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    SINGLE-STRANDED CIRCULAR OLIGONUCLEOTIDES
    124.
    发明申请
    SINGLE-STRANDED CIRCULAR OLIGONUCLEOTIDES 审中-公开
    单条圆形半球形

    公开(公告)号：WO1996030384A1

    公开(公告)日：1996-10-03

    申请号：PCT/US1996003757

    申请日：1996-03-21

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  KOOL, Eric, T.

    IPC: C07H21/00

    CPC classification number: A61K31/7088 ,  A61K31/70 ,  A61K38/00 ,  C07H21/00 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/1135 ,  C12N2310/152 ,  C12N2310/3183 ,  C12N2310/321 ,  C12N2310/53 ,  C12Q1/6813 ,  C12Q1/6839 ,  C12Q1/6886 ,  C12Q1/703 ,  C12Q2600/154 ,  C12N2310/3521

    Abstract: The present invention provides single-stranded circular oligonucleotides each with at least one parallel binding (P) domain and/or at least one corresponding anti-parallel binding (AP) domain separated from each other by loop domains. When more than one P or AP domain is included in a circular oligonucleotide of the present invention, the additional P or AP domains can constitute loop domains for a pair of corresponding P and AP domains, and vice versa. The present invention further provides single-stranded circular oligonucleotides with at least one Hoogsten anti-parallel (HAP) domain. Each P, AP and HAP domain has sufficient complementarity to bind to one strand of a defined nucleic acid target wherein the P domain binds in a parallel manner to the target and the HAP or AP domain binds in an anti-parallel manner to the target. Moreover, the present single-stranded circular oligonucleotides can bind to both single-stranded and double-stranded target nucleic acids. The present invention also provides methods of making and using these oligonucleotides as well as kits and pharmaceutical compositions containing these oligonucleotides.

    Abstract translation: 本发明提供单链的环状寡核苷酸，每一个具有至少一个平行结合（P）结构域和/或至少一个相应的反并行结合（AP）结构域，其通过环结构域彼此分离。 当本发明的环状寡核苷酸中包含多于一个的P或AP结构域时，附加的P或AP结构域可以构成一对相应的P和AP结构域的环结构域，反之亦然。 本发明还提供具有至少一个Hoogsten反平行（HAP）结构域的单链环状寡核苷酸。 每个P，AP和HAP结构域具有足够的互补性以结合定义的核酸靶的一条链，其中P结构域以平行的方式与靶结合，并且HAP或AP结构域以反平行方式结合靶。 此外，本发明的单链环状寡核苷酸可以结合单链和双链靶核酸。 本发明还提供制备和使用这些寡核苷酸的方法以及含有这些寡核苷酸的试剂盒和药物组合物。

    METHODS OF TREATING DISEASE USING SERTOLI CELLS AND ALLOGRAFTS OR XENOGRAFTS
    126.
    发明申请
    METHODS OF TREATING DISEASE USING SERTOLI CELLS AND ALLOGRAFTS OR XENOGRAFTS 审中-公开
    使用丝氨酸细胞和合成酶或XENOGRAFTS治疗疾病的方法

    公开(公告)号：WO1995028167A1

    公开(公告)日：1995-10-26

    申请号：PCT/US1995004565

    申请日：1995-04-13

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  SELAWRY, Helena, P.

    IPC: A61K35/48

    CPC classification number: C12N5/0683 ,  A61K35/39 ,  A61K35/48 ,  A61K38/13 ,  A61K38/28 ,  A61K48/00 ,  C12N5/0676 ,  C12N5/0677 ,  C12N2502/246 ,  C12N2510/00 ,  C12N2510/04 ,  Y10S435/975 ,  A61K2300/00

    Abstract: The present invention describes a method of treating a disease that results from a dificiency of a biological factor which comprises administering to a mammal Sertoli cells and cells that produce the biological factor. In particular, the present invention describes a method of treating diabetes mellitus by transplanting pancreatic islet of Langerhans cells in conjunction with Sertoli cells to create an immunologically privileged site. A method of creating an immunologically privileged site in a mammal for cellular transplants is further described by the present invention. A pharmaceutical composition comprising Sertoli cells and cells that produce a biological factor is also provided.

    Abstract translation: 本发明描述了一种治疗由生物因子的差异引起的疾病的方法，其包括向产生生物因子的哺乳动物Sertoli细胞和细胞施用。 特别地，本发明描述了通过移植胰腺细胞胰岛胰岛细胞与Sertoli细胞结合来产生免疫特异性位点来治疗糖尿病的方法。 通过本发明进一步描述了在哺乳动物中为细胞移植创建免疫特异性位点的方法。 还提供了包含产生生物因子的Sertoli细胞和细胞的药物组合物。

    DIAGNOSIS OF METASTATIC CANCER BY THE MTS-1 GENE
    127.
    发明申请
    DIAGNOSIS OF METASTATIC CANCER BY THE MTS-1 GENE 审中-公开
    由MTS-1基因诊断分子癌

    公开(公告)号：WO1995020656A1

    公开(公告)日：1995-08-03

    申请号：PCT/US1995001214

    申请日：1995-01-31

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  ZAIN, Sayeeda ,  LUKANIDIN, Eugene

    IPC: C12N15/12

    CPC classification number: C07K14/4728 ,  A61K38/00 ,  C07K16/18 ,  C07K2319/00 ,  C12N2799/026 ,  Y10S435/81

    Abstract: The present invention is directed towards the diagnosis of malignant cancer by detection of the mts-1 mRNA or the mts-1 protein, encoded by the mts-1 gene. The present invention contemplates the use of recombinant mts-1 DNA and antibodies directed against the mts-1 protein to diagnose the metastatic potential of several types of tumor cells, including, for example, thyroid, epithelial, lung, liver and kidney tumor cells. The present invention is also directed to mammalian cell lines and tumors with high and low metastatic potential which have been developed to serve as useful model systems for in vitro and in vivo anti-metastasis drug screening.

    Abstract translation: 本发明涉及通过检测由mts-1 mRNA编码的mts-1mRNA或mts-1蛋白来诊断恶性肿瘤， / u基因。 本发明考虑使用重组mts-1 DNA和针对mts-1蛋白的抗体来诊断几种类型的肿瘤细胞的转移潜能，包括对于 例如甲状腺，上皮，肺，肝，肾等肿瘤细胞。 本发明还涉及哺乳动物细胞系和具有高和低转移潜力的肿瘤，其已被开发用作在体外和/或体外的有用的模型系统 抗转移药物筛选。

    METAL ION BINDING MONOMER AND POLYMER
    128.
    发明申请
    METAL ION BINDING MONOMER AND POLYMER 审中-公开
    金属离子结合单体和聚合物

    公开(公告)号：WO1995009854A1

    公开(公告)日：1995-04-13

    申请号：PCT/US1994011232

    申请日：1994-10-03

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  IPPOLITI, J., Thomas ,  MABBOTT, Gary, A. ,  HANS, Jeremy ,  STOHLMEYER, Michelle

    IPC: C07D403/08

    CPC classification number: C07D233/64 ,  B01J45/00 ,  C08F12/26 ,  C08F20/36 ,  C08F26/06 ,  G01N27/44747

    Abstract: The present invention relates to bis-imidazolyl compounds of formula (I) and polymers having the above-identified bis-imidazolyl compounds as a polymerizable unit. The present invention further relates to a method for scavenging trace quantities of metal ions from various effluents sources using the polymers of the instant invention. The instant invention also is directed to the use of the above-identified polymers as corrosion inhibiting agents and as a film for use in gel electrophoresis.

    Abstract translation: 本发明涉及式（I）的双咪唑基化合物和具有上述双咪唑基化合物作为可聚合单元的聚合物。 本发明还涉及使用本发明的聚合物从各种流出物源中清除微量金属离子的方法。 本发明还涉及使用上述聚合物作为腐蚀抑制剂和用作凝胶电泳的膜。

    MONOLITHIC PRESTRESSED CERAMIC DEVICES AND METHOD FOR MAKING SAME
    130.
    发明申请
    MONOLITHIC PRESTRESSED CERAMIC DEVICES AND METHOD FOR MAKING SAME 审中-公开
    单晶预处理陶瓷器件及其制造方法

    公开(公告)号：WO1994019834A1

    公开(公告)日：1994-09-01

    申请号：PCT/US1994001629

    申请日：1994-02-17

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  HAERTLING, Gene, Henry

    IPC: H01L41/22

    CPC classification number: H01L41/33 ,  H01H57/00 ,  H01L41/098 ,  H01L41/253 ,  H01L41/29 ,  Y10T29/42 ,  Y10T29/49169

    Abstract: Monolithic, internally asymmetrically stress biased electrically active ceramic devices and a method for making same is disclosed. The first step in the method of the present invention is to fabricate a ceramic element having first and second opposing surfaces. Next, only the first surface is chemically reduced by heat treatment in a reducing atmosphere. This produces a concave shaped, internally asymmetrically stress biased ceramic element and an electrically conducting, chemically reduced layer on the first surface which serves as one of the electrodes of the device. Another electrode can be deposited on the second surface to complete the device. In another embodiment of the present invention two dome shaped ceramic devices can be placed together to form a completed clamshell structure or an accordion type structure. In a further embodiment, the clamshell or accordion type structures can be placed on top of one another. In another embodiment, a pair of dome shaped ceramic devices having opposing temperature characteristics can be placed on top of each other to produce an athermalized ceramic device.

    Abstract translation: 公开了一种内部非对称应力偏置电活性陶瓷器件及其制造方法。 本发明方法的第一步是制造具有第一和第二相对表面的陶瓷元件。 接下来，通过在还原气氛中的热处理，仅第一表面被化学还原。 这产生凹形，内部不对称应力偏置陶瓷元件和在第一表面上的导电化学还原层，其用作器件的电极之一。 另一电极可沉积在第二表面上以完成该装置。 在本发明的另一个实施例中，两个圆顶形陶瓷装置可以放置在一起以形成完整的蛤壳结构或手风琴式结构。 在另一个实施例中，蛤壳式或手风琴式结构可以放置在彼此之上。 在另一个实施例中，具有相反温度特性的一对圆顶形陶瓷装置可以彼此顶部放置，以产生无热化陶瓷装置。

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