luminous signal of controlled wavelength, having means for conducting it to a scanning head where the luminous signals are picked up by a single CCD sensor, constituting a digital processing system for evaluating the absorbency of the corresponding sample.

Abstract translation: 用于测量液体样品，方法和反应容器的光学吸收性的装置，用于实施。 该装置包括用于接收携带待分析样品的反应容器的接收体，具有使每个反应容器通过受控波长的发光信号通过的装置，具有将其传导到扫描头的装置， 发光信号由单个CCD传感器拾取，构成用于评估相应样品的吸收性的数字处理系统。

公开(公告)号：US07448991B2

公开(公告)日：2008-11-11

申请号：US10293331

申请日：2002-11-14

Applicant: Robert C. Lanier, Jr. ,  Tejinder Gill ,  Steven M. Campbell ,  Stephen J. Bellamah

Inventor： Robert C. Lanier, Jr. ,  Tejinder Gill ,  Steven M. Campbell ,  Stephen J. Bellamah

IPC: B31C13/00

CPC classification number: G01N21/8903 ,  A24D3/0295 ,  G01N21/952 ,  G01N2021/8416 ,  G01N2021/8444 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A system and process for monitoring a continuous element being incorporated within a cigarette filter includes a light source and a photoresponsive device facing each other and on opposite sides of a measuring gap, and passing the continuous element through the measuring gap and detecting movement of the continuous element by the effect of the movement on at least one light beam present between the light source and the photoresponsive device. Individual lengths of the continuous cigarette filter rod being produced can be selectively rejected based on a determination of whether the continuous element has a break or a knot along its length.

Abstract translation: 用于监测香烟过滤嘴内的连续元件的系统和过程包括彼此面对并且在测量间隙的相对侧面上的光源和光响应装置，并且使连续元件通过测量间隙并检测连续元件的运动 通过运动对光源和光响应装置之间存在的至少一个光束的影响。 根据确定连续元件是否具有断裂或其长度的结，可以选择性地拒绝所生产的连续卷烟过滤棒的单独长度。

公开(公告)号：US20080144009A1

公开(公告)日：2008-06-19

申请号：US11612228

申请日：2006-12-18

Applicant: Robert T. Krivacic ,  Huangpin B. Hsieh ,  Douglas N. Curry ,  Richard H. Bruce

Inventor： Robert T. Krivacic ,  Huangpin B. Hsieh ,  Douglas N. Curry ,  Richard H. Bruce

IPC: G01N21/00

CPC classification number: G01N21/6428 ,  A61B5/0059 ,  G01N21/6456 ,  G01N2021/6421 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0833

Abstract: A system and method permits for the separation of auto-fluorescence from a signal by applying a single probe to a sample, exciting the sample with a single wavelength light source, thereby emitting a light a distance from the light source. The emitted light is split, and the split light is collected into two or more distinct channels. A first channel of the distinct channels is positioned closer to the light source than a second distinct channel of the distinct channels, and the second channel is closer to the emission frequency of the single probe than is the first channel. The light collected in the first channel and the light collected in the second channel are investigated, and an output signal is generated based upon the investigation.

Abstract translation: 一种系统和方法允许通过将单个探针施加到样品上来从信号中分离自体荧光，用单个波长光源激发样品，从而从光源发射一定距离的光。 发射的光被分裂，并且分离的光被收集到两个或更多个不同的通道中。 不同通道的第一通道定位成比不同通道的第二不同通道更靠近光源，并且第二通道比第一通道更接近单个探针的发射频率。 研究在第一通道中收集的光和在第二通道中收集的光，并且基于调查产生输出信号。

公开(公告)号：US07298477B1

公开(公告)日：2007-11-20

申请号：US11506639

申请日：2006-08-18

Applicant: Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

Inventor： Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.

公开(公告)号：US20070041012A1

公开(公告)日：2007-02-22

申请号：US11404485

申请日：2006-04-13

Applicant: Brian Cunningham ,  Peter Li ,  Frank DeFilippi

Inventor： Brian Cunningham ,  Peter Li ,  Frank DeFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.

公开(公告)号：US07148964B2

公开(公告)日：2006-12-12

申请号：US11404162

申请日：2006-04-13

Applicant: Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

Inventor： Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.

公开(公告)号：US20060181704A1

公开(公告)日：2006-08-17

申请号：US11404162

申请日：2006-04-13

Applicant: Brian Cunningham ,  Peter Li ,  Frank DeFilippi

Inventor： Brian Cunningham ,  Peter Li ,  Frank DeFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.

公开(公告)号：US20060181703A1

公开(公告)日：2006-08-17

申请号：US11404158

申请日：2006-04-13

Applicant: Brian Cunningham ,  Peter Li ,  Frank DeFilippi

Inventor： Brian Cunningham ,  Peter Li ,  Frank DeFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.