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    Method for producing 2-(5-fluoro-2-nitrophenyl)-2-substituted acetate derivative
    152.
    发明专利
    Method for producing 2-(5-fluoro-2-nitrophenyl)-2-substituted acetate derivative 有权
    2-（5-氟-2-硝基苯基）-2-取代的乙酸酯衍生物的制备方法

    公开(公告)号：JP2004203767A

    公开(公告)日：2004-07-22

    申请号：JP2002373496

    申请日：2002-12-25

    Applicant: Ube Ind Ltd ,  宇部興産株式会社

    Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  TAKAHASHI TAKESHI ,  OKADA NAOKO ,  ODA HIROYUKI

    IPC: C07C201/14 ,  C07C205/56 ,  C07C253/30 ,  C07C255/41

    Abstract: PROBLEM TO BE SOLVED: To provide an industrially suitable method for producing a 2-(5-fluoro-2-nitrophenyl)-2-substituted acetate derivative, by which the 2-(5-fluoro-2-nitrophenyl)-2-substituted acetic ester derivative can be produced from a 2,4-difluoronitobenzene derivative in a high yield by the simple method.
    SOLUTION: This method for producing a 2-(5-fluoro-2-nitrophenyl)-2-substituted acetic ester derivative is characterized by reacting a 2,4-difluoronitrobenzene derivative with 2-mono-substituted acetic ester derivative in the presence of a metal alkoxide in an organic solvent at -25 to 15°C.
    COPYRIGHT: (C)2004,JPO&NCIPI

    Abstract translation: 待解决的问题：为了提供工业上合适的2-（5-氟-2-硝基苯基）-2-取代的乙酸酯衍生物的制备方法，通过该方法将2-（5-氟-2-硝基苯基）-2- 2-取代的乙酸酯衍生物可以通过简单的方法从2,4-二氟代苯衍生物以高产率制备。 解决方案：该2-（5-氟-2-硝基苯基）-2-取代的乙酸酯衍生物的制备方法的特征在于使2,4-二氟硝基苯衍生物与2-单取代的乙酸酯衍生物在 金属醇盐在-25至15℃下在有机溶剂中的存在。 版权所有（C）2004，JPO＆NCIPI

    PRODUCTION OF 3-METHYL-4-NITROBENZOIC ACID
    155.
    发明专利
    PRODUCTION OF 3-METHYL-4-NITROBENZOIC ACID 失效

    公开(公告)号：JP2001011026A

    公开(公告)日：2001-01-16

    申请号：JP18948499

    申请日：1999-07-02

    Applicant: FUSO CHEMICAL CO LTD

    Inventor： KIDA HIROYUKI ,  HAMAMURA KOICHI ,  NIIJIMA TOMOYUKI

    IPC: B01J31/04 ,  C07B61/00 ,  C07C201/14 ,  C07C205/57

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound in high yield by oxidizing nitroxylene in a lower fatty acid solvent in the presence of a cobalt catalyst and an initiator with an oxygen-containing gas. SOLUTION: This compound of formula II is obtained by oxidizing (A) 4- nitro-m-xylene of formula I in (B) a fatty acid solvent e.g. acetic acid, propionic acid or butyric acid in the presence of (C) a cobalt catalyst e.g. cobalt naphthenate, cobalt acetylacetonate or lower fatty acid cobalt salt such as cobalt acetate and (D) an initiator e.g. 2-butanone, 4-methyl-2-pentanone or acetaldehyde with (E) an oxygen-containing gas (e.g. air). In above mentioned reaction, it is preferable to use 1.0-5 weight times component B, 0.001-0.2 mol times component C and 0.5-3.0 mol times component D based on the component A.

    PRODUCTION OF PARA-NITROBENZOIC ACID
    156.
    发明专利
    PRODUCTION OF PARA-NITROBENZOIC ACID 失效

    公开(公告)号：JPH09165358A

    公开(公告)日：1997-06-24

    申请号：JP34714195

    申请日：1995-12-15

    Applicant: KANAGAWA PREFECTURE

    Inventor： SATOU ROU ,  KIMURA KOICHI ,  HOSOI KIYOSHI

    IPC: C07C201/14 ,  C07B61/00 ,  C07C205/57

    Abstract: PROBLEM TO BE SOLVED: To produce p-nitrobenzoic acid with a single reaction step in high selectivity by heating a styrene-based polymer and nitric acid in the presence of a compound containing a metallic atom. SOLUTION: p-Nitrobenzoic acid is produced by heating (A) a styrene-based polymer and (B) nitric acid in the presence of (C) a compound containing a metallic atom (e.g. manganese dioxide, chromium oxide, iron oxide, cobalt oxide, copper hydroxide or cobalt chloride). The component B may be used in combination with (D) acetic acid. The concentration of the component B is preferably 20-100wt.%, more preferably 30-90wt.%, especially 40-80wt.%. In the case of using the component D, the weight ratio of the component D to the component B is preferably 10-500%, more preferably 20-300%, especially 50-200%.

    PRODUCTION OF ALLYLQUINONE DERIVATIVE AND INTERMEDIATE
    158.
    发明专利
    PRODUCTION OF ALLYLQUINONE DERIVATIVE AND INTERMEDIATE 失效

    公开(公告)号：JPH07291902A

    公开(公告)日：1995-11-07

    申请号：JP29963794

    申请日：1994-12-02

    Applicant: EISAI KAGAKU KK

    Inventor： HAMAMURA KICHISABURO ,  SEKI CHIAKI ,  KONISHI YUSUKE

    IPC: A61K31/12 ,  A61K31/122 ,  A61P3/08 ,  B01J27/25 ,  C07B61/00 ,  C07C201/12 ,  C07C201/14 ,  C07C205/37

    Abstract: PURPOSE:To provide a method for producing a quinone derivative as an intermediate for producing a chromone derivative useful as a medicine such as a hypoglycemic agent in a high yield, safely and industrially. CONSTITUTION:(A) A hydroquinone derivative of formula I (R is H, an aliphatic acyl or an aromatic acyl) as a novel compound is oxidized with air, 2,3- dichloro-5,6-dicyano-1,4-benzoquinone or chloranil in the presence of manganese dioxide, ammonium ceric nitrate, chromic anhydride, nitric acid, air or lithium chloride and cupric chloride or (B) an acylhydroquinone of formula II (R is an aliphatic acyl or aromatic acyl) is hydrolyzed with a Claisen alkali and oxidized to provide a quinone derivative of the formula III. The compound of the formula I is obtained by reacting a trimethylhydroquinone derivative of the formula IV with a primary allyl derivative derivative of the formula V or a tertiary alcohol derivative of the formula VI.

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