公开(公告)号：EP2563817A4

公开(公告)日：2013-10-30

申请号：EP11775562

申请日：2011-04-28

Applicant: STC UNM ,  MARKIV ANATOLIY ,  DURVASULA RAVI ,  KANG ANGRAY SINGH ,  QUEEN MARY & WESTFIELD COLLEGE

Inventor： MARKIV ANATOLIY ,  DURVASULA RAVI ,  KANG ANGRAY SINGH

IPC: C07K19/00 ,  A61K49/00 ,  C07K16/30 ,  C07K16/32 ,  C12N15/62 ,  C12Q1/04 ,  G01N33/52

CPC classification number: C12N15/62 ,  A61K49/0045 ,  A61K49/0058 ,  A61N5/062 ,  C07K14/001 ,  C07K16/18 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/60 ,  C12N15/63 ,  C12Q1/04 ,  G01N33/53 ,  G01N33/582

Abstract: Embodiments of the present invention provide for the facile generation of a stable recombinant fusion polypeptides with intrinsic fluorescent properties. The recombinant antibodies may be suitable for qualitative and/or quantitative immunofluorescence analysis. Generally, the fluorescent polypeptides include a fluorescent domain comprising a C-terminus and an N-terminus; a first antibody domain covalently linked to the C-terminus; and a second antibody domain covalently linked to the N-terminus.

Abstract translation: 本发明的实施方案提供容易地产生具有固有荧光性质的稳定的重组融合多肽。 重组抗体可适用于定性和/或定量免疫荧光分析。 通常，荧光多肽包括包含C末端和N末端的荧光结构域; 与C-末端共价连接的第一抗体结构域; 和与N末端共价连接的第二抗体结构域。

公开(公告)号：EP2097751A4

公开(公告)日：2013-05-08

申请号：EP07871291

申请日：2007-10-30

Applicant: STC UNM

Inventor： BENTLEY PAUL A ,  DAVENPORT MICHAEL

IPC: G01N33/543 ,  B03C1/28 ,  C12M1/00 ,  C12M1/34 ,  C12M3/00 ,  G01N33/53 ,  G01N33/544 ,  G01N33/551 ,  G01N33/553

CPC classification number: G01N33/54326 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/22

公开(公告)号：EP1948686A4

公开(公告)日：2009-06-10

申请号：EP06836509

申请日：2006-10-26

Applicant: STC UNM

Inventor： DU CLOS TERRY W ,  MOLD CAROLYN

IPC: A61K38/17

CPC classification number: A61K38/1709

公开(公告)号：EP0935672A4

公开(公告)日：2004-03-17

申请号：EP97910799

申请日：1997-10-03

Applicant: STC UNM

Inventor： SARTO GLORIA E ,  THOMPSON DONALD M

IPC: C12Q1/68 ,  G02B21/34

CPC classification number: G02B21/34 ,  C12Q1/6841 ,  C12Q2547/101 ,  C12Q2537/101 ,  C12Q2565/501

Abstract: A method, as shown in the figure, of preparing fluorescent in situ hybridization slides, comprising: providing a slide with a raised ring thereon; providing to the slide a DNA probe; providing to the slide cells and target DNA; providing to the slide a formamide-free mixture of 10 % +/- 2 % by weight dextran sulfate, and 15 %-25 % glycerol and 0.9 % by weight salt or a solution of 10 % +/- 2 % by weight dextran sulfate, 10-30 % by volume formamide and 0.9 % by weight salt; placing a coverglass on the ring; denaturing and hybridizing the slide; and performing a post-hybridization wash of the slide.

Abstract translation: 如图所示，制备荧光原位杂交载玻片的方法，包括：提供其上具有凸起环的载玻片; 向载玻片提供DNA探针; 向载玻片和靶DNA提供; 向载玻片提供10％+/- 2％重量硫酸葡聚糖和15％-25％甘油和0.9％重量盐的无甲酰胺混合物或10％+/- 2％重量硫酸葡聚糖溶液 ，10-30体积％甲酰胺和0.9重量％盐; 将盖玻片放在环上; 使载玻片变性和杂交; 并进行载玻片的杂交后清洗。

公开(公告)号：EP3152788A4

公开(公告)日：2018-02-28

申请号：EP15807428

申请日：2015-06-09

Applicant: STC UNM

Inventor： BRUECK STEVEN R J ,  NEUMANN ALEXANDER ,  ZARKESH-HA PAYMAN

IPC: G01J1/02 ,  F21S2/00 ,  G01J3/02 ,  G01J3/18 ,  H01L33/48 ,  H01L33/58

CPC classification number: G01J1/06 ,  G01J1/44 ,  G01J3/0218 ,  G01J3/0259 ,  G01J3/18 ,  G01J3/1895 ,  G01J3/2803 ,  G01J2001/448 ,  G02B6/10 ,  G02B6/12004 ,  G02B6/122 ,  G02B6/124 ,  H01L27/1446 ,  H01L31/02019 ,  H01L31/02164 ,  H01L31/02327 ,  H01L31/103

Abstract: A 2-D sensor array includes a semiconductor substrate and a plurality of pixels disposed on the semiconductor substrate. Each pixel includes a coupling region and a junction region, and a slab waveguide structure disposed on the semiconductor substrate and extending from the coupling region to the region. The slab waveguide includes a confinement layer disposed between a first cladding layer and a second cladding layer. The first cladding and the second cladding each have a refractive index that is lower than a refractive index of the confinement layer. Each pixel also includes a coupling structure disposed in the coupling region and within the slab waveguide. The coupling structure includes two materials having different indices of refraction arranged as a grating defined by a grating period. The junction region comprises a p-n junction in communication with electrical contacts for biasing and collection of carriers resulting from absorption of incident radiation.

公开(公告)号：EP3077407A4

公开(公告)日：2017-07-19

申请号：EP14867520

申请日：2014-12-03

Applicant: MILLENNIUM PHARM INC ,  INVICRO LLC ,  UNIV IOWA RES FOUND ,  STC UNM

Inventor： CVET DONNA ,  RAUT SWAPNIL ,  SCHULTZ MICHAEL K ,  NORENBERG JEFFREY P ,  DANIELS TAMARA ANDERSON ,  HOPPIN JOHN WILLIAM

IPC: C07K7/08 ,  A61K38/50 ,  A61K45/06 ,  A61K51/04 ,  A61K51/08 ,  A61K51/10 ,  C07K16/30 ,  C07K16/40 ,  C12N9/88 ,  G01N33/50 ,  G01N33/60

CPC classification number: A61K51/0482 ,  A61K38/50 ,  A61K45/06 ,  A61K51/08 ,  A61K51/1063 ,  C07K7/08 ,  C07K16/3046 ,  C07K16/40 ,  C12N9/88 ,  C12Y305/01001 ,  C12Y406/01002 ,  G01N33/5011 ,  G01N33/60 ,  A61K2300/00

Abstract: This disclosure provides radiolabeled compounds that bind to guanylyl cyclase C (GCC) and which can bind cancer cells that express GCC. Exemplary compounds comprise a chelating moiety capable of binding a radioactive atom, a peptide capable of binding GCC, and a linker moiety connecting the two. This disclosure also provides methods of detecting and treating cancer using the compounds described herein.

Abstract translation: 本公开提供了与鸟苷酸环化酶C（GCC）结合并且可以结合表达GCC的癌细胞的放射性标记的化合物。 示例性化合物包含能够结合放射性原子的螯合部分，能够结合GCC的肽和连接两者的接头部分。 本公开还提供了使用本文所述的化合物检测和治疗癌症的方法。

公开(公告)号：EP3039547A4

公开(公告)日：2017-04-26

申请号：EP14840028

申请日：2014-08-28

Applicant: STC UNM

Inventor： PLUSQUELLIC JAMES

IPC: G06F11/10 ,  G09C1/00 ,  H04L9/08

CPC classification number: G06F7/588 ,  G06F2207/58 ,  G09C1/00 ,  H04L9/002 ,  H04L9/0866 ,  H04L2209/12 ,  H04L2209/26 ,  Y04S40/24

Abstract: This disclosure describes techniques for analyzing statistical quality of bitstrings produced by a physical unclonable function (PUF). The PUF leverages resistance variations in the power grid wires of an integrated circuit. Temperature and voltage stability of the bitstrings are analyzed. The disclosure also describes converting a voltage drop into a digital code, wherein the conversion is resilient to simple and differential side-channel attacks.

Abstract translation: 本发明描述用于分析由物理不可克隆功能（PUF）中产生位串的统计质量的技术。 所述PUF利用在集成电路的电网电线的电阻变化。 的位串的温度和电压的稳定性进行了分析。 所以本发明描述的电压降转换成数字码，worin转换是有弹性的，以简单和差速器侧信道攻击。

公开(公告)号：EP2906711A4

公开(公告)日：2016-06-01

申请号：EP13845074

申请日：2013-10-08

Applicant: STC UNM

Inventor： TIMMINS GRAHAM ,  SILKS LOUIS PETE

IPC: C12Q1/04 ,  A61B5/083 ,  A61K51/12 ,  C12Q1/02 ,  G01N33/497 ,  G01N33/569 ,  G01N33/60 ,  G21H5/02

CPC classification number: C12Q1/04 ,  A61B5/082 ,  A61B5/0836 ,  A61B5/14507 ,  A61B5/14546 ,  A61B5/207 ,  C12Q1/02 ,  G01N33/497 ,  G01N33/56911 ,  G01N33/60 ,  G01N2333/33 ,  G21H5/02

Abstract: The present invention is directed to methods of determining the presence or absence of a bacterial infection in a patient using isotopically-labeled tyrosine and/or isotopically-labeled p-hydroxyphenylacetic acid.

Abstract translation: 本发明涉及使用同位素标记的酪氨酸和/或同位素标记的对羟基苯基乙酸来确定患者中细菌感染的存在或不存在的方法。

公开(公告)号：EP2616485A4

公开(公告)日：2014-04-02

申请号：EP11825972

申请日：2011-09-15

Applicant: STC UNM

Inventor： PAUL SUROJIT

IPC: C07K14/47 ,  A61K38/17 ,  A61P25/00 ,  C07K19/00 ,  C12N9/16

CPC classification number: C12N9/16 ,  A61K38/00 ,  A61K38/465 ,  C12Y301/03048

公开(公告)号：EP2307350A4

公开(公告)日：2013-12-04

申请号：EP09771137

申请日：2009-06-26

Applicant: STC UNM

Inventor： WHITTEN DAVID ,  TANG YANLI ,  ZHOU ZHIJUN ,  ISTA LINNEA ,  OGAWA MOTOKATSU ,  KELLER DAVID ,  ANDREZEJEWSKI BRETT ,  LOPEZ GABRIEL ,  SCHANZE KIRK

IPC: C07C211/63 ,  A01N33/06 ,  A01N33/12 ,  C07C69/76 ,  C12M1/00 ,  C12Q1/00 ,  G01N27/00

CPC classification number: C07C217/20 ,  A01N33/12 ,  A01N37/38