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    APPARATUS AND METHODS OF BIOELECTRICAL IMPEDANCE ANALYSIS OF BLOOD FLOW
    141.
    发明申请
    APPARATUS AND METHODS OF BIOELECTRICAL IMPEDANCE ANALYSIS OF BLOOD FLOW 审中-公开
    血流动力学阻抗分析装置及方法

    公开(公告)号：WO1997038628A1

    公开(公告)日：1997-10-23

    申请号：PCT/US1997006369

    申请日：1997-04-17

    Applicant: UROHEALTH, INC. (CALIFORNIA) ,  SHMULEWITZ, Ascher

    Inventor： UROHEALTH, INC. (CALIFORNIA)

    IPC: A61B05/05

    CPC classification number: A61B5/0538 ,  A61B5/0535

    Abstract: Apparatus and methods are provided for monitoring cardiac output using bioelectrical impedance techniques in which first and second electrodes are placed in the trachea (103) and/or bronchus (104a) in the vicinity of the ascending aorta (101a), while an excitation current is injected into the thorax (100) via first and second current electrodes (13), so that bioelectrical impedance measurements based on the voltage drop sensed by the first and second electrodes reflect voltage changes induced primarily by blood flow dynamics, rather than respiratory or non-cardiac related physiological effects. Additionally sense electrodes (12) may be provided, either internally, or externally, for which bioelectrical impedance values may be obtained. Methods are provided for computing cardiac output from bioelectrical impedance values. Apparatus and methods are also provided so that the measured cardiac output may be used to control administration of intravenous fluids to an organism or to optimize a heart rate controlled by a pacemaker.

    Abstract translation: 提供了使用生物电阻抗技术监测心输出量的装置和方法，其中第一和第二电极被放置在升主动脉（101a）附近的气管（103）和/或支气管（104a）中，而激励电流为 经由第一和第二电流电极（13）注入胸部（100），使得基于由第一和第二电极感测的电压降的生物电阻抗测量反映主要由血流动力学引起的电压变化，而不是呼吸或非 - 心脏相关生理作用。 可以在内部或外部提供感测电极（12），为此可获得生物电阻抗值。 提供了用于计算生物电阻抗值的心输出量的方法。 还提供了装置和方法，使得测量的心输出量可用于控制对生物体的静脉内流体的施用或优化由起搏器控制的心率。

    DEVICE FOR MEASURING ELECTRICAL CONDUCTIVITY OF THE SKIN
    143.
    发明申请
    DEVICE FOR MEASURING ELECTRICAL CONDUCTIVITY OF THE SKIN 审中-公开
    用于测量皮肤电导率的装置

    公开(公告)号：WO1997024063A1

    公开(公告)日：1997-07-10

    申请号：PCT/RU1997000044

    申请日：1997-02-25

    Applicant: YALESTOWN CORPORATION N.V. ,  GRECHUSHKIN, Boris Alexeevich ,  KOMAROV, Vladimir Mikhailovich

    Inventor： YALESTOWN CORPORATION N.V.

    IPC: A61B05/05

    CPC classification number: A61B5/442 ,  A61B5/0533

    Abstract: The invention pertains to medical engineering and can be used for rapid diagnosis of the functional state of a human organism. The proposed device comprises a device for converting measured and reference conductivities into a pulse sequence whose on-off time ratio is proportional to the measured conductivity. The circuit includes means for protecting the measurement electrodes from pulse voltages. An opto-electronic unit is provided and the power source is designed as a computer serial port voltage inverter, with the primary and secondary windings on separate magnetic circuits which are interconnected by a short-circuited loop; these measures ensure electrical safety and reduce mutual interference between the device and computer.

    Abstract translation: 本发明涉及医学工程，可用于快速诊断人体的功能状态。 所提出的装置包括用于将测量和参考电导率转换成开关时间比与测得的电导率成比例的脉冲序列的装置。 电路包括用于保护测量电极免受脉冲电压的装置。 提供光电单元，电源设计为计算机串口电压逆变器，其中初级和次级绕组在通过短路环路互连的单独磁路上; 这些措施可确保电气安全，减少设备与计算机之间的相互干扰。

    REGISTRATION PROCESS FOR MYOCARDIAL IMAGES
    144.
    发明申请
    REGISTRATION PROCESS FOR MYOCARDIAL IMAGES 审中-公开
    MYOCARDIAL图像的注册过程

    公开(公告)号：WO1997017894A1

    公开(公告)日：1997-05-22

    申请号：PCT/US1996017772

    申请日：1996-11-13

    Applicant: FOCUS GRAPHICS, INC.

    Inventor： FOCUS GRAPHICS, INC. ,  GORIS, Michael, L.

    IPC: A61B05/05

    CPC classification number: G06T3/0081

    Abstract: Registration of organ images, such as myocardial images obtained by myocardial perfusion scintigraphy (820, 840, 860), is performed by an elastic transformation which includes a rigid transformation, a global affine transformation, and local transformations. The elastic transformation eliminates normal morphological variances such as variances in orientation, size and shape, so that the remaining differences represent important functional differences (810, 830, 850). The method can be used to register a patient's organ against a template obtained by averaging organ images from many patients (800). For scintigraphic images the boundary of the organ is determined by a "segmentation" procedure involving the analysis of spatial derivatives of the count density. After the elastic transformations of the surface of the organ, the scintigraphic count densities are redistributed. The method decreases the effects of operator variability and increases the reliability of diagnoses of organ irregularities.

    Abstract translation: 通过包括刚性变换，全局仿射变换和局部变换的弹性变换来执行器官图像的登记，例如通过心肌灌注闪烁扫描（820,840,860）获得的心肌图像。 弹性变换消除了正常的形态学变化，如取向，大小和形状的差异，因此剩余的差异代表重要的功能差异（810,830,850）。 该方法可用于对患者器官进行登记，以通过平均来自许多患者的器官图像获得的模板（800）。 对于闪烁图像，器官的边界由涉及对计数密度的空间导数的分析的“分割”程序确定。 在器官表面的弹性变换后，重新分布闪烁计数密度。 该方法降低了运营商变异性的影响，增加了器官不规则诊断的可靠性。

    METHOD AND APPARATUS FOR USE IN IMAGING A BODY
    145.
    发明申请
    METHOD AND APPARATUS FOR USE IN IMAGING A BODY 审中-公开
    用于成像身体的方法和装置

    公开(公告)号：WO1997000642A1

    公开(公告)日：1997-01-09

    申请号：PCT/GB1996001499

    申请日：1996-06-21

    Applicant: BRITISH TECHNOLOGY GROUP LIMITED ,  BOONE, Kevin, Graham ,  HOLDER, David, Simon

    Inventor： BRITISH TECHNOLOGY GROUP LIMITED

    IPC: A61B05/05

    CPC classification number: A61B5/0536 ,  A61B5/0042

    Abstract: The present invention relates to imaging, and more particularly to a method and apparatus for use in imaging a body by means of the technique of electrical impedance tomography (EIT). A plurality of electrodes (E, to E16) are provided in electrical contact with the body (10) around the periphery of the body. A first electrical input signal is applied to at least one of the electrodes over a first time period (T1), and a second electrical input signal, which is preferably in inverted form of the first, is then applied to the at least one of the electrodes over a subsequent, second time period (T2). The resulting electrical output signal is measured at one or more of the remaining electrodes over the first and second time periods and the difference between the measured signal obtained during the first time period and that obtained during the second time period is calculated to provide a difference signal. The difference signal can be stored and used for image reconstruction. The invention has particular application in imaging neurological function within the body, where the impedance changes associated with neuronal depolarisations are very small and the resulting electrical signals measured at the body periphery are even smaller. By use of this technique electrical signals corresponding to the dynamic components of impedance change can be reinforced whilst those corresponding to other unwanted components can be cancelled.

    Abstract translation: 本发明涉及成像，更具体地涉及一种通过电阻抗层析成像（EIT）技术用于成像身体的方法和装置。 多个电极（E，至E16）设置成与身体（10）电连接在身体周围。 第一电输入信号在第一时间段（T1）中被施加到至少一个电极，然后将优选地以第一时间的反向形式的第二电输入信号施加到第一时间段 电极在随后的第二时间段（T2）中。 所得到的电输出信号在第一和第二时间段的一个或多个剩余电极处测量，并且计算在第一时间段期间获得的测量信号与在第二时间段期间获得的测量信号之间的差，以提供差分信号 。 差分信号可以存储并用于图像重建。 本发明在体内成像神经功能方面具有特别的应用，其中与神经元去极化相关的阻抗变化非常小，并且在体周边测量的所得电信号甚至更小。 通过使用这种技术，可以加强对应于阻抗变化的动态分量的电信号，而可以取消对应于其它不需要的部件的电信号。

    METHOD AND SYSTEM FOR NAVIGATING A CATHETER PROBE
    146.
    发明申请
    METHOD AND SYSTEM FOR NAVIGATING A CATHETER PROBE 审中-公开
    导管探头的方法和系统

    公开(公告)号：WO1997000043A1

    公开(公告)日：1997-01-03

    申请号：PCT/US1996010050

    申请日：1996-06-11

    Applicant: MARTINELLI, Michael, A.

    IPC: A61B05/05

    CPC classification number: A61B34/20 ,  A61B5/062 ,  A61B2034/2051 ,  A61B2034/256

    Abstract: A system for navigating a catheter probe through a body cavity includes a sensing coil (14) affixed to a distal end of the probe. Magnetic fields are projected into the body cavity to induce voltage signals in the sensing coil (14) that are sufficient to describe the orientation and position of the probe. A set of magnetic coils (20-26, 30-32, 36-42) each generates a substantially uniform field (27, 33, 43) in a single respective dimension. The orientation angles of the sensing coil may be determined from known values of the unidirectional fields and the measured induced voltage signals. Gradient magnetic fields with components in two dimensions are projected into the body cavity to induce another group of voltage signals. The geometrical intersection of constant voltage surfaces developed by certain gradient fields that produce the measured induced voltage signals is a set of lines on which the catheter is located. The point of intersection of such lines yields the positional coordinates.

    Abstract translation: 用于通过体腔导航导管探针的系统包括固定在探针的远端的传感线圈（14）。 磁场被投射到体腔中以感测感测线圈（14）中足以描述探针的取向和位置的电压信号。 一组电磁线圈（20-26,30-32,36-42）各自在单个相应尺寸上产生基本均匀的场（27,33,43）。 感测线圈的取向角可以由单向场和测量的感应电压信号的已知值确定。 具有二维部件的梯度磁场被投射到体腔中以引起另一组电压信号。 由产生测量的感应电压信号的某些梯度场产生的恒定电压表面的几何交点是导管所在的一组线。 这些线的相交点产生位置坐标。

    IMPROVEMENTS IN PHOTO-REFRACTIVE KERATECTOMY
    148.
    发明申请
    IMPROVEMENTS IN PHOTO-REFRACTIVE KERATECTOMY 审中-公开
    照相机中的改进

    公开(公告)号：WO1995027436A1

    公开(公告)日：1995-10-19

    申请号：PCT/US1995004177

    申请日：1995-04-05

    Applicant: SUMMIT TECHNOLOGY, INC.

    Inventor： SUMMIT TECHNOLOGY, INC. ,  MULLER, David, F. ,  D'AGATI, Mike ,  FRIEDMAN, Marc ,  HARMON, Troy ,  KLOPOTEK, Peter ,  SACHAROFF, Alex ,  SHERR, Evan

    IPC: A61B05/05

    CPC classification number: A61F9/008 ,  A61F9/00804 ,  A61F9/00817 ,  A61F2009/00844 ,  A61F2009/00872

    Abstract: The invention features improvements in PRK procedures that relate to preventing non-uniform removal of material from the corneal surface. It has been realized that protoablation by-products resulting during the PRK procedure can affect the accuracy and the predictability of the procedure. Under certain conditions, the plume of photoablation by-products (44) that have left the corneal surface (60) can non-uniformly redeposit onto the ablation area and thus affect the uniformity of subsequent material removal. The plume of photoablation by-products, in the space above the corneal surface, can also non-uniformly affect the escape of further photoablation products from the surface. In addition to the plume effects, it has been realized that the hydration level of the corneal tissue during the PRK procedure can vary over the ablation area and likewise non-uniformly affect the PRK procedure.

    Abstract translation: 本发明的特征在于PRK程序的改进涉及防止材料从角膜表面的不均匀去除。 已经意识到，在PRK程序期间产生的原型化副产物可能影响程序的准确性和可预测性。 在某些条件下，离开角膜表面（60）的光消除副产物（44）的羽毛可能不均匀地再沉积到消融区域上，从而影响随后的材料去除的均匀性。 在角膜表面以上的空间中，光消融副产物的羽毛也可以不均匀地影响进一步的光消化产物从表面的逸出。 除了羽流效应之外，已经认识到在PRK程序期间角膜组织的水合水平可以在消融区域上变化，并且同样不均匀地影响PRK程序。

    THERAPEUTIC HOMEOPATHIC DILUTIONS OF GROWTH FACTORS AND METHODS OF THEIR USE
    149.
    发明申请
    THERAPEUTIC HOMEOPATHIC DILUTIONS OF GROWTH FACTORS AND METHODS OF THEIR USE 审中-公开
    生长因子的治疗性家庭性衰老及其使用方法

    公开(公告)号：WO1995026679A1

    公开(公告)日：1995-10-12

    申请号：PCT/US1995003984

    申请日：1995-03-30

    Applicant: BIOMEDICAL EXPLORATIONS, LLC

    Inventor： BIOMEDICAL EXPLORATIONS, LLC ,  BREWITT, Barbara, A.

    IPC: A61B05/05

    CPC classification number: A61K41/0004 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/193 ,  A61K38/30

    Abstract: The present invention comprises homeopathic dilutions of growth factors and methods for their use. Disorders which may be effectively treated with the compositions of the present invention include chronic viral disorders, such as HIV, AIDS, chronic fatigue syndrome and Epstein-Barr viral infections, cancer and diabetes. Homeopathic dilutions of growth factors are preferably administered orally. In alternative embodiment, patients are treated with radiofrequency signals corresponding to homeopathic dilutions of growth factors.

    Abstract translation: 本发明包括生长因子的顺势疗法稀释液及其使用方法。 可以用本发明的组合物有效治疗的疾病包括慢性病毒性疾病，例如HIV，AIDS，慢性疲劳综合征和爱泼斯坦 - 巴尔病毒感染，癌症和糖尿病。 生长因子的顺势疗法稀释液优选口服施用。 在替代实施例中，患者接受对应于生长因子顺势疗法稀释的射频信号。

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