公开(公告)号：NO20081595L

公开(公告)日：2008-06-02

申请号：NO20081595

申请日：2008-03-31

Applicant: ARRAY BIOPHARMA INC

Inventor： LYSSIKATOS JOSEPH P ,  MIKNIS GREG ,  LAIRD ELLEN ,  TARLTON EUGENE ,  BUCKMELTER ALEXANDRE J ,  REN LI ,  RAST BRYSON ,  SCHLACHTER STEPHEN T ,  WENGLOWSKY STEVEN MARK

IPC: C07D491/04 ,  C07D495/04

Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：NO20081595A

公开(公告)日：2008-06-02

申请号：NO20081595

申请日：2008-03-31

Applicant: ARRAY BIOPHARMA INC

Inventor： LYSSIKATOS JOSEPH P ,  MIKNIS GREG ,  LAIRD ELLEN ,  TARLTON EUGENE ,  BUCKMELTER ALEXANDRE J ,  REN LI ,  RAST BRYSON ,  SCHLACHTER STEPHEN T ,  WENGLOWSKY STEVEN MARK

IPC: C07D491/04 ,  C07D495/04

CPC classification number: C07D491/04 ,  C07D495/04

公开(公告)号：CA2635813A1

公开(公告)日：2007-08-09

申请号：CA2635813

申请日：2007-01-26

Applicant: ARRAY BIOPHARMA INC

Inventor： GRONEBERG ROBERT ,  LAIRD ELLEN ,  EARY CHARLES TODD ,  WATSON DANIEL ,  RODRIGUEZ MARTHA ,  RIZZI JAMES ,  MUNSON MARK ,  BURGESS LAURENCE E ,  HARVEY DARREN

IPC: C07D231/40 ,  A61K31/416 ,  A61P29/00 ,  C07D231/56

Abstract: The compound of Formula (I) and pharmaceutically acceptable salts and prodru gs thereof are useful in the treatment and prevention of various disorders mediated by kinases.

公开(公告)号：NO20072558L

公开(公告)日：2007-07-18

申请号：NO20072558

申请日：2007-05-18

Applicant: ARRAY BIOPHARMA INC

Inventor： WALLACE ELI M ,  ZHAO QIAN ,  LYSSIKATOS JOSEPH P ,  HANS JEREMY ,  AICHER TOM ,  LAIRD ELLEN ,  ROBINSON JOHN ,  ALLEN SHELLEY

IPC: C07D413/00 ,  A61K31/4245 ,  A61P35/00 ,  C07D417/00

Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.

公开(公告)号：MX2007004547A

公开(公告)日：2007-06-07

申请号：MX2007004547

申请日：2005-10-18

Applicant: ARRAY BIOPHARMA INC

Inventor： ZHAO QIAN ,  WALLACE ELI M ,  LYSSIKATOS JOSEPH P ,  HANS JEREMY ,  AICHER TOM ,  LAIRD ELLEN ,  ROBINSON JOHN ,  ALLEN SHELLEY

IPC: A61K31/00 ,  C07D413/00 ,  C07D417/00

Abstract: La presente invencion se refiere a inhibidores de quinesinas mitoticas, particularmente KSP, y metodos para producir estos inhibidores. La invencion tambien proporciona composiciones farmaceuticas que comprenden los inhibidores de la invencion y metodos de utilizacion de los inhibidores y composiciones farmaceuticas en el tratamiento y prevencion de varios trastornos.