公开(公告)号：DE3045720A1

公开(公告)日：1982-07-08

申请号：DE3045720

申请日：1980-12-04

Applicant: BASF AG

Inventor： SCHARWAECHTER PETER DIPL CHEM ,  GUTSCHE KLAUS DIPL CHEM DR ,  KOHLMANN FRIEDRICH-WILHELM DR ,  BECK HINRICH DR

IPC: A61K31/505 ,  A61K31/63 ,  A61K31/635 ,  A61P31/04 ,  C07D239/48 ,  C07D239/49

Abstract: 2-Carbamic acid esters of 2,4-diamino-5-(3',4',5'-trimethoxybenzyl)-pyrimidine (trimethoprim), a process for their preparation, and drugs containing these compounds, which, as pro-drugs of trimethoprim, have valuable antibacterial properties and potentiate the antibacterial action of sulfonamides.

公开(公告)号：CH634566A5

公开(公告)日：1983-02-15

申请号：CH220878

申请日：1978-03-01

Applicant: BASF AG

Inventor： SCHARWAECHTER PETER DR ,  GUTSCHE KLAUS DR ,  KOHLMANN FRIEDRICH-WILHELM DR

IPC: A61K31/505 ,  A61P31/04 ,  C07D239/48 ,  C07D239/49

公开(公告)号：DE3126818A1

公开(公告)日：1983-01-27

申请号：DE3126818

申请日：1981-07-08

Applicant: BASF AG

Inventor： GRAMLICH WALTER DIPL CHEM DR ,  HIMMELE WALTER DIPL CHEM DR ,  SIEGEL HARDO DIPL CHEM DR ,  HEBERLE WOLFGANG DIPL BIOL DR ,  WESENBERG WALTER DR MED ,  KOHLMANN FRIEDRICH-WILHELM DR

IPC: C07C45/69 ,  C07C45/74 ,  C07C47/225 ,  C07D295/02 ,  C07D295/03 ,  C07D211/14 ,  A61K31/395 ,  A61K31/41 ,  A61K31/435 ,  A61K31/535 ,  A61K31/55 ,  C07D265/30

Abstract: The invention relates to novel, useful N-[3-(4'-tert-butylcyclohexen-3-yl)-2-methyl-1-propyl]cycloalkylamines and their physiologically tolerated acid addition salts, to processes for their preparation and to antimycotic agents containing these compounds.

公开(公告)号：AT60593T

公开(公告)日：1991-02-15

申请号：AT84101905

申请日：1984-02-23

Applicant: BASF AG

Inventor： JANSSEN BERND DR ,  MEYER NORBERT DR ,  POMMER ERNST-HEINRICH DR ,  AMMERMANN EBERHARD DR ,  KOHLMANN FRIEDRICH-WILHELM DR ,  WESENBERG WALTER ,  HEBERLE WOLFGANG DR

IPC: A61K31/41 ,  A61K31/415 ,  C07D233/58 ,  C07D233/60 ,  C07D249/08 ,  C07D401/08 ,  C07D405/08 ,  C07D409/08

公开(公告)号：DE3225879A1

公开(公告)日：1984-01-12

申请号：DE3225879

申请日：1982-07-10

Applicant: BASF AG

Inventor： HIMMELE WALTER DR ,  HEBERLE WOLFGANG DR ,  KOHLMANN FRIEDRICH-WILHELM DR ,  WESENBERG WALTER

IPC: A61K31/13 ,  A61K20060101 ,  A61P31/04 ,  A61P31/10 ,  C07C67/00 ,  C07C209/00 ,  C07C209/72 ,  C07C211/17 ,  C07D20060101 ,  C07C85/24 ,  C07C87/34 ,  C07C87/40

公开(公告)号：DE3129620A1

公开(公告)日：1983-02-17

申请号：DE3129620

申请日：1981-07-28

Applicant: BASF AG

Inventor： SCHARWAECHTER PETER DIPL CHEM ,  GUTSCHE KLAUS DIPL CHEM DR ,  KOHLMANN FRIEDRICH-WILHELM DR

IPC: C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D239/46 ,  A61K31/505

Abstract: Novel acetamidinophenylpyrimidines of the general formula I in which R denotes hydrogen and R denotes an alkyl radical having 1 to 4 C atoms, a phenyl, benzyl or furfuryl radical, or the group -C6H4-SO2NH-R , where R is a pyrimidin-2-yl, 4-methylpyrimidin-2-yl, 5-methylpyrimidin-2-yl, 2,6-dimethylpyrimidin-4-yl, 4,6-dimethylpyrimidin-2-yl, 5-methoxypyrimidin-2-yl, 5,6-dimethoxypyrimidin-4-yl, 3-methoxypyridazin-2-yl, pyridin-2-yl or 5-methylisoxazol-3-yl radical, or in which R and R , together with the nitrogen atom to which they are bound, form a polymethylene chain having 4 or 5 methylene groups, which chain can be interrupted by an oxygen atom.

公开(公告)号：DE2822326A1

公开(公告)日：1979-11-29

申请号：DE2822326

申请日：1978-05-22

Applicant: BASF AG

Inventor： HIMMELE WALTER DIPL CHEM DR ,  HEBERLE WOLFGANG ,  KOHLMANN FRIEDRICH-WILHELM DR

IPC: A61K31/445 ,  A61K31/535 ,  A61K31/54

公开(公告)号：DE2823715A1

公开(公告)日：1979-08-23

申请号：DE2823715

申请日：1978-05-31

Applicant: BASF AG

Inventor： SCHARWAECHTER PETER DIPL CHEM ,  GUTSCHE KLAUS DIPL CHEM DR ,  KOHLMANN FRIEDRICH-WILHELM DR

IPC: C07D239/48 ,  C07D239/49 ,  A61K31/505

Abstract: Pyrimidine deriv. of formula (I) is new. (I) is prepd. by reacting trimethoprim with a dichloroacetic acid deriv. at 20-150 degrees C, opt. in presence of solvent and acid acceptor. (I) is an antimicrobial and also potentiates the activity of sulphonamides. It is formulated conventionally for treating e.g. throat, nose, ear, respiratory, digestive or urinary tract infections. It is more active in vivo that trimethoprim e.g. 2.7 times more active against Streptococcus agalactiae in mice.

公开(公告)号：DE2544702A1

公开(公告)日：1977-04-21

申请号：DE2544702

申请日：1975-10-07

Applicant: BASF AG

Inventor： FLEIG HELMUT DIPL CHEM DR ,  HAGEN HELMUT DIPL ING DR ,  DOCKNER TONI DIPL CHEM DR ,  KOHLMANN FRIEDRICH-WILHELM DR

IPC: A61K31/415 ,  A61K31/44 ,  A61K31/445 ,  A61P31/04 ,  A61P33/02 ,  C07D417/06 ,  A61K31/425

Abstract: 2-(5-Nitroimidazol-2-ylvinyl)thiadiazoles of formula (I) are new: (where R1 is 1-4C alkyl opt. substd. by OH; or 1-4C alkoxy; R2 is H or Me; R3 is H, 1-24C alkyl, opt. substd. phenyl or heteroaryl). Specif. (I) are 2-methyl-5- 2-(1-methyl-5-nitroimidazol-2-yl)vinyl -1,3,4-thiadia- zole and its i-ethyl analogue. (I) also have bactericidal activity. A typical cpd. 2-methyl-5-2-(1-methyl-5-nitroimidazol-2-yl)vinyl -1,3,4-thiadia- zole is prepd. in 62% yield by heating a mixt. of 2,5-dimethyl-1,3,4-thiadiazole, 1-methyl-5-nitroimidazole-2-carboxaldehyde and ZnCl2 in acetic acid and acetic anhydride.

公开(公告)号：DE3307479A1

公开(公告)日：1984-09-13

申请号：DE3307479

申请日：1983-03-03

Applicant: BASF AG

Inventor： JANSSEN BERND DR ,  MEYER NORBERT DR ,  KOHLMANN FRIEDRICH-WILHELM DR ,  WESENBERG WALTER ,  HEBERLE WOLFGANG DR

IPC: A01N43/50 ,  A01N43/653 ,  A61K31/41 ,  A61K31/415 ,  B27K3/34 ,  C07C29/14 ,  C07C33/24 ,  C07C45/44 ,  C07C47/457 ,  C07D233/56 ,  C07D249/08 ,  C07D521/00

Abstract: Azolylmethylcycloalkanes of the formula I in which A and B are identical or different and denote hydrogen, alkyl having 1 to 4 C atoms, which can optionally be substituted by halogen, naphthyl, heteroaryl, biphenyl or phenyl, where the phenyl radical can be substituted by halogen, nitro, alkyl, alkoxy or haloalkyl each having 1 to 4 C atoms, phenoxy or the phenylsulphenyl radical, D and E are identical or different and denote hydrogen or halogen, Z denotes CH or N, m can be 1, 2, 3 or 4 and n can be 0, 1 or 2, and their physiologically tolerable acid addition salts and their preparation are described. The compounds are suitable for combating diseases.