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    POLYMER MICROFILTRATION DEVICES, METHODS OF MANUFACTURING THE SAME AND THE USES OF THE MICROFILTRATION DEVICES
    141.
    发明公开
    POLYMER MICROFILTRATION DEVICES, METHODS OF MANUFACTURING THE SAME AND THE USES OF THE MICROFILTRATION DEVICES 审中-公开
    高分子微过滤装置，工艺用于生产和微滤设备的使用

    公开(公告)号：EP2782653A2

    公开(公告)日：2014-10-01

    申请号：EP12851440.3

    申请日：2012-11-21

    Applicant: Creatv Microtech, Inc.

    Inventor： TANG, Cha-Mei ,  ZHANG, Yunqi

    IPC: B01D25/02

    CPC classification number: G01N33/5005 ,  B01D29/00 ,  B01D39/16 ,  B01D39/1692 ,  B01L3/50 ,  B01L3/502 ,  B01L3/5635 ,  B01L9/00 ,  B01L2300/0681 ,  G01N1/4005 ,  G01N1/4077 ,  G01N2001/4088 ,  Y10T29/49826 ,  Y10T29/49963

    Abstract: A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A microfilter comprising two or more polymer layers formed from epoxy-based photo-definable dry film, and a plurality of apertures or open areas each extending through the polymer layer. A method of forming a microfilter is also disclosed. The method includes providing a first layer of epoxy-based photo-definable dry film disposed on a substrate, exposing the first layer to energy through a mask to form a pattern, defined by the mask, in the first layer of dry film, forming, from the exposed first layer of dry film, a polymer layer having a plurality of apertures extending therethrough, the plurality of apertures having a distribution defined by the pattern, and removing the polymer layer from the substrate. Unique filter holder designs and methods appropriate to hold microfilters to collect the rare cells and allow performing assays in the filter holder are provided. The invention also describes the use of the microfilter and filter holder to collect rare cells from body fluids and perform assays. Rare cells collected on the microfilter in accordance with embodiments of the present invention can be used for medical and biological research applications.

    TWO-DIMENSIONAL, ANTI-SCATTER GRID AND COLLIMATOR DESIGNS, AND ITS MOTION, FABRICATION AND ASSEMBLY
    142.
    发明公开
    TWO-DIMENSIONAL, ANTI-SCATTER GRID AND COLLIMATOR DESIGNS, AND ITS MOTION, FABRICATION AND ASSEMBLY 审中-公开
    二维防散射格栅kollimatorentwürfe-and，和他们的运动，制造和安装。

    公开(公告)号：EP1249023A4

    公开(公告)日：2007-07-11

    申请号：EP00984257

    申请日：2000-12-13

    Applicant: CREATV MICROTECH INC

    Inventor： TANG CHA-MEI

    IPC: G21K1/02 ,  G21K1/00

    CPC classification number: G21K1/025

    Abstract: A grid (30), for use with electromagnetic energy emitting devices, includes at least metal layer, which is formed, for example, by electroplating. The metal layer includes top and bottom surfaces, and a plurality of solid integrated walls (32). Each of the solid integrated walls extends from the top to bottom surface and having a plurality of side surfaces. The side surfaces of the solid integrated walls (32), are arranged to define a plurality of openings extending entirely through the layer. At least some of the walls also can include projections extending into the respective openings formed by the walls. The projections can be of various shapes and sizes, and are arranged so that a total amount of wall material intersected by a line propagating in a direction along an edge of the grid is substantially the same as another total amount of wall material intersected by another line propagating in another direction substantially parallel to the edge of the grid at any distance from the edge.

    A METHOD AND APPARATUS FOR MAKING LARGE AREA TWO-DIMENSIONAL GRIDS
    143.
    发明公开
    A METHOD AND APPARATUS FOR MAKING LARGE AREA TWO-DIMENSIONAL GRIDS 失效
    一种方法和生产的大平面的二维网格的VORICHTUNG

    公开(公告)号：EP0990239A1

    公开(公告)日：2000-04-05

    申请号：EP98930469.6

    申请日：1998-06-19

    Applicant: Creatv Microtech, Inc.

    Inventor： TANG, Cha-Mei

    IPC: G21K1/00

    CPC classification number: G03F7/0007 ,  G03F7/201 ,  G21K1/025

    Abstract: Disclosed are methods for making large area antiscatter grids consisting of focussed and unfocussed holes in sheets of metal. The grid consists of thin metal walls (30) surrounding hollow openings (31). The projections of all walls converge to a focal spot in the focussed grid, and are parallel in an unfocussed grid. A grid having a large area is made by interlocking together smaller grid pieces. A tall device is made by stacking layers of focussed grids. The openings of the grid can be filled with phosphor or other scintillating material (33) to make an integrated grid/scintillator structure.

    USE OF CIRCULATING TUMOR CELL MITOTIC INDEX IN CANCER STRATIFICATION AND DIAGNOSTICS
    147.
    发明公开
    USE OF CIRCULATING TUMOR CELL MITOTIC INDEX IN CANCER STRATIFICATION AND DIAGNOSTICS 审中-公开
    循环肿瘤细胞有丝分裂指数在肿瘤分层和诊断中的应用

    公开(公告)号：EP3304074A1

    公开(公告)日：2018-04-11

    申请号：EP16731403.8

    申请日：2016-05-26

    Applicant: Creatv Microtech, Inc.

    Inventor： ADAMS, Daniel ,  TANG, Cha-Mei

    IPC: G01N33/50 ,  G01N33/574

    Abstract: Circulating tumor cells (CTCs) are associated with metastasis of malignant solid tumors in a patient. Presented here is evidence that CTCs exhibit cell cycle phase variability and that there is a strong correlation between the number of CTCs in a mitotic cell cycle phase and the prospects for long term survival of the subject from which the cells were obtained. Also presented herein are methods of determining the mitotic cell cycle phase of CTCs from a patient having cancer and using the information in grading malignant solid tumors and predicting the likelihood of survival of the patient.

    tNTI-SCATTER GRIDS AND COLLIMATOR DESIGNS, AND THEIR MOTION, FABRICATION AND ASSEMBLY
    149.
    发明公开
    tNTI-SCATTER GRIDS AND COLLIMATOR DESIGNS, AND THEIR MOTION, FABRICATION AND ASSEMBLY 审中-公开
    “TNTI杂散和格栅KOLLIMATORENTWÜRFE和你的举动，生产和组成”

    公开(公告)号：EP1364374A4

    公开(公告)日：2006-11-22

    申请号：EP02707629

    申请日：2002-02-01

    Applicant: CREATV MICROTECH INC

    Inventor： TANG CHA-MEI ,  MAKAROVA OLGA

    IPC: G21K1/02

    CPC classification number: G21K1/025

    Abstract: Grids (30) and collimators, for use with electromagnetic energy emitting devices (61), include at least a metal layer that is formed, for example, by electroplating/electroforming or casting. The metal layer includes top and bottom surfaces, and a plurality of solid integrated walls (32). Each of the solid integrated walls extends from the top to bottom surface and has a plurality of side surfaces. The side surfaces of the solid integrated walls are arranged to define a plurality of openings (31) extending entirely through the layer. At least some of the walls (32) also can include projections extending into the respective openings formed by the walls (32). The projections can be of various shapes and sizes, and are arranged so that a total amount of wall material intersected by a line propagating in a direction along an edge of the grid (30) is substantially the same as another total amount of wall material intersected by another line propagating in another direction substantially parallel to the edge of the grid (30) at any distance from the edge. Methods to fabricate these grids (30) using copper, lead, nickel, gold, any other electroplating/electroforming materials or low melting temperature metals are described.

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