公开(公告)号：US20110193270A1

公开(公告)日：2011-08-11

申请号：US13025861

申请日：2011-02-11

Applicant: Yung-Chieh Tan

Inventor： Yung-Chieh Tan

IPC: B29C59/00 ,  B29B7/72

CPC classification number: B29C44/385 ,  B01D39/00 ,  B26F1/26 ,  B26F1/28 ,  B26F3/004 ,  B29C31/042 ,  B29C33/0033 ,  B29C39/24 ,  B29C39/26 ,  B29C39/42 ,  B29C41/12 ,  B29C41/36 ,  B29C41/38 ,  B29C2793/0045 ,  B29L2031/14 ,  B29L2031/737 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00373 ,  B82Y30/00

Abstract: Methods of and devices for making pores, nozzles, and slits are described. In some embodiments, the methods create pattern in the molded substrate by controlling the location and direction of a controlled flow stream through molding plates. The molding plate contains a predefined pattern that is able to be used to create the desired pattern in the molding plate.

Abstract translation: 描述了制造孔，喷嘴和狭缝的方法和装置。 在一些实施例中，该方法通过控制通过模制板的受控流动流的位置和方向在模制基底中产生图案。 成型板包含能够用于在模制板中产生所需图案的预定图案。

公开(公告)号：US07906273B2

公开(公告)日：2011-03-15

申请号：US11798884

申请日：2007-05-17

Applicant: Chien-Chung Fu

Inventor： Chien-Chung Fu

IPC: G03F7/00

CPC classification number: B29C35/0894 ,  A61M37/0015 ,  A61M2037/0053 ,  B29C2035/0827 ,  B81B2201/055 ,  B81C1/00111

Abstract: A method of manufacturing a hollow micro-needle structure includes the steps of: disposing a first mask layer and a second mask layer respectively aside a first substrate and aside a rear surface of the first substrate, wherein the first substrate is transparent to predetermined light; forming a photoresist layer on the front surface of the first substrate and the first mask layer; providing the predetermined light to illuminate the first substrate in a direction from the rear surface to the front surface so as to expose the photoresist layer to form an exposed portion and an unexposed portion; and removing the unexposed portion to form the micro-needle structure, which is formed by the exposed portion. The micro-needle structure has an inclined sidewall and a through hole surrounded by the inclined sidewall.

Abstract translation: 一种中空微针结构体的制造方法，其特征在于，包括：将第一掩模层和第二掩模层分别配置在第一基板的外侧，将第一基板的背面放置在第一基板的背面， 在所述第一基板和所述第一掩模层的前表面上形成光致抗蚀剂层; 提供所述预定光以在从所述后表面到所述前表面的方向上照亮所述第一基板，以暴露所述光致抗蚀剂层以形成暴露部分和未曝光部分; 并且去除未曝光部分以形成由暴露部分形成的微针结构。 微针结构具有倾斜侧壁和由倾斜侧壁包围的通孔。

公开(公告)号：US20100193997A1

公开(公告)日：2010-08-05

申请号：US11916468

申请日：2006-06-08

Applicant: Franklyn L. Frederickson ,  Dennis E. Ferguson

Inventor： Franklyn L. Frederickson ,  Dennis E. Ferguson

IPC: B29C33/42 ,  B29C59/02 ,  B29C35/08

CPC classification number: B81C99/009 ,  B29C33/00 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00111

Abstract: The present invention is directed to a method of forming a mold for use in making molded articles having a plurality of microprojections. Additionally, the present invention provides a method of forming a molded article having a plurality of microprojections. In one aspect, a mold workpiece is provided, a tool having a tip with a shape corresponding to the microprojection, wherein the hardness of the tool is greater than that of the mold workpiece, is pressed into the mold workpiece and removed, thereby creating a mold with a microprojection cavity suitable for use in making the molded article.

Abstract translation: 本发明涉及一种形成用于制造具有多个微喷射体的模制品的模具的方法。 另外，本发明提供了形成具有多个微喷射体的成型品的方法。 一方面，提供了模具工件，具有具有对应于微喷射体的形状的尖端的工具，其中刀具的硬度大于模具工件的硬度，被压入模具工件并移除，从而形成 具有适合用于制造模制品的微型喷射腔的模具。

公开(公告)号：US20100185162A1

公开(公告)日：2010-07-22

申请号：US12749001

申请日：2010-03-29

Applicant: Kazuhiko SHIOMITSU ,  Hiroshi Sugimura ,  Toshiaki Kurosu ,  Gaku Suzuki ,  Takao Tomono

Inventor： Kazuhiko SHIOMITSU ,  Hiroshi Sugimura ,  Toshiaki Kurosu ,  Gaku Suzuki ,  Takao Tomono

IPC: A61M5/00 ,  C23F1/00 ,  B28B11/08

CPC classification number: B44C1/227 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0038 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C33/42 ,  B81B2201/055 ,  B81C1/00111 ,  B81C2201/0198

Abstract: The invention discloses a method of manufacturing a microneedle including the steps of forming an island etching mask having thickness distribution on a substrate, and processing the substrate into a needle by taking advantage of a difference in etching rates between the etching mask and the substrate. The invention enables to readily control a point angle and height of the manufactured needle.

Abstract translation: 本发明公开了一种制造微针的方法，包括以下步骤：在衬底上形成具有厚度分布的岛蚀刻掩模，并通过利用蚀刻掩模和衬底之间的蚀刻速率差来将衬底处理成针。 本发明能够容易地控制所制造的针的点角度和高度。

公开(公告)号：US20090239072A1

公开(公告)日：2009-09-24

申请号：US12313935

申请日：2008-11-26

Applicant: Yang Wei ,  Liang Liu ,  Shou-Shan Fan

Inventor： Yang Wei ,  Liang Liu ,  Shou-Shan Fan

IPC: D01F9/12 ,  H05B6/00

CPC classification number: C01B32/168 ,  B81B2201/055 ,  B81C1/00111 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/162 ,  C01B2202/02 ,  C01B2202/04 ,  C01B2202/06 ,  C01B2202/08 ,  C01B2202/34 ,  C01B2202/36 ,  Y10T428/2982

Abstract: A carbon nanotube needle comprising: an end portion and a broken end portion, the broken end portion comprising a single carbon nanotube tip. A method for manufacturing a carbon nanotube needle, the method comprising the steps of: (a) providing a carbon nanotube film comprising of a plurality of commonly aligned carbon nanotubes, a first electrode, and a second electrode; (b) fixing the carbon nanotube film to the first electrode and the second electrode, the carbon nanotube film extending from the first electrode to the second electrode; (c) treating the carbon nanotube film with an organic solvent to form at least one carbon nanotube string; and (d) applying a voltage to the carbon nanotube string until the carbon nanotube string snaps.

Abstract translation: 一种碳纳米管针，包括：端部和断端部，所述断端部包括单个碳纳米管尖端。 一种制造碳纳米管针的方法，所述方法包括以下步骤：（a）提供由多个共同排列的碳纳米管组成的碳纳米管膜，第一电极和第二电极; （b）将碳纳米管膜固定到第一电极和第二电极，碳纳​​米管膜从第一电极延伸到第二电极; （c）用有机溶剂处理碳纳米管膜以形成至少一个碳纳米管串; 和（d）向碳纳米管串施加电压，直到碳纳米管柱咬合为止。

公开(公告)号：US20090220710A1

公开(公告)日：2009-09-03

申请号：US12397197

申请日：2009-03-03

Applicant: Douglas Ray Sparks ,  Nader Najafi

Inventor： Douglas Ray Sparks ,  Nader Najafi

IPC: B32B1/08 ,  H01L21/50

CPC classification number: B81B1/002 ,  B01L3/5027 ,  B81B2201/0242 ,  B81B2201/055 ,  B81B2203/0323 ,  B81B2203/0338 ,  B81C1/00 ,  B81C1/00119 ,  B81C1/0019 ,  B81C1/00357 ,  B81C1/00468 ,  G01F1/84 ,  G01F1/8404 ,  G01F1/8409 ,  G01F1/844 ,  G01F1/8445 ,  Y10T428/13 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A process for producing a micromachined tube (microtube) suitable for microfluidic devices. The process entails isotropically etching a surface of a first substrate to define therein a channel having an arcuate cross-sectional profile, and forming a substrate structure by bonding the first substrate to a second substrate so that the second substrate overlies and encloses the channel to define a passage having a cross-sectional profile of which at least half is arcuate. The substrate structure can optionally then be thinned to define a microtube and walls thereof that surround the passage.

Abstract translation: 一种适用于微流体装置的微加工管（微管）的制造方法。 该方法需要各向同性蚀刻第一衬底的表面以在其中限定具有弓形横截面轮廓的通道，并且通过将第一衬底粘合到第二衬底来形成衬底结构，使得第二衬底覆盖并封闭沟道以限定 具有至少一半弧形的截面轮廓的通道。 衬底结构可任选地被减薄以限定围绕通道的微管及其壁。

公开(公告)号：US07560036B2

公开(公告)日：2009-07-14

申请号：US11133245

申请日：2005-05-20

Applicant: Nevenka Golubovic-Liakopoulos ,  Glenn Fricano ,  Michael Danielson

Inventor： Nevenka Golubovic-Liakopoulos ,  Glenn Fricano ,  Michael Danielson

IPC: A61B17/20

CPC classification number: B81C1/00111 ,  A61B17/205 ,  A61B2017/00526 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055

Abstract: The invention relates to a method of fabricating a microneedle array in a substrate, a drug delivery device comprising one or more microneedles extending upwards from the front surface of the substrate, the microneedles having a generally conical-shaped body defined by a plurality of surfaces sloping upwards from a relatively broad base to a tip, and one or more substances coating the microneedles, the one or more substances being operable to be administered to a patient, wherein the tips of the one or more microneedles are sufficiently sharp to penetrate an outer layer of the skin of the patient, and a method of administering one or more substances to a patient using the device.

Abstract translation: 本发明涉及一种在衬底中制造微针阵列的方法，药物递送装置包括从衬底的前表面向上延伸的一个或多个微针，所述微针具有由倾斜的多个表面限定的大致圆锥形体 从相对宽的基部向上延伸至尖端，以及一种或多种涂覆微针的物质，所述一种或多种物质可操作地施用于患者，其中所述一个或多个微针的尖端足够锋利以穿透外层 的患者皮肤，以及使用该装置向患者施用一种或多种物质的方法。

公开(公告)号：US20090162798A1

公开(公告)日：2009-06-25

申请号：US12379308

申请日：2009-02-18

Applicant: Takao Tomono

Inventor： Takao Tomono

IPC: G03F7/20 ,  B32B3/10 ,  B29C33/00 ,  G03B27/52

CPC classification number: B81C1/00111 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053 ,  B81B2201/055 ,  G03F7/201 ,  G03F7/2022 ,  Y10T428/24479

Abstract: A method of manufacturing a master plate includes the steps of forming a photoresist film on a substrate, disposing a photomask having a plurality of island radiation shields on the photoresist film followed by integrating the photomask and the photoresist film, applying light from a light source to the photoresist film through the photomask for selectively exposing the photoresist film, and developing the photoresist film to form a master plate, in which the method includes irradiating the photoresist film with the light from plural directions through the photomask to selectively expose the photoresist film from the respective directions.

Abstract translation: 制造母板的方法包括以下步骤：在衬底上形成光致抗蚀剂膜，将具有多个岛状辐射屏蔽的光掩模设置在光致抗蚀剂膜上，然后将光掩模和光致抗蚀剂膜整合，将来自光源的光施加到 所述光致抗蚀剂膜通过所述光掩模用于选择性地暴露所述光致抗蚀剂膜，以及显影所述光致抗蚀剂膜以形成母板，其中所述方法包括用来自多个方向的光照射所述光致抗蚀剂膜通过所述光掩模，以选择性地将所述光致抗蚀剂膜从 各自的方向。

公开(公告)号：US20090131905A1

公开(公告)日：2009-05-21

申请号：US12150945

申请日：2008-05-01

Applicant: Mark G. Allen ,  Mark R. Prausnitz ,  Devin V. McAllister ,  Florent Paul Marcel Cros

Inventor： Mark G. Allen ,  Mark R. Prausnitz ,  Devin V. McAllister ,  Florent Paul Marcel Cros

IPC: A61M5/32 ,  A61N1/32 ,  B29C45/00 ,  G03F7/20 ,  B22D23/00

CPC classification number: B81C1/00111 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61B17/205 ,  A61B2010/008 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  A61N1/303 ,  B33Y80/00 ,  B81B2201/055

Abstract: Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.

公开(公告)号：US20090093776A1

公开(公告)日：2009-04-09

申请号：US12296672

申请日：2006-08-25

Applicant: Ruifeng Yue ,  Yan Wang ,  Litian Liu

Inventor： Ruifeng Yue ,  Yan Wang ,  Litian Liu

IPC: A61M5/32 ,  A61B17/32 ,  B44C1/22

CPC classification number: A61B17/3211 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61B10/0045 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  A61M2205/0244 ,  B81B1/008 ,  B81B2201/055 ,  B81C1/00111

Abstract: The present invention discloses a linear-edged 3D solid or hollow microneedle or microknife. A tip edge of the microneedle or microknife is a linear edge parallel to a group of (111) oriented facets of monocrystalline silicon. The linear edge extends along a straight or curved line and has a narrow width. An opening is formed on one or each side adjoining the linear tip edge, or is formed at the middle of the linear tip edge. The opening is communicated with a channel formed from the bottom surface of the microneedle or microknife, so as to form a through hole from the tip to the bottom of the microneedle or microknife. The triangular channel has six side walls of (111) oriented facets. The microneedle or microknife is used for transdermal drug delivery, body fluid withdrawing or the like. Methods for producing a microneedle or microknife are also disclosed.

Abstract translation: 本发明公开了一种线性边缘3D实心或中空微针或微刀。 微针或微刀的尖端边缘是平行于一组（111）单晶硅定向小面的线性边缘。 线性边缘沿直线或曲线延伸并且具有窄的宽度。 开口形成在与线性末端边缘相邻的一侧或每侧上，或者形成在线状末端边缘的中间。 开口与由微针或微刀的底面形成的通道连通，以形成从微针或微刀的尖端到底部的通孔。 三角形通道具有（111）取向小面的六个侧壁。 微针或微刀用于透皮药物递送，体液抽出等。 还公开了生产微针或微刀的方法。