公开(公告)号：MX9703488A

公开(公告)日：1998-07-31

申请号：MX9703488

申请日：1997-05-09

Applicant: COR THERAPEUTICS INC

Inventor： GIESE NEILL A ,  LOKKER NATHALIE ,  LAIBELMAN ALAN M ,  SCARBOROUGH ROBERT M

IPC: A61K31/415 ,  C07D231/38 ,  A61K31/4155 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/455 ,  A61P43/00 ,  C07D231/40 ,  C07D401/06 ,  C07D405/04 ,  C07D409/06 ,  A61K31/45

Abstract: Se describe un método para inhibir selectivamente una cinasa, el cual comprende poner en contacto una composicion que contiene una cinasa con un compuesto de formula (I), en donde: R1 es alquilo inferior, hidrocarbilo inferior, arilalquilo inferior, hheteroarilalquilo inferior, aromático hheterocíclico de 5 o 6 miembros, poliaromático, carbonilo poliaromático, polihheteroaromático o carbonilo polihheteroaromático; R2 es alquilo inferior, hidrocarbilo inferior, arilalquilo inferior, hheteroarilalquilo inferior, aromático hheterociclico de 5 o 6 miembros, hidrocarbilo inferior, carbonilo aromático hheterocíclico de 5 o 6 miembros, poliaromático o polihheteroaromático; R3 es H o alquilo inferior; R5 es H, alquilo inferior, hidrocarbilo inferior, arilalquilo inferior, hheteroarilalquilo inferior, o aromático hheterocíclico de 5 a 6 miembros, halogeno, o ciano; y R6 es H o hidrocarboilo inferior.

公开(公告)号：CA2271935A1

公开(公告)日：1998-05-28

申请号：CA2271935

申请日：1997-11-21

Applicant: COR THERAPEUTICS INC

Inventor： PHILLIPS DAVID R ,  JENKINS ALISON L

IPC: A61K38/39 ,  C07K14/705 ,  C07K14/78

Abstract: The present invention describes a direct interaction between myosin and the cytoplasmic domain of membrane proteins, particularly the phosphorylated cytoplasmic domains of the .beta.-subunit of integrins. The invention provides methods of identifying agents which block integrin binding to myosin, methods of using agents which block integrin binding to myosin to modulate biological and pathological processes, and provides agents that block integrin mediated binding to myosin and thereby modulate related cellular or cellular component movement.

公开(公告)号：AR002425A1

公开(公告)日：1998-03-11

申请号：AR10308496

申请日：1996-06-07

Applicant: COR THERAPEUTICS INC

IPC: A61K38/00 ,  A61P7/02 ,  C07C279/24 ,  C07C281/06 ,  C07C309/30 ,  C07C335/38 ,  C07K5/06 ,  C07K5/068 ,  C07K5/072 ,  C07K5/08 ,  C07K7/06 ,  A61K38/55

公开(公告)号：AU677930B2

公开(公告)日：1997-05-08

申请号：AU4564696

申请日：1996-02-20

Applicant: COR THERAPEUTICS INC

Inventor： WOLF DAVID

IPC: A61K38/43 ,  A61K38/00 ,  A61P7/02 ,  C07K14/00 ,  C07K14/475 ,  C07K14/745 ,  C07K14/81 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12P21/02 ,  A61K38/36

Abstract: Analogs of Factor Xa (Factor Xai) which are inactive as proteases in the prothrombinase reaction are useful in treatment of diseases characterized by thrombosis. These antithrombotic agents can be conveniently prepared using recombinant techniques.

公开(公告)号：AU665752B2

公开(公告)日：1996-01-18

申请号：AU1456892

申请日：1992-02-19

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： COUGHLIN SHAUN R ,  SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K49/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07K7/02 ,  C07K7/06 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/74 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/53 ,  C07K7/00 ,  A61K37/02 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07K7/08 ,  C07K13/00

公开(公告)号：NZ241666A

公开(公告)日：1995-07-26

申请号：NZ24166692

申请日：1992-02-19

Applicant: UNIV CALIFORNIA ,  COR THERAPEUTICS INC

Inventor： COUGHLIN SHAUN R ,  SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K49/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07K7/02 ,  C07K7/06 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/74 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/53 ,  A61K37/02 ,  C07K5/10 ,  C07K7/08 ,  C07K15/28 ,  G01N33/50

公开(公告)号：IL106197D0

公开(公告)日：1994-05-30

申请号：IL10619793

申请日：1993-06-30

Applicant: COR THERAPEUTICS INC

IPC: A61K38/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P29/00 ,  C07K5/062 ,  C07K5/065 ,  C07K5/083 ,  C07K5/087 ,  C07K5/103 ,  C07K5/107 ,  C07K7/02 ,  C07K7/06 ,  C07K7/08 ,  C07K

公开(公告)号：NZ241480A

公开(公告)日：1993-09-27

申请号：NZ24148092

申请日：1992-01-31

Applicant: COR THERAPEUTICS INC ,  ESCORBEDO JAIME A ,  WILLIAMS LEWIS T

Inventor： WOLF DAVID ,  TOMLINSON JAMES E ,  FRETTO LARRY J ,  GIESE NEILL A ,  ESCORBEDO JAIME A

IPC: A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  C12N15/63 ,  C07K15/06 ,  C07K15/28 ,  C07H21/04 ,  G01N33/50

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.

公开(公告)号：AU636159B2

公开(公告)日：1993-04-22

申请号：AU6036990

申请日：1990-06-15

Applicant: COR THERAPEUTICS, INC.

Inventor： ROBERT M. SCARBOROUGH ,  DAVID LAWRENCE WOLF ,  ISRAEL F. CHARO

IPC: A61K38/00 ,  A61K35/58 ,  A61K38/02 ,  A61K38/12 ,  A61K38/17 ,  A61K38/36 ,  A61K38/57 ,  A61P7/02 ,  C07K1/14 ,  C07K1/20 ,  C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/56 ,  C12R1/19 ,  G01N33/86

Abstract: An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R 2 N(CH2)4CHNHCO- wherein each R is independently H, alkyl(1-6C) or at most one R is R -C=NR wherein R is H, alkyl(1-6C), phenyl or benzyl, or is NR 2 in which each R is independently H or alkyl(1-6C) and R is H, alkyl(1-6C), phenyl or benzyl, or R -C=NR is a radical selected from the group consisting of: where m is an integer of 2-3, and each R is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

公开(公告)号：AU1456892A

公开(公告)日：1992-09-15

申请号：AU1456892

申请日：1992-02-19

Applicant: COR THERAPEUTICS INC ,  UNIV CALIFORNIA

Inventor： COUGHLIN SHAUN R ,  SCARBOROUGH ROBERT M JR

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K49/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P43/00 ,  C07K7/02 ,  C07K7/06 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/74 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/53 ,  C07K7/00 ,  C07K13/00 ,  C12N15/63