公开(公告)号：PL338144A1

公开(公告)日：2000-09-25

申请号：PL33814498

申请日：1998-07-07

Applicant: BASF AG

Inventor： JANSSEN BERND ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  ZIERKE THOMAS ,  KLING ANDREAS

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K7/06 ,  C12P19/34

Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L  (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

公开(公告)号：SK187999A3

公开(公告)日：2000-09-12

申请号：SK187999

申请日：1998-07-07

Applicant: BASF AG

Inventor： JANSSEN BERND ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  ZIERKE THOMAS ,  KLING ANDREAS

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K7/06 ,  C12P19/34

Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L  (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

公开(公告)号：CZ62099A3

公开(公告)日：2000-05-17

申请号：CZ62099

申请日：1997-08-21

Applicant: BASF AG

Inventor： SCHAFER BERND ,  ZIERKE THOMAS

IPC: C07B43/00 ,  C07D213/78 ,  C07D271/06 ,  C07D401/12 ,  C07D413/12

公开(公告)号：DE59507755D1

公开(公告)日：2000-03-09

申请号：DE59507755

申请日：1995-11-25

Applicant: BASF AG

Inventor： BOEHM HANS JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61P7/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087

公开(公告)号：AU715743B2

公开(公告)日：2000-02-10

申请号：AU4299797

申请日：1997-08-21

Applicant: BASF AG

Inventor： SCHAFER BERND ,  ZIERKE THOMAS

IPC: C07D213/81 ,  C07B43/00 ,  C07C257/10 ,  C07D213/73 ,  C07D213/78 ,  C07D271/06 ,  C07D401/12 ,  C07D413/12 ,  C07K1/06 ,  C07K5/062

Abstract: A process for preparing amidines and their salts with inorganic or organic acids comprises reacting the corresponding nitrile with ammonia, C1-C6-alkylamine or hydrazine in the presence of a mercaptocarboxylic acid and in the presence or absence of an in-organic or organic ammonium salt.

公开(公告)号：ZA9806358B

公开(公告)日：2000-01-17

申请号：ZA9806358

申请日：1998-07-17

Applicant: BASF AG

Inventor： JANSSEN BERND ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  ZIERKE THOMAS ,  KLING ANDREAS

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K7/06 ,  C12P19/34 ,  C07K ,  A61K

CPC classification number: C07K7/06 ,  A61K38/00 ,  C12P19/34

公开(公告)号：NO20000231L

公开(公告)日：2000-01-17

申请号：NO20000231

申请日：2000-01-17

Applicant: BASF AG

Inventor： JANSSEN BERND ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  ZIERKE THOMAS ,  KLING ANDREAS

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K7/06 ,  C12P19/34 ,  C07K

Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L  (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

公开(公告)号：PL331330A1

公开(公告)日：1999-07-05

申请号：PL33133097

申请日：1997-07-14

Applicant: BASF AG

Inventor： MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS ,  BALKENHOHL FRIEDHELM ,  LANGE UDO

IPC: C12P17/04 ,  C07D207/22 ,  C07D401/12 ,  C12P17/10

Abstract: PCT No. PCT/EP97/03752 Sec. 371 Date Jan. 22, 1999 Sec. 102(e) Date Jan. 22, 1999 PCT Filed Jul. 14, 1997 PCT Pub. No. WO98/04523 PCT Pub. Date Feb. 5, 19983-Pyrroline-2-carboxylic acid derivatives of the formula I are prepared by eliminating the sulfonic acid residue, with the aid of a base, from a compound of the formula II

公开(公告)号：CZ9900311A3

公开(公告)日：1999-06-16

申请号：CZ31199

申请日：1997-07-29

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  PFEIFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED GOLDENER

IPC: A61K31/40 ,  A61K31/44 ,  A61K38/00 ,  A61P1/18 ,  A61P7/02 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07D207/22 ,  C07D211/78 ,  C07K5/00 ,  C07K5/02 ,  C07K5/083 ,  A61K38/02

CPC classification number: C07K5/0222 ,  A61K38/00 ,  C07D207/22 ,  C07D211/78 ,  Y02P20/55

公开(公告)号：AU704270B2

公开(公告)日：1999-04-15

申请号：AU6615596

申请日：1996-07-12

Applicant: BASF AG

Inventor： BUSCHMANN ERNST ,  ZIERKE THOMAS

IPC: C07C231/02 ,  C07C237/02 ,  C07K1/06 ,  C07K1/08 ,  C07K7/06

Abstract: PCT No. PCT/EP96/03075 Sec. 371 Date Jan. 20, 1998 Sec. 102(e) Date Jan. 20, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/05096 PCT Pub. Date Feb. 13, 1997A process for preparing alpha -(N,N-dialkylamino) carboxamides of the formula I where the substituents have the stated meanings, comprises reacting the corresponding free acids with primary or secondary amines in the presence of anhydrides of an alkanephosphonic acid.