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    Plasmonic dark field and fluorescence microscopy
    131.
    发明授权
    Plasmonic dark field and fluorescence microscopy 有权
    等离子体暗场和荧光显微镜

    公开(公告)号：US09304234B2

    公开(公告)日：2016-04-05

    申请号：US13418097

    申请日：2012-03-12

    Applicant: Zhaowei Liu ,  Feifei Wei

    Inventor： Zhaowei Liu ,  Feifei Wei

    IPC: G02B5/00 ,  G01N21/552 ,  G01N21/64

    CPC classification number: G02B5/008 ,  G01N21/553 ,  G01N21/6458 ,  G01N21/648 ,  G01N2201/062 ,  G01N2201/0628

    Abstract: Plasmonic condensers for generating surface plasmon at an evanescent wave surface can include a substrate layer, a metal layer comprising the evanescent wave surface; and a media layer disposed between the metal layer and the substrate layer. The media layer can be active or passive and can include a source of radiation that interacts with the metal layer to create surface plasmons that are not substantially optically detectable as far field radiation until an interfering object is brought into proximity with the evanescent wave surface. When an interfering object such as a sample or specimen is brought into proximity with the evanescent wave surface, it causes coupling of at least some of the surface plasmons into propagating radiation detectable by an objective lens. Systems, methods, and the like are disclosed, as are features of a plasmonic meta-materials illuminator.

    Abstract translation: 用于在ev逝波表面产生表面等离子体激元的等离子体冷凝器可以包括基底层，包含ev逝波面的金属层; 以及设置在金属层和基底层之间的介质层。 介质层可以是有源的或无源的，并且可以包括与金属层相互作用的辐射源，以产生表面等离子体，这些表面等离激元不是远场光辐射，直到干扰物体接近于ev逝波面。 当诸如样品或样品的干扰物体与ev逝波表面接近时，其使至少一些表面等离子体激元耦合到由物镜可检测的传播辐射。 公开了系统，方法等，以及等离子体激元间材料照明器的特征。

    ILLUMINATION DEVICE
    132.
    发明申请
    ILLUMINATION DEVICE 有权
    照明装置

    公开(公告)号：US20150293339A1

    公开(公告)日：2015-10-15

    申请号：US14437508

    申请日：2013-10-22

    Applicant: LEICA MICROSYSTEMS CMS GMBH

    Inventor： Christian Schuman ,  Ralf Krueger ,  Tobias Bauer ,  Arnold Mueller-Rentz ,  Klaus Hermanns ,  Christian Schulz

    IPC: G02B21/06 ,  G01N21/31 ,  F21V33/00

    CPC classification number: G02B21/06 ,  F21V33/0068 ,  F21Y2103/00 ,  F21Y2105/00 ,  F21Y2115/15 ,  F21Y2115/20 ,  G01N21/31 ,  G01N2201/061 ,  G01N2201/0628 ,  G02B21/088 ,  G02B21/18

    Abstract: An illumination device for an optical device, a microscope or a macroscope includes a first illumination source configured to emit light which is directed via an illumination beam path onto an object to be illuminated that is arranged in an object plane. At least one second illumination source is positionable in the illumination beam path, and is transparent or semitransparent as well as self-luminous. The at least one second illumination source is configured to allow light emitted from the first illumination source to pass through at least in part. The object plane having the object to be illuminated is configured to be illuminated both by the first and by the at least one second illumination source.

    Abstract translation: 用于光学装置，显微镜或宏观显微镜的照明装置包括：第一照明源，被配置为发射经由照明光束路径引导到被布置在物体平面中的被照射物体上的光。 至少一个第二照明源可定位在照明光束路径中，并且是透明的或半透明的以及自发光的。 至少一个第二照明源被配置为允许从第一照明源发射的光至少部分地通过。 具有被照明物体的物体被配置为由第一照明源和至少一个第二照明光源照亮。

    Apparatus and Method for Differentiating Multiple Fluorescence Signals by Excitation Wavelength
    133.
    发明申请
    Apparatus and Method for Differentiating Multiple Fluorescence Signals by Excitation Wavelength 审中-公开
    通过激发波长区分多个荧光信号的装置和方法

    公开(公告)号：US20150293024A1

    公开(公告)日：2015-10-15

    申请号：US14741319

    申请日：2015-06-16

    Applicant: APPLIED BIOSYSTEMS, LLC

    Inventor： Howard G. King ,  Steven J. Boege ,  Eugene F. Young ,  Mark F. Oldham

    IPC: G01N21/64 ,  B01L7/00

    CPC classification number: G01N21/6428 ,  B01L7/52 ,  B01L2300/1805 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/062 ,  G01N2201/0627 ,  G01N2201/0628 ,  Y10S435/808

    Abstract: An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.

    Abstract translation: 提供一种用于通过激发波长区分多个可检测信号的装置和方法。 该装置可以包括可以例如在一个井中的样品保留区域中的样品发射相应的激发光波长或波长范围的光源。 样品可以包含两种或更多种可检测的标记，例如荧光染料，其中当荧光染料在靶组分存在下被激发时，其能够产生增加的可检测的发射。 可检测标记物可以具有与其它可检测标记物的范围重叠的激发波长范围和/或发射波长范围。 可以设置检测器，用于检测在至少一个其他标记的重叠波长范围内从第一标记发射的发射波长或波长范围。

    DEVICE TO DETECT ANALYTES IN A BIOLOGICAL SAMPLE
    135.
    发明申请
    DEVICE TO DETECT ANALYTES IN A BIOLOGICAL SAMPLE 审中-公开
    在生物样本中检测分析的设备

    公开(公告)号：US20140128293A1

    公开(公告)日：2014-05-08

    申请号：US14153666

    申请日：2014-01-13

    Applicant: Patrizia MELPIGNANO

    Inventor： Patrizia MELPIGNANO

    IPC: G01N33/543 ,  G01N21/64

    CPC classification number: G01N33/54373 ,  B01L3/502715 ,  B01L2300/027 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0825 ,  B01L2300/0851 ,  G01N21/05 ,  G01N21/6454 ,  G01N21/6486 ,  G01N2021/0346 ,  G01N2021/056 ,  G01N2021/6439 ,  G01N2201/0628

    Abstract: Device to detect at least an analyte, comprising a transparent substrate (2), having a first surface (3) with which a light source (7) is associated, and a second surface (4) on which a plurality of biological protein probes (12) are disposed, a layer (6) of polymer being interposed between said second surface (4) and said biological protein probes (12). A marker (fluorophore) is associated with said analyte, having determinate characteristics of fluorescence and/or phosphorescence correlated to the emission wavelength of the light source (7). Said light source (7) is suitable to emit a light radiation in a range of wavelengths equal to 400-550 nm, inside which range the absorption peak of said marker (fluorophore) used is comprised. The value of the distance (“s”) between the wavelength corresponding to the absorption peak of the marker (fluorophore) and the wavelength corresponding to the emission peak of fluorescence (phosphorescence) is comprised between 25 and 150 nm.

    Abstract translation: 用于检测至少一种分析物的装置，包括具有与光源（7）相关联的第一表面（3）的透明基底（2），以及第二表面（4），多个生物蛋白探针（ 12），聚合物层（6）插入在所述第二表面（4）和所述生物蛋白质探针（12）之间。 标记（荧光团）与所述分析物相关联，具有与光源（7）的发射波长相关的荧光和/或磷光的确定特性。 所述光源（7）适于发射在等于400-550nm的波长范围内的光辐射，其中包括所使用的所述标记（荧光团）的吸收峰。 对应于标记（荧光团）的吸收峰的波长与对应于荧光（磷光）的发射峰的波长之间的距离（“s”）的值为25-150nm。

    Integrated test element
    137.
    发明申请
    Integrated test element 失效
    集成测试元件

    公开(公告)号：US20090061076A1

    公开(公告)日：2009-03-05

    申请号：US12231119

    申请日：2008-08-29

    Applicant: Bernd Rosicke ,  Kai Hebestreit ,  Claudia Gassler-Dietsche ,  Frederic Wehowski

    Inventor： Bernd Rosicke ,  Kai Hebestreit ,  Claudia Gassler-Dietsche ,  Frederic Wehowski

    IPC: B05D5/06 ,  G01N21/64 ,  A61B5/00

    CPC classification number: G01N21/8483 ,  G01N21/255 ,  G01N2201/0628

    Abstract: An integrated test element (110) is proposed for detecting for detecting at least one analyte in a sample (142), in particular in a liquid sample (142). The integrated test element (110) has a carrier element (112), with an application face (114) on which at least one organic electroluminescent component (126) is applied. Furthermore, at least one indicator substance (136) is applied on the application face (114), which indicator substance (136) alters at least one optical characteristic, in particular an emission characteristic (e.g. a fluorescence characteristic), when it comes into contact with the at least one analyte. Furthermore, the integrated test element (110) has at least one photodetector element (116).

    Abstract translation: 提出了一种集成测试元件（110），用于检测样品（142）中的至少一种分析物，特别是在液体样品（142）中。 集成测试元件（110）具有载体元件（112），其上施加有至少一个有机电致发光元件（126）的施加面（114）。 此外，在应用面（114）上施加至少一个指示物质（136），该指示物质（136）在接触时改变至少一种光学特性，特别是发射特性（例如荧光特性） 与至少一种分析物。 此外，集成测试元件（110）具有至少一个光电检测元件（116）。

    Electrophoretic system with multi-notch filter and laser excitation source
    138.
    发明授权
    Electrophoretic system with multi-notch filter and laser excitation source 有权
    具有多陷波滤波器和激光源的电泳系统

    公开(公告)号：US07486396B2

    公开(公告)日：2009-02-03

    申请号：US11894829

    申请日：2007-08-22

    Applicant: Mark F. Oldham ,  Eric S. Nordman ,  Richard T. Reel ,  Janice G. Shigeura, legal representative

    Inventor： John S. Shigeura

    IPC: G01N21/00

    CPC classification number: G01N21/6456 ,  B82Y10/00 ,  B82Y20/00 ,  G01N27/44721 ,  G01N2021/6417 ,  G01N2021/6419 ,  G01N2021/6471 ,  G01N2201/0628

    Abstract: Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecting at least one charge corresponding to an emission beam emitted from the detection zone, the detector having an output; and a time delay integration system coupled to the detector for effecting time delay integration of the at least one charge by accumulating the at least one charge before reading the at least one charge at the output of the detector. Various embodiments provide an apparatus with a multi-notch filter. Various embodiments provide a solid state laser, a micro-wire laser, or an organic light-emitting diode as a irradiation source.

    Abstract translation: 提供了用于检测样品中分析物的装置和方法。 该装置可以包括：具有检测区域的一个或多个通道; 设置用于辐射照射检测区域的一个或多个照射源; 检测器，其能够收集对应于从所述检测区域发射的发射光束的至少一个电荷，所述检测器具有输出; 以及耦合到所述检测器的时间延迟积分系统，用于通过在所述检测器的输出读取所述至少一个电荷之前积累所述至少一个电荷来实现所述至少一个电荷的时间延迟积分。 各种实施例提供具有多陷波滤波器的装置。 各种实施例提供固态激光器，微线激光器或有机发光二极管作为照射源。

    Electrophoretic system with multi-notch filter and laser excitation source
    139.
    发明申请
    Electrophoretic system with multi-notch filter and laser excitation source 有权
    具有多陷波滤波器和激光源的电泳系统

    公开(公告)号：US20080043235A1

    公开(公告)日：2008-02-21

    申请号：US11894829

    申请日：2007-08-22

    Applicant: Mark Oldham ,  Eric Nordman ,  Richard Reel ,  John Shigeura ,  Janice Shigeura

    Inventor： Mark Oldham ,  Eric Nordman ,  Richard Reel ,  John Shigeura ,  Janice Shigeura

    IPC: G01N21/00

    CPC classification number: G01N21/6456 ,  B82Y10/00 ,  B82Y20/00 ,  G01N27/44721 ,  G01N2021/6417 ,  G01N2021/6419 ,  G01N2021/6471 ,  G01N2201/0628

    Abstract: Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecting at least one charge corresponding to an emission beam emitted from the detection zone, the detector having an output; and a time delay integration system coupled to the detector for effecting time delay integration of the at least one charge by accumulating the at least one charge before reading the at least one charge at the output of the detector. Various embodiments provide an apparatus with a multi-notch filter. Various embodiments provide a solid state laser, a micro-wire laser, or an organic light-emitting diode as a irradiation source.

    Abstract translation: 提供了用于检测样品中分析物的装置和方法。 该装置可以包括：具有检测区域的一个或多个通道; 设置用于辐射照射检测区域的一个或多个照射源; 检测器，其能够收集对应于从所述检测区域发射的发射光束的至少一个电荷，所述检测器具有输出; 以及耦合到所述检测器的时间延迟积分系统，用于通过在所述检测器的输出读取所述至少一个电荷之前积累所述至少一个电荷来实现所述至少一个电荷的时间延迟积分。 各种实施例提供具有多陷波滤波器的装置。 各种实施例提供固态激光器，微线激光器或有机发光二极管作为照射源。

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