公开(公告)号：DE2137276A1

公开(公告)日：1973-02-08

申请号：DE2137276

申请日：1971-07-26

Applicant: BASF AG

Inventor： HIMMELE WALTER DR ,  AQUILA WERNER DR ,  SIEGEL HARDO DR ,  AMANN AUGUST DR ,  GIERTZ HUBERT PROF DR

IPC: C07D295/02 ,  C07D295/03 ,  C07C87/42

Abstract: New 1-aminomethylindans and methods of producing them. The compounds are distinguished by their pharmacological effectiveness, particularly by their actions of lowering blood pressure and inhibiting inflammation and by their parasympathicolytic and central nervous system stimulating effects.

公开(公告)号：DE2114096A1

公开(公告)日：1972-10-05

申请号：DE2114096

申请日：1971-03-24

Applicant: BASF AG

Inventor： ROHR WOLFGANG DR ,  FRANKE ALBRECHT DR ,  GIERTZ HUBERT PROF DR

IPC: A61K31/27 ,  C07C271/06

Abstract: Anti-inflammatory, antipyretic, pain-alleviating cpds. acting on the CNS and increasing the excretion of Na+ in urine, have the formula: (in which R1 and R2 are the same or different and denote an aliphatic gp. opt. phenyl-substd.; preF. R1 is a 1-4C alkyl, or phenylmethyl; R2 is pref. methyl).

公开(公告)号：DE2150685A1

公开(公告)日：1973-04-19

申请号：DE2150685

申请日：1971-10-12

Applicant: BASF AG

Inventor： LEBKUECHER ROLF DR ,  KOENIG HORST DR ,  AMANN AUGUST DR ,  GIERTZ HUBERT PROF DR ,  SCHUSTER JOERG DR

IPC: C07D237/12 ,  A61K20060101 ,  A61K31/50 ,  C07D20060101 ,  C07D237/04 ,  C07D51/04

公开(公告)号：DE2139687A1

公开(公告)日：1973-02-15

申请号：DE2139687

申请日：1971-08-07

Applicant: BASF AG

Inventor： REICHENEDER FRANZ DR ,  KROPP RUDOLF ,  AMANN AUGUST DR ,  GIERTZ HUBERT PROF DR ,  SCHUSTER JOERG DR

IPC: A61K20060101 ,  A61K31/50 ,  C07D20060101 ,  A61K27/00

公开(公告)号：DE2137275A1

公开(公告)日：1973-02-08

申请号：DE2137275

申请日：1971-07-26

Applicant: BASF AG

Inventor： HIMMELE WALTER DR ,  AQUILA WERNER DR ,  SIEGEL HARDO DR ,  AMANN AUGUST DR ,  GIERTZ HUBERT PROF DR

IPC: C07D295/02 ,  C07D295/03 ,  C07D41/04

公开(公告)号：CH599111A5

公开(公告)日：1978-05-12

申请号：CH279574

申请日：1974-02-27

Applicant: BASF AG

Inventor： KOENIG HORST DR ,  THIEME PETER DR ,  GIERTZ HUBERT PROF DR

IPC: C07C67/00 ,  C07C213/00 ,  C07C215/60 ,  C07D319/08 ,  C07C91/34 ,  C07C121/43 ,  C07C149/24

公开(公告)号：DE2210799A1

公开(公告)日：1973-09-20

申请号：DE2210799

申请日：1972-03-07

Applicant: BASF AG

Inventor： THIELE UWE DR ,  KOENIG HORST DR ,  FOEHLISCH BALDUR DR ,  AMANN AUGUST DR ,  GIERTZ HUBERT PROF DR ,  SCHUSTER JOERG DR

IPC: C07D493/08 ,  C07D5/04

Abstract: Hexahydro-benzocyclononenes of formula (I): (where X is O and R' and R2 are different; R' being OH and R2 being 1-6C alkoxy; 7-9C aralkoxy; amino carrying a 1-6 C alkyl, 3-6C cycloalkyl or 7-9C aralkyl residue; or hydrazino opt. substd. by aryl, or R' and R2 are identical, and are amino groups carrying a 1-6C alkyl, 3-6C cycloalkyl or 7-9C aralkyl residue; amino groups derived from a 5- to 7-membered secondary cyclic amine; or hydrazino opt. subst. by aryl; or X is imino and R' and R2 are each OH). (I) have anticonvulsant, sedative, analgesic or anti-inflammatory activity. (I; X= O, R'=R2=pyrrolidino) also has hypertensive activity.

公开(公告)号：DE2157454A1

公开(公告)日：1973-05-24

申请号：DE2157454

申请日：1971-11-19

Applicant: BASF AG

Inventor： HIMMELE WALTER DR ,  AQUILA WERNER DR ,  SIEGEL HARDO DR ,  AMANN AUGUST DR ,  GIERTZ HUBERT PROF DR

IPC: A01N45/02 ,  C07C67/00 ,  C07C209/00 ,  C07C209/26 ,  C07C211/31 ,  C07C211/44 ,  C07C213/00 ,  C07C217/06 ,  C07C229/52 ,  C07C241/00 ,  C07C243/18 ,  C07C275/24 ,  C07C301/00 ,  C07C303/40 ,  C07C311/03 ,  C07C311/16 ,  C07D207/26 ,  C07D207/267 ,  C07D213/38 ,  C07D295/02 ,  C07D295/03 ,  C07C87/00

公开(公告)号：CH615430A5

公开(公告)日：1980-01-31

申请号：CH211975

申请日：1975-02-20

Applicant: BASF AG

Inventor： AMANN AUGUST DR ,  KOENIG HORST DR ,  THIEME PETER DR ,  GIERTZ HUBERT PROF DR ,  KRETZSCHMAR ROLF DR

IPC: C07D285/12 ,  A61K31/41 ,  A61K31/433 ,  A61P25/08 ,  C07D285/125

Abstract: 1494757 1,3,4-Thiadiazolium compounds BASF AG 20 Feb 1975 [21 Feb 1974] 7106/75 Heading C2C The invention comprises novel compounds (I) in which (a) R 2 , R 3 , R 4 , R 5 and R 6 are identical or different and are hydrogen, fluorine, chlorine, bromine, iodine, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 , at least one of the substituents R 2 to R 6 being different from hydrogen, and R 1 is alkyl or 2 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (b) R 1 is methyl optionally substituted by phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring when at least two of R 2 to R 6 are different from hydrogen, or, when R 2 , R 3 , R 5 and R 6 have the above meanings, R 4 is hydrogen, fluorine, bromine, iodine, alkyl of 2 to 4 carbon atoms, alkoxy of 2 to 4 carbon atoms in the alkyl moiety, trifluoromethyl or NO 2 and at least one of R 2 , R 3 , R 4 , R 6 and R 6 is different from H, or (c) R 2 , R 3 , R 4 , R 5 and R 6 are each hydrogen when R 1 is alkyl of 3 to 6 carbon atoms which is optionally substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring or when R 1 is ethyl which is #-substituted by OH, CN, phenyl or cycloalkyl of 3 to 6 carbon atoms in the ring, or (d) R 1 is methyl substituted by cycloalkyl of 3 to 6 carbon atoms in the ring when R 2 , R 3 , R 4 , R 5 and R 6 are each hydrogen or R 2 , R 3 , R 5 and R 6 are hydrogen and R 4 is chlorine. They are made by reacting compounds (II) (obtained by reacting compounds III with R 1 NHNH 2 ; the free acids corresponding to III are also prepared as are compounds IV) with carbon disulphide or thiophosgene. Pharmaceutical preparations having anticonvulsive action contain (I) as active ingredient. Administration is preferably orally.

公开(公告)号：DE2304977A1

公开(公告)日：1974-08-08

申请号：DE2304977

申请日：1973-02-01

Applicant: BASF AG

Inventor： LEBKUECHER ROLF DR ,  KOENIG HORST DR ,  AMANN AUGUST DR ,  GIERTZ HUBERT PROF DR

IPC: C07D237/04 ,  C07D51/04

Abstract: Cpds. of formula (I): (where R1 is lower alkyl; R2 is H or lower alkyl; and R3 is H or acyl) have valuable pharmaceutical (e.g., cardiovascular and antiphlogistic) props. They are prepd. by cyclising a cpd. of formula (II) with R2NHNH2 and opt. exchanging a halogen atom present in an acyl gp. R3 for an amino gp. so as to give a cpd. in which R3 is aminoacyl. Prodts. in which R3 is H may be N-acylated to give prodts. in which R3 is acyl.