Biol. active 1-aminomethyl-acenaphthenes - prepd. by reductive amina-tion of 1-formyl-acenaphthene

    公开(公告)号:DE2252945A1

    公开(公告)日:1974-05-09

    申请号:DE2252945

    申请日:1972-10-28

    Applicant: BASF AG

    Abstract: 1-Aminomethyl-acenaphthenes of formula (I):- (where R5 is a heterocyclic residue, alkyl or alkenyl substd. by heterocyclic, alkoxy and/or carboxy gps. or alkenylcarbonyl or alkylcarbonyl substd. by heterocyclic, alkoxy, aroxy and/or carboxy gps.; and R6 is H, an araliphatic, (cyclo)aliphatic or aromatic residue, NH2, OH, alkylamino, -SO2-R3 (R3 = aliphatic or aromatic residue), -CON(R4)2 (each R4 = H or an aliphatic or aromatic residue), or alkenyl, alkyl, alkenylcarbonyl or alkylcarbonyl substd. by heterocyclic, alkoxy, aroxy and/or carboxy gps.), are prepd. by reacting 1-formyl-acenaphthene with HNR5R6 and with a reducing agent. (I) are CNS active and have hypotensive and antiinflammatory props.

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