中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

299 records (took 0.025 seconds)

    161.
    发明专利
    失效

    公开(公告)号：JPS4432791B1

    公开(公告)日：1969-12-26

    申请号：JP6889666

    申请日：1966-10-21

    IPC: C07D201/06

    Ammonium Sulphate Production on Industrial Scale
    162.
    发明申请
    Ammonium Sulphate Production on Industrial Scale 有权

    公开(公告)号：US20230054797A1

    公开(公告)日：2023-02-23

    申请号：US17796631

    申请日：2021-02-04

    Applicant: CAP III B.V.

    Inventor： Johan Thomas Tinge ,  Jarno Martijn Westerhof ,  Olaf Poorter

    IPC: C01C1/242 ,  C07D201/06 ,  C07D201/16

    Abstract: The invention provides a process for the production of crystalline ammonium sulfate, wherein the process comprises performing a Beckmann rearrangement reaction, neutralizing the Beckmann rearrangement reaction mixture, separating a first aqueous ammonium sulfate phase and an aqueous ε-caprolactam phase, charging the first ammonium sulfate phase to a first evaporative type crystallization section wherein crystalline ammonium sulfate is obtained, discharging from the first evaporative type crystallization section mother liquor enriched in organic components, extracting the aqueous ε-caprolactam phase to obtain an extracted ε-caprolactam phase and a second aqueous ammonium sulfate phase, discharging the mother liquor that is discharged from the first evaporative type crystallization section and/or the second aqueous ammonium sulfate phase to a second evaporative type crystallization section wherein evaporative type crystallization is performed so that a three-phase system occurs. At least a liquid oily phase is recovered from the three-phase system. The invention further provides a plant suitable to carry out the process of the invention, crystalline ammonium sulfate and a liquid oily phase obtained by the process of the invention.

    Substituted naphthyridinyl hydrazines as anti-liver cancer agents
    165.
    发明授权
    Substituted naphthyridinyl hydrazines as anti-liver cancer agents 有权

    公开(公告)号：US09855255B1

    公开(公告)日：2018-01-02

    申请号：US15607397

    申请日：2017-05-26

    Applicant: KING SAUD UNIVERSITY

    Inventor： Nagy Mahmoud Hassan Khalifa ,  Mohamed A. Al-Omar ,  Abd El-Galil E. Amr

    IPC: C07D201/06 ,  A61K31/15 ,  A61K31/4375

    CPC classification number: A61K31/4375 ,  C07D201/06

    Abstract: The substituted naphthyridinyl hydrazine compounds as anti-liver cancer agents are anti-liver cancer agents that inhibit proliferative pathways of cancer cells, thereby exhibiting potent in vitro and in vivo anticancer activity. The compounds have the formula: wherein R1 and R2 each are selected independently from hydrogen, mercapto, and C1-C5-alkyl, preferably methyl, ethyl, propyl, isopropyl or halogen; R3 and R4 each are selected independently from hydrogen, alkyl or halogen; and R5 is selected from substituted or unsubstituted aryl, more preferably from substituted phenyl, naphthyl, and substituted or unsubstituted heteroaryl, more preferably from furyl, pyrrolyl, thienyl, imidazolyl, thiadiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, benzothiazolyl, oxadiazolyl or sugar moities. These agents exert their action through topoisomerase II inhibition.

Patent Agency Ranking