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公开(公告)号：US09089819B2
公开(公告)日：2015-07-28
申请号：US13250575
申请日：2011-09-30
Applicant: Sameer Walavalkar , Aditya Rajagopal , Axel Scherer , Thomas A. Tombrello
Inventor： Sameer Walavalkar , Aditya Rajagopal , Axel Scherer , Thomas A. Tombrello
CPC classification number: B01D67/0062 , B01D61/027 , B01D61/145 , B01D69/06 , B01D71/027 , B07B1/00 , B07B1/4618 , B81C1/00031 , B81C1/00111 , B81C1/00119 , B81C1/00158 , B81C1/00531 , B81C1/00539 , B82Y40/00 , G01N33/48721 , H01L21/0331
Abstract: Methods and devices for isolating and sorting nanoparticles are disclosed herein. Nanopores of a desired size can be formed in silicon dioxide membranes and used as filters to separate nanoparticles. Devices are also provided herein for sorting nanoparticles with multiple filters having various sized nanopores.
Abstract translation: 本文公开了用于分离和分选纳米颗粒的方法和装置。 所需尺寸的纳米孔可以在二氧化硅膜中形成并用作分离纳米颗粒的过滤器。 本文还提供了用于对具有各种尺寸的纳米孔的多个过滤器分选纳米颗粒的装置。
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公开(公告)号：US09018684B2
公开(公告)日：2015-04-28
申请号：US12952181
申请日：2010-11-22
Applicant: Andrew P. Homyk , Michael D. Henry , Axel Scherer , Sameer Walavalkar
Inventor： Andrew P. Homyk , Michael D. Henry , Axel Scherer , Sameer Walavalkar
IPC: H01L29/772 , H01L29/02 , H01L29/06 , B82Y10/00 , H01L29/775 , G01N27/414 , B82Y15/00
CPC classification number: G01N27/4146 , B82Y10/00 , B82Y15/00 , H01L29/0676 , H01L29/66666 , H01L29/775
Abstract: Methods for fabricating silicon nanowire chemical sensing devices, devices thus obtained, and methods for utilizing devices for sensing and measuring chemical concentration of selected species in a fluid are described. Devices may comprise a metal-oxide-semiconductor field-effect transistor (MOSFET) structure.
Abstract translation: 描述了制造硅纳米线化学感测装置的方法，如此获得的装置，以及利用用于感测和测量流体中选定物种的化学浓度的装置的方法。 器件可以包括金属氧化物半导体场效应晶体管（MOSFET）结构。
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153.发明授权公开(公告)号：US08980550B2
公开(公告)日：2015-03-17
申请号：US13009785
申请日：2011-01-19
Applicant: Imran R. Malik , Axel Scherer
Inventor： Imran R. Malik , Axel Scherer
CPC classification number: G01N21/6428 , B01L7/52 , B01L2300/023 , B01L2300/0654 , G01N21/0332 , G01N21/645 , G01N21/8483 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2201/0627
Abstract: Methods for measuring and analyzing biological or chemical samples using consumer electronic devices and systems are described. Moreover, an accessory to enable using devices such as cell phones and smartphones with fluidic illumination chambers are described.
Abstract translation: 描述了使用消费电子设备和系统测量和分析生物或化学样品的方法。 此外，描述了能够使用具有流体照明室的诸如手机和智能手机的装置的附件。
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公开(公告)号：US08883088B2
公开(公告)日：2014-11-11
申请号：US13407644
申请日：2012-02-28
Applicant: Imran R. Malik , Axel Scherer
Inventor： Imran R. Malik , Axel Scherer
CPC classification number: B01L3/502784 , B01L3/502 , B01L3/502715 , B01L3/502753 , B01L3/502776 , B01L7/52 , B01L2200/0621 , B01L2200/10 , B01L2300/0681 , B01L2300/0867 , B01L2300/087 , B01L2300/165 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0644 , C12Q1/68 , F17D3/00 , G01N35/1097 , G01N2001/4088 , Y10T137/0318 , Y10T137/8593 , Y10T137/85978
Abstract: Devices and system for preparing samples are described. Such devices can comprise fluidic chambers, reservoirs, and movable structures for controlling the movement of samples. The device can also comprise functional elements for performing specific operations.
Abstract translation: 描述用于制备样品的装置和系统。 这样的装置可以包括用于控制样品运动的流体室，储存器和可移动结构。 该装置还可以包括用于执行特定操作的功能元件。
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公开(公告)号：US08846183B2
公开(公告)日：2014-09-30
申请号：US13278061
申请日：2011-10-20
Applicant: Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake
Inventor： Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake
IPC: B32B3/00 , F16C1/06 , F16K1/00 , F16K7/00 , F16K31/145 , B29C65/00 , B29C45/14 , B01L3/00 , C12Q1/68 , B81C1/00 , F04B43/04 , F15C5/00 , B01L9/00 , F16K99/00 , B32B37/10 , B01L7/00
CPC classification number: B32B3/00 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/005 , B01J2219/00527 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0681 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/046 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , B32B2037/1081 , B81B3/0032 , B81B3/0051 , B81B2201/036 , B81B2201/054 , B81C1/00119 , B81C2201/019 , C12Q1/6874 , F04B43/043 , F15C5/00 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , Y10T137/0491 , Y10T137/2224 , Y10T137/87716 , Y10T137/87804 , Y10T137/87812 , Y10T137/87893 , Y10T156/10 , Y10T156/1002 , Y10T156/1064 , Y10T428/24479 , Y10T428/2457 , Y10T428/24612 , Y10T428/24744 , C12Q2535/125
Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.
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Patent Agency Ranking
156.发明授权公开(公告)号：US08673645B2
公开(公告)日：2014-03-18
申请号：US13603263
申请日：2012-09-04
Applicant: Stephen R. Quake , Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer
Inventor： Stephen R. Quake , Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer
IPC: G01N15/06
CPC classification number: G01N33/00 , B01D57/02 , B01D61/18 , B01D61/28 , B01D63/081 , B01D63/088 , B01D2313/08 , B01D2313/90 , B01F5/0646 , B01F5/0647 , B01F7/00 , B01F11/0071 , B01F13/0059 , B01F13/1013 , B01F13/1022 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502761 , B01L2200/0631 , B01L2200/10 , B01L2300/0627 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2300/1822 , B01L2300/1827 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0633 , B01L2400/0655 , B01L2400/082 , C12M23/16 , C12M41/46 , F04B43/043 , F16K99/0001 , F16K99/0009 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G01N15/06 , G01N27/44743 , G01N27/44791 , G01N33/5005 , G01N33/5008 , G01N33/56966 , Y10T436/11 , Y10T436/117497 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
Abstract: The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel.
Abstract translation: 本发明提供微流体装置及其使用方法。 特别地，本发明的微流体装置可用于进行各种测定和高通量筛选。 本发明的微流体装置包括弹性体部件并且包括主流动通道; 多个分支流动通道; 多个控制信道; 和多个阀。 优选地，每个阀包括控制通道中的一个和可响应于施加到控制通道的致动力而从阀或液流通道偏转进入或从其中缩回的弹性体段。
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公开(公告)号：US08480978B2
公开(公告)日：2013-07-09
申请号：US13206362
申请日：2011-08-09
Applicant: Emil P. Kartalov , Axel Scherer , Koichi Sayano
Inventor： Emil P. Kartalov , Axel Scherer , Koichi Sayano
CPC classification number: B01L3/502753 , A61M1/3472 , A61M1/3496 , A61M1/3633 , A61M2205/0244 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2400/0424 , Y10T436/25125 , Y10T436/25375
Abstract: A microfluidic fluid separator for separating target components of a fluid by filtration is described. Methods for separating target components of a fluid by filtration and methods for processing blood on a large scale with the microfluidic fluid separator are provided.
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158.发明申请公开(公告)号：US20130140181A1
公开(公告)日：2013-06-06
申请号：US13603263
申请日：2012-09-04
Applicant: Stephen R. Quake , Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer
Inventor： Stephen R. Quake , Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer
IPC: G01N27/447
CPC classification number: G01N33/00 , B01D57/02 , B01D61/18 , B01D61/28 , B01D63/081 , B01D63/088 , B01D2313/08 , B01D2313/90 , B01F5/0646 , B01F5/0647 , B01F7/00 , B01F11/0071 , B01F13/0059 , B01F13/1013 , B01F13/1022 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502761 , B01L2200/0631 , B01L2200/10 , B01L2300/0627 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2300/1822 , B01L2300/1827 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0633 , B01L2400/0655 , B01L2400/082 , C12M23/16 , C12M41/46 , F04B43/043 , F16K99/0001 , F16K99/0009 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G01N15/06 , G01N27/44743 , G01N27/44791 , G01N33/5005 , G01N33/5008 , G01N33/56966 , Y10T436/11 , Y10T436/117497 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
Abstract: The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel.
Abstract translation: 本发明提供微流体装置及其使用方法。 特别地，本发明的微流体装置可用于进行各种测定和高通量筛选。 本发明的微流体装置包括弹性体部件并且包括主流动通道; 多个分支流动通道; 多个控制信道; 和多个阀。 优选地，每个阀包括控制通道中的一个和可响应于施加到控制通道的致动力而从阀或液流通道偏转进入或从其中缩回的弹性体段。
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公开(公告)号：US08413088B1
公开(公告)日：2013-04-02
申请号：US12426188
申请日：2009-04-17
Applicant: Frank Armbruster , Sandeep Pagey , F. Erich Marschner , Dan Leibovich , Alok Jain , Axel Scherer , Yaron Peri-Glass
Inventor： Frank Armbruster , Sandeep Pagey , F. Erich Marschner , Dan Leibovich , Alok Jain , Axel Scherer , Yaron Peri-Glass
IPC: G06F17/50
CPC classification number: G06F17/5022 , G01R31/2848 , G06F17/504
Abstract: A method and apparatus for producing a verification of digital circuits are provided. In an exemplary embodiment on the invention, a plurality of verification scopes of an integrated circuit design as defined as part of a verification plan. A plurality of verification runs are executed within two or more verification scopes defined by the verification plan. At least two verification runs are selected to merge verification results together. Like named scenarios are merged together for each verification scope to generate merged verification results that are then stored into a merge database. A verification report is generated for the integrated circuit design from the merged verification results. A merge point may be specified so like named subtrees and subgroups may be merged across different verification scopes of selected verification runs. The merge point may combine check and coverage results obtained during simulation with check and coverage results obtained during formal verification.
Abstract translation: 提供了一种用于产生数字电路验证的方法和装置。 在本发明的示例性实施例中，定义为验证计划的一部分的集成电路设计的多个验证范围。 在由验证计划定义的两个或多个验证范围内执行多个验证运行。 选择至少两次验证运行以将验证结果合并在一起。 对于每个验证范围，像命名方案一样合并生成合并的验证结果，然后将其存储到合并数据库中。 从合并的验证结果生成集成电路设计的验证报告。 可以指定合并点，以便命名子树和子组可以在所选验证运行的不同验证范围之间合并。 合并点可以将在模拟期间获得的检查和覆盖结果与在正式验证期间获得的检查和覆盖结果相结合。
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公开(公告)号：US08395773B2
公开(公告)日：2013-03-12
申请号：US12820104
申请日：2010-06-21
Applicant: Imran R. Malik , Axel Scherer
Inventor： Imran R. Malik , Axel Scherer
CPC classification number: B01L3/5085 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0829 , G01N21/645 , G01N21/6452 , G01N2021/6482 , G01N2201/062
Abstract: Optical devices and methods for measuring samples while minimizing stray light are described. Such methods and devices are applicable to multiple fluid chambers with multiple sources as an integrated optical element. Light sources can be embedded onto a chip or microarray with multiple chambers, or can be part of an instrument arrangement.
Abstract translation: 描述了在最小化杂散光的同时测量样品的光学装置和方法。 这种方法和装置可应用于具有多个源的多个流体室作为集成的光学元件。 光源可以嵌入到具有多个室的芯片或微阵列上，或者可以是仪器装置的一部分。
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