公开(公告)号：US09932632B2

公开(公告)日：2018-04-03

申请号：US13833349

申请日：2013-03-15

Applicant: Streck, Inc.

Inventor： Matthew R. Kreifels ,  Scott E. Whitney ,  Joel R. TerMaat

IPC: G01N21/00 ,  C12Q1/68 ,  G01N21/64

CPC classification number: C12Q1/686 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6484 ,  G01N2201/0627 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate reduced sample read time and rapid reading of multiple light wavelengths.

公开(公告)号：US09739600B1

公开(公告)日：2017-08-22

申请号：US15184034

申请日：2016-06-16

Applicant: FOGALE NANOTECH

Inventor： Gilles Fresquet ,  Alain Courteville ,  Philippe Gastaldo

IPC: G01N21/00 ,  G01B11/22 ,  G01N21/95

CPC classification number: G01N21/9501 ,  G01B11/022 ,  G01B11/0608 ,  G01B11/22 ,  G01B11/245 ,  G01B2210/50 ,  G01B2210/56 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/18 ,  G01J3/453 ,  G01N21/8851 ,  G01N21/956 ,  G01N2201/063 ,  G01N2201/0833 ,  G01N2201/105 ,  G02B21/0064 ,  H01L22/12

Abstract: A confocal chromatic device for inspecting the surface of an object such as a wafer, including a plurality of optical measurement channels with collection apertures arranged for collecting the light reflected by the object through a chromatic lens at a plurality of measurement points, the plurality of optical measurement channels including optical measurement channels with an intensity detector for measuring a total intensity of the collected light. A method is also provided for inspecting the surface of an object such as a wafer including tridimensional structures.

公开(公告)号：US20170216846A1

公开(公告)日：2017-08-03

申请号：US15429765

申请日：2017-02-10

Applicant: STOKES BIO LIMITED

Inventor： Mark DAVIES ,  Tara DALTON

IPC: B01L7/00 ,  C12Q1/68 ,  B01L3/00

CPC classification number: B01L7/525 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/185 ,  B01L2400/0487 ,  C12Q1/686 ,  G01N21/6428 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A thermal cycling device comprising a number of fixed thermal zones and a fixed conduit passing through the thermal zones. A controller maintains each thermal zone including its section of conduit at a constant temperature. A series of droplets flows through the conduit so that each droplet is thermally cycled, and a detection system detects fluorescence from droplets at all of the thermal cycles. The conduit is in a single plane, and so a number of thermal cycling devices may be arranged together to achieve parallelism. The flow conduit comprises a channel and a capillary tube inserted into the channel. The detection system may perform scans along a direction to detect radiation from a plurality of cycles in a pass.

公开(公告)号：US09546960B2

公开(公告)日：2017-01-17

申请号：US14541630

申请日：2014-11-14

Applicant: Lightwave Science, Inc.

Inventor： William Bryan Pierce, III ,  Jason D. Pierce

IPC: G01J3/00 ,  G01N21/84 ,  G01N21/25 ,  G01J3/28 ,  G01N21/35 ,  G01N33/94 ,  G01N21/47

CPC classification number: G01N33/948 ,  G01J3/2803 ,  G01N21/255 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/474 ,  G01N21/84 ,  G01N2021/4742 ,  G01N2021/8466 ,  G01N2201/0221 ,  G01N2201/0692 ,  G01N2201/0833 ,  G01N2201/129

Abstract: A system including a light source, sampling tray, and at least three detectors mounted at angles with respect to each other receives light reflected from a sample of cannabis-based matter. Light from the three detectors is fed to a spectrometer which converts the reflected light into a fingerprint corresponding to the concentration of at least one substance in the sample. The fingerprint is processed by a statistical model to determine concentration level of the at least one substance in the sample and the concentration level is then displayed.

Abstract translation: 包括光源，采样托盘以及相对于彼此以角度安装的至少三个检测器的系统接收从基于大麻的物质样本反射的光。 来自三个检测器的光被馈送到光谱仪，其将反射光转换成对应于样品中至少一种物质的浓度的指纹。 通过统计模型处理指纹，以确定样品中至少一种物质的浓度水平，然后显示浓度水平。

公开(公告)号：US09488574B2

公开(公告)日：2016-11-08

申请号：US12682939

申请日：2008-10-13

Applicant: Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

Inventor： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

IPC: G01N21/47 ,  A61B5/00 ,  G01N21/17

CPC classification number: G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  A61B2562/146 ,  G01N2021/1787 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.

Abstract translation: 提供了用于对光学混浊介质的内部成像的装置（1）。 该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。 所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。 光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。 联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接 所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

公开(公告)号：US09267895B2

公开(公告)日：2016-02-23

申请号：US14427735

申请日：2013-09-12

Applicant: The University of Tokyo ,  Kyoto University ,  OK Lab. Co. Ltd.

Inventor： Blair Thornton ,  Tetsuo Sakka ,  Koichi Oki

IPC: G01J3/30 ,  G01N21/71

CPC classification number: G01N21/718 ,  G01N2201/0612 ,  G01N2201/08 ,  G01N2201/0833

Abstract: Provided is a chemical analysis device to analyze a chemical composition of a sample, including a main body including a laser light source, a chemical analysis unit, and a housing; an optical head that is arranged to be faced to the sample; and a pressureproof-feedthrough-equipped fiber that is extended from the housing to the optical head to guide laser light emitted from the laser light source to the optical head. The housing houses the laser light source and the chemical analysis unit as having a pressure-resistant function. The optical head includes a mirror system that causes the sample to be irradiated with laser light outgoing from the pressureproof-feedthrough-equipped fiber and to cause plasma emission light occurring at the sample owing to irradiation with the laser light to reenter to the pressureproof-feedthrough-equipped fiber. The chemical analysis unit performs spectroscopic analysis on the plasma emission light that reentered to the pressureproof-feedthrough-equipped fiber.

Abstract translation: 本发明提供一种化学分析装置，用于分析样品的化学成分，包括：包含激光光源，化学分析单元和壳体的主体; 布置成面向样品的光学头; 以及一个从外壳延伸到光头的防压通孔纤维，用于将从激光光源发出的激光导向光头。 外壳容纳激光光源和化学分析单元，具有耐压功能。 该光学头包括一个反射镜系统，该反射镜系统使得从具有防压穿孔的光纤射出的激光照射样品，并且由于激光的照射而导致在样品处产生的等离子体发射光重新进入防压馈通 装备的纤维。 化学分析单元对重新输入到防压穿通纤维的等离子体发射光进行光谱分析。

公开(公告)号：US20150247806A1

公开(公告)日：2015-09-03

申请号：US14422886

申请日：2013-08-06

Applicant: Beri Cohen

Inventor： Beri Cohen

IPC: G01N21/76 ,  G01N33/53

CPC classification number: G01N21/76 ,  G01N21/253 ,  G01N33/5302 ,  G01N2201/0221 ,  G01N2201/064 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/084

Abstract: A clam-shell luminometer that, when closed, completely encloses an assay reaction mixture-containing reaction vessel and some portion of a reaction carousel or ring. The luminometer includes first and second portions that are coupled to each other, a photomultiplier tube, and plural fiber optic bundles that are optically coupled to the photomultiplier tube. First ends of the fiber optic bundles are disposed adjacent to the reaction vessel in the second portion so that the fiber optic bundles completely surround the perimeter or periphery of the reaction vessel.

Abstract translation: 一种蛤壳式发光计，当关闭时，完全包含含有测定反应混合物的反应容器和一部分反应转盘或环。 光度计包括彼此耦合的第一和第二部分，光电倍增管和光学耦合到光电倍增管的多个光纤束。 光纤束的第一端在第二部分邻近反应容器设置，使得光纤束完全包围反应容器的周边或周边。

公开(公告)号：US09052290B2

公开(公告)日：2015-06-09

申请号：US13842034

申请日：2013-03-15

Applicant: Chemimage Corporation

Inventor： Patrick J. Treado ,  Matthew Nelson ,  Charles Gardner

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/02 ,  G01J3/28 ,  G01J3/36 ,  G01N33/22 ,  G01N21/17

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/0221 ,  G01J3/0264 ,  G01J3/2823 ,  G01J3/36 ,  G01J3/44 ,  G01N33/22 ,  G01N2021/1738 ,  G01N2021/174 ,  G01N2021/1744 ,  G01N2201/0833 ,  G01N2201/0846

Abstract: The present disclosure provides for a system and method for analyzing a sample comprising at least one unknown material. A first location may be scanned to generate a SWIR hyperspectral image. The SWIR hyperspectral image may be generated using dual polarization techniques. The SWIR hyperspectral image may be analyzed to target a second location comprising the unknown material. This second location may be further analyzed using Raman spectroscopic techniques and a Raman data set may be generated. The Raman data set may be further analyzed to associate the unknown material with a know material.

Abstract translation: 本公开提供了用于分析包含至少一种未知材料的样品的系统和方法。 可以扫描第一位置以产生SWIR高光谱图像。 可以使用双极化技术生成SWIR高光谱图像。 可以分析SWIR高光谱图像以瞄准包括未知材料的第二位置。 可以使用拉曼光谱技术进一步分析该第二位置，并且可以生成拉曼数据集。 可以进一步分析拉曼数据集以将未知材料与知识材料相关联。

公开(公告)号：US20140011266A1

公开(公告)日：2014-01-09

申请号：US13639584

申请日：2011-04-06

Applicant: IT-IS INTERNATIONAL LIMITED

Inventor： Benjamin Masterman Webster ,  James Richard Howell

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L3/50851 ,  B01L3/50853 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1894 ,  G01N21/0332 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A chemical and/or biochemical system (1) having at least one reaction vessel (3) in which chemical and/or biochemical reactions may take place, the temperature of the reaction vessels being cycled between at least a highest predetermined temperature and a lowest predetermined temperature, the system comprising a thermal mount (4) for receiving the reaction vessel (s), the thermal mount being thermally coupled to a first, thermally conductive side of a thermoelectric module (5), a second thermally conductive side of the thermoelectric module being thermally coupled to a heat sink (6) and being provided with a pair of electrical contacts (33) to which a pair of electrically conductive wires (34) is connected for coupling to a power source, characterized in that a flexible adhesive (31, 32) is provided between the first thermally conductive side of the thermoelectric module and the thermal mount and between the second thermally conductive side of the thermoelectric module and the heat sink, whereby the adhesive is relatively thermally insulating compared to the first and second thermally conductive sides of the thermoelectric module and forms the sole coupling, thermal or mechanical, between the thermoelectric module and the thermal mount and between the thermoelectric module and the heat sink.

Abstract translation: 化学和/或生化系统（1）具有至少一个其中可能发生化学和/或生物化学反应的反应容器（3），反应容器的温度在至少最高预定温度和最低预定温度之间循环 所述系统包括用于接收所述反应容器的热安装座（4），所述热安装件热耦合到热电模块（5）的第一导热侧，所述热电模块的第二导热侧 被热耦合到散热器（6）并且设置有一对电触点（33），一对导电线（34）连接到所述一对电触头（34）以耦合到电源，其特征在于，柔性粘合剂（31） ，32）设置在热电模块的第一导热侧和热座之间以及热电模块的第二导热侧之间，并且热sin k，由此与热电模块的第一和第二导热侧相比，粘合剂相对热绝缘，并且在热电模块和热安装座之间以及热电模块和散热器之间形成热耦合或机械的单独耦合。

公开(公告)号：US20130286385A1

公开(公告)日：2013-10-31

申请号：US13994755

申请日：2011-12-07

Applicant: Yusuke Miyazaki ,  Takahiro Jingu ,  Katsuya Suzuki

Inventor： Yusuke Miyazaki ,  Takahiro Jingu ,  Katsuya Suzuki

IPC: G01N21/95

CPC classification number: G01N21/9501 ,  G01N2201/0833

Abstract: To increase the speed of inspection, an inspection apparatus may conduct an inspection by irradiating a wafer surface with a thin light beam and acquiring an image of an irradiated region with a photodetector. However, it is not easy to have the photodetector properly form the image of the irradiated region. This problem is not solved by prior art technologies.The present invention includes an image formation optical system having an optical fiber bundle, and additionally includes a mechanism for rotating the light condensing side of the optical fiber bundle. The present invention enables the photodetector to properly form the image of light scattered from the irradiated region.

Abstract translation: 为了提高检查速度，检查装置可以通过用薄光束照射晶片表面并用光电检测器获取照射区域的图像来进行检查。 然而，使光电检测器适当地形成照射区域的图像是不容易的。 这个问题不能由现有技术解决。 本发明包括具有光纤束的图像形成光学系统，并且还包括用于旋转光纤束的聚光侧的机构。 本发明使得光电检测器能够适当地形成从照射区域散射的光的图像。