公开(公告)号：NZ302649A

公开(公告)日：2000-01-28

申请号：NZ30264996

申请日：1996-02-12

Applicant: BASF AG

Inventor： BOHM HANS-JOACHIM ,  HOFFKEN HAN WOLFGANG ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495

Abstract: he present invention relates to carbo- and heterocyclic amidines, the preparation thereof and the use as thrombin inhibitors of the formula 1 Where D is formula 1a R2 is H, C1-4 alkyl, phenyl and phenyl C1-4 alkyl, R18O-CH2, R18CO- R18-O-CH2-CO-, R18O-CO-CO-, R18-NH-CO-CO, where R18 is H or C1-4-alkyl, CF3-CO- or C2F5-Co- A is formula IIa, IIb or Iic B is selected from IIIa-IIIg The other substituents are defined in the specification.

公开(公告)号：ZA9806064B

公开(公告)日：2000-01-10

申请号：ZA9806064

申请日：1998-07-09

Applicant: BASF AG

Inventor： SUBKOWSKI THOMAS ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K39/395 ,  A61P7/02 ,  A61P7/04 ,  A61P39/02 ,  C07K16/00 ,  C07K16/40 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  G01N33/573 ,  C07K ,  A61K ,  G01N

CPC classification number: G01N33/573 ,  A61K38/00 ,  C07K16/40 ,  G01N2333/96433

公开(公告)号：AU708001B2

公开(公告)日：1999-07-29

申请号：AU4875196

申请日：1996-02-12

Applicant: BASF AG

Inventor： BOHM HANS-JOACHIM ,  HOFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495

Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.

公开(公告)号：HU9800634A2

公开(公告)日：1999-06-28

申请号：HU9800634

申请日：1996-02-06

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HORNBERGER WILFRIED ,  HOEFFKEN HANS WOLFGANG ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087

Abstract: PCT No. PCT/EP96/00472 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 6, 1996 PCT Pub. No. WO96/24609 PCT Pub. Date Aug. 15, 1996Thrombin inhibitors of the formula where R1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described. The compounds I are suitable for controlling diseases.

公开(公告)号：AU706834B2

公开(公告)日：1999-06-24

申请号：AU4787596

申请日：1996-02-06

Applicant: BASF AG

Inventor： SEITZ WERNER ,  MACK HELMUT ,  ZIERKE THOMAS ,  BOHM HANS-JOACHIM ,  HOFFKEN HANS WOLFGANG ,  KOSER STEFAN ,  PFEIFFER THOMAS ,  HORNBERGER WILFRIED

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087

Abstract: PCT No. PCT/EP96/00472 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 6, 1996 PCT Pub. No. WO96/24609 PCT Pub. Date Aug. 15, 1996Thrombin inhibitors of the formula where R1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described. The compounds I are suitable for controlling diseases.

公开(公告)号：CZ48699A3

公开(公告)日：1999-05-12

申请号：CZ48699

申请日：1997-07-29

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065

Abstract: PCT No. PCT/EP97/04104 Sec. 371 Date Feb. 10, 1999 Sec. 102(e) Date Feb. 10, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/06741 PCT Pub. Date Feb. 19, 1998Compounds of the formula where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.

公开(公告)号：TR9900310T2

公开(公告)日：1999-04-21

申请号：TR9900310

申请日：1997-07-29

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065

CPC classification number: C07K5/06078 ,  A61K38/00

公开(公告)号：NO990662L

公开(公告)日：1999-02-12

申请号：NO990662

申请日：1999-02-12

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065

Abstract: PCT No. PCT/EP97/04104 Sec. 371 Date Feb. 10, 1999 Sec. 102(e) Date Feb. 10, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/06741 PCT Pub. Date Feb. 19, 1998Compounds of the formula where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.

公开(公告)号：CA2295218A1

公开(公告)日：1999-01-21

申请号：CA2295218

申请日：1998-06-23

Applicant: BASF AG

Inventor： SUBKOWSKI THOMAS ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K39/395 ,  A61P7/02 ,  A61P7/04 ,  A61P39/02 ,  C07K16/00 ,  C07K16/40 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  G01N33/573

Abstract: The invention relates to ancrod specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof and the use thereof in pharmaceutical preparations or in diagnostics. The invention also relates to cells which express said antibodies, antibody fragments and mixtures or derivatives thereof.

公开(公告)号：AU699501B2

公开(公告)日：1998-12-03

申请号：AU2787595

申请日：1995-06-06

Applicant: BASF AG

Inventor： BOHM HANS-JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07C279/00 ,  C07D205/04 ,  C07D207/06 ,  C07D207/16 ,  C07D207/48 ,  C07D211/60 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078

Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.