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公开(公告)号：NO990662D0
公开(公告)日：1999-02-12
申请号：NO990662
申请日：1999-02-12
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , SEITZ WERNER , ZIERKE THOMAS , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K38/00 , A61K38/05 , A61P7/02 , A61P29/00 , A61P35/00 , A61P35/04 , C07K5/06 , C07K5/062 , C07K5/065 , C07K
Abstract: PCT No. PCT/EP97/04104 Sec. 371 Date Feb. 10, 1999 Sec. 102(e) Date Feb. 10, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/06741 PCT Pub. Date Feb. 19, 1998Compounds of the formula where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.
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公开(公告)号：BR9607582A
公开(公告)日：1998-07-07
申请号：BR9607582
申请日：1996-02-12
Applicant: BASF AG
Inventor： HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED , BOHM HANS-JOACHIM , KOSER STEFAN , ZIERKE THOMAS , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER
IPC: A61K31/00 , A61K38/55 , A61P7/02 , C07D205/04 , C07D207/16 , C07D213/53 , C07D213/63 , C07D213/72 , C07D213/78 , C07D213/79 , C07D239/28 , C07D241/14 , C07D241/24 , C07D401/12 , C07K5/06 , C07K5/062 , C07K5/078 , A61K31/40 , A61K31/445 , A61K31/495
Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R 1 , R 2 , A, B, C and D have the meanings described in the specification.
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公开(公告)号：BR9607412A
公开(公告)日：1998-07-07
申请号：BR9607412
申请日：1996-02-06
Applicant: BASF AG
Inventor： HORNBERGER WILFRIED , PFEIFFER THOMAS , SEITZ WERNER , MACK HELMUT , ZIERKE THOMAS , BOHM HANS-JOACHIM , HOFFKEN HANS WOLFGANG , KOSER STEFAN
Abstract: PCT No. PCT/EP96/00472 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 6, 1996 PCT Pub. No. WO96/24609 PCT Pub. Date Aug. 15, 1996Thrombin inhibitors of the formula where R1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described. The compounds I are suitable for controlling diseases.
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公开(公告)号：ES2115673T3
公开(公告)日：1998-07-01
申请号：ES92913125
申请日：1992-06-23
Applicant: BASF AG
Inventor： MACK HELMUT , PFEIFFER THOMAS , HOEFFKEN HANS WOLFGANG , BOEHM HANS-JOACHIM , HORNBERGER WILFRIED
IPC: A61K38/00 , A61K38/05 , A61P7/02 , A61K38/55 , C07K1/113 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/078
Abstract: PCT No. PCT/EP92/01411 Sec. 371 Date Dec. 28, 1993 Sec. 102(e) Date Dec. 28, 1993 PCT Filed Jun. 23, 1992 PCT Pub. No. WO93/01208 PCT Pub. Date Jan. 21, 1993.2-Substituted 3-(4-amidinophenyl)propionic acid derivatives of the formula in which A, Ar and B have the meanings stated in the description, and the preparation thereof are described. The compounds are suitable for controlling diseases.
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公开(公告)号：DE59209327D1
公开(公告)日：1998-06-18
申请号：DE59209327
申请日：1992-06-23
Applicant: BASF AG
Inventor： MACK HELMUT , PFEIFFER THOMAS , HOEFFKEN HANS , BOEHM HANS-JOACHIM , HORNBERGER WILFRIED
IPC: A61K38/55 , A61K38/00 , A61K38/05 , A61P7/02 , C07K1/113 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/078
Abstract: PCT No. PCT/EP92/01411 Sec. 371 Date Dec. 28, 1993 Sec. 102(e) Date Dec. 28, 1993 PCT Filed Jun. 23, 1992 PCT Pub. No. WO93/01208 PCT Pub. Date Jan. 21, 1993.2-Substituted 3-(4-amidinophenyl)propionic acid derivatives of the formula in which A, Ar and B have the meanings stated in the description, and the preparation thereof are described. The compounds are suitable for controlling diseases.
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Patent Agency Ranking
公开(公告)号：BG101835A
公开(公告)日：1998-05-29
申请号：BG10183597
申请日：1997-08-15
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , HOEFFKEN HANS W , HORNBERGER WILFRIED , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K31/00 , A61K38/55 , A61P7/02 , C07D205/04 , C07D207/16 , C07D213/53 , C07D213/63 , C07D213/72 , C07D213/78 , C07D213/79 , C07D239/28 , C07D241/14 , C07D241/24 , C07D401/12 , C07K5/06 , C07K5/062 , C07K5/078 , A61K31/40 , A61K31/445 , A61K31/495
Abstract: The description relates to compounds of formulain which A, B, D, R' and R have the meanings given in thespecification. the compounds am suitable for the treatment ofdiseases The novel compounds are produced via compounds of theformula H2N-CH2.G-M in which G and M have the meanings given in4 claims
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公开(公告)号：HUT77289A
公开(公告)日：1998-03-30
申请号：HU9702107
申请日：1995-11-25
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , HORNBERGER WILFRIED , HOEFFKEN HANS WOLFGANG , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
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公开(公告)号：CA2263344A1
公开(公告)日：1998-02-19
申请号：CA2263344
申请日：1997-07-29
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , HORNBERGER WILFRIED , HOEFFKEN HANS WOLFGANG , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K31/40 , A61K31/44 , A61K38/00 , A61K38/05 , A61P1/18 , A61P7/02 , A61P11/02 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P43/00 , C07D207/22 , C07D211/78 , C07K5/00 , C07K5/02 , C07K5/083 , C07K5/062 , C07K5/065
Abstract: Disclosed are compounds having formula (I) wherein the radicals R, R1, R2, R3, R4, R5 and R6, as well as l, m, and n have the meaning indicated in the description, and the production of said compounds. The new compounds can be used to combat illness. Also described are compounds having formula (II) wherein the radicals R, R1, R2, R3, R4, R5 and R6, as well as l, m, and n have the meaning indicated in claim 1, and compounds having formula (III) wherein l and R have the meaning indicated in claim 1 and Y is an N protective group, or N-terminal protected or unprotected amino acid or represents H.
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公开(公告)号：CA2261628A1
公开(公告)日：1998-02-05
申请号：CA2261628
申请日：1997-07-14
Applicant: BASF AG
Inventor： PFEIFFER THOMAS , ZIERKE THOMAS , BALKENHOHL FRIEDHELM , LANGE UDO , MACK HELMUT , SEITZ WERNER
IPC: C12P17/04 , C07D207/22 , C07D401/12 , C12P17/10 , C12P41/00 , C07D403/12
Abstract: A process is disclosed for preparing 3-pyrroline-2-carboxylic acid derivatives of formula (I), in which R1 stands for H, C1-C6-alkyl, benzyl, benzyl substituted at the phenyl radical, allyloxycarbonyl, C1-C6-alkyloxycarbonyl, benzyloxycarbonyl, in which the benzyl radical can be substituted by OCH3 radicals, or for C1-C4-alkylcarbonyl; or R1 stands for an amino acid radical which can be alkylated or acylated at the nitrogen and is linked by the Cterminal; and R2 stands for OH, C1-C4-alkyloxy, benzyloxy or an N3R4 group, in which R3 and R4 represent independently from each other H, C1-C4-alkyl, benzyl, phenyl or pyridyl, in which the aromatic compounds in R3 and R4 can be substituted by up to three identical or different substituents selected from the group composed of methyl, methoxy, hydroxy, cyano or halogen. According to this process, the sulphonic acid radical is eliminated by means of a base from a compound having the formula (II), in which R1 and R2 have the above meanings and R5 stands for C1-C6-alkyl, benzyl, trifluoromethyl, naphthyl or phenyl optionally substituted by radicals from the group composed of methyl, nitro and halogen.
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公开(公告)号：NO973657L
公开(公告)日：1997-10-03
申请号：NO973657
申请日：1997-08-08
Applicant: BASF AG
Inventor： SEITZ WERNER , MACK HELMUT , ZIERKE THOMAS , BOEHM HANS-JOACHIM , HOEFFKEN HANS WOLFGANG , KOSER STEFAN , PFEIFFER THOMAS , HORNBERGER WILFRIED
Abstract: PCT No. PCT/EP96/00472 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 6, 1996 PCT Pub. No. WO96/24609 PCT Pub. Date Aug. 15, 1996Thrombin inhibitors of the formula where R1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described. The compounds I are suitable for controlling diseases.
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