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    PROCESS FOR SYNTHESIZING $g(b)-LACTAM
    1.
    发明公开
    PROCESS FOR SYNTHESIZING $g(b)-LACTAM 有权
    方法合成的？内酰胺

    公开(公告)号：EP1346981A4

    公开(公告)日：2004-03-24

    申请号：EP01912138

    申请日：2001-03-07

    Applicant: NAT INST OF ADVANCED IND SCIEN

    Inventor： HATAKEDA KIYOTAKA ,  SATO OSAMU ,  KANAKUBO MITSUHIRO ,  IKUSHIMA YUTAKA ,  TORII KAZUO

    IPC: C07D205/08 ,  C07D201/08

    CPC classification number: C07D201/08 ,  Y02P20/582

    Abstract: A process for synthesizing a β-lactam in water at a high temperature under a high pressure; and a process for producing a β-lactam. Namely, a process for synthesizing a ß-lactam characterized by reacting aβ-amino acid in water at a high temperature under a high pressure, wherein the β-lactam is synthesized at a high rate by cyclizing the β-amino acid in water at a high temperature of 200 °C or more under a high pressure of 10 Mpa or more; and a process for producing a β-lactam characterized by synthesizing the β-lactam by reacting a β-amino acid in water at a high temperature under a high pressure and then separating and purifying the β-lactam with the use of a column separating agent.

    SUBSTRATE INTRODUCTION METHOD FOR REACTOR UNDER HIGH TEMPERATURE AND HIGH PRESSURE
    3.
    发明专利
    SUBSTRATE INTRODUCTION METHOD FOR REACTOR UNDER HIGH TEMPERATURE AND HIGH PRESSURE 失效

    公开(公告)号：JP2001269565A

    公开(公告)日：2001-10-02

    申请号：JP2000087581

    申请日：2000-03-27

    Applicant: NAT INST OF ADVANCED IND SCIEN

    Inventor： HATADA KIYOTAKA ,  IKUSHIMA YUTAKA ,  TORII KAZUO

    IPC: G01N30/56 ,  B01J3/02

    Abstract: PROBLEM TO BE SOLVED: To provide a substrate introduction method for a reactor under high temperature and high pressure. SOLUTION: A running reaction system is characterized by a constitution in which a means for stably introducing a substrate into a reactor under the high temperature and high pressure are added to the system, namely such means as a high pressure pump, the reactor, a pressure adjuster for adjusting the pressure inside a reaction system, a slurry feed tank, feed liquid balance coils for adjusting the flow rate of the liquid fed into the reactor and the slurry feed tank and and a screw for feeding slurry as constituting components, and a liquid flow is pressed into the reaction system with the high pressure pump to feed a liquid into the reactor and the slurry feed tank, and the pressure of the above feed lines (balance coils) is equalized by the adjustment carried out by the pressure adjuster so that the reaction system is adjusted not to generate the pressure fluctuation in the reaction system, and the substrate in the slurry feed tank is introduced into the reactor by rotating the slurry feed screw. Also, a substrate introduction method for the reactor by using the reaction system is provided.

    METHOD OF CONTINUOUSLY DEGRADING PROTEIN
    4.
    发明公开
    METHOD OF CONTINUOUSLY DEGRADING PROTEIN 审中-公开
    方法连续下降的蛋白质

    公开(公告)号：EP1312611A4

    公开(公告)日：2006-12-06

    申请号：EP00977971

    申请日：2000-11-28

    Applicant: NAT INST OF ADVANCED IND SCIEN

    Inventor： HATAKEDA KIYOTAKA ,  IKUSHIMA YUTAKA ,  MARUYAMA SUSUMU ,  TORII KAZUO

    IPC: C07C227/20 ,  C07K1/12 ,  A23J3/30 ,  A23L1/305 ,  A61K31/195 ,  C07C227/18 ,  C07C227/28 ,  C07C229/00 ,  C07C229/02 ,  C07C237/12 ,  C07C237/22 ,  C07K14/415 ,  C07K14/425 ,  G01N33/68

    CPC classification number: C07K1/12 ,  A23J3/30 ,  A23L33/175 ,  A23L33/18 ,  C07C227/18 ,  C07C227/28 ,  Y02P20/544 ,  C07C229/02

    Abstract: A method of continuously and quickly degrading a protein into peptides and/or amino acids in supercritical water or high-pressure hot water at around the supercritical point. Namely, a method of continuously and quickly producing peptides and/or amino acids from a protein which comprises using a flow-through type reactor consisting of a substrate-introducing line for supplying a substrate, a pre-heating oven for supplying high-pressure hot water, a reaction oven for heating a liquid reaction mixture and reacting the same and a cooling unit for cooling the liquid reaction mixture, and continuously hydrolyzing the substrate protein supplied into the reaction oven in supercritical water or high-pressure hot water at around the supercritical point under a pressure of 22.05 MPa or above and at a temperature of 375?C or above; and a method of continuously and quickly hydrolyzing a protein by the above-described process. By using this method, it is possible to obtain preparations which are substantially different from the products obtained by the batch method and contaminated with little secondary and tertiary reaction products. Thus, this method is highly useful particularly in, for example, production of physiologically active peptides and pretreatment for the evaluation and analysis of amino acid composition.

    TEMPERATURE-VARIABLE MAGNETIC RESONATOR
    6.
    发明专利
    TEMPERATURE-VARIABLE MAGNETIC RESONATOR 失效

    公开(公告)号：JP2001281314A

    公开(公告)日：2001-10-10

    申请号：JP2000090226

    申请日：2000-03-29

    Applicant: NAT INST OF ADVANCED IND SCIEN ,  NIKKISO CO LTD

    Inventor： KANAKUBO MITSUHISA ,  AIZAWA TAKASHI ,  IKUSHIMA YUTAKA ,  HACHINA JIYUNZOU ,  YAMAZAKI HIROMI ,  NAKAGAWA KAZUO

    IPC: G01R33/31

    Abstract: PROBLEM TO BE SOLVED: To provide a temperature-variable magnetic resonator capable of precisely controlling the sample temperature of a supercritical fluid, keeping the sample temperature of an observation area evenly, and changing the sample temperature in a short time. SOLUTION: This resonator is provided with a detection container formed into a cylinder having a central axis in the vertical direction for detecting a magnetic resonance signal of a sample and housing a fluid as a heating medium inside, a measurement sample housing part 7 arranged inside the fluid of the detection container and housing the sample for measurement, a plurality of heaters 9, 11 arranged in the vertically different positions inside the detection container, a plurality of temperature detectors 10, 12 arranged in compliance with the heaters and detecting temperature of the heaters or that of fluid around the heaters, and a temperature controlling means 14, 15 driving the heaters corresponding to the temperature detected by the temperature detectors and controlling the temperature to a predetermined temperature.

    9.
    发明专利
    未知

    公开(公告)号：DE60029284T2

    公开(公告)日：2007-07-05

    申请号：DE60029284

    申请日：2000-09-12

    Applicant: NAT INST OF ADVANCED IND SCIEN

    Inventor： IKUSHIMA YUTAKA ,  SATO OSAMU ,  HATAKEDA KIYOTAKA

    IPC: C07C29/147 ,  C07C33/22 ,  C07B61/00 ,  C07C27/00 ,  C07C27/04 ,  C07C29/14 ,  C07C51/16 ,  C07C51/235 ,  C07C51/295 ,  C07C63/06

    Abstract: The invention provides a method of increasing the reaction rate of an organic synthesis reaction by utilizing supply of OH from water in the absence of catalyst without adding a basic catalyst in supercritical water or subcritical water of at least 350 DEG C , and a method of generating alcohol and carboxylic acid with high reaction rate by performing a Cannizzaro reaction in the absence of catalyst without adding a basic catalyst in supercritical water, and to a method of synthesis of alcohol and carboxylic acid from an aldehyde in the absence of catalyst without adding a basic catalyst near the critical point (375 to 380 DEG C , 22.5 to 25 MPa) of supercritical water.

    10.
    发明专利
    未知

    公开(公告)号：DE60029284D1

    公开(公告)日：2006-08-24

    申请号：DE60029284

    申请日：2000-09-12

    Applicant: NAT INST OF ADVANCED IND SCIEN

    Inventor： IKUSHIMA YUTAKA ,  SATO OSAMU ,  HATAKEDA KIYOTAKA

    IPC: C07C29/147 ,  C07C33/22 ,  C07B61/00 ,  C07C27/00 ,  C07C27/04 ,  C07C29/14 ,  C07C51/16 ,  C07C51/235 ,  C07C51/295 ,  C07C63/06

    Abstract: The invention provides a method of increasing the reaction rate of an organic synthesis reaction by utilizing supply of OH from water in the absence of catalyst without adding a basic catalyst in supercritical water or subcritical water of at least 350 DEG C , and a method of generating alcohol and carboxylic acid with high reaction rate by performing a Cannizzaro reaction in the absence of catalyst without adding a basic catalyst in supercritical water, and to a method of synthesis of alcohol and carboxylic acid from an aldehyde in the absence of catalyst without adding a basic catalyst near the critical point (375 to 380 DEG C , 22.5 to 25 MPa) of supercritical water.

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