公开(公告)号：US08654326B2

公开(公告)日：2014-02-18

申请号：US14013359

申请日：2013-08-29

Applicant: PD-LD, Inc.

Inventor： Boris Leonidovich Volodin ,  Vladimir Sinisa Ban

IPC: G01J3/44

CPC classification number: G01J3/0256 ,  G01J3/00 ,  G01J3/10 ,  G01J3/1895 ,  G01J3/44 ,  G01J3/4412 ,  G01J2003/104 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/1793 ,  G01N2201/0221 ,  G01N2201/129 ,  G01N2201/1296 ,  G02B6/29319 ,  H01S5/005 ,  H01S5/32 ,  H01S5/4012 ,  H01S5/4087

Abstract: Apparatus for performing Raman spectroscopy may include a first laser source having a first emission wavelength and a second laser source having a second emission wavelength. A separation between the first and second emission wavelengths may correspond to a width of a Raman band of a substance of interest. A switch may provide switching between the first and second laser sources. An ensemble of individually addressable laser emitters may be provided. A Bragg grating element may receive laser light from the ensemble. An optical system may direct light from the Bragg grating element into an optical fiber. A combined beam through the optical fiber may contain light from each of the emitters.

Abstract translation: 用于执行拉曼光谱的装置可以包括具有第一发射波长的第一激光源和具有第二发射波长的第二激光源。 第一和第二发射波长之间的间隔可以对应于感兴趣物质的拉曼带的宽度。 开关可以提供第一和第二激光源之间的切换。 可以提供可单独寻址的激光发射器的组合。 布拉格光栅元件可以接收来自集合体的激光。 光学系统可以将来自布拉格光栅元件的光引导到光纤中。 通过光纤的组合光束可以包含来自每个发射器的光。

公开(公告)号：US20140002818A1

公开(公告)日：2014-01-02

申请号：US14013359

申请日：2013-08-29

Applicant: PD-LD, Inc.

Inventor： Boris Leonidovich Volodin ,  Vladimir Sinisa Ban

IPC: G01J3/10

CPC classification number: G01J3/0256 ,  G01J3/00 ,  G01J3/10 ,  G01J3/1895 ,  G01J3/44 ,  G01J3/4412 ,  G01J2003/104 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/1793 ,  G01N2201/0221 ,  G01N2201/129 ,  G01N2201/1296 ,  G02B6/29319 ,  H01S5/005 ,  H01S5/32 ,  H01S5/4012 ,  H01S5/4087

Abstract: Apparatus for performing Raman spectroscopy may include a first laser source having a first emission wavelength and a second laser source having a second emission wavelength. A separation between the first and second emission wavelengths may correspond to a width of a Raman band of a substance of interest. A switch may provide switching between the first and second laser sources. An ensemble of individually addressable laser emitters may be provided. A Bragg grating element may receive laser light from the ensemble. An optical system may direct light from the Bragg grating element into an optical fiber. A combined beam through the optical fiber may contain light from each of the emitters.

Abstract translation: 用于执行拉曼光谱的装置可以包括具有第一发射波长的第一激光源和具有第二发射波长的第二激光源。 第一和第二发射波长之间的间隔可以对应于感兴趣物质的拉曼带的宽度。 开关可以提供第一和第二激光源之间的切换。 可以提供可单独寻址的激光发射器的组合。 布拉格光栅元件可以接收来自集合体的激光。 光学系统可以将来自布拉格光栅元件的光引导到光纤中。 通过光纤的组合光束可以包含来自每个发射器的光。

公开(公告)号：US20120062873A1

公开(公告)日：2012-03-15

申请号：US13153775

申请日：2011-06-06

Applicant: Shona Stewart ,  John Maier ,  Jeffrey Cohen

Inventor： Shona Stewart ,  John Maier ,  Jeffrey Cohen

IPC: G01N21/00 ,  G01J3/44 ,  G01N21/64 ,  G01J5/08

CPC classification number: A61B5/417 ,  A61B5/0075 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/36 ,  G01J3/44 ,  G01J2003/2826 ,  G01N21/35 ,  G01N21/6456 ,  G01N21/65 ,  G01N33/57415 ,  G01N2021/1765 ,  G01N2021/1793 ,  G01N2021/6423 ,  G01N2021/656 ,  G01N2201/1293 ,  G01N2201/1296 ,  G01N2800/7028

Abstract: A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference SWIR data sets is provided where each reference SWIR data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test SWIR data set. The test SWIR data set is compared to the plurality of reference SWIR data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state.

Abstract translation: 一种用于提供测试乳房样品的乳腺疾病状态诊断的系统和方法。 提供了包含多个参考SWIR数据集的数据库，其中每个参考SWIR数据集具有相关联的已知乳房样本和相关联的已知乳腺疾病状态。 用基本上单色的光照射测试乳房样品以产生散射的光子，得到测试SWIR数据集。 使用化学计量技术将测试SWIR数据集与多个参考SWIR数据集进行比较。 基于比较，提供了测试乳房样品的乳腺疾病状态的诊断。 乳腺疾病状态包括浸润性导管癌或侵袭性小叶癌疾病状态。

公开(公告)号：US07610170B2

公开(公告)日：2009-10-27

申请号：US11858442

申请日：2007-09-20

Applicant: Chun Hung Ko ,  Yi Sha Kuo ,  Chung Chu Chang

Inventor： Chun Hung Ko ,  Yi Sha Kuo ,  Chung Chu Chang

IPC: G06F19/00

CPC classification number: G01N21/47 ,  G01B21/08 ,  G01B21/20 ,  G01N21/211 ,  G01N2201/1296

Abstract: A method for improving the measurement capability of multi-parameter inspection systems includes performing a measuring procedure to acquire a measured signature of a sample, calculating weighting factors representing a correlation between structural parameters of the sample by using a weighting algorithm, transforming the weighting factors into a sampling function by using a transforming rule, updating the measured signature to form an updated measured signature and generating a plurality of updated nominal signatures according to the sampling function, and comparing the updated measured signature and the updated nominal signatures to determine the structural parameters of the sample.

Abstract translation: 一种用于提高多参数检测系统的测量能力的方法，包括执行测量程序以获取样本的测量签名，通过使用加权算法来计算表示样本的结构参数之间的相关性的加权因子，将加权因子转换成 通过使用变换规则的采样函数，更新测量的签名以形成更新的测量签名并根据采样函数生成多个更新的标称签名，以及比较更新的测量签名和更新的标称签名，以确定 例子。

公开(公告)号：US20090002702A1

公开(公告)日：2009-01-01

申请号：US12206467

申请日：2008-09-08

Applicant: John Maier ,  Shona Stewart ,  Jeffrey Cohen

Inventor： John Maier ,  Shona Stewart ,  Jeffrey Cohen

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/10 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/417 ,  A61B5/7264 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/2826 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656 ,  G01N2201/1293 ,  G01N2201/1296 ,  G02B21/365 ,  G06F19/00 ,  G16H50/70

Abstract: A system and method to provide a diagnosis of the renal disease state of a test renal sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known renal sample and an associated known renal disease state. A test renal sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a renal disease state of the test renal sample is provided. The renal disease state includes renal oncocytoma or chromophobe renal carcinoma disease state.

Abstract translation: 一种用于提供测试肾脏样本的肾脏疾病状态诊断的系统和方法。 提供了包含多个参考拉曼数据集的数据库，其中每个参考拉曼数据集具有相关联的已知肾脏样本和相关联的已知肾病状态。 用基本单色光照射测试肾脏样品，以产生散射光子，得到测试拉曼数据集。 使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。 基于比较，提供了测试肾脏样本的肾脏疾病状态的诊断。 肾脏疾病状态包括肾细胞瘤或发色团肾癌疾病状态。

公开(公告)号：US20080206804A1

公开(公告)日：2008-08-28

申请号：US12016051

申请日：2008-01-17

Applicant: Guillermo J. Tearney ,  Brett E. Bouma ,  Leilei Peng ,  Tayyaba Hasan ,  Sarika Verma

Inventor： Guillermo J. Tearney ,  Brett E. Bouma ,  Leilei Peng ,  Tayyaba Hasan ,  Sarika Verma

IPC: C12Q1/02 ,  C12M1/34 ,  G01N21/63 ,  G01N21/76

CPC classification number: G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/6489 ,  G01N33/582 ,  G01N2201/1296

Abstract: Exemplary embodiments of arrangements and methods providing information associated with a sample are described. For example, using such exemplary arrangements and methods, it is possible to receive an unpartitioned electro-magnetic radiation from the sample. Further, first data associated with first luminescent characteristics of at least one first molecule of the sample and second data associated with second luminescent characteristics of at least one second molecule of the sample can be obtained based on the unpartitioned electro-magnetic radiation. At least two of the photo-luminescent properties of the sample may be measured simultaneously as a function of the first and second data. Further, the information regarding the molecules of the sample may be determined as a function of the photo-luminescent properties.

Abstract translation: 描述了提供与样本相关联的信息的布置和方法的示例性实施例。 例如，使用这样的示例性布置和方法，可以从样品接收未分割的电磁辐射。 此外，可以基于未分割的电磁辐射获得与样品的至少一个第一分子的第一发光特性相关联的第一数据和与样品的至少一个第二分子的第二发光特性相关的第二数据。 可以同时测量样品的至少两种光致发光性质作为第一和第二数据的函数。 此外，关于样品分子的信息可以根据光致发光性质来确定。

公开(公告)号：US07292949B2

公开(公告)日：2007-11-06

申请号：US10856883

申请日：2004-06-01

Applicant: Feng Ding

Inventor： Feng Ding

IPC: G01N21/00 ,  G01N21/88 ,  G01J3/00 ,  G01J3/46

CPC classification number: B07C5/14 ,  G01J3/462 ,  G01N21/25 ,  G01N21/3554 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/55 ,  G01N21/85 ,  G01N21/8986 ,  G01N33/343 ,  G01N33/46 ,  G01N2201/1296 ,  Y10T428/31957

Abstract: Method and apparatus for estimating surface moisture content of wood chips employing a surface moisture measurement obtained from a non-contact surface moisture sensor, which measurement is calibrated with values of a set of optical parameters, such as HSL color camera signals, representing light reflection characteristics of the wood chips in order to estimate the surface moisture content thereof.

Abstract translation: 使用从非接触表面水分传感器获得的表面水分测量来估计木片的表面含水量的方法和装置，该测量用诸如HSL彩色照相机信号的一组值的值进行校准，其表示光反射特性 的木屑以估计其表面含水量。

公开(公告)号：US20070065857A1

公开(公告)日：2007-03-22

申请号：US11520753

申请日：2006-09-14

Applicant: John Glaser ,  Kenneth Copenhaver ,  George May

Inventor： John Glaser ,  Kenneth Copenhaver ,  George May

IPC: C12Q1/68

CPC classification number: G01N21/3563 ,  G01N21/314 ,  G01N21/359 ,  G01N21/4738 ,  G01N2021/3155 ,  G01N2021/8466 ,  G01N2201/1296

Abstract: A system is provided to monitor targeted pest populations, disease, presence of transgenic and non-transgenic plants, or targeted pest population in a transgenic crop using remote imagery to discern differences in crops along with pest infestation in all crop varieties. The system relies on the fact that plant leaves are known to change color based on stress, herbivory, and other environmental factors. The system provides a special camera that can see reflected light energy across the visible and near infrared (about 400-1000 nm) to identify these effects.

Abstract translation: 提供一个系统来监测目标害虫种群，疾病，转基因植物或非转基因植物的存在，或转基因作物中的目标有害生物种群，使用遥感图像来鉴别作物与所有作物品种的虫害相关的差异。 系统依赖于植物叶片基于胁迫，食草和其他环境因素改变颜色的事实。 该系统提供了一个特殊的相机，可以看到可见光和近红外（约400-1000 nm）的反射光能量来识别这些影响。

公开(公告)号：US20070019199A1

公开(公告)日：2007-01-25

申请号：US11493020

申请日：2006-07-25

Applicant: Gregory Palmer ,  Nirmala Ramanujam

Inventor： Gregory Palmer ,  Nirmala Ramanujam

IPC: G01N21/47

CPC classification number: G01N21/4738 ,  G01N2021/4742 ,  G01N2021/4752 ,  G01N2201/1296

Abstract: The presently disclosed subject matter provides methods, systems, and computer program products for optimizing a probe geometry for spectroscopic measurement in a turbid medium. According to one method, a probe geometry comprising one emitting entity for emitting electromagnetic radiation into a turbid medium and at least on collecting entity for collecting the electromagnetic radiation that has interacted with the turbid medium is selected. A simulation is performed with inputs of the probe geometry and a plurality of sets of optical property values associated with the turbid medium to generate output comprising optical parameter values measured by the probe geometry for each set of input optical property values. The measured optical parameter values are input to an inversion algorithm to produce corresponding optical properties as output. The produced optical properties are compared with optical properties known to correspond to the measured optical parameter values and a degree of matching between the produced optical properties and the known optical properties is determined. The simulation and inversion steps are repeated for a plurality of additional probe geometries. Each additional probe geometry differs from the previously tested probe geometry in at least one property. The property may be a quantity of collecting entities, a diameter of at least one emitting or collecting entity, a linear between the emitting and collecting entities, or combinations thereof. An optimization algorithm is applied at each iteration to select a probe geometry such that the resulting degree of matching will converge to an optimum value. An optimal geometry is selected based on the degree of matching determined for each geometry.

Abstract translation: 目前公开的主题提供了用于优化用于在混浊介质中进行光谱测量的探针几何形状的方法，系统和计算机程序产品。 根据一种方法，选择包括用于将电磁辐射发射到混浊介质中的至少一个发射实体的探针几何形状，并且至少在用于收集与混浊介质相互作用的电磁辐射的收集体上。 使用探针几何的输入和与浑浊介质相关联的多组光学性质值的输入来执行模拟，以产生包括由每组输入光学性质值由探针几何测量的光学参数值的输出。 测量的光学参数值被输入到反演算法中以产生相应的光学特性作为输出。 将所产生的光学性质与已知对应于测量的光学参数值的光学性质进行比较，并且确定所产生的光学性质和已知的光学性质之间的匹配程度。 对于多个额外的探针几何形状，重复模拟和反转步骤。 每个附加的探针几何与至少一个属性中先前测试的探针几何不同。 该属性可以是一定数量的收集实体，至少一个发射或收集实体的直径，发射和收集实体之间的线性，或其组合。 在每个迭代中应用优化算法来选择探针几何，使得所得到的匹配度将会收敛到最佳值。 基于为每个几何确定的匹配程度来选择最佳几何。

公开(公告)号：US20040199079A1

公开(公告)日：2004-10-07

申请号：US10407848

申请日：2003-04-03

Applicant: The Regents of the University of California ,  The University of Southern California

Inventor： Roy S. Chuck ,  Peter J. McDonnell ,  Ramez Emile Necola Shehada

IPC: A61B006/00

CPC classification number: A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/411 ,  A61B5/441 ,  A61B5/7267 ,  G01J3/4406 ,  G01N21/64 ,  G01N21/6402 ,  G01N21/6408 ,  G01N21/645 ,  G01N21/718 ,  G01N2021/1782 ,  G01N2021/6417 ,  G01N2201/06113 ,  G01N2201/0633 ,  G01N2201/0697 ,  G01N2201/1296

Abstract: Methods and systems for the quantitative and qualitative determination of one or more exogenous substances within a material are described. A flow of fluorescence-exciting/ablative energy (e.g., laser pulse(s), preferably in the ultraviolet region (e.g. 193-nm)), is directed onto the material to ablate a thin layer (e.g. null0.3-nullm) of the material using photochemical decomposition. Simultaneously, the laser energy induces the fluorescence of the substance(s) of interest within the ablated layer of the material. The fluorescence emitted by the substance(s) of interest is then received by a device (e.g., a spectrometer), which measures the spectrum (i.e. intensity versus wavelength) of the received fluorescence. The fluorescence spectra are then transmitted to a spectral processing device (e.g., a microprocessor or computer) which is programmed or otherwise adapted to determine, on the basis of the fluorescence spectra, whether the substance(s) of interest is/are present in the material and/or the concentration at which the substance(s) of interest is/are present in the material. This process may be repeated for each layer of the material to determine the concentration gradient of the substance(s) of interest in the material.

Abstract translation: 描述了用于定量和定性测定材料内的一种或多种外源物质的方法和系统。 荧光激发/消融能量（例如，激光脉冲，优选在紫外区域（例如193nm））的流动被引导到材料上以消融薄层（例如≈0.3μm） 材料使用光化学分解。 同时，激光能量在材料的烧蚀层内感应感兴趣的物质的荧光。 由感兴趣的物质发射的荧光然后由测量接收的荧光的光谱（即强度对波长）的装置（例如，光谱仪）接收。 然后将荧光光谱传输到频谱处理装置（例如，微处理器或计算机），该处理装置被编程或以其他方式适应于基于荧光光谱来确定目的物质是否存在于 材料和/或感兴趣物质存在于材料中的浓度。 可以针对材料的每层重复该过程以确定材料中感兴趣的物质的浓度梯度。