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171.发明申请公开(公告)号：US20180021457A1
公开(公告)日：2018-01-25
申请号：US15541784
申请日：2016-01-06
Inventor： Dong Wook KIM , Jin Soo KIM , Chul Yong PARK , Duk Hyoung KIM , Jung Eun KWEON , Ji Yeon KWEON
IPC: A61K48/00 , A61K35/545 , C12N5/074 , C12N15/11 , C12N9/22
CPC classification number: A61K48/005 , A61K35/12 , A61K35/545 , A61K48/00 , C07K14/755 , C12N5/0696 , C12N9/22 , C12N15/11 , C12N15/113 , C12N2310/20 , C12N2501/73 , C12N2506/09
Abstract: The present invention provides a method for inducing an inversion of normal blood coagulation factor VIII (F8) gene, a method for correcting an inversion of blood coagulation factor VIII gene in which the inversion has occurred, and a Hemophilia A patient-derived induced pluripotent stem cell in which the inversion is corrected, constructed using the same. The method of the present invention effectively reproduces the inversion of intron 1 and intron 22 of the F8 gene, which is responsible for the majority of severe hemophilia A, and thereby may be effectively used for studying the development mechanism of hemophilia A and as a research tool for screening therapeutic agents. The inversion-corrected induced pluripotent stem cell constructed according the method of the present invention enables an efficient and fundamental treatment for hemophilia A by restoring a genotype in which mutation has occurred to a wild type-like state, without limitation via normal gene or protein delivery.
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公开(公告)号：US20170349905A1
公开(公告)日：2017-12-07
申请号：US15527837
申请日：2015-11-19
Applicant: INSTITUTE FOR BASIC SCIENCE
Inventor： Jin Soo Kim , Tae Young Koo
IPC: C12N15/74 , C12N15/864 , C12N15/11 , C12N15/867 , C12N9/22
CPC classification number: C12N15/746 , C12N9/16 , C12N9/22 , C12N15/11 , C12N15/63 , C12N15/8645 , C12N15/867
Abstract: The present invention relates to a method for regulating gene expression, comprising introducing into a cell each of a recombinant vector which expresses a first domain comprising N-terminus of a Cas9 protein, and a recombinant vector which expresses a second domain comprising C-terminus of a Cas9 protein, a composition comprising the recombinant vectors, a kit for regulating gene expression, and a method for intracellular production of Cas9 protein. Moreover, the present invention relates to a transformed cell introduced with a viral vector which packages the first domain, and a viral vector which packages the second domain, and to a composition comprising a virus produced therefrom.
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公开(公告)号：US09827313B2
公开(公告)日：2017-11-28
申请号：US14670890
申请日：2015-03-27
Applicant: SNU R&DB FOUNDATION , Institute for Basic Science , The Catholic University of Korea Industry-Academic Cooperation Foundation
Inventor： Taeghwan Hyeon , Kun Na , Daishun Ling , Wooram Park , Sin-jung Park , Yang Lu , Kyoung Sub Kim , Michael J. Hackett , Byung Hyo Kim , Hyeona Yim , Yong Sun Jeon
CPC classification number: A61K41/0071 , A61K49/0036 , A61K49/0054 , A61K49/1857
Abstract: The present invention relates to a nanoformulated self-assembled pharmaceutical composition for photodynamic therapy. More particularly, the present invention is directed to a self-assembled pharmaceutical composition for photodynamic therapy comprising a photosensitizer, a ligand A which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range and a method for manufacturing the same.
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公开(公告)号：US20170321176A1
公开(公告)日：2017-11-09
申请号：US15525280
申请日：2015-11-09
Inventor： Daehyeong KIM , Seunghong CHOI , Taeghwan HYEON , Seokjoo KIM , Hyerim CHO , Kyoungwon CHO
IPC: C12M3/00 , B05D1/00 , B05D3/10 , C12M1/12 , C12M1/42 , G01N27/04 , C23C16/26 , C23C14/24 , C12M1/34 , C01B32/186 , B82Y30/00 , B82Y40/00
CPC classification number: C12M21/08 , B05D1/005 , B05D3/107 , B82Y30/00 , B82Y40/00 , C01B32/186 , C01B32/20 , C01B2204/06 , C12M1/42 , C12M3/00 , C12M25/14 , C12M35/02 , C12M41/12 , C12M41/36 , C23C14/06 , C23C14/24 , C23C16/26 , G01N27/04 , G01N33/4833 , Y10S977/734 , Y10S977/843 , Y10S977/923
Abstract: The present invention relates to a cell sheet manufacturing device and a manufacturing method therefor. More specifically, the present invention relates to a cell sheet manufacturing device comprising a support layer made of silicon rubber, a patterned electrode formed adjacent to the support layer and a graphene layer formed adjacent to the electrode, and a manufacturing method therefor.
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175.发明授权公开(公告)号：US09812333B2
公开(公告)日：2017-11-07
申请号：US14583492
申请日：2014-12-26
Inventor： Sang Ouk Kim , Hyoung-Seok Moon
IPC: H01L21/308 , B81C1/00 , H01L21/033 , H01L21/311 , H01L21/02
CPC classification number: H01L21/3086 , B81C1/00031 , B81C2201/0149 , H01L21/02178 , H01L21/0337 , H01L21/0338 , H01L21/31144 , Y10T428/24802
Abstract: Provided is a nanoscale patterning method using self-assembly, wherein nanoscale patterns having desirable shapes such as a lamella shape, a cylinder shape, and the like, may be formed by using a self-assembly property of a block copolymer, and low segment interaction caused in a structure of 10 nm or less which is a disadvantage of the block copolymer may be prevented. In addition, even though single photolithography is used, pattern density may double as that of the existing nano patterns, and pitch and cycle of the patterns may be controlled to thereby be largely utilized for electronic apparatuses requiring high integration of circuits such as a semiconductor device, and the like.
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Patent Agency Ranking
公开(公告)号：US09765187B2
公开(公告)日：2017-09-19
申请号：US14670805
申请日：2015-03-27
Applicant: SNU R&DB FOUNDATION , Institute for Basic Science , The Catholic University of Korea Industry-Academic Cooperation Foundation
Inventor： Taeghwan Hyeon , Kun Na , Daishun Ling , Wooram Park , Byung Hyo Kim , Hyeona Yim , Kyoung Sub Kim , Michael J. Hackett , Sin-jung Park , Yang Lu , Yong Sun Jeon
CPC classification number: C08G69/40 , A61K49/1857 , C08G69/08 , C08G81/00
Abstract: The present invention relates to MRI contrasting agent for contrasting cancer cell which contains ultrafine nanoparticles. More particularly, the present invention is directed to a self-assembled ligand composition comprising a ligand A, which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range, MRI contrast agent for contrasting cancer cell comprising said ligand composition and MRI contrasting nanoparticles, and the methods for preparing them.
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公开(公告)号：US20170256730A1
公开(公告)日：2017-09-07
申请号：US15519453
申请日：2015-07-22
Inventor： Daehyeong KIM , Taeghwan HYEON , Moonkee CHOI , Jiwoong YANG , Kwanghun KANG
CPC classification number: H01L51/502 , B41F9/00 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C09D11/037 , C09D11/50 , C09D11/52 , C09K11/883 , H01L51/0004 , H01L51/003 , H01L51/0035 , H01L51/0037 , H01L51/0039 , H01L51/0043 , H01L51/0097 , H01L51/5056 , H01L51/5072 , H01L51/5088 , H01L51/5092 , H01L51/5253 , H01L51/56 , H01L2251/301 , H01L2251/5338 , H01L2251/558 , H05B33/145 , Y02E10/549 , Y10S977/774 , Y10S977/824 , Y10S977/892 , Y10S977/95
Abstract: A quantum dot electronic device comprises a first encapsulation layer, a first electrode disposed on the first encapsulation layer, a quantum dot pattern disposed on the first electrode, a second electrode disposed on the quantum dot pattern and a second encapsulation layer disposed on the second electrode. The quantum dot pattern may be formed by an intaglio transfer printing method, where the method comprises forming a quantum dot layer on a donor substrate, picking up the quantum dot layer using a stamp, putting the quantum dot layer into contact with an intaglio substrate using the stamp and separating the stamp from the intaglio substrate. Using the quantum dot transfer printing method, a subminiature quantum dot pattern can be transferred at a high transfer rate. Accordingly, a highly integrated quantum dot electronic device exhibiting excellent performance and a high integrated quantum dot light emitting device with an ultrathin film can be realized.
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公开(公告)号：US09707548B2
公开(公告)日：2017-07-18
申请号：US15303710
申请日：2015-04-16
Inventor： Kimoon Kim , Gyeongwon Yun , Zahid Hassan , Jiyeong Lee , Jeehong Kim , Nam Hoon Kim , Kangkyun Baek , Iiha Hwang
IPC: B01J31/06 , C12Q1/70 , C12Q1/68 , G01N33/53 , C07F5/00 , C12M1/34 , C07D487/22 , C08J7/06 , C08J7/12 , B01J23/44 , B01J23/42 , B01J23/52 , B01J35/00 , B01J13/18 , B01J33/00 , B82Y30/00 , B01J37/16
CPC classification number: B01J23/52 , B01J13/14 , B01J13/18 , B01J13/20 , B01J23/42 , B01J23/44 , B01J31/06 , B01J33/00 , B01J35/002 , B01J35/0033 , B01J35/0086 , B01J35/02 , B01J35/023 , B01J37/0201 , B01J37/16 , B82Y30/00 , C08J7/06 , C08J7/12 , C08J2381/02
Abstract: Provided are a polymer capsule loaded with transition metal particles having excellent water dispersibility and stability, and a method for preparing the same. Specifically, the polymer capsule loaded with transition metal particles according to the present invention includes a surface-modified polymer capsule surface-modified to thereby have a positive zeta potential in a dispersed state in water; and transition metal particles loaded on a surface of the surface-modified polymer capsule. In addition, a method for preparing a polymer capsule loaded with transition metal particles according to the present invention includes a) preparing a polymer capsule; b) surface-modifying the polymer capsule to prepare a polymer capsule having a positive zeta potential in a dispersed state in water; and c) sequentially adding a water-soluble transition metal precursor and a reducing agent to a water dispersion of the surface-modified polymer capsule obtained in step b).
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179.发明申请公开(公告)号：US20170145040A1
公开(公告)日：2017-05-25
申请号：US15359474
申请日：2016-11-22
Inventor： Won Jong KIM , Jihoon KIM , Hyung Woo CHOI
CPC classification number: C07F7/1804 , A61K31/655 , A61K31/695 , A61K33/00 , A61K47/54 , A61K47/6923 , A61K47/6929 , B01J20/048 , B01J20/22 , B82Y5/00 , C01B21/24
Abstract: Provided is a method of controlling release of nitric oxide, and more particularly, to a method of selectively releasing nitric oxide depending on a change in pH using calcium phosphate.The method of selectively releasing nitric oxide according to the present invention may stably deliver nitric oxide to a desired site, and induce release of nitric oxide by a change in pH, thereby making it possible to improve a therapeutic effect while preventing a loss of nitric oxide.
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180.发明申请POLYMER CAPSULE HAVING LOADED THEREON TRANSITION METAL PARTICLES HAVING EXCELLENT WATER DISPERSIBILITY AND STABILITY, AND METHOD FOR PREPARING SAME 有权具有良好的水分散性和稳定性的具有负载的过渡金属颗粒的聚合物胶囊及其制备方法公开(公告)号：US20170028389A1
公开(公告)日：2017-02-02
申请号：US15303710
申请日：2015-04-16
Inventor： Kimoon KIM , Gyeongwon YUN , Zahid HASSAN , Jiyeong LEE , Jeehong KIM , Nam Hoon KIM , Kangkyun BAEK , Ilha HWANG
IPC: B01J31/06 , C08J7/12 , B01J23/44 , B01J13/18 , B01J23/52 , B01J35/00 , B01J35/02 , B01J37/16 , C08J7/06 , B01J23/42
CPC classification number: B01J23/52 , B01J13/14 , B01J13/18 , B01J13/20 , B01J23/42 , B01J23/44 , B01J31/06 , B01J33/00 , B01J35/002 , B01J35/0033 , B01J35/0086 , B01J35/02 , B01J35/023 , B01J37/0201 , B01J37/16 , B82Y30/00 , C08J7/06 , C08J7/12 , C08J2381/02
Abstract: Provided are a polymer capsule loaded with transition metal particles having excellent water dispersibility and stability, and a method for preparing the same. Specifically, the polymer capsule loaded with transition metal particles according to the present invention includes a surface-modified polymer capsule surface-modified to thereby have a positive zeta potential in a dispersed state in water; and transition metal particles loaded on a surface of the surface-modified polymer capsule. In addition, a method for preparing a polymer capsule loaded with transition metal particles according to the present invention includes a) preparing a polymer capsule; b) surface-modifying the polymer capsule to prepare a polymer capsule having a positive zeta potential in a dispersed state in water; and c) sequentially adding a water-soluble transition metal precursor and a reducing agent to a water dispersion of the surface-modified polymer capsule obtained in step b).
Abstract translation: 提供一种装载有具有优异的水分散性和稳定性的过渡金属颗粒的聚合物胶囊及其制备方法。 具体地说，根据本发明的装有过渡金属颗粒的聚合物胶囊包括表面改性的表面改性聚合物胶囊，从而在水中分散状态具有正的ζ电位; 以及负载在表面改性聚合物胶囊的表面上的过渡金属颗粒。 另外，本发明的负载有过渡金属粒子的聚合物胶囊的制备方法包括：a）制备聚合物胶囊; b）对聚合物胶囊进行表面改性以制备在水中具有分散状态的正ζ电位的聚合物胶囊; 和c）依次向步骤b）中获得的表面改性聚合物胶囊的水分散体中加入水溶性过渡金属前体和还原剂。
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