公开(公告)号：WO02058200A9

公开(公告)日：2003-05-30

申请号：PCT/US0131256

申请日：2001-10-05

Applicant: STC UNM

Inventor： STINTZ ANDREAS ,  VARANGIS PETROS N ,  MALLOY KEVIN J ,  LESTER LUKE F ,  NEWELL TIMOTHY C ,  LI HUA

IPC: H01S5/343 ,  H01S5/12 ,  H01S5/125 ,  H01S5/14 ,  H01S5/183 ,  H01S5/22 ,  H01S5/34 ,  H01S5/40 ,  H01S5/00

CPC classification number: B82Y30/00 ,  B82Y10/00 ,  B82Y20/00 ,  H01S5/1228 ,  H01S5/143 ,  H01S5/3412 ,  H01S5/4031 ,  H01S5/4043 ,  H01S5/4087

Abstract: A quantum dot active region is disclosed in which quantum dot layers are formed using a self-assembled growth technique. In one embodiment, growth parameters are selected to control the dot density and dot size distribution to achieve desired optical gain spectrum characteristics. In one embodiment, the distribution in dot size and the sequence of optical transition energy values associated with the quantum confined states of the dots are selected to facilitate forming a continuous optical gain spectrum over an extended wavelength range. In another embodiment, the optical gain is selected to increase the saturated ground state gain for wavelengths of 1260 nanometers and greater. In other embodiments, the quantum dots are used as the active region in laser devices, including tunable lasers and monolithic multi-wavelength laser arrays.

Abstract translation: 公开了量子点活性区域，其中量子点层使用自组装生长技术形成。 在一个实施例中，选择生长参数以控制点密度和点尺寸分布以实现期望的光学增益谱特性。 在一个实施例中，选择点尺寸分布和与点的量子限制状态相关联的光学跃迁能量值的顺序以有助于在扩展的波长范围上形成连续的光增益谱。 在另一个实施例中，选择光增益以增加1260纳米和更大波长的饱和基态增益。 在其他实施例中，量子点被用作激光器件中的有源区域，包括可调谐激光器和单片多波长激光器阵列。

公开(公告)号：WO2017200620A3

公开(公告)日：2018-01-18

申请号：PCT/US2017019907

申请日：2017-02-28

Applicant: STC UNM

Inventor： OSINSKI MAREK ,  SMOLYAKOV GENNADY A

IPC: H01S5/10

CPC classification number: H01S5/4006 ,  H01S5/021 ,  H01S5/026 ,  H01S5/1032 ,  H01S5/1071 ,  H01S5/141 ,  H01S5/142

Abstract: The present invention provides one or more injection-lockable whistle-geometry semiconductor ring lasers, which may be cascaded, that are integrated on a common silicon-on-insulator (SOI) substrate with a single-frequency semiconductor master laser, wherein the light output from the semiconductor master laser is used to injection-lock the first of the semiconductor ring lasers. The ring lasers can be operated in strongly injection-locked mode, while at least one of them is subjected to direct injection current modulation.

Abstract translation: 本发明提供了一种或多种可级联连接的可注入锁定的口哨几何结构半导体环形激光器，其通过单频半导体主激光器集成在公共绝缘体上硅（SOI）衬底上，其中光输出 从半导体主激光器被用于注入锁定第一半导体环形激光器。 环形激光器可以在强烈的注入锁定模式下工作，而其中至少有一个受到直接注入电流调制。

公开(公告)号：WO2017040547A3

公开(公告)日：2017-04-27

申请号：PCT/US2016049529

申请日：2016-08-30

Applicant: STC UNM

Inventor： KRISHNA SANJAY ,  KLEIN BRIANNA ,  CAVALLO FRANCESCA ,  ZAMIRI SEYEDEH MARZIYEH

IPC: H01L21/20

CPC classification number: H01L21/02631 ,  H01L21/02398 ,  H01L21/02463 ,  H01L21/02466 ,  H01L21/02507 ,  H01L21/02546 ,  H01L21/02549 ,  H01L21/02664 ,  H01L21/6835 ,  H01L2221/6835 ,  H01L2221/68368

Abstract: A method for forming a semiconductor structure, includes: providing a host substrate; forming at least one sacrificial layer having two or more group-V species over the host substrate; forming at least one semiconductor layer over the at least one sacrificial layer; and transferring at least a portion of the at least one semiconductor layer from the host substrate onto an alternate substrate.

Abstract translation: 一种形成半导体结构的方法，包括：提供主基板; 在主衬底上形成具有两种或更多种V族物质的至少一个牺牲层; 在至少一个牺牲层上形成至少一个半导体层; 以及将所述至少一个半导体层的至少一部分从所述主衬底转移到替代衬底上。

公开(公告)号：WO2016145279A8

公开(公告)日：2017-04-27

申请号：PCT/US2016021933

申请日：2016-03-11

Applicant: STC UNM ,  THE OFFICE OF INNOVATION COMMERCIALIZATION ,  HALL PAMELA R ,  DALY SETH MICHAEL ,  OBERLIES NICHOLAS HUNTER ,  RAJA HUZEFA A ,  FIGUEROA-SALDIVAR MARIO A ,  HORSWILL ALEXANDER ROBERT ,  KAVANAUGH JEFFREY SCOTT

Inventor： HALL PAMELA R ,  DALY SETH MICHAEL ,  OBERLIES NICHOLAS HUNTER ,  RAJA HUZEFA A ,  FIGUEROA-SALDIVAR MARIO A ,  HORSWILL ALEXANDER ROBERT ,  KAVANAUGH JEFFREY SCOTT

IPC: A61K31/122 ,  A61K31/7056 ,  A61P3/10 ,  A61P29/00 ,  A61P31/00

CPC classification number: A61K31/122

Abstract: This disclosure describes pharmaceutical compositions and methods that involve the use of a polyhydroxyanthraquinone to inhibit quorum sensing in a microbe. In some embodiments, the polyhydroxyanthraquinone may be effective to antagonize AgrA function in a microbe. In other embodiments, the polyhydroxyanthraquinone may be effective for prophylactic and/or therapeutic treatment of a skin and soft tissue infection (SSTI) of a subject by a microbe. In still other embodiments, the polyhydroxyanthraquinone may be effective to reduce, limit progression, ameliorate, or resolve, to any extent, a symptom or clinical sign of infection by a microbe.

Abstract translation: 本公开描述了涉及使用聚羟基蒽醌抑制微生物群体感应的药物组合物和方法。 在一些实施方案中，聚羟基蒽醌可有效拮抗微生物中的AgrA功能。 在其他实施方案中，聚羟基蒽醌可有效预防和/或治疗受试者的微生物的皮肤和软组织感染（SSTI）。 在其他实施方案中，聚羟基蒽醌可有效降低，限制进展，改善或解决任何程度的微生物感染的症状或临床征兆。

公开(公告)号：WO2017023387A3

公开(公告)日：2017-03-30

申请号：PCT/US2016031301

申请日：2016-05-06

Applicant: STC UNM

Inventor： BRUECK STEVEN R J ,  KRISHNA SANJAY ,  DAPKUS P DANIEL

IPC: H01S5/18

CPC classification number: H01S5/1212 ,  G01N2021/1704 ,  G01N2021/394 ,  G01N2021/399 ,  H01S5/0085 ,  H01S5/021 ,  H01S5/02208 ,  H01S5/02248 ,  H01S5/041 ,  H01S5/042 ,  H01S5/34306 ,  H01S5/4087

Abstract: A tunable laser device includes a laser structure and a plurality of individually addressable, separated contact stripes disposed on the laser structure. The laser structure includes a substrate, an active portion disposed on the substrate, and a chirped distributed feedback (DFB) grating disposed on the active portion. The active portion includes at least top and bottom contact layers and a gain medium.

Abstract translation: 可调激光器件包括激光器结构和设置在激光器结构上的多个单独寻址的分开的接触条。 激光器结构包括衬底，设置在衬底上的有源部分和设置在有源部分上的啁啾分布反馈（DFB）光栅。 活性部分至少包括顶部和底部接触层和增益介质。

公开(公告)号：WO2015126922A3

公开(公告)日：2015-11-05

申请号：PCT/US2015016349

申请日：2015-02-18

Applicant: STC UNM

Inventor： TIMMINS GRAHAM ,  CHOI SEONG WON ,  SILKS LOUIS PETE A

IPC: G01N33/569 ,  A61K9/14 ,  A61K9/72 ,  A61K49/00 ,  A61M15/00 ,  G01N33/532

CPC classification number: G01N33/58 ,  A61K49/0004 ,  G01N33/5695 ,  G01N2333/35 ,  G01N2458/15 ,  G01N2800/52

Abstract: In one embodiment, the invention provides methods of identifying the sensitivity and resistance to therapeutic drug regimens in a subject who suffers from, or who is suspected of suffering from, a Mycobacterium infection, the method comprising administering (1) isotopically labeled Pretomanid and/or Delaminid, or (2) isotopically labeled ethionamide and/or prothionamide, or (3) isotopically labeled pyrazinamide, or (4) isotopically-labeled isoniazid to the subject and thereafter measuring levels in a subject-derived sample of one or more isotopically-labeled markers corresponding to Mycobacterium-actiwated drug metabolites or degradation products, wherein the absence of detectable levels of Mycobacterium-activated drug metabolites or degradation products indicates either that the subject does not suffer from a Mycobacterium infection or suffers from a Mycobacterium infection which is resistant to treatment with the administered drug regimen.

Abstract translation: 在一个实施方案中，本发明提供了鉴定患有或疑似患有分枝杆菌感染的受试者中对治疗药物方案的敏感性和抗性的方法，所述方法包括给予（1）同位素标记的Pretomanid和/或 （2）同位素标记的乙硫异烟胺和/或丙硫异烟胺，或（3）同位素标记的吡嗪酰胺，或（4）同位素标记的异烟肼，然后测量受试者衍生的样品中一种或多种同位素标记的 对应于分枝杆菌活化的药物代谢物或降解产物的标记，其中不存在可检测水平的分枝杆菌属活化的药物代谢物或降解产物表明对象不患有分枝杆菌感染或患有对治疗有抗性的分枝杆菌感染 与管理的药物疗法。

公开(公告)号：WO2014011831A8

公开(公告)日：2015-02-19

申请号：PCT/US2013050006

申请日：2013-07-11

Applicant: STC UNM ,  SEROV ALEXEY ,  ATANASSOV PLAMEN B

Inventor： SEROV ALEXEY ,  ATANASSOV PLAMEN B

IPC: B01J37/08 ,  B01J23/745 ,  C07D235/30

CPC classification number: H01M4/9075 ,  B01J23/745 ,  B01J37/084 ,  C07D235/30 ,  C07D235/32 ,  H01M4/90 ,  H01M4/9041 ,  H01M2008/1095 ,  Y02E60/50

Abstract: A method of preparation of M-N-C catalytic material utilizing a sacrificial support approach and using inexpensive and readily available metal precursors and carbendazim (CBDZ) as the carbon source is described.

Abstract translation: 描述了使用牺牲支持方法并使用廉价且容易获得的金属前体和多菌灵（CBDZ）作为碳源制备M-N-C催化材料的方法。

公开(公告)号：WO2013055417A2

公开(公告)日：2013-04-18

申请号：PCT/US2012045598

申请日：2012-07-05

Applicant: STC UNM ,  UNIV FLORIDA ,  SCHANZE KIRK S ,  PARTHSARAY ANAND ,  GOSWAMI SUBHADIP ,  WHITTEN DAVID G ,  JI EUNKYUNG ,  CORBITT THOMAS ,  DASCIER DIMITRI

Inventor： SCHANZE KIRK S ,  PARTHSARAY ANAND ,  GOSWAMI SUBHADIP ,  WHITTEN DAVID G ,  JI EUNKYUNG ,  CORBITT THOMAS ,  DASCIER DIMITRI

IPC: C07D409/14 ,  A01N43/10 ,  A01P3/00 ,  C07D417/14

CPC classification number: A01N43/82 ,  A01N43/10 ,  A01N43/647 ,  A61L2/084 ,  A61L2/16 ,  C07D409/14 ,  C07D417/14

Abstract: Thiophene containing water-soluble oligomers were synthesized and characterized. The photophysical properties of these compounds were studied; transient absorption spectroscopy was used to probe the triplet excited state and their ability to sensitize singlet oxygen was spectroscopically monitored in deuterated methanol. The above compounds were tested for their light activated biocidal properties against S. aureus both under UV and visible radiation. Among the oligomers studied, the terthiophene derivative was found to kill the bacteria efficiently.

Abstract translation: 合成含有噻吩的水溶性低聚物并进行表征。 研究了这些化合物的光物理性质; 瞬态吸收光谱法用于探测三重激发态，并且在氘代甲醇中光谱监测其对单线态氧敏化的能力。 在UV和可见光辐射下，测试了上述化合物对金黄色葡萄球菌的光活化杀生物性质。 在研究的低聚物中，发现三噻吩衍生物有效杀死细菌。

公开(公告)号：WO2012079085A3

公开(公告)日：2012-08-09

申请号：PCT/US2011064460

申请日：2011-12-12

Applicant: STC UNM ,  WHITTEN DAVID ,  SCHANZE KIRK ,  JI EUNKYUNG ,  CORBITT THOMAS ,  DASCIER DIMITRI

Inventor： WHITTEN DAVID ,  SCHANZE KIRK ,  JI EUNKYUNG ,  CORBITT THOMAS ,  DASCIER DIMITRI

IPC: C08F238/00 ,  A01N31/08 ,  C08F220/00 ,  C08F220/56 ,  C12N15/87

CPC classification number: A01N41/04 ,  A01N33/12 ,  C08F230/08 ,  A01N25/10 ,  A01N37/38

Abstract: The present disclosure provides novel polyampholyte compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various polyampholytes show antibacterial activity and may also demonstrate antiviral antifungal and/or antibiofilm activity.

Abstract translation: 本公开提供了新的聚阴离子化合物，合成这些化合物的方法，以及掺入这些化合物的材料和物质。 各种多聚电解质显示抗菌活性，并且还可以显示抗病毒抗真菌和/或抗菌膜活性。

公开(公告)号：WO2012037078A3

公开(公告)日：2012-06-21

申请号：PCT/US2011051330

申请日：2011-09-13

Applicant: STC UNM ,  CHACKERIAN BRYCE C ,  PEABODY DAVID S

Inventor： CHACKERIAN BRYCE C ,  PEABODY DAVID S

IPC: A61K38/16 ,  A61K39/12 ,  A61K47/42 ,  A61K47/48 ,  A61K48/00 ,  A61P11/00 ,  A61P31/12

CPC classification number: A61K39/155 ,  A61K39/12 ,  A61K39/295 ,  A61K47/48776 ,  A61K47/48884 ,  A61K47/6901 ,  A61K47/6929 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/55566 ,  A61K2039/6075 ,  C07K14/005 ,  C07K2319/40 ,  C12N7/00 ,  C12N2760/18523 ,  C12N2760/18534 ,  C12N2795/00023

Abstract: The invention provides immunotherapeutic and prophylactic bacteriophage viral-like particle (VLPs) which are useful in the treatment and prevention of Respiratory Syncytial Virus (RSV) infections and related disorders, including bronchiolitis and viral pneumonia. Related compositions (e.g, vaccines), nucleic acid constructs, and therapeutic methods are also provided. VLPs and related compositions of the invention induce high titer antibody responses against RSV. VLPs, VLP-containing compositions, and therapeutic methods of the invention induce an immunogenic response against RSV infection, confer immunity against RSV infection, protect against RSV infection, and reduce the likelihood of infection by RSV infection.

Abstract translation: 本发明提供了可用于治疗和预防呼吸道合胞病毒（RSV）感染和相关疾病（包括细支气管炎和病毒性肺炎）的免疫治疗和预防性噬菌体病毒样颗粒（VLP）。 还提供了相关组合物（例如疫苗），核酸构建体和治疗方法。 本发明的VLP和相关组合物诱导针对RSV的高效价抗体应答。 VLP，含VLP的组合物和本发明的治疗方法诱导针对RSV感染的免疫原性应答，赋予针对RSV感染的免疫，防止RSV感染，并降低RSV感染感染的可能性。