公开(公告)号：WO2019212349A2

公开(公告)日：2019-11-07

申请号：PCT/NL2019/050262

申请日：2019-05-02

Applicant: LUMICKS TECHNOLOGIES B.V. ,  STICHTING VU

Inventor： WUITE, Gijs Jan Lodewijk ,  SORKIN, Raya ,  KAMSMA, Douwe ,  SITTERS, Gerrit ,  PETERMAN, Erwin Johannes Gerard ,  BERGAMASCHI, Giulia ,  DE GROOT, Mattijs

Abstract: A method for probing mechanical properties of cellular bodies is described wherein the method includes: providing a plurality of particles in a fluid medium contained in a holding space of a sample holder, each of the plurality of particles being attached to a cellular body and each cellular body being positioned on a surface of the holding space; generating a resonant bulk acoustic wave in the holding space, the resonant bulk acoustic wave exerting an acoustic force on each of the plurality of particles in a direction away from the surface of the holding space or in a direction towards the surface of the holding space, each of the plurality of particles having an acoustic contrast factor and a size, the acoustic contrast factor and the size being selected such that the force exerted on a particle is larger than the force exerted on the cellular body to which the particle is attached; and, for at least part of the particles attached to the cellular bodies, measuring a displacement of a particle in response to the exertion of the force on the particle, the measured displacement being associated with at least one mechanical property of the cellular body attached to the particle.

公开(公告)号：WO2018007498A1

公开(公告)日：2018-01-11

申请号：PCT/EP2017/066890

申请日：2017-07-06

Applicant: STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN ,  UNIVERSITEIT VAN AMSTERDAM ,  STICHTING VU ,  ASML NETHERLANDS B.V. ,  ASML HOLDING N.V.

Inventor： POIESZ, Thomas ,  ACHANTA, Satish ,  AKBAS, Mehmet, Ali ,  ANTONOV, Pavlo ,  BOUWKNEGT, Jeroen ,  FRENKEN, Joost, Wilhelmus, Maria ,  PACITTI, Evelyn, Wallis ,  TEN KATE, Nicolaas ,  TIRRI, Bruce ,  VERHOEVEN, Jan

IPC: G03F7/20 ,  H01L21/687

Abstract: There is disclosed a substrate holder, a method of manufacturing a substrate holder, a lithographic apparatus comprising the substrate holder, and a method of manufacturing devices using the lithographic apparatus. In one arrangement, there is provided a substrate holder for use in a lithographic apparatus. The substrate holder supports a substrate. The substrate holder comprises a main body. The main body has a main body surface. A plurality of burls are provided projecting from the main body surface. Each burl has a burl side surface and a distal end surface. The distal end surface of each burl engages with the substrate. The distal end surfaces of the burls substantially conform to a support plane and support the substrate. A layer of carbon based material is provided in a plurality of separated regions of carbon based material. The layer of carbon based material provides a surface with a lower coefficient of friction than a part of the main body surface outside the plurality of separated regions of carbon based material. The layer of carbon based material covers only part of the distal end surface of at least one of the burls. Alternatively, the layer of carbon based material covers the distal end surface and at least a portion of the burl side surface of at least one of the burls.

Abstract translation: 公开了一种衬底保持器，制造衬底保持器的方法，包括该衬底保持器的光刻设备，以及使用该光刻设备制造器件的方法。 在一种布置中，提供了一种用于光刻设备中的衬底保持器。 衬底支架支撑衬底。 衬底支架包括主体。 主体具有主体表面。 设置从主体表面突出的多个突起。 每个钻头都有一个钻头侧表面和一个远端表面。 每个套管的远端表面与基底接合。 突起的远端表面基本上符合支撑平面并支撑基板。 在碳基材料的多个分离区域中提供一层碳基材料。 碳基材料层提供比多个碳基材料的分离区域外部的主体表面的一部分具有更低摩擦系数的表面。 碳基材料层仅覆盖至少一个突起的远端表面的一部分。 或者，碳基材料层覆盖至少一个突起的末端表面和至少一部分突起侧表面。

公开(公告)号：WO2017157645A1

公开(公告)日：2017-09-21

申请号：PCT/EP2017/054476

申请日：2017-02-27

Applicant: STICHTING VU ,  UNIVERSITEIT VAN AMSTERDAM ,  STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN ,  ASML NETHERLANDS B.V.

Inventor： BOONZAJER FLAES, Dirk, Ewoud ,  WITTE, Stefan, Michiel ,  EIKEMA, Kjeld, Sijbrand, Eduard

IPC: G03F7/20 ,  G02B21/16 ,  G01N21/47

Abstract: In an inspection apparatus, a target on the surface is illuminated with illuminating radiation that comprises first and second illuminating components. The illuminating components form one or more periodic illuminating patterns on the surface. A plurality of scattered radiation patterns formed by the illuminating radiation after scattering by the target is captured at a detector for a number of values of a controllable characteristic of at least one of the illuminating components. The captured radiation is then used to reconstruct data describing the target.

Abstract translation: 在检查设备中，表面上的目标用包括第一和第二照明部件的照射辐射照射。 照明组件在表面上形成一个或多个周期性照明图案。 在检测器上捕获由目标散射之后由照射辐射形成的多个散射辐射图案，用于多个照射分量中的至少一个的可控特性的值。 捕获的辐射然后用于重建描述目标的数据。

公开(公告)号：WO2015194954A1

公开(公告)日：2015-12-23

申请号：PCT/NL2015/050447

申请日：2015-06-18

Applicant: STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN ,  STICHTING VU-VUMC ,  RIJKSUNIVERSITEIT GRONINGEN ,  ACADEMISCH ZIEKENHUIS GRONINGEN ,  BIOFORDRUG SRL, SPIN-OFF DELL'UNIVERSITA DEGLI STUDI DI BARI

Inventor： LUURTSEMA, Gert ,  WINDHORST, Albert Dirk ,  COLABUFO, Nicola Antonio ,  CANTORE, Mariangela ,  SAVOLAINEN, Heli

IPC: C07D217/04 ,  A61K49/00 ,  A61K51/04 ,  A61K31/472 ,  G01N33/58 ,  G01N33/60 ,  G21H5/02 ,  A61P25/28

CPC classification number: C07D217/04 ,  A61K51/0455 ,  G21H5/02

Abstract: The present invention relates to a 6,7-dioxyalkyltetrahydroisoquinoline compound, or a salt or solvate thereof according to formula I: (formula I), (I) wherein R represents hydrogen or a fluorinated alkyl group, and R 2 and R 3 independently represents hydrogen or an alkyl group.

Abstract translation: 本发明涉及式I的6,7-二氧烷基四氢异喹啉化合物或其盐或溶剂合物：（Ⅰ）式（Ⅰ）其中R代表氢或氟化烷基，R2和R3独立地代表氢或 烷基。

公开(公告)号：WO2015185222A1

公开(公告)日：2015-12-10

申请号：PCT/EP2015/001150

申请日：2015-06-08

Applicant: STICHTING VU-VUMC ,  FOM-NIKHEF

Inventor： HENNES, Eric ,  BERTOLINI, Alessandro ,  VAN DEN BRAND, Johannes, Franciscus

IPC: B81B3/00 ,  B81B7/00

CPC classification number: B81B3/0078 ,  B81B2201/0235 ,  B81B2201/0285 ,  B81B2203/0163 ,  G01P15/125

Abstract: A MEMS sensor comprising preloaded suspension springs and a method for mechanically preloading suspension springs of a MEMS sensor are described. The MEMS sensor comprises a MEMS support structure; a plurality of suspension springs connected to said support structure; and, a proof mass flexibly suspended by said suspension springs; wherein at least one of said suspension springs is mechanically preloaded with a compressive force for reducing the natural frequency of said proof mass.

Abstract translation: 描述了包括预加载悬架弹簧的MEMS传感器和用于机械预加载MEMS传感器的悬架弹簧的方法。 MEMS传感器包括MEMS支撑结构; 连接到所述支撑结构的多个悬架弹簧; 以及由所述悬架弹簧柔性地悬挂的证明质量块; 其中所述悬架弹簧中的至少一个机械地预加载有用于减小所述证明物质的固有频率的压缩力。

公开(公告)号：WO2015156673A1

公开(公告)日：2015-10-15

申请号：PCT/NL2015/050235

申请日：2015-04-10

Applicant: STICHTING VU-VUMC

Inventor： VAN DER VLIET, Johannes Jelle ,  DE BRUIN, Renée Cornelia Gerarda ,  DE GRUIJL, Tanja Denise ,  VERHEUL, Hendrik Marinus Willem

IPC: C07K16/28

CPC classification number: C07K16/2809 ,  C07K2317/21 ,  C07K2317/22 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/70 ,  C07K2317/75 ,  C07K2317/76

Abstract: The invention is in the field of medicine and relates to immunology, and relates in particular to human Vγ9Vδ2 T cell receptor bindingimmunoglobulin molecules. Human Vγ9Vδ2 T cell receptor binding immunoglobulin molecules are in particular for use in medical treatment and/or useful in assays with human Vγ9Vδ2 T cells, wherein human Vγ9Vδ2 T cells may be modulated.

Abstract translation: 本发明涉及医学领域，涉及免疫学，特别涉及人Vγ9Vδ2T细胞受体结合免疫球蛋白分子。 人Vγ9Vδ2T细胞受体结合免疫球蛋白分子特别用于医学治疗和/或可用于与人Vγ9Vδ2T细胞的测定中，其中可以调节人Vγ9Vδ2T细胞。

公开(公告)号：WO2015084166A1

公开(公告)日：2015-06-11

申请号：PCT/NL2014/050821

申请日：2014-12-02

Applicant: STICHTING VU-VUMC

Inventor： OSSENKOPPELE, Gerrit Johan ,  SCHUURHUIS, Gerrit Jan ,  ZEIJLEMAKER, Wendelien

IPC: G01N33/574

CPC classification number: G01N33/57426 ,  G01N15/14 ,  G01N33/5011 ,  G01N33/5073 ,  G01N33/57492 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/149 ,  G01N2800/52

Abstract: The present invention relates to a method for identifying Leukemic stem cells (LSC), based on measurement of the presence of a specific set of markers. The invention further relates to a container for use in performing the method. Also provided is application of the method for predicting response to therapy and/or chance of relapse of Acute Myeloid Leukemia, and application of the method in the context of screening for compounds that specifically eradicate Leukemic cells and not benign cells.

Abstract translation: 本发明涉及一种用于鉴别白血病干细胞（LSC）的方法，该方法是基于特定标记物组的存在的测量。 本发明还涉及一种用于执行该方法的容器。 还提供了预测对急性骨髓性白血病的治疗反应和/或复发机率的方法的应用，以及在筛选特异性根除白血病细胞而不是良性细胞的化合物的上下文中应用该方法。

公开(公告)号：WO2015020523A1

公开(公告)日：2015-02-12

申请号：PCT/NL2014/050550

申请日：2014-08-05

Applicant: STICHTING VU-VUMC ,  RUHR-UNIVERSITÄT BOCHUM ,  UNIVERSITÄT DUISBURG-ESSEN

Inventor： CHIASSERINI, Davide ,  TEUNISSEN, Charlotte Elisabeth ,  JIMENEZ, Cornelia Ramona ,  MÜLLER, Thorsten ,  MARCUS, Katrin ,  MEYER, Helmut Erich ,  WILTFANG, Jens

IPC: G01N33/68

CPC classification number: G01N33/6896

Abstract: The present invention relates to methods and kits for classifying an individual as being at risk of developing Alzheimer's disease, in particular Alzheimer's disease type-dementia.

Abstract translation: 本发明涉及将个体分类为处于发展阿尔茨海默氏病，特别是阿尔茨海默氏病型痴呆风险的方法和试剂盒。

公开(公告)号：WO2014195477A1

公开(公告)日：2014-12-11

申请号：PCT/EP2014/061874

申请日：2014-06-06

Applicant: STICHTING VU-VUMC ,  FOM-NIKHEF

Inventor： BULTEN, Henk Jan ,  VAN DEN BRAND, Johannes Franciscus Josephina

IPC: H04W72/04

CPC classification number: H04W72/005 ,  H04B7/2656 ,  H04W52/0216 ,  H04W72/0446 ,  H04W72/048 ,  H04W84/18 ,  Y02D70/00 ,  Y02D70/144 ,  Y02D70/162 ,  Y02D70/164 ,  Y02D70/22 ,  Y02D70/449

Abstract: A method for managing communication in a wireless mesh network comprising a plurality of wireless nodes and a wireless node for use in such network are described, wherein said method may comprise: providing a time slot schedule (frame), preferably a TDMA time slot schedule (frame), comprising one or more time slots, including a transmission time slot enabling a node to transmit a broadcast message, a reception time slot enabling a node to receive a broadcast message from one or more other nodes; and/or a sleep time slot for configuring said node in an idle state; and, assigning said time slots to nodes in said network on the basis of the position of said nodes in said network.

Abstract translation: 描述了一种用于管理无线网状网络中的通信的方法，该无线网状网络包括用于这种网络的多个无线节点和无线节点，其中所述方法可以包括：提供时隙调度（帧），优选地，TDMA时隙调度（ 帧），包括一个或多个时隙，包括使得节点能够发送广播消息的传输时隙;使得节点能够从一个或多个其他节点接收广播消息的接收时隙; 和/或用于将所述节点配置为空闲状态的休眠时隙; 并且基于所述网络中的所述节点的位置，将所述时隙分配给所述网络中的节点。

公开(公告)号：WO2014118197A1

公开(公告)日：2014-08-07

申请号：PCT/EP2014/051659

申请日：2014-01-28

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  STICHTING VU-VUMC

Inventor： SLOBBE, Paul ,  POOT, Alex Johannes ,  VAN DONGEN, Augustinus Antonius Maria Silvester ,  NIESSEN, Heiko ,  WINDHORST, Albert Dirk

IPC: C07D405/12 ,  A61K51/04

CPC classification number: C07D405/12 ,  A61K51/0459 ,  C07B2200/05

Abstract: Novel radiotracer for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging are described. Specifically, the invention relates to 18 F-labeled afatinib suitable as a PET or SPECT tracer for imaging epidermal growth factor receptor (EGFR, erbB1) and human epidermal growth factor receptor 2 (Her2, erbB2), to a precursor compound for use in its synthesis, to methods for the preparation 18 F-iabeled afatinib, as well as to the use thereof in in vivo diagnosis, tumor imaging or patient stratification on the basis of mutational status of EGFR (erbB1) and Her2 (erbB2).

Abstract translation: 描述了用于正电子发射断层扫描（PET）或单光子发射计算机断层摄影（SPECT）成像的新型放射性示踪剂。 具体地说，本发明涉及适用于成像表皮生长因子受体（EGFR，erbB1）和人表皮生长因子受体2（Her2，erbB2）的PET或SPECT示踪剂的18F-标记的阿片碱，用于其合成中的前体化合物 ，依据EGFR（erbB1）和Her2（erbB2）的突变状态制备18F-标记的阿伐替尼的方法，以及其在体内诊断，肿瘤成像或患者分层中的应用。