公开(公告)号：KR1020100023538A

公开(公告)日：2010-03-04

申请号：KR1020080082368

申请日：2008-08-22

Applicant: 삼성전자주식회사

Inventor： 이양의 ,  송미정 ,  박재찬 ,  조윤경 ,  이정건

IPC: G01N37/00

CPC classification number: G01N33/491 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502738 ,  B01L2200/16 ,  B01L2300/0803 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/0688 ,  B29C39/006 ,  B29C39/10 ,  B29K2075/00

Abstract: PURPOSE: A method for manufacturing a solid reagent and a microfluidic device receiving the solid reagent are provided to manufacture a frozen and dried solid reagent by eliminating moisture from the frozen reagent after injecting a liquid reagent into a receiving part and freezing the reagent and to receive the frozen and dried solid reagent. CONSTITUTION: A method for manufacturing a solid reagent comprises: a step of preparing a mold in which a plurality of reagent receiving parts(301) are included; a step of injecting a liquid reagent into a plurality of the reagent receiving parts; a step of freezing the liquid reagent; a step of separating the frozen reagent from the mold; and a step of eliminating a moisture from the frozen reagent and drying the reagent. The step for drying the reagent includes a step of sublimating the moisture which is contained in the frozen reagent.

Abstract translation: 目的：提供一种制备固体试剂和接收固体试剂的微流体装置的方法，用于在将液体试剂注入接收部分并冷冻试剂之后，通过从冷冻试剂中除去水分来制造冷冻和干燥的固体试剂，并接收 冷冻和干燥的固体试剂。 构成：制造固体试剂的方法包括：制备其中包含多个试剂接收部分（301）的模具的步骤; 将液体试剂注入多个试剂接收部的工序; 冷冻液体试剂的步骤; 将冷冻试剂与模具分离的步骤; 以及从冷冻试剂中除去水分并干燥试剂的步骤。 干燥试剂的步骤包括使包含在冷冻试剂中的水分升华的步骤。

公开(公告)号：KR1020090017013A

公开(公告)日：2009-02-18

申请号：KR1020070081410

申请日：2007-08-13

Applicant: 삼성전자주식회사

Inventor： 강경호 ,  황정주 ,  박재찬 ,  남윤우 ,  손준일

IPC: G01N27/72 ,  G01N33/48

CPC classification number: G01N15/0656

Abstract: An apparatus and a method for detecting micro-particles and microorganisms using a magnetic field are provided to identify the micro-particles or the microorganisms in real time by using electrical characteristics of the micro-particles or the microorganisms. An apparatus for detecting micro-particles and microorganisms using a magnetic field includes magnetic sensors(211,212), electrodes(221,22,223,224), and a signal processor(250). The magnetic sensors are located outside a flow pipe(203) and measure a magnetic field induced by a fluid flowing in the flow pipe. The electrodes apply a current to the fluid to measure impedance. The signal processor determines concentrations of micro-particles and microorganisms included in the fluid by using the intensity of the magnetic field and the impedance.

Abstract translation: 提供使用磁场检测微粒和微生物的装置和方法，通过使用微粒或微生物的电特性来实时识别微粒或微生物。 使用磁场检测微粒和微生物的装置包括磁传感器（211,212），电极（221,22,223,224）和信号处理器（250）。 磁传感器位于流管203的外侧，并测量由流管中流动的流体感应的磁场。 电极向流体施加电流以测量阻抗。 信号处理器通过使用磁场和阻抗的强度来确定流体中包含的微粒和微生物的浓度。

公开(公告)号：KR100823304B1

公开(公告)日：2008-04-18

申请号：KR1020060079524

申请日：2006-08-22

Applicant: 삼성전자주식회사

Inventor： 박정제 ,  김홍식 ,  장우영 ,  박재찬

IPC: A61B5/04 ,  A61B5/00

CPC classification number: A61B5/0531 ,  A61B5/442

Abstract: 본 발명에 따른 피부 수화도 측정 장치는, R 전극(Reference Electrode), C 전극(Current Carrying Electrode), 및 M 전극(Measuring Electrode)을 포함하는 전극부; 제1 전압이 인가되는 반전(inverting) 입력 단자가 상기 R 전극과 연결되고, 출력 단자가 상기 C 전극과 연결되는 연산 증폭기(Op Amp: Operational Amplifier); 상기 출력 단자 및 상기 C 전극 간의 연결을 제어하는 스위치; 및 상기 제1 전압과 상기 출력 단자의 전압을 비교하여 상기 출력 단자의 전압이 상기 제1 전압과 선정된(predetermined) 상수(constant)를 곱한 값 이하인 경우, 상기 출력 단자 및 상기 C 전극이 연결되도록 상기 스위치를 제어하는 비교 제어부를 포함하는 것을 특징으로 한다.
피부 수화도, 수분, R 전극, C 전극, M 전극

Abstract translation: 根据本发明的用于测量皮肤水分含量的设备包括：包括R电极（参比电极），C电极（电流携带电极）和M电极（测量电极）的电极单元; 一种运算放大器（运算放大器），其中施加有第一电压的反相输入端子连接到R电极，并且输出端子连接到C电极; 控制输出端子和C电极之间的连接的开关; 并且将第一电压与输出端子的电压进行比较，使得当输出端子的电压等于或小于通过将第一电压乘以预定常数而获得的值时， 以及用于控制开关的比较控制单元。

公开(公告)号：KR1020070117876A

公开(公告)日：2007-12-13

申请号：KR1020060052054

申请日：2006-06-09

Applicant: 삼성전자주식회사

Inventor： 김홍식 ,  장우영 ,  박재찬 ,  박정제

IPC: A61B5/053

CPC classification number: A61B5/0531 ,  A61B5/442 ,  A61B2562/02

Abstract: A skin impedance measuring sensor is provided to measure skin impedance accurately by contacting a measuring electrode with a user's skin after the contact of a reference electrode and a current carrying electrode. A reference electrode(311) and a current carrying electrode(313) contact with a skin(320) of a user. A measuring electrode(312) measures impedance of a current flowing between the reference electrode and the current carrying electrode. The measuring electrode has a stepped portion for the reference electrode and the current carrying electrode. The measuring electrode is interposed between the reference electrode and the current carrying electrode, and the stepped portion contacts with the skin after the contact of the reference electrode and the current carrying electrode.

Abstract translation: 提供一种皮肤阻抗测量传感器，通过在参考电极和载流电极接触之后使测量电极与使用者的皮肤接触来准确地测量皮肤阻抗。 参考电极（311）和载流电极（313）与使用者的皮肤（320）接触。 测量电极（312）测量在参考电极和载流电极之间流动的电流的阻抗。 测量电极具有用于参考电极和载流电极的阶梯部分。 测量电极插入在参考电极和载流电极之间，并且阶梯部分在参考电极和载流电极接触之后与皮肤接触。

公开(公告)号：KR100756409B1

公开(公告)日：2007-09-10

申请号：KR1020060063160

申请日：2006-07-05

Applicant: 삼성전자주식회사

Inventor： 장우영 ,  박정제 ,  박재찬 ,  김홍식

IPC: A61B5/04 ,  A61B5/00

CPC classification number: A61B5/0531 ,  A61B5/442

Abstract: An apparatus and a method for measuring skin moisture are provided to perform optimized skin moisture measurement according to specific skin of a user by determining an automatic or manual mode after performing a calibration operation. A method for measuring skin moisture includes the steps of: starting skin moisture measurement by receiving a skin moisture measurement request from a user(911); converting to a calibration mode in case of first measurement(913); measuring skin impedance of a user and determining whether the skin impedances in a wet skin area and a dry skin area are distinguished by comparing the skin impedance and a threshold value(914); and generating a current state of the skin by determining whether the skin is wet or dry(920).

Abstract translation: 提供了一种用于测量皮肤水分的装置和方法，用于通过在执行校准操作之后确定自动或手动模式，根据用户的特定皮肤来执行优化的皮肤水分测量。 用于测量皮肤水分的方法包括以下步骤：通过接收来自用户（911）的皮肤水分测量请求来开始皮肤水分测量; 在第一次测量的情况下转换为校准模式（913）; 测量用户的皮肤阻抗并通过比较皮肤阻抗和阈值来区分湿皮肤区域和干性皮肤区域中的皮肤阻抗（914）; 以及通过确定皮肤是湿还是干的来产生皮肤的当前状态（920）。

公开(公告)号：KR1020050047936A

公开(公告)日：2005-05-23

申请号：KR1020030081740

申请日：2003-11-18

Applicant: 삼성전자주식회사 ,  구한서

Inventor： 장우영 ,  신상훈 ,  박재찬 ,  기호성

IPC: A61N2/08

CPC classification number: A61N2/02 ,  A61N2/06

Abstract: 혈류의 흐름을 촉진시킬 수 있는 자장을 이용한 혈류 제어 장치 및 그 방법이 개시된다. 개시된 장치는 소정의 방향으로 혈액이 흐를 수 있는 혈관을 갖는 인간과 같은 생명체의 질병을 치료하거나 건강을 증진시키기 위하여, 혈액이 흐르는 방향과 벡터적으로 자기장의 방향이 일치하도록 자기장을 발생시키는 자장발생수단과 자장발생수단을 고정시키기 위한 고정수단을 구비한다. 전술한 자장을 이용한 혈류 제어 장치 및 그 방법은 종래의 자장 치료 방법과 달리 혈류의 방향으로 자장을 벡터적으로 인가함으로써 혈류의 흐름을 개선할 수 있는 효과가 있다.

公开(公告)号：KR1020050024123A

公开(公告)日：2005-03-10

申请号：KR1020030061944

申请日：2003-09-04

Applicant: 삼성전자주식회사

Inventor： 여형석 ,  박재찬 ,  신건수 ,  김경호 ,  김연호 ,  이정환

IPC: G06Q50/22 ,  A61B5/0482

CPC classification number: A63B69/00 ,  A61B5/0002 ,  A61B5/02427 ,  A61B5/02438 ,  A61B5/486 ,  A61B5/6816 ,  A63B24/00 ,  A63B71/0686 ,  A63B2071/0625 ,  A63B2225/50 ,  A63B2230/065 ,  G06F19/00

Abstract: PURPOSE: A method and a device for controlling exercise/stabilization training using bio-feedback are provided to make an exercising user perform the training according to a level by recognizing bio-changes from the bio-feedback information, as bio-signals of the user are collected/analyzed, and an analysis result and the bio-feedback information matched with each change level of the bio-signals are offered to the user. CONSTITUTION: A bio-signal measuring module(111) is attached to a body of the user, measures the bio-signals of the user, and provides the bio-feedback information as an audio signal. A bio-information feedback module(121) sets an object exercise/stabilization range of the user by using the bio-signals received from the bio-signal measuring part and user information, and comparing the bio-signals with the maximum/minimum value of the object exercise/stabilization range according to a training mode. According to a comparison result, the bio-information feedback module provides the position or negative bio-feedback information to the bio-signal measuring module.

Abstract translation: 目的：提供使用生物反馈来控制运动/稳定训练的方法和装置，以使运动用户根据生物反馈信息识别生物变化来根据水平进行训练，作为用户的生物信号 被收集/分析，并且向用户提供与生物信号的每个变化水平匹配的分析结果和生物反馈信息。 构成：将生物信号测量模块（111）附接到用户的身体，测量用户的生物信号，并将生物反馈信息提供为音频信号。 生物信息反馈模块（121）通过使用从生物信号测量部分接收到的生物信号和用户信息来设置用户的对象锻炼/稳定范围，并将生物信号与最大/最小值 对象运动/稳定范围根据训练模式。 根据比较结果，生物信息反馈模块向生物信号测量模块提供位置或负生物反馈信息。

公开(公告)号：KR1020050022201A

公开(公告)日：2005-03-07

申请号：KR1020030058782

申请日：2003-08-25

Applicant: 삼성전자주식회사

Inventor： 정성욱 ,  서승주 ,  박재찬

IPC: C12Q1/68

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00432 ,  B01J2219/00439 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00677 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  C40B40/06 ,  C40B40/10 ,  C40B50/14 ,  C40B60/14 ,  G03F7/0045 ,  G03F7/40 ,  Y10S430/115 ,  Y10S430/122 ,  Y10S430/123 ,  Y10S430/127

Abstract: PURPOSE: A composition containing a photoacid generator monomer, a substrate coated with the same composition, a method for synthesizing a compound on the substrate using the same composition and a microarray produced therefrom are provided, thereby performing the coating of the substrate with the photoacid generator monomer without polymerization, and simplifying the synthesis process of a compound on the substrate by coating the substrate with the photoacid generator monomer. CONSTITUTION: The composition containing a photoacid generator monomer and nonionic surfactant is provided, wherein the photoacid generator monomer is sulfonium-based or iodonium-based photoacid generator; the sulfonium-based photoacid generator is represented by formula (I) in which R is CF3SO3- or C4F9SO3-, and R1 is CH3, formula (II) in which R is CF3SO3- or C4F9SO3-, or formula (III) in which R is CF3SO3-, C4F9SO3-, CF3(CF2)3SO3 or p-TSO, R1 is hydroxy or H, and R2 is hydroxy or H; the iodonium photoacid generator is represented by formula (IV) in which R is CF3SO3 or C4F9SO3, or formula (V) in which R is CF3SO3, C4F9SO3 or p-TSO; and the nonionic surfactant is 100% fluoroaliphatic polymer ester or a mixture of 95% fluoroaliphatic polymer ester and 5% NMP. The method for synthesizing a compound on the substrate comprises the steps of: (a) coating a first molecule layer having an acid unstable protecting group on the solid substrate; (b) coating the photoacid generator monomer composition on the first molecule layer; (c) exposing the composition layer to light and heating the composition layer to remove the acid unstable protecting group from the first molecule; (d) cleaning the photoacid generator monomer composition layer; and (e) binding a second molecule to the exposed first molecule, wherein the compound is nucleic acid or protein.

Abstract translation: 目的：提供含有光致酸发生剂单体的组合物，用相同组合物涂布的基材，使用相同组成的基板上合成化合物的方法和由其制备的微阵列，从而进行用光致酸产生剂涂布基材 单体，并且通过用光酸产生剂单体涂布基板来简化基材上的化合物的合成过程。 构成：提供含有光酸产生剂单体和非离子表面活性剂的组合物，其中光酸产生剂单体是锍基或碘鎓基光酸产生剂; 锍基光酸产生剂由式（I）表示，其中R是CF 3 SO 3 - 或C 4 F 9 SO 3 - ，R 1是CH 3，式（II）其中R是CF 3 SO 3 - 或C 4 F 9 SO 3 - 或式（III），其中R 是CF 3 SO 3 - ，C 4 F 9 SO 3 - ，CF 3（CF 2）3 SO 3或p-TSO，R 1是羟基或H，R 2是羟基或H; 碘鎓光酸发生剂由式（IV）表示，其中R是CF 3 SO 3或C 4 F 9 SO 3，或式（V）其中R是CF 3 SO 3，C 4 F 9 SO 3或p-TSO; 非离子表面活性剂为100％氟代脂族聚合物酯或95％氟代脂族聚合物酯和5％NMP的混合物。 在基材上合成化合物的方法包括以下步骤：（a）在固体基质上涂覆具有酸不稳定保护基团的第一分子层; （b）在第一分子层上涂覆光酸产生剂单体组合物; （c）将组合物层曝光并加热组合物层以从第一分子除去酸不稳定的保护基团; （d）清洁光致酸发生剂单体组合物层; 和（e）将第二分子与暴露的第一分子结合，其中所述化合物是核酸或蛋白质。

公开(公告)号：KR100429002B1

公开(公告)日：2004-04-29

申请号：KR1020017000382

申请日：2000-06-07

Applicant: 삼성전자주식회사

Inventor： 김민환 ,  김도윤 ,  문봉석 ,  박재찬 ,  김영희 ,  서승주

IPC: C12Q1/68

CPC classification number: B82Y30/00 ,  B01J2219/00432 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00711 ,  B01J2219/00729 ,  C07B2200/11 ,  C07K14/003 ,  C40B50/14 ,  C40B60/14 ,  Y02P20/55

Abstract: The present invention relates to a process for preparing arrays of oligopeptide nucleic acid probes immobilized on a solid matrix by employing polymeric photoacid generator. Arrays of peptide nucleic acid probes of the invention are prepared by the steps of: (i) derivatizing the surface of a solid matrix with aminoalkyloxysilane in alcohol and attaching a linker with acid-labile protecting group on the solid matrix; (ii) coating the solid matrix with polymeric photoacid generator (PAG); (iii) exposing the solid matrix thus coated to light to generate acid for eliminating acid-labile protecting group; (iv) washing the solid matrix with alkaline solution or organic solvent and removing residual polymeric photoacid generator; and, (v) attaching a monomeric peptide nucleic acid with acid-labile protecting group to the solid matrix, and repeating the previous Steps of (ii) to (v). In accordance with the present invention, neutral peptide nucleic acid probes, as the promising substitute for conventional negatively-charged oligonucleotide probes, can be prepared by employing polymeric photoacid generator in a simple and efficient manner, while overcoming the problems confronted in the prior art DNA chip fabrication using PR system and PPA system.

Abstract translation: 本发明涉及通过使用聚合的光酸产生剂制备固定在固体基质上的寡肽核酸探针阵列的方法。 通过以下步骤制备本发明的肽核酸探针阵列：（i）用氨基烷氧基硅烷在醇中衍生化固体基质的表面，并在所述固体基质上连接具有酸不稳定保护基的接头; （ii）用聚合的光酸产生剂（PAG）涂覆固体基质; （iii）将如此涂覆的固体基质暴露于光下以产生酸以消除酸不稳定性保护基团; （iv）用碱性溶液或有机溶剂洗涤固体基质并除去残留的聚合物光酸产生剂; （v）将具有酸不稳定保护基的单体肽核酸连接至固体基质，并重复（ii）至（v）的前述步骤。 根据本发明，中性肽核酸探针作为常规带负电寡核苷酸探针的有希望的替代物，可以通过以简单且有效的方式使用聚合光致酸生成剂来制备，同时克服了现有技术DNA中遇到的问题 采用PR系统和PPA系统进行芯片制造。

公开(公告)号：KR1020010053471A

公开(公告)日：2001-06-25

申请号：KR1020017000382

申请日：2000-06-07

Applicant: 삼성전자주식회사

Inventor： 김민환 ,  김도윤 ,  문봉석 ,  박재찬 ,  김영희 ,  서승주

IPC: C12Q1/68

CPC classification number: B82Y30/00 ,  B01J2219/00432 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00711 ,  B01J2219/00729 ,  C07B2200/11 ,  C07K14/003 ,  C40B50/14 ,  C40B60/14 ,  Y02P20/55

Abstract: PURPOSE: A process for preparing peptide nucleic acid probe is provided to prepare arrays of oligopeptide nucleic acid probes which is immobilized on a solid matrix by employing polymeric photoacid generator and is capable of using the production of a biochip in a simple and efficient manner in a simple and efficient manner. CONSTITUTION: A process for preparing peptide nucleic acid probe consists of the following steps of: (a) derivatizing the surface of a solid matrix with aminoalkyloxysilane in alcohol and attaching a linker with acid-labile protecting group on the solid matrix; (b) coating the solid matrix with polymeric photoacid generator(PAG); (c) exposing the solid matrix thus coated to light to generate acid for eliminating acid-labile protecting group; (d) washing the solid matrix with alkaline solution or organic solvent and removing residual polymeric photoacid generator; (e) attaching a monomeric peptide nucleic acid with acid-labile protecting group to the solid matrix; and repeating the previous steps of (b) to (c).

Abstract translation: 目的：提供制备肽核酸探针的方法，以制备寡聚核酸探针的阵列，其通过使用聚合物光酸发生剂固定在固体基质上，并能够以简单有效的方式在生物芯片中生产 简单高效的方式。 构成：制备肽核酸探针的方法包括以下步骤：（a）用醇中的氨基烷氧基硅烷衍生固体基质的表面，并在固体基质上连接具有酸不稳定保护基的连接体; （b）用聚合光致酸发生剂（PAG）涂覆固体基质; （c）将由此涂覆的固体基质曝光以产生酸以消除酸不稳定保护基团; （d）用碱性溶液或有机溶剂洗涤固体基质，除去残留的聚合光致酸发生剂; （e）将具有酸不稳定保护基团的单体肽核酸连接到固体基质上; 并重复前述（b）至（c）的步骤。