公开(公告)号：US4029686A

公开(公告)日：1977-06-14

申请号：US638655

申请日：1975-12-08

Applicant: John Crosby ,  Robert Allan Campbell Rennie ,  Robert Michael Paton

Inventor： John Crosby ,  Robert Allan Campbell Rennie ,  Robert Michael Paton

IPC: C07C265/14 ,  C07C67/00 ,  C07C207/00 ,  C07C241/00 ,  C07C263/08 ,  C07C265/10 ,  C07D271/08 ,  C07D271/12 ,  C08G18/75 ,  C08G18/81 ,  C08L75/04 ,  C07C118/00

CPC classification number: C07C263/08 ,  C07C201/00 ,  C07C263/12 ,  C07D271/08 ,  C07D271/12 ,  C08G18/75 ,  C08G18/8125 ,  C07C2101/08 ,  C07C2102/22

Abstract: A furoxan, especially one in which the furoxan ring is fused to a strained aliphatic ring system, is heated in the presence of sulphur dioxide to give an isocyanate. The process enables furoxans, such as dicyclopentadiene furoxan, which ring-open at temperatures

Abstract translation: 将呋喃糖环，其中呋喃环与稠应的脂肪族环系稠合的呋喃糖，在二氧化硫存在下加热得到异氰酸酯。 该方法使得呋喃香糖如二环戊二烯呋喃糖在<180℃的温度下开环转化为异氰酸酯。 在不存在二氧化硫的情况下，可能难以控制反应，并且在某些情况下不能获得异氰酸酯。 通过该方法制备的二异氰酸酯可以通过与合适的羟基化合物反应而转化为聚氨酯。

公开(公告)号：US3931343A

公开(公告)日：1976-01-06

申请号：US441610

申请日：1974-02-11

Applicant: John Pisanchyn ,  Stylianos Sifniades ,  Robert Fuhrmann ,  Fred W. Koff

Inventor： John Pisanchyn ,  Stylianos Sifniades ,  Robert Fuhrmann ,  Fred W. Koff

IPC: C07C241/00 ,  C07C20060101 ,  C07C67/00 ,  C07C291/08 ,  C07C81/00

CPC classification number: C07C201/00

Abstract: Cyclo-olefins are converted in high yield to the corresponding chloro-nitroso dimers by dissolving the cyclo-olefin in liquid SO.sub.2 and contacting with NOCl while maintaining a substantially oxygen-free environment. Even higher yields are attained by controlling the gradual addition of the NOCl and by using a molar ratio of NOCl to cyclo-olefin of less than about 0.92:1.

Abstract translation: 通过将环烯烃溶解在液体SO 2中并与NOCl接触同时保持基本上无氧的环境，将环烯烃以高产率转化成相应的氯 - 亚硝基二聚体。 通过控制NOCl的逐渐加入和通过使用小于约0.92:1的NOCl与环烯烃的摩尔比来获得更高的收率。

公开(公告)号：US3810893A

公开(公告)日：1974-05-14

申请号：US16229771

申请日：1971-07-13

Applicant: WOOD H ,  STUART A ,  AL HASSAN S ,  CURRAN A

Inventor： STUART A ,  CURRAN A ,  WOOD H ,  AL HASSAN S

IPC: C07C29/147 ,  C07C205/15 ,  C07C207/00 ,  C07C207/04 ,  C07D239/46 ,  C07D239/48 ,  C07D475/04 ,  C07D51/38

CPC classification number: C07D239/47 ,  C07C29/147 ,  C07C67/00 ,  C07C67/08 ,  C07C201/00 ,  C07C201/12 ,  C07D239/48 ,  C07D475/04 ,  C07C33/18 ,  C07C205/15 ,  C07C207/04 ,  C07C69/145

Abstract: A PHARMACUETICAL FORMULATION OF A COMPOUND OF FORMULA II''

2-NH2,6-Y,7,7-DI(CH3-)-3,4,7,8-TETRAHYDROPTERIDIN-4-ONE

WHEREIN Y IS A LOWER ALKYL GROUP, IN ASSOCIATION WITH A PHARMACEUTICALLY ACCEPTABLE CARRIER, AS AN ANTIBACTERIAL PRODUCT, AND METHODS INVOLVING THE PREPARATION AND REDUCTIVE CYCLIZATION OF A COMPOUND OF FORMULA IV

2-NH2,5-NO2,6-(HO-N=C(-Z)-C(-CH3)2-NH-)PYRIMIDIN-4(3H)-ONE

WHEREIN Z IS A LOWER ALYL GROUP OR A HYDROXYMETHYL GROUP.

公开(公告)号：US3770834A

公开(公告)日：1973-11-06

申请号：US3770834D

申请日：1970-04-02

Applicant: HERCULES INC

Inventor： PROSSER T

IPC: C07C201/00 ,  C07C205/22 ,  C07C207/04 ,  C07C39/02 ,  C07C79/22

CPC classification number: C07C201/06 ,  C07C201/00 ,  C07C205/22 ,  C07C207/04

Abstract: DISCLOSED IS A PROCESS FOR NITROSATING NITROSATABLE PHENOLIC MATERIAL. NITROGEN TRIOXIDE AND THE PHENOLIC MATERIAL ARE INTRODUCED SIMULTANEOUSLY AT SPECIFIC RATES INTO AN AGITATED, ACIDIC, AQUEOUS MEDIUM ESTABLIXHED AND MAINTAINED IN THE TEMPERATURE RANGE FROM ABOUT -20 TO ABOUT 20* C., AND HAVING AN INITIAL CONCENTRATION OF NITROUS ACID IN A RANGE FROM ANOUT 0 TO ABOUT 1% BY WEIGHT OF THE AQUEOUS MEDIUM. THE INITIAL PH OF THE AQUEOUS MEDIUM IS LESS THAN ABOUT 5, PREFERABLY ABOUT 1, AND COMPRISES WATER AND, DISSOLVED IN THE WATER, ACID MATERIAL SELECTED FROM THE GROUP CONSISTING OF WATER-SOLUBLE STRONG ACIDS LIKE NITRIC ACID AND SULFURIC ACID. THE RATE OF INTRODUCTION OF THE PHENOLIC MATERIAL INTO THE AQUEOUS MEDIUM IS PREFERABLY SUBSTANTIALLY THE RATE AT WHICH THE PHENOLIC MATERIAL IS NITROSATED IN THE AQUEOUS MEDIUM. THE RATE OF INTRODUCTION OF NITROGEN TRIOXIDE INTO THE AQUEOUS MEDIUM IS SUBSTANTIALLY AT THE RATE AT WHICH A SLIGHT STOICHIOMETRIC EXCESS, RELATIVE TO THE PHENOLIC MATERIAL BEING INTRODUCED INTO THE AQUEOUS MEDIUM OF NITROUS ACID IS ESTABLISHED AND MAINTAINED IN THE REACTION MEDIUM. AS REACTION TAKES PLACE NITROSATED PHENOLIC PRODUCT FORMS AND PRECIPITATES. PREFERABLY THE REACTION MIXTURE THAT RESULTS IS MAINTAINED WITH AGITATION IN THE TEMPERATURE RANGE UNTIL THE REACTION IS SUBSTANTIALLY COMPLETE, AND THEN THE PRECIPITATED NITROSATED PHENOLIC PRODUCT IS SEPARATED FROM THE REACTION MIXTURE.

公开(公告)号：US3714267A

公开(公告)日：1973-01-30

申请号：US3714267D

申请日：1970-06-03

Applicant: KERR MC GEE CORP

Inventor： BALDWIN R ,  CHENG M

IPC: C07C207/04 ,  C07C39/02

CPC classification number: C07C201/00 ,  C07C207/04

Abstract: The invention provides a process for the nitrosation of m-cresol which includes the simultaneous addition of separate streams of a nitrosating agent and m-cresol to a quantity of a cold aqueous acid solution.

Abstract translation: 本发明提供了间甲酚亚硝化方法，其中包括将亚硝化剂和间甲酚的单独物流同时加入到一定量的酸性酸水溶液中。

公开(公告)号：US3652586A

公开(公告)日：1972-03-28

申请号：US3652586D

申请日：1969-04-22

Applicant: GEIGY CHEM CORP

Inventor： DENSS ROLF ,  CLAUSON-KAAS NIELS ,  OSTERMAYER FRANZ

IPC: A61K31/535 ,  C07C205/56 ,  C07C207/00 ,  C07D207/32 ,  C07D207/327 ,  C07D265/02 ,  C07D27/24

CPC classification number: C07D207/327 ,  A61K31/535 ,  C07C201/00 ,  C07C201/12 ,  C07D207/32 ,  C07D265/02 ,  C07C207/00 ,  C07C205/56

Abstract: PROCESS FOR THE PRODUCTION OF P-(1-PYRRYL)-PHENYLACETIC ACIDS AND THEIR ESTERS WITH ANALEGSIC AND ANTI-INFLAMMATORY ACTIVITY, COMPRISING REACTING A P-NITROSOPHENYLACETIC ACID OR AN ESTER THEREOF WITH BUTADIENE TO OBTAIN THE CORRESPONDING P-(3,6-DIHYDRO-2H-1,2-OXAZIN-2-YL)-PHENYLACETIC ACID OR AN ESTER THEREOF AND SUBJECTING SAID ACID OR ESTER TO ACIDIC AND/OR TEMPERATURE CONDITIONS UNDER WHICH WATER IS SPLIT OFF AND RING CONTRACTION OCCURS, OPTIONALLY HYDROLYSING THE IMMEDIATE REACTION PRODUCT EITHER COMPLETELY TO FORM THE DESIRED ACID OF A SALT THEREOF CONVERTING IT COMPLETELY INTO A DESIRED ESTER.

公开(公告)号：US3417147A

公开(公告)日：1968-12-17

申请号：US38037764

申请日：1964-07-06

Applicant: HERCULES INC

Inventor： WILLIAMS FREDERICK E

IPC: C07C41/00 ,  C07C43/00

CPC classification number: C07C201/00 ,  Y02P20/582 ,  C07C207/04

公开(公告)号：US3396200A

公开(公告)日：1968-08-06

申请号：US64444267

申请日：1967-06-02

Applicant: ATOMIC ENERGY COMMISSION USA

Inventor： GEORGE RAYMOND S ,  ROHWER ROBERT K

IPC: C07C201/10 ,  C07C201/14 ,  C07C205/12 ,  C07C207/00

CPC classification number: C07C201/06 ,  C07C201/00 ,  C07C205/12 ,  C07C207/00

公开(公告)号：US3341589A

公开(公告)日：1967-09-12

申请号：US46992865

申请日：1965-07-06

Applicant: COMMERCIAL SOLVENTS CORP

Inventor： JONES LAWRENCE R

CPC classification number: C07C201/00

公开(公告)号：US3341588A

公开(公告)日：1967-09-12

申请号：US46991865

申请日：1965-07-06

Applicant: COMMERCIAL SOLVENTS CORP

Inventor： JONES LAWRENCE R

CPC classification number: C07C201/00