SYSTEM AND METHOD FOR NON-INVASIVE MEASUREMENT OF ANALYTES IN VIVO

    公开(公告)号:US20230314220A1

    公开(公告)日:2023-10-05

    申请号:US18312730

    申请日:2023-05-05

    Abstract: A system for non-invasively interrogating an in vivo sample for measurement of analytes comprises a pulse sensor coupled to the in vivo sample for detect a blood pulse of the sample and for generating a corresponding pulse signal, a laser generator for generating a laser radiation having a wavelength, power and diameter, the laser radiation being directed toward the sample to elicit Raman signals, a laser controller adapted to activate the laser generator, a spectrometer situated to receive the Raman signals and to generate analyte spectral data; and a computing device coupled to the pulse sensor, laser controller and spectrometer which is adapted to correlate the spectral data with the pulse signal based on timing data received from the laser controller in order to isolate spectral components from analytes within the blood of the sample from spectral components from analytes arising from non-blood components of the sample.

    Spectral reading using synchronized LED sources

    公开(公告)号:US09927299B2

    公开(公告)日:2018-03-27

    申请号:US15377772

    申请日:2016-12-13

    Abstract: A system for spectral reading includes a plurality of LEDs, an interface, and a processor. The plurality of LEDs are disposed in a physical array. Light from the plurality of LEDs is enabled to be collimated at a Fabry-Perot etalon. The interface is configured to receive a gap calibration table and power characteristics of a plurality of LEDs. The processor is configured to determine an LED switch table. The LED switch table indicates a set of the plurality of LEDs with power above a threshold at a plurality of wavelengths. The processor is further configured to cause measurement of a sample using the gap calibration table and the LED switch table for a set of gap values and determine measurement results.

    SPECTROMETER
    167.
    发明申请
    SPECTROMETER 审中-公开

    公开(公告)号:US20170211974A1

    公开(公告)日:2017-07-27

    申请号:US15328447

    申请日:2015-07-23

    Abstract: The present invention provides a spectrometer, comprising: an inlet for the receipt of incident light; an optical path for transmitting the incident light from the inlet to an analysis plane; a focusing element located along the optical path, wherein the spectrometer has an in-focus position in which a focal point of the spectrometer and the analysis plane coincide; and a controller adapted in use, when a removable light disperser is placed along the optical path, to cause the spectrometer to be in the in- focus position by controlling the position of the focusing element relative to the analysis plane. The spectrometer is used in the analysis of light from a light source and, due to the ability of the controller to manage the focus point by way of moving the focusing element, the spectrometer is able to bring itself into an in-focus configuration without the need for a user to intervene.

    CHARACTERIZATION OF ABSOLUTE SPECTRAL RADIANCE OF AN UNKNOWN IR SOURCE
    168.
    发明申请
    CHARACTERIZATION OF ABSOLUTE SPECTRAL RADIANCE OF AN UNKNOWN IR SOURCE 审中-公开
    表征未知红外光源的绝对光谱辐射

    公开(公告)号:US20160349113A1

    公开(公告)日:2016-12-01

    申请号:US14724247

    申请日:2015-05-28

    Inventor: Steven F. Cook

    CPC classification number: G01J3/453 G01J3/027 G01J3/0275 G01J5/522

    Abstract: The absolute spectral radiance of an unknown IR source is measured by bracketing the radiance measurements of the source over a spectral band with radiance measurements of a characterized blackbody at different temperatures. The absolute spectral radiance (or effective temperature) is calculated for the blackbody and paired with the relative radiance measurements. The absolute spectral radiance for the unknown IR source is derived via interpolation. The use of a characterized plate blackbody and a FTIRS allows for rapid and accurate characterization of the unknown IR source across a spectral band.

    Abstract translation: 未知红外光源的绝对光谱辐射度是通过在不同温度下通过在特征黑体的辐射测量的光谱带上包围光源的辐射度测量来测量的。 计算黑体的绝对光谱辐射度(或有效温度),并与相对辐射度测量值配对。 未知红外光源的绝对光谱辐射是通过插值得出的。 使用特征板黑体和FTIRS可以快速准确地表征光谱带上的未知红外源。

    Fourier transform infrared spectrophotometer
    169.
    发明授权
    Fourier transform infrared spectrophotometer 有权
    傅里叶变换红外分光光度计

    公开(公告)号:US09459150B2

    公开(公告)日:2016-10-04

    申请号:US14770849

    申请日:2013-02-28

    Inventor: Hisato Fukuda

    Abstract: A Fourier transform infrared spectrophotometer that is free from an effect of interference condition change resulting from an accessory being mounted and has a high measurement accuracy is provided. A Fourier transform infrared spectrophotometer according to the present invention is a Fourier transform infrared spectrophotometer including a common base on which a sample chamber 2 and an interference optical system are mounted, where an accessory 20 can be detachably in the sample chamber, the Fourier transform infrared spectrophotometer including: accessory information reading means 22 for reading accessory information provided to the accessory 20 when the accessory 20 is mounted in the sample chamber 2; and setting condition changing means (controller 30) for changing a setting condition for the interference optical system based on the accessory information read by the accessory information reading means 22, the setting condition varying depending on, e.g., a difference in weight between respective accessories 20.

    Abstract translation: 提供了一种傅立叶变换红外分光光度计,其不受由安装的附件引起的干扰条件变化的影响并具有高测量精度。 根据本发明的傅里叶变换红外分光光度计是一种傅里叶变换红外分光光度计,其包括:共用基底,其上安装有样品室2和干涉光学系统,其中附件20可拆卸地在样品室中,傅里叶变换红外 分光光度计包括:附件信息读取装置22,用于当附件20安装在样品室2中时,读取附件信息; 以及用于根据由附件信息读取装置22读取的附件信息来改变干涉光学系统的设置条件的设置条件改变装置(控制器30),该设置条件根据例如各个附件20之间的重量差异而变化 。

    HIGH SPEED SPECTROSCOPIC SENSOR ASSEMBLY AND SYSTEM
    170.
    发明申请
    HIGH SPEED SPECTROSCOPIC SENSOR ASSEMBLY AND SYSTEM 有权
    高速光谱传感器组件和系统

    公开(公告)号:US20160178434A1

    公开(公告)日:2016-06-23

    申请号:US14909213

    申请日:2014-07-31

    Applicant: TSI, INC.

    Abstract: A laser-based spectroscopy system that combines a distance/proximity standoff sensor, a high-repetition rate laser spectroscopy system, and software with a decision-making algorithm embedded in a processing unit which in combination performs selective firing of the laser when the target object is within an interrogation zone. In a related embodiment, the system provides selective sorting of spectroscopic signals based on information from the standoff signal and from information contained in the spectral signals themselves. The laser emission can be actively controlled while keeping the laser firing, thereby preserving the thermal stability and hence the power of the laser; and the standoff sensor information and the spectral information can be combined to determine the proper relative weighting or importance of each piece of spectral information.

    Abstract translation: 一种基于激光的光谱系统,其将距离/接近距离传感器,高重复率激光光谱系统和软件与嵌入在处理单元中的决策算法组合,所述处理单元在目标物体上组合执行激光的选择性点火 在询问区内。 在相关实施例中,系统基于来自间隔信号的信息和从包含在频谱信号本身中的信息提供对光谱信号的选择性分类。 可以在保持激光烧制的同时主动地控制激光发射,从而保持激光的热稳定性和因此的功率; 并且可以组合对立传感器信息和光谱信息以确定每条光谱信息的适当的相对权重或重要性。

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