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    1.
    发明专利
    未知

    公开(公告)号：AT217024T

    公开(公告)日：2002-05-15

    申请号：AT96900601

    申请日：1996-01-20

    Applicant: BASF AG

    Inventor： BALKENHOHL FRIEDHELM ,  DITRICH KLAUS ,  NUEBLING CHRISTOPH

    IPC: C12P13/02 ,  C12P41/00

    Abstract: A process for preparing optically active primary and secondary heteroatom-substituted amines from the corresponding racemates, which comprisesa) enantioselective acylation of a racemic heteroatom-substituted amine with an ester whose acid component carries a fluorine, nitrogen, phosphorus, oxygen or sulfur atom in the vicinity of the carbonyl carbon, in the presence of a hydrolase,b) separation of the mixture of optically active heteroatom-substituted amine and optically active acylated heteroatom-substituted amine to obtain one enantiomer of the heteroatom-substituted amine,c) if required isolation of the other enantiomer of the heteroatom-substituted amine from the acylated heteroatom-substituted amine by amide cleavage.

    2.
    发明专利
    未知

    公开(公告)号：PT850214E

    公开(公告)日：2000-09-29

    申请号：PT96931783

    申请日：1996-09-09

    Applicant: BASF AG

    Inventor： LADNER WOLFGANG ,  BALKENHOHL FRIEDHELM ,  DITRICH KLAUS

    IPC: C12M1/40 ,  B01J23/04 ,  C07B53/00 ,  C07B61/00 ,  C07C69/708 ,  C07C209/62 ,  C07C211/27

    Abstract: PCT No. PCT/EP96/03948 Sec. 371 Date Jan. 27, 1998 Sec. 102(e) Date Jan. 27, 1998 PCT Filed Sep. 9, 1996 PCT Pub. No. WO97/10201 PCT Pub. Date Mar. 20, 1997The present invention relates to a process for cleaving optically active amides to carboxylic acids and optically active amines with retention of the center of chirality, wherein the amides are hydrolyzed in the presence of a polyol or of an amino alcohol and of an alkali metal or alkaline earth metal hydroxide.

    3.
    发明专利
    未知

    公开(公告)号：ES2145485T3

    公开(公告)日：2000-07-01

    申请号：ES96931783

    申请日：1996-09-09

    Applicant: BASF AG

    Inventor： DITRICH KLAUS ,  BALKENHOHL FRIEDHELM ,  LADNER WOLFGANG

    IPC: C12M1/40 ,  B01J23/04 ,  C07B53/00 ,  C07B61/00 ,  C07C69/708 ,  C07C209/62 ,  C07C211/27

    Abstract: PCT No. PCT/EP96/03948 Sec. 371 Date Jan. 27, 1998 Sec. 102(e) Date Jan. 27, 1998 PCT Filed Sep. 9, 1996 PCT Pub. No. WO97/10201 PCT Pub. Date Mar. 20, 1997The present invention relates to a process for cleaving optically active amides to carboxylic acids and optically active amines with retention of the center of chirality, wherein the amides are hydrolyzed in the presence of a polyol or of an amino alcohol and of an alkali metal or alkaline earth metal hydroxide.

    7.
    发明专利
    未知

    公开(公告)号：DE59609156D1

    公开(公告)日：2002-06-06

    申请号：DE59609156

    申请日：1996-01-20

    Applicant: BASF AG

    Inventor： BALKENHOHL FRIEDHELM ,  DITRICH KLAUS ,  NUEBLING CHRISTOPH

    IPC: C12P13/02 ,  C12P41/00

    Abstract: A process for preparing optically active primary and secondary heteroatom-substituted amines from the corresponding racemates is characterised in that (a) a racemic heteroatom-substituted amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bear a fluorine, nitrogen, phosphorus, oxygen or sulphur atom next to the carbonyl carbon atom; (b) the mixture of optically active heteroatom-substituted amine and optically active acylated heteroatom-substituted amine is separated in order to produce an enantiomer of the heteroatom-substituted amine; (c) the other enantiomer of the heteroatom-substituted amine is optionally extracted from the acylated heteroatom-substituted amine by amide cleavage.

    10.
    发明专利
    未知

    公开(公告)号：NO932860L

    公开(公告)日：1994-02-14

    申请号：NO932860

    申请日：1993-08-11

    Applicant: BASF AG

    Inventor： KAISER KLAUS ,  BALKENHOHL FRIEDHELM ,  PAUST JOACHIM

    IPC: C07F9/655 ,  C07F9/572

    Abstract: Process for obtaining the calcium salt of ascorbyl 2-monophosphate from aqueous/alkaline reaction mixtures as they are obtained when ascorbic acid is reacted with a molar excess of phosphorus oxychloride in the presence of a tertiary amine while maintaining a pH of 12 to 13 during the reaction by means of an aqueous alkali metal solution, which process is characterised in that a) starting from a reaction mixture which has been obtained by reacting ascorbic acid with phosphorus oxychloride in the presence of pyridine while maintaining a pH of 12 to 13 by means of an aqueous potassium hydroxide solution, b) the phosphoric acid ions formed during this reaction are precipitated by means of magnesium chloride in amounts of approximately 1 mol per mol of phosphoric acid ions as potassium magnesium phosphate, c) the potassium magnesium phosphate is separated off, d) the pyridine together with some of the water is removed from the remaining aqueous solution by distillation, e) the resulting aqueous solution is reacted with calcium chloride and f) the calcium salt of ascorbyl 2-monophosphate, which crystallises out during this process in the form of the calcium salt, is isolated, or in that, after process step a), the pyridine/water mixture is first removed as described in process step d) and process steps (b), (c), (e) and (f) are subsequently carried out.

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