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公开(公告)号：KR1020130064461A
公开(公告)日：2013-06-18
申请号：KR1020110131088
申请日：2011-12-08
Applicant: 한국전자통신연구원
IPC: G01N35/08 , G01N33/49 , G01N1/28 , G01N33/574
Abstract: PURPOSE: A device for separating tumor cells from blood is provided to minimize damage to collected tumor cells by using a microstructure which controls pressures. CONSTITUTION: A device for separating tumor cells from blood includes inlets(102i), a fluid channel(110), and outlets(102o). Blood is injected through the inlets. The fluid channel is equipped with at least one loop-shaped microstructure(120). The blood is transferred through the fluid channel, and the fluid channel collects tumor cells from the blood. Blood without the tumor cells is discharged through the outlet. The microstructure includes a body(B), an introducing unit, a discharging unit, and a plurality of inlets, and a plurality of outlets. The body is composed of two parallel lines. The introducing unit and the discharging unit are hemi-circular shapes and are adjacent to the inlet and outlet by being in contact with both sides of the body. The inlets are larger than the tumor cells and are formed at 45 degrees of the center of the hemi-circular shape. The outlets are smaller than the tumor cells and larger than blood corpuscle. The outlets are formed over the entire discharging unit.
Abstract translation: 目的：提供用于从血液中分离肿瘤细胞的装置，以通过使用控制压力的微结构来最小化对收集的肿瘤细胞的损伤。 构成：用于从血液中分离肿瘤细胞的装置包括入口（102i），流体通道（110）和出口（102o）。 血液通过入口注射。 流体通道配备有至少一个环形微结构（120）。 血液通过流体通道传输，流体通道从血液中收集肿瘤细胞。 没有肿瘤细胞的血液通过出口排出。 微结构包括主体（B），引入单元，排出单元和多个入口以及多个出口。 身体由两条平行线组成。 引入单元和排出单元是半圆形的并且通过与主体的两侧接触而与入口和出口相邻。 入口大于肿瘤细胞，并形成在半圆形中心的45度处。 出口小于肿瘤细胞，大于血小板。 出口形成在整个排放单元上。
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公开(公告)号：KR1020130063775A
公开(公告)日：2013-06-17
申请号：KR1020110130321
申请日：2011-12-07
Applicant: 한국전자통신연구원
IPC: G01N33/53 , G01N33/541 , G01N33/50
Abstract: PURPOSE: A lab-on-a-chip comprising a first reaction agent in a recessed region is provided to increase probability of reacting a fluid sample and the first reaction agent, and to improve diagnosis efficiency. CONSTITUTION: A lab-on-a-chip comprises an inlet(120o), a fluid channel, a first reaction part(A), and one or more second reaction parts(170,180,190). The inlet is used for injecting a fluid sample. The fluid channel is used for transferring the fluid sample. The first reaction part has a first reaction agent which reacts with a sample of the fluid sample and forms a first sample-reaction agent reactant. The second reaction part contains a second reaction agent which reacts with the first sample-reaction agent reactant and forms a second sample-reaction agent reactant, and is formed on the surface of the fluid channel.
Abstract translation: 目的：提供包括凹陷区域中的第一反应剂的片上实验室，以增加流体样品和第一反应剂的反应的可能性，并提高诊断效率。 构成：片上实验室包括入口（120o），流体通道，第一反应部分（A）和一个或多个第二反应部分（170,180,190）。 入口用于注入流体样品。 流体通道用于转移流体样品。 第一反应部分具有与流体样品的样品反应并形成第一样品反应剂反应物的第一反应剂。 第二反应部分含有与第一样品反应剂反应物反应形成第二样品反应剂反应物并形成在流体通道表面上的第二反应剂。
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公开(公告)号：KR1020130014322A
公开(公告)日：2013-02-07
申请号：KR1020120016463
申请日：2012-02-17
Applicant: 한국전자통신연구원
IPC: G01N33/574 , G01N33/532 , G01N27/72 , B82Y15/00
Abstract: PURPOSE: A multiple analyzer and a method for analyzing cancer cells in blood are provided to analyze cancer cells in each cancer. CONSTITUTION: A multiple analyzer comprises a magnetophoresis sorting part, a magnetic field measuring unit, and an analyzing and determining unit. The magnetophoresis sorting part comprises: a solution inlet; a saline solution inlet; a channel which is connected to the solution inlet and the saline solution inlet; one or more ferromagnetism patterns which are placed under the bottom of the channel; a first discharging path which is connected to the channel and discharges a first kind of material contained in the solution; and a second discharge path which is connected to the channel and discharges a second kind of material contained in the solution. A method for analyzing cancer cells in blood comprises the following steps: a step of mixing blood to be tested with a magnetic nanoparticle which is conjugated with a cancer cell-specific antibody, and preparing a mixture solution(S10); a step of dividing the mixture solution into normal cells and cancer cells by magnetophoresis(S20); a step of continuously measuring a magnetic field of the cancer cells(S30); and a step of analyzing and determining cancer cells in each cancer using the magnetic field of the cancer cell(S40). [Reference numerals] (AA) Blood; (BB) Magnetic nanoparticles; (CC) Mixture solution; (S20) Magnetophoresis division: dividing cancer cells and normal cells; (S30) Continuously measuring the magnetic field of the cancer cells; (S40) Analyzing/determining the cancer kinds of cancer cells
Abstract translation: 目的：提供多种分析仪和分析血液中癌细胞的方法，以分析各种癌症中的癌细胞。 构成：多分析仪包括磁电泳分选部，磁场测定部以及分析判断部。 磁电泳分选部分包括：溶液入口; 盐水溶液入口; 连接到溶液入口和盐水溶液入口的通道; 放置在通道底部下方的一个或多个铁磁图案; 第一排出路径，其连接到所述通道并排出所述溶液中包含的第一种材料; 以及第二排出路径，其连接到通道并排出溶液中包含的第二种材料。 用于分析血液中的癌细胞的方法包括以下步骤：将待测血液与与癌细胞特异性抗体结合的磁性纳米颗粒混合，制备混合液（S10）; 通过磁电泳将混合溶液分成正常细胞和癌细胞的步骤（S20）; 连续测量癌细胞的磁场的步骤（S30）; 以及使用癌细胞的磁场分析和确定各癌症中的癌细胞的步骤（S40）。 （附图标记）（AA）血液; （BB）磁性纳米粒子; （CC）混合溶液; （S20）磁电泳分割：分割癌细胞和正常细胞; （S30）连续地测量癌细胞的磁场; （S40）分析/确定癌细胞的癌症种类
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公开(公告)号：KR1020130014305A
公开(公告)日：2013-02-07
申请号：KR1020110130311
申请日：2011-12-07
Applicant: 한국전자통신연구원
IPC: G01N33/574 , G01N33/553 , G01N27/72
Abstract: PURPOSE: A multiple sorting apparatus and a method for sorting cancer cells in blood using the same are provided to sort the cancer cells by each kind of cancer and to simply diagnose cancer development. CONSTITUTION: A multiple sorting apparatus(100) comprises a first magnetophoresis sorting part(MP1) and a second magnetophoresis sorting part(MP2). The first magnetophoresis sorting part has a first channel(CH1). One side of the first channel is connected with a mixture solution inlet port(IP1) and a first saline solution inlet port(IP2). The other side of the first channel is connected with a first outlet port(OP1) and a preliminary separation path(PSP). The second magnetophoresis sorting part has a second channel. One side of the first channel is connected with a second saline solution inlet port(IP3) and a preliminary separation path. The other side of the second channel is connected with the second outlet port(OP2).
Abstract translation: 目的：提供使用其分选血液中的癌细胞的多重分选装置和方法，以通过各种癌症对癌细胞进行分类并简单地诊断癌症发展。 构成：多重分选装置（100）包括第一磁电泳分选部（MP1）和第二磁电泳分选部（MP2）。 第一磁电泳分选部具有第一通道（CH1）。 第一通道的一侧与混合溶液入口（IP1）和第一盐水溶液入口（IP2）连接。 第一通道的另一侧与第一出口（OP1）和初步分离路径（PSP）连接。 第二磁电泳分选部件具有第二通道。 第一通道的一侧与第二盐水溶液入口（IP3）和初步分离路径连接。 第二通道的另一侧与第二出口（OP2）连接。
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公开(公告)号：KR1020120130677A
公开(公告)日：2012-12-03
申请号：KR1020110123504
申请日：2011-11-24
Applicant: 한국전자통신연구원
CPC classification number: B01D71/021 , B01D69/02 , B01D2325/028 , C01B32/182 , C23C14/0605
Abstract: PURPOSE: A separating apparatus using self-assembling material-based graphene nanostructure as a separating part and a manufacturing method of the same are provided to improve the reducibility of components and to be integrated with microfluidic channels and electric components. CONSTITUTION: A manufacturing method of a separating apparatus using self-assembling material-based graphene nanostructure includes the following steps: protective layers are formed on the lower side and the upper side of a substrate(201); parts of the lower side and the upper side of the substrate are exposed by patterning the protective layers; the protective layers on the exposed parts of the substrate are etched; graphene nanostructure with columnar pores is transferred on the upper side of the substrate; and a nanostructure etching mask layer is removed from the graphene nanostructure.
Abstract translation: 目的：提供使用自组装材料的石墨烯纳米结构作为分离部分的分离装置及其制造方法，以提高部件的还原性并与微流体通道和电气部件集成。 构成：使用自组装材料的石墨烯纳米结构的分离装置的制造方法包括以下步骤：在基板（201）的下侧和上侧形成保护层; 通过图案化保护层来暴露基板的下侧和上侧的部分; 蚀刻衬底的暴露部分上的保护层; 具有柱状孔的石墨烯纳米结构转移到基板的上侧; 并且从石墨烯纳米结构去除纳米结构蚀刻掩模层。
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Patent Agency Ranking
公开(公告)号：KR101189129B1
公开(公告)日：2012-10-10
申请号：KR1020080131856
申请日：2008-12-23
Applicant: 한국전자통신연구원
IPC: G01N30/26 , G01N33/563 , G01N33/553
CPC classification number: B01L3/50273 , B01L9/527 , B01L2400/0457 , G01N35/08 , Y10T436/11
Abstract: 본 발명은 미세유체 소자의 유체 흐름 조절 방법 및 미세유체분석장치에 관한 것으로, 이 방법은 수평에 대한 미세유체소자의 기울기를 조절함으로써, 미세유체소자 내에서 간단하고 정밀하게 유체의 흐름을 제어할 수 있다. 이로써 유체의 이송을 완벽하게 제어할 수 있으며, 적은 양의 시료만으로 검사를 진행할 수 있다. 이 방법은 사용자에 의해 수동으로 진행될 수 있어 전력을 필요로 하지 않아 경제적이며, 간단하다. 또한 이 미세유체 분석 장치는 수평에 대해 상기 미세유체소자 수용부의 기울기를 유발하기 위한 기울기 작동수단과 상기 기울기 작동수단의 동작 상태를 제어하기 위한 기울기 제어부를 구비함으로써, 간단하고 정밀하게 유체의 흐름을 제어하여 유체를 정확하게 분석할 수 있다.
미세유체소자, 미세유체분석장치, 기울기, 중력, 모세관력-
公开(公告)号：KR101179553B1
公开(公告)日：2012-09-05
申请号：KR1020080131297
申请日：2008-12-22
Applicant: 한국전자통신연구원
Abstract: 세포 배양 컴파트먼트 유닛은 다공성 멤브레인을 사이에 두고 분리된 세포 배양 영역과 바이오 물질 방출 영역과, 상기 세포 배양 영역의 상기 다공성 멤브라인 위에 구비된 압전 소자와, 상기 압전 소자 상에 구비되며 그 위에 세포가 안착되는 세포 부착용 박막을 포함한다.
압전 고분자(piezoelectric polymer), 전도성 고분자(conducting polymer), 세포 배양(cell culture), 줄기 세포 분화(stem cell differentiation), 전기장(electric field)-
公开(公告)号：KR101075124B1
公开(公告)日：2011-10-24
申请号：KR1020090089107
申请日：2009-09-21
Applicant: 한국전자통신연구원
Abstract: 본발명의액체성분추출장치는유리기판; 유리기판위에덮혀있는덮개층; 덮개층의하부를식각하여형성하며, 주입되는액상시료가흘러가는미세도관부; 및덮개층을식각하여형성한공간으로, 미세도관부와연결되며, 주입되는액상시료를흡수하는하이드로젤을저장하는젤 저장부를포함한다. 따라서, 다른특별한장비가없는상황에서도하이드로젤의흡습성을이용하여액상시료중 액체성분을추출할수 있다.
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公开(公告)号：KR1020110115065A
公开(公告)日：2011-10-20
申请号：KR1020100091588
申请日：2010-09-17
Applicant: 한국전자통신연구원
Abstract: 본 발명은 정량이 가능한 일회용 바이오 샘플 채취 및 토출 장치에 관한 것으로서, 관 형태를 가지며, 일측 끝단의 샘플 주입구로부터 소정 거리 이격된 위치에 형성된 개구부를 포함하는 유체 채널; 상기 유체 채널의 타측 끝단에 결합되며, 상기 유체 채널에 인입되어 채취된 샘플의 토출을 조절하는 조절부를 포함한다. 본 발명에 따르면, 일정한 양의 샘플을 용이하게 채취할 수 있다. 또한, 샘플 채취 장치의 구조가 간단하므로, 저렴한 비용으로 일회용 장치로 제작이 가능하다.
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公开(公告)号：KR1020100073061A
公开(公告)日：2010-07-01
申请号：KR1020080131644
申请日：2008-12-22
Applicant: 한국전자통신연구원
CPC classification number: G01N21/253 , G01N21/8483 , G01N2201/0256 , G01N2201/0826
Abstract: PURPOSE: A liquid sample analysis chip reading system, an analysis method using thereof, and a ubiquitous reading system are provided to effectively obtain the optical sensing result accurately, and to receive or transfer the optical sensing result to a remote site. CONSTITUTION: A ubiquitous liquid sample analysis chip reading system(100) comprises the following; an analysis chip(210) including three sensors applied with the same samples; a lighting-emitting area(132) including three light sources emitting each colors; three light guide paths; a photo diode(134) including three light receiving devices; a controller(118) for analyzing the electric signal transformed by the photo diode; a display unit(120) displaying the result from the controller; and a communication unit for transferring the result.
Abstract translation: 目的：提供液体样品分析芯片读取系统，其使用的分析方法和普遍存在的读取系统，以有效地获得光学感测结果，并将光学感测结果接收或传输到远程站点。 构成：普遍存在的液体样品分析芯片读取系统（100）包括： 分析芯片（210），其包括应用相同样本的三个传感器; 包括发射各种颜色的三个光源的发光区域（132） 三条导光路; 包括三个光接收装置的光电二极管（134） 用于分析由光电二极管变换的电信号的控制器（118）; 显示单元（120），显示来自控制器的结果; 以及用于传送结果的通信单元。
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