公开(公告)号：WO2007109137A1

公开(公告)日：2007-09-27

申请号：PCT/US2007/006637

申请日：2007-03-15

Applicant: WORCESTER POLYTECHNIC INSTITUTE ,  CORNWELL, Kevin, G. ,  PINS, George, D. ,  BILLIAR, Kristen

Inventor： CORNWELL, Kevin, G. ,  PINS, George, D. ,  BILLIAR, Kristen

IPC: A61L27/56

CPC classification number: A61L27/225 ,  A61K38/363 ,  A61L31/046 ,  A61L2300/252 ,  A61L2400/04 ,  A61L2430/34

Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.

Abstract translation: 提供包含纤维蛋白微丝的组合物。 组合物可以包括一种或多种治疗剂，包括细胞因子和白介素，细胞外基质蛋白和/或其生物活性片段（例如，含RGD的肽），激素，维生素，核酸，化学治疗剂，抗生素和细胞。 还提供了制备包含纤维蛋白微丝的组合物的方法。 还提供了使用组合物修复或改善损坏或缺陷的器官或组织的方法。

公开(公告)号：WO2007059265A3

公开(公告)日：2007-05-24

申请号：PCT/US2006/044460

申请日：2006-11-15

Applicant: WORCESTER POLYTECHNIC INSTITUTE ,  MCGIMPSEY, W., Grant

Inventor： MCGIMPSEY, W., Grant

IPC: C12M1/34

Abstract: The present invention is directed, at least in part, to methods for imagewise patterning of a surface. Such patterned surfaces can be used, e.g., in microfluidic devices. Accordingly, the present invention is also directed, at least in part, to nanopatterned devices which include a microchannel structure and methods for forming such devices.

公开(公告)号：WO1994004459A1

公开(公告)日：1994-03-03

申请号：PCT/US1993007751

申请日：1993-08-18

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： WORCESTER POLYTECHNIC INSTITUTE ,  MOSER, William, R.

IPC: C01B13/36

CPC classification number: B82Y30/00 ,  C01B13/36 ,  C01F7/34 ,  C01G23/006 ,  C01G25/02 ,  C01P2004/04 ,  C01P2004/50 ,  C01P2004/64

Abstract: A process for the preparation of nanophase solid state materials having crystallite morphology and particle sizes in the range of from about 1 nm to 30 nm is disclosed. Novel nanophase solid state materials are also disclosed.

Abstract translation: 公开了一种制备具有约1nm至30nm范围内的微晶形态和粒度的纳米相固体材料的方法。 还公开了新型纳米相固体材料。

公开(公告)号：WO1994000584A2

公开(公告)日：1994-01-06

申请号：PCT/US1993005950

申请日：1993-06-22

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： WORCESTER POLYTECHNIC INSTITUTE ,  WEATHERS, Pamela, J. ,  CHEETHAM, Ronald, D. ,  DiIORIO, Alexander

IPC: C12N15/82

CPC classification number: C07D493/20 ,  C12N5/04 ,  C12N15/8205 ,  C12P17/181

Abstract: A method of transforming Artemisia annua with Agrobacterium rhizogenes. More particularly, a method for producing an Agrobacterium rhyzogenes hairy root cell culture of Artemisia annua. The method of transformation of A. annua includes the transformation of whole plants with A. rhyzogenes, and also includes transformation of A. annua root cultures with A. rhizogenes. The present invention also relates to transformed A. annua. The present invention also relates to a method for extracting enhanced amounts of a plant secondary metabolite from plant tissue with limited loss of tissue viability by reversibly permeabilizing the tissue membrane is disclosed.

Abstract translation: 用发根农杆菌转化青蒿的方法。 更具体地说，涉及一种用于生产艾蒿的根癌土壤杆菌毛根细胞培养物的方法。 A. annua的转化方法包括用A. rhyzogenes转化整株植物，还包括A.Anua根培养物与A.nizogenes的转化。 本发明还涉及转化的A. annua。 本发明还涉及一种从植物组织中提取增加量的植物次生代谢物的方法，其中通过可逆地透化组织膜来限制组织活力的丧失。

公开(公告)号：WO1993000424A1

公开(公告)日：1993-01-07

申请号：PCT/US1992005211

申请日：1992-06-19

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： WORCESTER POLYTECHNIC INSTITUTE ,  WEATHERS, Pamela, J. ,  CHEETHAM, Ronald, D. ,  DIIORIO, Alexander

IPC: C12N05/04

CPC classification number: C12N5/04 ,  C12P17/181

Abstract: A process for extracting enhanced amounts of a plant secondary metabolite from plant tissue with limited loss of tissue viability by reversibly permeabilizing the tissue membrane is disclosed.

Abstract translation: 公开了一种通过可逆地渗透组织膜从植物组织中提取增加量的植物次生代谢物的方法，其中有限的组织活力丧失。

公开(公告)号：WO1991015992A1

公开(公告)日：1991-10-31

申请号：PCT/US1991002633

申请日：1991-04-17

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： WORCESTER POLYTECHNIC INSTITUTE ,  HARJUNMAA, Hannu ,  PEURA, Robert, A. ,  MENDELSON, Yitzhak

IPC: A61B05/00

CPC classification number: A61B5/1455 ,  A61B5/14532

Abstract: A non-invasive system for measuring the concentration of an analyte in an absorbing matrix is described. The system directs a beam of radiation at the matrix. The beam consists of a series of successive alternate pulses of electro-magnetic radiation, one of which is highly absorbed by the analyte and the other of which is non-absorbed. The transmitted or reflected beam is optically detected and an electrical signal proportional to beam intensity is used to adjust the beam intensity and as a measure of analyte concentration.

公开(公告)号：WO2023044020A1

公开(公告)日：2023-03-23

申请号：PCT/US2022/043825

申请日：2022-09-16

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： SHUE, Craig ,  HARRISON, Lane

IPC: G06F21/53 ,  G06F21/31 ,  G06F9/455 ,  G06F21/44

Abstract: Embodiments of the innovation relate to a server device, comprising a controller having a memory and a processor, the controller configured to establish a first secure environment with a client device, the first secure environment having an associated server asset policy; provide the asset to the client device via the first secure environment; receive a request from the client device, via the first secure environment, to utilize the asset with a user-selected application according to a user-selected asset policy; establish a second secure environment with the client device, the second secure environment having the user-selected application and the associated user-selected asset policy and the second secure environment isolated from the first secure environment; and provide the asset to the client device via the second secure environment.

公开(公告)号：WO2023039277A1

公开(公告)日：2023-03-16

申请号：PCT/US2022/043301

申请日：2022-09-13

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： SCARLATA, Suzanne F. ,  GRIMM, Ronald L. ,  RAHBAR, Nima ,  GILCHRIST, Rebecca

IPC: C04B24/40 ,  C04B40/06 ,  B01J31/16 ,  C04B111/00

Abstract: Methods and compositions are described for concrete repair using a non-naturally occurring or a synthetic catalyst. The catalyst includes an aromatic hydrocarbon having an active zinc ion configured to facilitate interaction between carbon dioxide and water and to precipitate concrete repairing calcium carbonate crystals. The catalyst is an analog of zinc cyclen, zinc and an indole-based molecule, and zinc tris(2-pyridylmethyl)amine (TPA).

公开(公告)号：WO2022232389A1

公开(公告)日：2022-11-03

申请号：PCT/US2022/026727

申请日：2022-04-28

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： HEIGHTON, Carolyn ,  GAUDETTE, Logan ,  KALESHIAN, Gregory ,  HOLM, Camden ,  BONARRIGO, Paul ,  PINS, George ,  MAGIT, David ,  PHANEUF, Matthew ,  LONG, Nathaniel ,  KASSAB, Rayan

IPC: A61F2/08 ,  A61L27/56 ,  A61L27/54 ,  A61L27/24 ,  A61L27/36

Abstract: A ligament repair device and method is particularly suited to the demands of UCL repair using a scaffold device for surgical implantation across a torn ligament section. The implantable device includes an encapsulation of a therapeutic element for increasing cell proliferation and growth eluted through a controlled release storage element adapted to release the therapeutic agent over time as the cell growth progresses and the scaffold structure degrades or is absorbed in favor of the new cell growth for ligament repair. Reduced recovery time is afforded by the need for only an relatively small incision for implantation. The introduction of a physiologically relevant drug delivery scaffold encourages more rapid cell growth over passive, physical repairs to the connective tissue.

公开(公告)号：WO2022212803A1

公开(公告)日：2022-10-06

申请号：PCT/US2022/022982

申请日：2022-04-01

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： ARNOLD, Andrea ,  FICHERA, Loris

IPC: A61B18/20 ,  A61B18/00 ,  A61B2018/00636 ,  A61N2005/0659 ,  A61N5/067

Abstract: A method of assessing optical properties of surgical tissue by observing the tissue thermal response to laser irradiation includes exposing the tissue in a surgical region to a short laser pulse for triggering a localized temperature increase, and observing the triggered temperature increase by a thermal sensor. Optical properties of the tissue are then estimated, for determining laser surgery parameters for an eminent procedure, based on the observed temperature increase. In an example configuration, the thermal sensor is a thermal infrared camera, and estimation includes using an Ensemble Kalman Filter (EnKF) for comparing the temperature sensor data with the output of a computational laser-tissue interaction model.